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Figure 5 | Molecular Medicine

Figure 5

From: Myosin Light Chain Kinase Knockout Improves Gut Barrier Function and Confers a Survival Advantage in Polymicrobial Sepsis

Figure 5

Effect of genetic deletion of MLCK on intestinal integrity 24 h after CLP. Intestinal apoptosis was similar between MLCK−/− and WT mice following CLP whether measured by (A) H&E (n = 12/group, p = 0.58) or (B) active caspase 3 (n = 8–9/group, p = 0.07). (C) Proliferation as measured by number of S-phase cells (n = 8–9/group, p = 0.37) and (D) villus length (n = 12/group, p = 0.07) were also similar between septic MLCK−/− and WT mice.

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