Figure 6

Effect of genetic deletion of MLCK on lung injury 24 h after CLP. (A) Lung wet-to-dry ratio was similar between MLCK^−/− and WT mice following CLP (n = 10/group, p = 0.78) as were (B) lung (n = 8/group, p = 0.85) and (C) BAL MPO (n = 8/group, p = 0.10). Concentrations in BAL fluid of (D) TNF (n = 7/group, p = 0.46), (E) IL-6 (n = 6/group, p = 0.81), (F) IL-10 (n = 7–8/group, p = 0.47), (G) IL-13 (n = 7–8/group, p > 0.99) and (H) IFN-γ (n = 8/group, p = 0.37) were all statistically similar between MLCK^−/− and WT mice.