Figure 4
From: Cathepsin L Promotes Vascular Intimal Hyperplasia after Arterial Injury
An illustration of potential mechanisms in injury-induced vascular intimal hyperplasia is depicted. We propose that IH is driven, in part, by TLR4 -MyD88 signaling on macrophages and cathepsin L pathway responding to injured and stressed cells in the vessel wall. SQV can be a potential therapeutic drug to inhibit cathepsin L activity and IH. For detailed discussion of the pathways, please see the text. (+ indicates stimulatory effect; — I indicates inhibitory effect)