Figure 9

Effect of genetic deletion of MLCK on adaptive immune system 24 h after CLP. (A) CD4 + counts were higher in septic MLCK^−/− mice (p = 0.008), whereas (B) CD8 + (p = 0.20), (C) CD11c + (n = 4–8/group, p = 0.51) and (D) CD19 + (p = 0.11) counts were similar between septic MLCK^−/− and WT mice. (E) The percentage of CD4 + CD25 + cells was lower in septic MLCK^−/− mice (p = 0.02), while there was (F) no difference in CD4 + CD69 + cells (p = 0.97). Similarly, (G) the percentage of CD8 + CD25 + cells was lower in septic MLCK^−/− mice (p = 0.03) while there was (H) no difference in CD8 + CD69 + cells (p = 0.28).