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Figure 5 | Molecular Medicine

Figure 5

From: miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria

Figure 5

miR-155 deficiency is associated with increased inflammation during P. berghei ANKA (PbA)-induced ECM. Median plasma protein levels of inflammatory cytokine markers in albino C57BL/6 miR-155−/− versus wild-type miR-155+/+ littermate controls on d 6 post-PbA infection (1 × 106 parasitized erythrocytes), measured by Cytometric Bead Array. IFN-γ, IL-6, MCP-1 and TNF:IL-10 ratio were all significantly higher in miR-155−/− versus wild-type PbA-infected mice (*P < 0.05, **P < 0.01, ****P < 0.0001; Mann-Whitney test; n = 23–25/group). Experiment was repeated for confirmation of findings. Error bars represent interquartile range. Abbreviations: IFN-γ, interferon-gamma; TNF, tumor necrosis factor; IL-6, interleukin-6; MCP-1, monocyte chemotactic-1; IL-10, interleukin-10.

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