Figure 8
From: Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery
(A)Fasudil reverses LPS-induced vascular leakage and ROS production. Fasudil has an EC50 of 3.852 µM. (B, C) Fasudil mitigates LPS-induced vascular leakage and the resulting leakage of FITC-dextran and its accumulation at the tail fin (an average of 3 trials of 10 larvae/treatment). (D, E) Fasudil also rescued LPS-induced ROS production at the tail fin (an average of 3 trials of 3 larvae/treatment) and (F) LPS-induced reduction of ROS in the swim bladder (an average of 3 trials of 3 larvae/treatment).