Table 1 Autophagy regulation of inflammasome activation.
From: Inflammasome and Autophagy Regulation: A Two-way Street
Manipulation of Autophagy Pathway | Inflammasome Activator | Downstream Signaling Pathway | Cell Type | References |
|---|---|---|---|---|
Loss of | LPS | ↑ caspase 1 activation | Macrophage | (17) |
Atg16L1 |  | ↑ IL-1β/IL-18 production |  |  |
Loss of Atg7 | LPS | ↑ caspase 1 activation | Macrophage | |
|  | Viral RNA | ↑ IL-1β production |  |  |
| Â | Alum | Â | Â | Â |
| Â | Nigericin | Â | Â | Â |
Loss of Atg5 | LPS | ↑ caspase 1 activation | Macrophage | |
|  | MSU | ↑ IL-1β production |  |  |
| Â | Nigericin | Â | Â | Â |
Loss of beclin1 | LPS | ↑ mtDNA release | Macrophage | |
|  | MSU | ↑ caspase 1 activation |  |  |
|  | Nigericin | ↑ IL-1β production |  |  |
Loss of LC3B | LPS + ATP | ↑ caspase 1 activation ↑ IL-1β production | Macrophage | (20) |
3-MA | LPS | ↑ NLRP3 activation | Macrophage | |
|  |  | ↑ caspase 1 activation | Dendritic cells |  |
|  |  | ↑ IL-1β production |  |  |
Rapamycin | Poly(dA:dT) | ↓ AIM2 activation | Macrophage | |
|  |  | ↓ caspase 1 activation | Non-parenchymal |  |
|  |  | ↓ IL-1β production | cells |  |
Starvation | Poly(dA:dT) | ↓ AIM2 activation | Macrophage | (31) |
|  |  | ↓ caspase 1 activation |  |  |
|  |  | ↓ IL-1β production |  |  |