Figure 5
From: A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia
Spontaneous firing of TRG neurons transfected with Met136Val mutant channels. (A) Representative current-clamp traces of spontaneous firing in TRG neurons expressing Met136Val mutant channels. The traces were recorded for 30 s without current injection. (B) Expansion of a single action potential from a spontaneously firing cell expressing M136V channels shown in (A). (C) Bar graphs showing the proportion of spontaneous firing cells (orange) compared with evoked cells (gray) for TRG neurons expressing WT and Met136Val mutant channels. Numbers in the bar show the percentage values for WT and Met136Val mutant channels.