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Figure 8 | Molecular Medicine

Figure 8

From: AMP-Activated Protein Kinase and Glycogen Synthase Kinase 3β Modulate the Severity of Sepsis-induced Lung injury

Figure 8

Metformin diminishes sepsis-mediated immunosuppression. Mice were treated with saline, metformin, CLP or metformin and CLP for 24 h followed by i.t. instillation of P. aeruginosa (PAK, 2.5 × 107/mouse) for an additional 4 h. Next, amounts of surviving bacteria were determined in lung homogenates using CFU assay. (A,C) Representative images show the amounts of bacterial colonies grown on agar plates, whereas (B,D) show CFU data obtained from lung homogenates of control, metformin, CLP, or metformin and CLP mice. Panel (E) shows the amounts of bacteria in peritoneal lavages of mice treated with CLP or a combination of metformin and CLP for 7 d (means ± SD n = 5, *p < 0.05).

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