TY - JOUR AU - Singer, M. PY - 2016 DA - 2016// TI - The third international consensus definitions for sepsis and septic shock (Sepsis-3) JO - JAMA VL - 315 UR - https://doi.org/10.1001/jama.2016.0287 DO - 10.1001/jama.2016.0287 ID - Singer2016 ER - TY - JOUR AU - Shankar-Hari, M. PY - 2016 DA - 2016// TI - Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3) JO - JAMA VL - 315 UR - https://doi.org/10.1001/jama.2016.0289 DO - 10.1001/jama.2016.0289 ID - Shankar-Hari2016 ER - TY - JOUR AU - Gaieski, D. F. AU - Edwards, J. M. AU - Kallan, M. J. AU - Carr, B. G. PY - 2013 DA - 2013// TI - Benchmarking the incidence and mortality of severe sepsis in the United States JO - Crit. Care Med. VL - 41 UR - https://doi.org/10.1097/CCM.0b013e31827c09f8 DO - 10.1097/CCM.0b013e31827c09f8 ID - Gaieski2013 ER - TY - JOUR AU - Rhodes, A. PY - 2017 DA - 2017// TI - Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 JO - Crit. Care Med. VL - 45 UR - https://doi.org/10.1097/CCM.0000000000002255 DO - 10.1097/CCM.0000000000002255 ID - Rhodes2017 ER - TY - JOUR AU - Mittal, R. AU - Coopersmith, C. M. PY - 2014 DA - 2014// TI - Redefining the gut as the motor of critical illness JO - Trends Mol. Med. VL - 20 UR - https://doi.org/10.1016/j.molmed.2013.08.004 DO - 10.1016/j.molmed.2013.08.004 ID - Mittal2014 ER - TY - JOUR AU - Klingensmith, N. J. AU - Coopersmith, C. M. PY - 2016 DA - 2016// TI - The gut as the motor of multiple organ dysfunction in critical illness JO - Crit Care Clin. VL - 32 UR - https://doi.org/10.1016/j.ccc.2015.11.004 DO - 10.1016/j.ccc.2015.11.004 ID - Klingensmith2016 ER - TY - JOUR AU - Carrico, C. J. AU - Meakins, J. L. AU - Marshall, J. C. AU - Fry, D. AU - Maier, R. V. PY - 1986 DA - 1986// TI - Multiple-organ-failure syndrome. The gastrointestinal tract: the “motor” of MOF JO - Arch. Surg. VL - 121 UR - https://doi.org/10.1001/archsurg.1986.01400020082010 DO - 10.1001/archsurg.1986.01400020082010 ID - Carrico1986 ER - TY - JOUR AU - Sertaridou, E. AU - Papaioannou, V. AU - Kolios, G. AU - Pneumatikos, I. PY - 2015 DA - 2015// TI - Gut failure in critical care: old school versus new school JO - Ann. Gastroenterol. VL - 28 ID - Sertaridou2015 ER - TY - JOUR AU - Clark, J. A. AU - Coopersmith, C. M. PY - 2007 DA - 2007// TI - Intestinal crosstalk: a new paradigm for understanding the gut as the “motor” of critical illness JO - Shock VL - 28 UR - https://doi.org/10.1097/shk.0b013e31805569df DO - 10.1097/shk.0b013e31805569df ID - Clark2007 ER - TY - STD TI - Fay KT, Ford ML, Coopersmith CM. (2017) The intestinal microenvironment in sepsis. Biochim. Biophys. Acta. ID - ref10 ER - TY - JOUR AU - Lyons, J. D. AU - Coopersmith, C. M. PY - 2017 DA - 2017// TI - Pathophysiology of the Gut and the Microbiome in the Host Response JO - Pediatr. Crit. Care Med. VL - 18 UR - https://doi.org/10.1097/PCC.0000000000001046 DO - 10.1097/PCC.0000000000001046 ID - Lyons2017 ER - TY - JOUR AU - Clark, J. A. AU - Clark, A. T. AU - Hotchkiss, R. S. AU - Buchman, T. G. AU - Coopersmith, C. M. PY - 2008 DA - 2008// TI - Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis JO - Shock VL - 30 UR - https://doi.org/10.1097/SHK.0b013e31815D0820 DO - 10.1097/SHK.0b013e31815D0820 ID - Clark2008 ER - TY - JOUR AU - Clark, J. A. AU - Gan, H. AU - Samocha, A. J. AU - Fox, A. C. AU - Buchman, T. G. AU - Coopersmith, C. M. PY - 2009 DA - 2009// TI - Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis JO - Am. J. Physiol Gastrointest. Liver Physiol VL - 297 UR - https://doi.org/10.1152/ajpgi.00012.2009 DO - 10.1152/ajpgi.00012.2009 ID - Clark2009 ER - TY - JOUR AU - Coopersmith, C. M. PY - 2002 DA - 2002// TI - Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice JO - Crit. Care Med. VL - 30 UR - https://doi.org/10.1097/00003246-200201000-00028 DO - 10.1097/00003246-200201000-00028 ID - Coopersmith2002 ER - TY - JOUR AU - Coopersmith, C. M. PY - 2003 DA - 2003// TI - Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest JO - Crit. Care Med. VL - 31 UR - https://doi.org/10.1097/01.CCM.0000055385.29232.11 DO - 10.1097/01.CCM.0000055385.29232.11 ID - Coopersmith2003 ER - TY - JOUR AU - Dominguez, J. A. PY - 2013 DA - 2013// TI - Inhibition of IKKbeta in enterocytes exacerbates sepsis-induced intestinal injury and worsens mortality JO - Crit. Care Med. VL - 41 UR - https://doi.org/10.1097/CCM.0b013e31828a44ed DO - 10.1097/CCM.0b013e31828a44ed ID - Dominguez2013 ER - TY - JOUR AU - Liang, Z. PY - 2014 DA - 2014// TI - Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice JO - PLoS. ONE. VL - 9 UR - https://doi.org/10.1371/journal.pone.0101828 DO - 10.1371/journal.pone.0101828 ID - Liang2014 ER - TY - STD TI - Yoseph BP, et al. (2016) Mechanisms of intestinal barrier dysfunction in sepsis. Shock. In press. ID - ref18 ER - TY - JOUR AU - Fink, M. P. PY - 2003 DA - 2003// TI - Intestinal epithelial hyperpermeability: update on the pathogenesis of gut mucosal barrier dysfunction in critical illness JO - Curr. Opin. Crit Care VL - 9 UR - https://doi.org/10.1097/00075198-200304000-00011 DO - 10.1097/00075198-200304000-00011 ID - Fink2003 ER - TY - JOUR AU - Klaus, D. A. PY - 2013 DA - 2013// TI - Increased plasma zonulin in patients with sepsis JO - Biochem. Med. (Zagreb.) VL - 23 UR - https://doi.org/10.11613/BM.2013.013 DO - 10.11613/BM.2013.013 ID - Klaus2013 ER - TY - JOUR AU - Li, Q. AU - Zhang, Q. AU - Wang, C. AU - Liu, X. AU - Li, N. AU - Li, J. PY - 2009 DA - 2009// TI - Disruption of tight junctions during polymicrobial sepsis in vivo JO - J. Pathol. VL - 218 UR - https://doi.org/10.1002/path.2525 DO - 10.1002/path.2525 ID - Li2009 ER - TY - JOUR AU - Moore, F. A. PY - 1991 DA - 1991// TI - Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma JO - J. Trauma VL - 31 UR - https://doi.org/10.1097/00005373-199105000-00006 DO - 10.1097/00005373-199105000-00006 ID - Moore1991 ER - TY - JOUR AU - Alverdy, J. C. AU - Laughlin, R. S. AU - Wu, L. PY - 2003 DA - 2003// TI - Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined JO - Crit. Care Med. VL - 31 UR - https://doi.org/10.1097/01.CCM.0000045576.55937.67 DO - 10.1097/01.CCM.0000045576.55937.67 ID - Alverdy2003 ER - TY - JOUR AU - Krezalek, M. A. AU - Defazio, J. AU - Zaborina, O. AU - Zaborin, A. AU - Alverdy, J. C. PY - 2016 DA - 2016// TI - The shift of an intestinal “microbiome” to a “pathobiome” governs the course and outcome of sepsis gollowing surgical injury JO - Shock VL - 45 UR - https://doi.org/10.1097/SHK.0000000000000534 DO - 10.1097/SHK.0000000000000534 ID - Krezalek2016 ER - TY - JOUR AU - Odenwald, M. A. AU - Turner, J. R. PY - 2013 DA - 2013// TI - Intestinal permeability defects: is it time to treat? JO - Clin. Gastroenterol. Hepatol. VL - 11 UR - https://doi.org/10.1016/j.cgh.2013.07.001 DO - 10.1016/j.cgh.2013.07.001 ID - Odenwald2013 ER - TY - JOUR AU - Nalle, S. C. PY - 2014 DA - 2014// TI - Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease JO - Sci. Transl. Med. VL - 6 UR - https://doi.org/10.1126/scitranslmed.3008941 DO - 10.1126/scitranslmed.3008941 ID - Nalle2014 ER - TY - JOUR AU - Turner, J. R. PY - 2009 DA - 2009// TI - Intestinal mucosal barrier function in health and disease JO - Nat. Rev. Immunol. VL - 9 UR - https://doi.org/10.1038/nri2653 DO - 10.1038/nri2653 ID - Turner2009 ER - TY - JOUR AU - Dominguez, J. A. PY - 2011 DA - 2011// TI - Epidermal growth factor improves survival and prevents intestinal injury in a murine model of pseudomonas aeruginosa pneumonia JO - Shock VL - 36 UR - https://doi.org/10.1097/SHK.0b013e31822793c4 DO - 10.1097/SHK.0b013e31822793c4 ID - Dominguez2011 ER - TY - JOUR AU - Chen, C. AU - Wang, P. AU - Su, Q. AU - Wang, S. AU - Wang, F. PY - 2012 DA - 2012// TI - Myosin light chain kinase mediates intestinal barrier disruption following burn injury JO - PLoS ONE VL - 7 UR - https://doi.org/10.1371/journal.pone.0034946 DO - 10.1371/journal.pone.0034946 ID - Chen2012 ER - TY - JOUR AU - Barreau, F. AU - Hugot, J. P. PY - 2014 DA - 2014// TI - Intestinal barrier dysfunction triggered by invasive bacteria JO - Curr. Opin. Microbiol. VL - 17 UR - https://doi.org/10.1016/j.mib.2013.12.003 DO - 10.1016/j.mib.2013.12.003 ID - Barreau2014 ER - TY - JOUR AU - Herrmann, J. R. AU - Turner, J. R. PY - 2016 DA - 2016// TI - Beyond Ussing’s chambers: contemporary thoughts on integration of transepithelial transport JO - Am. J. Physiol. Cell Physiol VL - 310 UR - https://doi.org/10.1152/ajpcell.00348.2015 DO - 10.1152/ajpcell.00348.2015 ID - Herrmann2016 ER - TY - JOUR AU - Khounlotham, M. PY - 2012 DA - 2012// TI - Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis JO - Immunity VL - 37 UR - https://doi.org/10.1016/j.immuni.2012.06.017 DO - 10.1016/j.immuni.2012.06.017 ID - Khounlotham2012 ER - TY - JOUR AU - Laukoetter, M. G. PY - 2007 DA - 2007// TI - JAM-A regulates permeability and inflammation in the intestine in vivo JO - J. Exp. Med. VL - 204 UR - https://doi.org/10.1084/jem.20071416 DO - 10.1084/jem.20071416 ID - Laukoetter2007 ER - TY - JOUR AU - Shen, L. AU - Weber, C. R. AU - Raleigh, D. R. AU - Yu, D. AU - Turner, J. R. PY - 2011 DA - 2011// TI - Tight junction pore and leak pathways: a dynamic duo JO - Annu. Rev. Physiol VL - 73 UR - https://doi.org/10.1146/annurev-physiol-012110-142150 DO - 10.1146/annurev-physiol-012110-142150 ID - Shen2011 ER - TY - JOUR AU - Cunningham, K. E. AU - Turner, J. R. PY - 2012 DA - 2012// TI - Myosin light chain kinase: pulling the strings of epithelial tight junction function JO - Ann. N.Y. Acad. Sci. VL - 1258 UR - https://doi.org/10.1111/j.1749-6632.2012.06526.x DO - 10.1111/j.1749-6632.2012.06526.x ID - Cunningham2012 ER - TY - JOUR AU - Jung, C. PY - 2012 DA - 2012// TI - Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling JO - J. Clin. Invest VL - 122 UR - https://doi.org/10.1172/JCI58147 DO - 10.1172/JCI58147 ID - Jung2012 ER - TY - JOUR AU - Meinzer, U. PY - 2012 DA - 2012// TI - Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction JO - Cell Host Microbe. VL - 11 UR - https://doi.org/10.1016/j.chom.2012.02.009 DO - 10.1016/j.chom.2012.02.009 ID - Meinzer2012 ER - TY - JOUR AU - Zahs, A. PY - 2012 DA - 2012// TI - Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury JO - Am. J. Physiol Gastrointest. Liver Physiol. VL - 303 UR - https://doi.org/10.1152/ajpgi.00157.2012 DO - 10.1152/ajpgi.00157.2012 ID - Zahs2012 ER - TY - JOUR AU - Shen, L. PY - 2012 DA - 2012// TI - Tight junctions on the move: molecular mechanisms for epithelial barrier regulation JO - Ann. N.Y. Acad. Sci. VL - 1258 UR - https://doi.org/10.1111/j.1749-6632.2012.06613.x DO - 10.1111/j.1749-6632.2012.06613.x ID - Shen2012 ER - TY - JOUR AU - Yu, D. PY - 2010 DA - 2010// TI - MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function JO - Proc. Natl. Acad. Sci. U.S.A. VL - 107 UR - https://doi.org/10.1073/pnas.0908869107 DO - 10.1073/pnas.0908869107 ID - Yu2010 ER - TY - JOUR AU - Zolotarevsky, Y. PY - 2002 DA - 2002// TI - A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease JO - Gastroenterology VL - 123 UR - https://doi.org/10.1053/gast.2002.34235 DO - 10.1053/gast.2002.34235 ID - Zolotarevsky2002 ER - TY - JOUR AU - Yuhan, R. AU - Koutsouris, A. AU - Savkovic, S. D. AU - Hecht, G. PY - 1997 DA - 1997// TI - Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability JO - Gastroenterology VL - 113 UR - https://doi.org/10.1016/S0016-5085(97)70006-4 DO - 10.1016/S0016-5085(97)70006-4 ID - Yuhan1997 ER - TY - JOUR AU - Clayburgh, D. R. PY - 2005 DA - 2005// TI - Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo JO - J. Clin. Invest. VL - 115 UR - https://doi.org/10.1172/JCI24970 DO - 10.1172/JCI24970 ID - Clayburgh2005 ER - TY - JOUR AU - Rittirsch, D. AU - Huber-Lang, M. S. AU - Flierl, M. A. AU - Ward, P. A. PY - 2009 DA - 2009// TI - Immunodesign of experimental sepsis by cecal ligation and puncture JO - Nat. Protoc. VL - 4 UR - https://doi.org/10.1038/nprot.2008.214 DO - 10.1038/nprot.2008.214 ID - Rittirsch2009 ER - TY - JOUR AU - Dellinger, R. P. PY - 2013 DA - 2013// TI - Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012 JO - Crit. Care Med. VL - 41 UR - https://doi.org/10.1097/CCM.0b013e31827e83af DO - 10.1097/CCM.0b013e31827e83af ID - Dellinger2013 ER - TY - JOUR AU - Vyas, D. PY - 2007 DA - 2007// TI - Epithelial apoptosis in mechanistically distinct methods of injury in the murine small intestine JO - Histol. Histopathol. VL - 22 ID - Vyas2007 ER - TY - JOUR AU - Lyons, J. D. PY - 2016 DA - 2016// TI - Murine lung cancer increases CD4+ T cell apoptosis and decreases gut proliferative capacity in sepsis JO - PLoS ONE VL - 11 UR - https://doi.org/10.1371/journal.pone.0149069 DO - 10.1371/journal.pone.0149069 ID - Lyons2016 ER - TY - JOUR AU - Noto, M. J. AU - Becker, K. W. AU - Boyd, K. L. AU - Schmidt, A. M. AU - Skaar, E. P. PY - 2017 DA - 2017// TI - RAGE-mediated suppression of interleukin-10 results in enhanced mortality in a murine model of cinetobacter baumannii sepsis JO - Infect. Immun. VL - 85 UR - https://doi.org/10.1128/IAI.00954-16 DO - 10.1128/IAI.00954-16 ID - Noto2017 ER - TY - JOUR AU - Hotchkiss, R. S. AU - Sherwood, E. R. PY - 2015 DA - 2015// TI - Immunology. Getting sepsis therapy right JO - Science VL - 347 UR - https://doi.org/10.1126/science.aaa8334 DO - 10.1126/science.aaa8334 ID - Hotchkiss2015 ER - TY - JOUR AU - Bruewer, M. PY - 2003 DA - 2003// TI - Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms JO - J. Immunol. VL - 171 UR - https://doi.org/10.4049/jimmunol.171.11.6164 DO - 10.4049/jimmunol.171.11.6164 ID - Bruewer2003 ER - TY - JOUR AU - Abreu, M. T. AU - Palladino, A. A. AU - Arnold, E. T. AU - Kwon, R. S. AU - McRoberts, J. A. PY - 2000 DA - 2000// TI - Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cells JO - Gastroenterology VL - 119 UR - https://doi.org/10.1053/gast.2000.20232 DO - 10.1053/gast.2000.20232 ID - Abreu2000 ER - TY - JOUR AU - Chin, A. C. AU - Flynn, A. N. AU - Fedwick, J. P. AU - Buret, A. G. PY - 2006 DA - 2006// TI - The role of caspase-3 in lipopolysaccharidemediated disruption of intestinal epithelial tight junctions JO - Can. J. Physiol. Pharmacol. VL - 84 UR - https://doi.org/10.1139/y06-056 DO - 10.1139/y06-056 ID - Chin2006 ER - TY - JOUR AU - Xiao, Y. T. AU - Yan, W. H. AU - Cao, Y. AU - Yan, J. K. AU - Cai, W. PY - 2016 DA - 2016// TI - Neutralization of IL-6 and TNF-alpha ameliorates intestinal permeability in DSS-induced colitis JO - Cytokine. VL - 83 UR - https://doi.org/10.1016/j.cyto.2016.04.012 DO - 10.1016/j.cyto.2016.04.012 ID - Xiao2016 ER - TY - JOUR AU - McDonald, D. PY - 2016 DA - 2016// TI - Extreme dysbiosis of the microbiome in critical illness JO - mSphere VL - 1 UR - https://doi.org/10.1128/mSphere.00199-16 DO - 10.1128/mSphere.00199-16 ID - McDonald2016 ER - TY - JOUR AU - Tamura, A. PY - 2011 DA - 2011// TI - Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine JO - Gastroenterology VL - 140 UR - https://doi.org/10.1053/j.gastro.2010.08.006 DO - 10.1053/j.gastro.2010.08.006 ID - Tamura2011 ER - TY - JOUR AU - Suzuki, H. PY - 2014 DA - 2014// TI - Crystal structure of a claudin provides insight into the architecture of tight junctions JO - Science VL - 344 UR - https://doi.org/10.1126/science.1248571 DO - 10.1126/science.1248571 ID - Suzuki2014 ER - TY - JOUR AU - Feng, L. PY - 2016 DA - 2016// TI - Deficiency of dietary niacin impaired intestinal mucosal immune function via regulating intestinal NF-kappaB, Nrf2 and MLCK signaling pathways in young grass carp (Ctenopharyngodon idella) JO - Fish Shellfish Immunol. VL - 49 UR - https://doi.org/10.1016/j.fsi.2015.12.015 DO - 10.1016/j.fsi.2015.12.015 ID - Feng2016 ER - TY - JOUR AU - Du, J. PY - 2015 DA - 2015// TI - 1,25-Dihydroxy vitamin D protects intestinal epithelial barrier by regulating the myosin light chain kinase signaling pathway JO - Inflamm. Bowel. Dis. VL - 21 UR - https://doi.org/10.1097/MIB.0000000000000526 DO - 10.1097/MIB.0000000000000526 ID - Du2015 ER - TY - JOUR AU - Deitch, E. A. PY - 2010 DA - 2010// TI - Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction JO - Ann. N.Y. Acad. Sci. VL - 1207 UR - https://doi.org/10.1111/j.1749-6632.2010.05713.x DO - 10.1111/j.1749-6632.2010.05713.x ID - Deitch2010 ER - TY - JOUR AU - Remick, D. G. PY - 1998 DA - 1998// TI - Exogenous interleukin-10 fails to decrease the mortality or morbidity of sepsis JO - Crit. Care Med. VL - 26 UR - https://doi.org/10.1097/00003246-199805000-00025 DO - 10.1097/00003246-199805000-00025 ID - Remick1998 ER - TY - JOUR AU - Montoya-Ruiz, C. PY - 2016 DA - 2016// TI - Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis JO - Immunol. Res. VL - 64 UR - https://doi.org/10.1007/s12026-016-8860-4 DO - 10.1007/s12026-016-8860-4 ID - Montoya-Ruiz2016 ER - TY - JOUR AU - Rajan, S. PY - 2007 DA - 2007// TI - Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis JO - Shock VL - 45 ID - Rajan2007 ER - TY - JOUR AU - Deng, M. PY - 2016 DA - 2016// TI - Toll-like receptor 4 signaling on dendritic cells suppresses polymorphonuclear leukocyte CXCR2 expression and trafficking via interleukin 10 during intra-abdominal sepsis JO - J. Infect. Dis. VL - 213 UR - https://doi.org/10.1093/infdis/jiv562 DO - 10.1093/infdis/jiv562 ID - Deng2016 ER - TY - JOUR AU - Poll, T. PY - 1995 DA - 1995// TI - Endogenous IL–10 protects mice from death during septic peritonitis JO - J. Immunol. VL - 155 ID - Poll1995 ER - TY - JOUR AU - Murphey, E. D. AU - Sherwood, E. R. PY - 2006 DA - 2006// TI - Bacterial clearance and mortality are not improved by a combination of IL-10 neutralization and IFN-gamma administration in a murine model of post-CLP immunosuppression JO - Shock VL - 26 UR - https://doi.org/10.1097/01.shk.0000226343.70904.4f DO - 10.1097/01.shk.0000226343.70904.4f ID - Murphey2006 ER - TY - JOUR AU - Ralay, R. H. PY - 2007 DA - 2007// TI - Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice JO - Am. J. Pathol. VL - 170 UR - https://doi.org/10.2353/ajpath.2007.060219 DO - 10.2353/ajpath.2007.060219 ID - Ralay2007 ER - TY - JOUR AU - Alverdy, J. C. AU - Krezalek, M. A. PY - 2017 DA - 2017// TI - Collapse of the microbiome, emergence of the pathobiome, and the immunopathology of sepsis JO - Crit. Care Med. VL - 45 UR - https://doi.org/10.1097/CCM.0000000000002172 DO - 10.1097/CCM.0000000000002172 ID - Alverdy2017 ER - TY - JOUR AU - Su, L. PY - 2009 DA - 2009// TI - Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis JO - Gastroenterology VL - 136 UR - https://doi.org/10.1053/j.gastro.2008.10.081 DO - 10.1053/j.gastro.2008.10.081 ID - Su2009 ER - TY - JOUR AU - Zheng, W. AU - Kou, Y. AU - Gao, F. L. AU - Ouyang, X. H. PY - 2016 DA - 2016// TI - Enzymatic changes in myosin regulatory proteins may explain vasoplegia in terminally ill patients with sepsis JO - Biosci. Rep. VL - 36 UR - https://doi.org/10.1042/BSR20150207 DO - 10.1042/BSR20150207 ID - Zheng2016 ER - TY - JOUR AU - Cohen, T. S. AU - DiPaolo, B. C. AU - Lawrence, G. G. AU - Margulies, S. S. PY - 2012 DA - 2012// JO - PLoS ONE VL - 7 UR - https://doi.org/10.1371/journal.pone.0038748 DO - 10.1371/journal.pone.0038748 ID - Cohen2012 ER -