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Table 2 List of the eight candidate genes ordered by the expression in the GWAT microarray selected as potential new targets.

From: Identification of Matrix Metalloproteinase-12 as a Candidate Molecule for Prevention and Treatment of Cardiometabolic Disease

  

Microarray (Fold change)

Meta-analysis

Gene name

Gene symbol

AortaA Ldlr−/− (HFSC) versus Ldlr−/− (CD)

GWAT WT (HFD) versus WT (CD)

Cardiovascular disease pVal

Type 2 diabetes pVal

Macrophage metalloelastase

MMP12/Mmp12

11.2

16.9

0.00232

0.00077

Triggering receptor expressed on myeloid cells 2

TREM2/Trem2

2.5

13.3

0.00067

0.01094

Macrophage-expressed gene 1 protein

MPEG1/Mpeg1

4.4

7.8

0.00097

0.00018

G protein-coupled receptor 137B

GPR137B/Gpr137b

2.0

5.7

0.03752

0.00298

Spleen tyrosine kinase

SYK/Syk

1.5

3.0

0.01389

0.00163

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B

MAFB/Mafb

-

2.7

0.00034

0.04552

Phospholipid transfer protein

PLTP/Pltp

1.4

2.3

0.04339

0.00107

Ribonucleoside-diphosphate reductase subunit M2

RRM2/Rrm2

-

1.8

0.04549

0.00726

  1. AThe aorta microarray experiment was not considered for gene selection, as no differentially expressed genes with an adjusted p < 0.05 was found.
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Molecular Medicine

ISSN: 1528-3658