Figure 9

Lung histopathology of the lungs of control mice and mice immunized twice with NP and treated with or without TAK-779. Mice were immunized twice with NP and treated with or without TAK-779 as scheduled. Two weeks after TAK-779 cessation, mice were challenged with 10 LD50 of H1N1 (A/FM/1/47). At 3 d post-viral challenge, all infected mice displayed significant perivascular and peribronchial inflammation, pulmonary edema and necrotizing bronchitis. Forty fields were analyzed per group (> 5 fields/section, 2 sections/mouse). Representative sections are shown. The data were representative of 2 independent experiments with 5 mice per group.