Figure 2
From: RAGE-aptamer Attenuates the Growth and Liver Metastasis of Malignant Melanoma in Nude Mice
Effects of RAGE-aptamer on (A, B) tumor growth and (C) body weight in nude mice. Two million G361 cells were intradermally administered into the upper flank of 6-wk-old female athymic nude mice (N = 14). Mice received continuous intraperitoneal injection of RAGE-aptamer (N = 6) or vehicle (N = 8) by an osmotic minipump. Then tumor volume and body weight were measured twice a week. Panel A shows typical photographs of G361 tumors 42 d after each injection. Arrowheads indicate tumors. * and **, p < 0.05 and p < 0.01 compared with the values of vehicle-treated mice, respectively.