Skip to main content
Figure 3 | Molecular Medicine

Figure 3

From: Myosin Light Chain Kinase Knockout Improves Gut Barrier Function and Confers a Survival Advantage in Polymicrobial Sepsis

Figure 3

Effect of genetic deletion of MLCK on ZO-1 and claudin 15 24 h after CLP. Protein levels of (A) ZO-1 and (B) claudin 15 in jejunal tissue were higher in MLCK−/− mice than WT mice following CLP (n = 3–6/group, p = 0.03 and 0.048, respectively). (B,E) Representative Western blots are shown for both of these proteins with actin controls. Although immunohistochemical staining was more pronounced for (C) ZO-1 and claudin (F) 15 on the villi of MLCK−/− mice, no apparent difference in subcellular localization was detected.

Back to article page