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Figure 8 | Molecular Medicine

Figure 8

From: Mechanical Ventilation Augments Poly(I:C)-Induced Lung Injury via a WISP1-Integrin β3-Dependent Pathway in Mice

Figure 8

Effects of integrin β3 knockout on WISP1 plus poly(I:C)-induced TNF-α production in macrophages. Peritoneal macrophages isolated from C57BL/6J and integrin β3 knockout mice were treated with WISP1 (10 µg/mL) and poly(I:C) (5 µg/mL) for 16 h in serum free medium. TNF-α levels in the supernatant were measured by ELISA. Data are presented as mean ± SEM (n = 5) and compared by two-way ANOVA. ***P < 0.001 C57BL/6J versus integrin β3 knockout after WISP1 plus poly(I:C) treatment.

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Molecular Medicine

ISSN: 1528-3658