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Figure 1 | Molecular Medicine

Figure 1

From: Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol

Figure 1

Dietary cholesterol in soybean oil diet enhanced NASH activity score, liver triglycerides and liver cholesterol. Mice were fed a standard diet (STD), soybean oil diet (SOD), soybean oil diet + 0.75% cholesterol (SOD + Cho) or lard diet + fructose in drinking water (LAD + Fru) for 20 wks. (A) Representative microphotographs of liver histology, magnification 20 ×. P: portal tract. (B) NASH activity score grading steatosis, ballooning (hypertrophy), inflammation and fibrosis. (C) Liver triglyceride and (D) liver cholesterol content per mg protein. Values represent (B) single score values and median per group or (C,D) mean ± standard error of the mean of 5 mice per group. Statistics: (B) Mann-Whitney U test, *p <0.05. (C, D) One-way analysis of variance with Dunnett’s post hoc test or, where appropriate, Tukey’s post hoc test for multiple comparisons, *p <0.05.

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