Figure 2From: Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver FailureDynamic network analysis (DyNA) of circulating inflammatory mediators in PALF patients. Circulating inflammatory mediators in serum samples from PALF spontaneous survivors (S, n = 61 patients), nonsurvivors (NS, n = 12 patients) and liver transplant recipients (LTx, n = 28 patients) were measured and DyNA (stringency level = 0.95) was performed during seven time frames, d 0–1, d 1–2, d 2–3, d 3–4, d 4–5, d 5–6, d 6–7, as described in Materials and Methods. Panel A shows an overview of all the networks and mediator connections (closed circles represent mediators with at least one connection to another mediator; open circles represent mediators that had no connections to other mediators as determined by DyNA). Panel B represents the total number of connections for each group of patients over all time intervals. Panel C shows the network complexity for each group of patients during each of the seven time frames calculated, as described in Materials and Methods.Back to article page