Table 3 Sensitivity analysis examining alternate phenotypes omitting the most- or least-strongly loading diagnoses
Topic # | Topic name | CHR | SNP | P value Full topic (all diagnoses) | P values in sensitivity analysis | ||
|---|---|---|---|---|---|---|---|
|  |  |  |  |  | Topic head (diagnoses loading ≥0.01) | Topic tail (diagnoses loading ≤0.05) | Single diagnosis (only top diagnosis) |
19 | Pulmonary disease and cystic fibrosis-plus | 7 | 7:117277554 | 1.049E-42 | 1.121E-4 | 7.178E-11 | 0.02882 |
19 | Pulmonary disease and cystic fibrosis-plus | 7 | 7:116967838 | 3.005E-32 | 1.686E-3 | 4.765E-3 | 0.0518 |
09 | Anemia and fracture-plus | 4 | 4:12459496 | 5.985E-29 | 0.3539 | 6.102E-51 | * |
24 | Rheumatoid arthritis-plus | 6 | 6:32570417 | 2.14E-28 | 2.895E-20 | 0.2878 | 7.586E-19 |
16 | Pregnancy complications-plus | 5 | 5:32198317 | 2.852E-20 | 0.1513 | 6.545E-44 | * |
19 | Pulmonary disease and cystic fibrosis-plus | 7 | 7:117220403 | 2.055E-19 | 4.268E-4 | 1.114E-08 | 0.05133 |
22 | Uterine neoplasm-plus | 14 | 14:62132727 | 3.294E-19 | 0.2401 | 0.7799 | 6.231E-3 |
07 | Viral-plus | 14 | 14:57647875 | 7.58E-19 | 0.3954 | 0.3554 | * |
22 | Uterine neoplasm-plus | 6 | 6:148020784 | 7.105E-18 | 0.5184 | 3.387E-3 | 5.874E-3 |
24 | Rheumatoid arthritis-plus | 6 | 6:32681992 | 9.832E-18 | 4.413E-14 | 0.2 | 4.409E-11 |
40 | Neoplasm-plus | 3 | 3:1145301 | 1.962E-17 | 9.212E-4 | 3.945E-6 | 0.01377 |
22 | Uterine neoplasm-plus | 2 | 2:209079758 | 7.645E-17 | 0.1993 | 0.8465 | * |
01 | Adrenal and electrolyte-plus | 4 | 4:41059660 | 1.813E-16 | 0.01646 | 0.1058 | * |
22 | Uterine neoplasm-plus | 4 | 4:84272944 | 1.993E-16 | 0.02548 | 0.8802 | * |
25 | Pituitary and adrenal disease-plus | 18 | 18:25741737 | 3.269E-16 | 0.06459 | 0.078 | 0.07633 |
24 | Rheumatoid arthritis-plus | 6 | 6:32303848 | 3.558E-16 | 5.129E-14 | 0.118 | 3.344E-13 |
07 | Viral-plus | 8 | 8:58987251 | 4.165E-16 | 0.01557 | 0.8416 | 0.09888 |