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Table 1 Overview of the study design.

From: Identification of Matrix Metalloproteinase-12 as a Candidate Molecule for Prevention and Treatment of Cardiometabolic Disease

Type of study

Species

Disease (model)

Tissue

Processing method

N° of samples

N° of genes/probe sets

Microarray

Mus musculus C57BL/6

Cardiovascular disease

Atherosclerotic tissue (aorta)

Expression Consoleâ„¢ Software (Benjamini-Hochberg correction)

3/3 Ldlr−/− (HSFC/CD)

26,995

Microarray

Mus musculus C57BL/6

Obesity and type 2 diabetes

Gonadal White adipose tissue

Expression Consoleâ„¢ Software (Benjamini-Hochberg-correction)

6/6 WT (HFD/CD)

26,995

Meta-analysis

Homo sapiens Mus musculus

Cardiovascular disease

Atherosclerotic tissue (coronary, carotid and aorta vasculatory tissue)

Bioconductor package MetaMA and Mixed Model (Benjamini-Hochberg-correction)

452

8,101

Meta-analysis

Homo sapiens Mus musculus Rattus norvegicus

Type 2 diabetes

Adipose tissue, liver, muscle, pancreatic islets, kidney and hypothalamus

Genome-wide association study (eGWAS) (Benjamini-Hochberg-correction)

1,175

24,898