Figure 1
From: IL-37 Suppresses MyD88-mediated Inflammatory Responses in Human Aortic Valve Interstitial Cells
IL-37 attenuates the inflammatory responses induced by TLR4 stimulation in human AVICs. AVICs were treated with lipopolysaccharide (LPS, 0.2 µg/mL) for 24 h in the presence and absence of recombinant IL-37 (0.1 and 1.0 ng/mL). (A) Representative immunoblots and densitometric data show that IL-37 reduced ICAM-1 production induced by LPS. (B) Cytokine data show that IL-37 suppressed production of IL-6, IL-8 and MCP-1 following stimulation with LPS, and the higher concentration of IL-37 had a greater effect. Data are mean ± SE. n = 6 experiments using cell isolates from distinct donor valves; *P <0.05 versus untreated control; #P <0.05 versus LPS alone.