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Figure 2 | Molecular Medicine

Figure 2

From: Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver Failure

Figure 2

Dynamic network analysis (DyNA) of circulating inflammatory mediators in PALF patients. Circulating inflammatory mediators in serum samples from PALF spontaneous survivors (S, n = 61 patients), nonsurvivors (NS, n = 12 patients) and liver transplant recipients (LTx, n = 28 patients) were measured and DyNA (stringency level = 0.95) was performed during seven time frames, d 0–1, d 1–2, d 2–3, d 3–4, d 4–5, d 5–6, d 6–7, as described in Materials and Methods. Panel A shows an overview of all the networks and mediator connections (closed circles represent mediators with at least one connection to another mediator; open circles represent mediators that had no connections to other mediators as determined by DyNA). Panel B represents the total number of connections for each group of patients over all time intervals. Panel C shows the network complexity for each group of patients during each of the seven time frames calculated, as described in Materials and Methods.

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