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Figure 1 | Molecular Medicine

Figure 1

From: Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver Failure

Figure 1

Dynamic Bayesian Network (DBN) analysis of circulating inflammatory mediators in PALF patients. Circulating inflammatory mediators in serum samples from PALF spontaneous survivors (S, n = 61 patients), nonsurvivors (NS, n = 12 patients) and liver transplant recipients (LTx, n = 28 patients) were measured and DBN analysis was performed, as described in Materials and Methods. Inflammatory mediators are shown as nodes, and the arrows connecting them suggest an influence of one mediator on the one(s) it is connected to. The arrows do not distinguish positive from negative influences. Semicircular arrows suggest either positive or negative feedback of a given mediator on itself.

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