Results from trans-ethnic fine mapping of the AFF3 locus. (A) The 90% credible set for candidate pathogenic variants (top) and selected annotations used to prioritize variants, with blue coloration indicating variants having a given annotation (bottom). (B–D) Zoom plot of association summary statistics versus genomic position for Asians, African Americans, and Europeans with RA. Each includes a heatmap for variants in the locus, colored according to a linkage disequilibrium LD heatmap generated from that population. The color bar (bottom middle) indicates the degree of linkage disequilibrium for variants in each LD heatmap.