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Figure 6 | Molecular Medicine

Figure 6

From: The Multi-target Effects of CNI-1493: Convergence of Antiamylodogenic and Antiinflammatory Properties in Animal Models of Alzheimer’s Disease

Figure 6

C1213 attenuates Aβ-induced cognitive deficits and reduces Aβ plaque volume in CRND8 transgenic mice. (A–C) An object location task was performed with Veh- and C1213-treated CRND8 mice. (A) Both treatment groups showed equivalent object exploration times in the test trial. (B) C1213-treated mice displayed preferential examination of the object moved to a novel location and (C) a significantly enhanced recognition index. (D–E) Immunohistochemical analysis of Aβ plaques in CRND8 mice. (D) Treatment with C1213 significantly reduced Aβ plaque volume while (E) plaque number remained unchanged. * P < 0.05; ** P < 0.01; *** P < 0.001. n.s., not significant.

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