Figure 2

Correlation of ADO levels with diagnosis and ISS stage. HPLC analysis of ADO levels in plasma obtained from BM aspirates from 39 patients at different stages of disease. (A) Median ADO levels from five patients with MGUS (median = 56.70 µmol/L; range: 42.29–85.90 µmol/L), 13 with SMM (median = 42.00 µmol/L; range: 18.40–87.39 µmol/L) and 21 with MM (median = 69.88 µmol/L; range: 22.00–210.84 µmol/L). (B) ADO levels in BM plasma from symptomatic MM patients, compared by ISS staging. Median ADO levels from eight patients with MM ISS I–II (median = 59.57 µmol/L; range: 39.26–107.8 µmol/L) and 13 with MM ISS III (median = 110.30 µmol/L; range: 22.00–210.84 µmol/L). The P value was calculated using the Mann-Whitney U test.