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Table 2 Myocardial contractile function measured in vivo in a rat model of I/R.

From: Nicotinic Acetylcholine Receptor-Mediated Protection of the Rat Heart Exposed to Ischemia Reperfusion

Function (post-I/R)

Sham surgery (n=6)

I/R + veh (n=10)

I/R + GTS (n=10)

LVDP (mmHg)

119 ± 18

66 ± 15***

97 ± 14*†

+dP/dt (mmHg·sec−1)

5542 ± 1106

3640 ± 1441**

5648 ± 576†

-dP/dt (mmHg·sec−1)

-6860 ± 1580

-3061 ± 1487***

-5636 ± 1423†

HR (bpm)

396 ± 27

380 ± 40

395 ± 40

WP (mmHg·bpm)

47175 ± 9000

25544 ± 7953***

38393 ± 6630*†

  1. One-way ANOVA with Student-Neuman-Keuls post hoc pairwise multiple-comparison test performed. *p < 0.05, **p < 0.01, ***p < 0.001 versus sham; †p < 0.001 versus I/R + veh; values are mean ± SD; (n) = number of animals/group.
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Molecular Medicine

ISSN: 1528-3658