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Figure 2 | Molecular Medicine

Figure 2

From: The Protective Effect of Heme Oxygenase-1 against Intestinal Barrier Dysfunction in Cholestatic Liver Injury Is Associated with NF-κB Inhibition

Figure 2

Effects of CoPP and CORM-2 on tight junctions, cell apoptosis, PCNA and TLR4/NF-κB expression in intestinal tissue from Sham/BDL rats. (A) Western blot images; (B) the relative expression of ZO-1 and occludin. The expression levels of the TJ proteins ZO-1 and claudin-1 expression were significantly increased in the CoPP and CORM-2 groups compared with the BDL group; (C) HO-1, TLR4 and NF-κB p65 were notably increased in BDL group compared with the Sham; (D) caspase 3, cleaved caspase 3 and PCNA expression. Data are presented as the mean ± SD from three independent experiments, *P < 0.05, **P < 0.01.

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Molecular Medicine

ISSN: 1528-3658