Figure 3
From: A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia
Resurgent sodium current increased in NaV1.8-null TRG neurons expressing Met136Val channels. Representative traces of resurgent currents recorded from NaV1.8-null TRG neurons expressing either WT (A) or Met136Val (B) mutant channels. TRG neurons were held at −100 mV and depolarized to +30 mV for 20 ms, followed by repolarization to a range of pulses (−10 mV to −80 mV) to elicit resurgent current. (C) Average peak amplitudes of resurgent current recorded from WT (n = 12) and Met136Val (n = 15) show an average 60% increase in NaV1.8-null TRG neurons expressing Met136Val mutant channels. Data represent mean ± SE.