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  1. Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease characterized by intestinal inflammation and injury, with high mortality risk. Extracellular cold-inducible RNA-binding protein (eCIRP) is a...

    Authors: Colleen P. Nofi, Jose M. Prince, Mariana R. Brewer, Monowar Aziz and Ping Wang
    Citation: Molecular Medicine 2024 30:156
    Content type: Research article Published on:

  3. Thoracic aortic dissection (TAD) is an irreversible cardiovascular disorder with high mortality and morbidity. However, the molecular mechanisms remain elusive. Thus, identifying an effective therapeutic targe...

    Authors: Liqing Jiang, Linhe Lu, Chao Xue, He Sun, Kai Ren, Liyun Zhang, Hanzhao Zhu, Bin Zhang, Xiaoya Wang, Xinan Qiao, Xiangyan Peng, Jincheng Liu and Weixun Duan
    Citation: Molecular Medicine 2024 30:154
    Content type: Research Published on:

  4. Specialized pro-resolving mediators (SPMs) promote resolution of inflammation, clear infections and stimulate tissue regeneration. These include resolvins, protectins, and maresins. During self-resolving acute...

    Authors: Charles N. Serhan, Nan Chiang and Robert Nshimiyimana
    Citation: Molecular Medicine 2024 30:153
    Content type: Research article Published on:

  5. VEXAS syndrome, an uncommon yet severe autoimmune disorder stemming from a mutation in the UBA1 gene, is the focus of this paper. The overview encompasses its discovery, epidemiological traits, genetic underpi...

    Authors: Xiao Xiao Li, Wen Hui Huang, Xiao Bin Yang, Qi Lin Yang, Yu Zheng, Yong Bao Huo, Ting Ting Xie, Cheng Hui Huang and Shui Lian Yu
    Citation: Molecular Medicine 2024 30:152
    Content type: Mini-review Published on:

  6. Erythropoietin (EPO), expressed in red blood progenitor cells, primarily regulates erythropoiesis by binding to its receptor. Besides anemia, recent studies have identified new therapeutic indications for EPO ...

    Authors: Xiao Liu, Mengxue Zhou, Yifan Wu, Xiang Gao, Lei Zhai, Liang Liu and Huan Geng
    Citation: Molecular Medicine 2024 30:151
    Content type: Research article Published on:

  7. Cis-dichlorodiammineplatinum(II) (CDDP), while widely utilized in tumor therapy, results in toxic side effects that patients find intolerable. The specific mechanism by which CDDP inflicts ovarian damage remai...

    Authors: Lu Zhang, Zhe Dong, Fan Jiang, Huaju Huang, Hui Ding and Meimei Liu
    Citation: Molecular Medicine 2024 30:150
    Content type: Research article Published on:

  8. Obesity is a global epidemic, and the low-grade chronic inflammation of adipose tissue in obese individuals can lead to insulin resistance and type 2 diabetes. Adipose tissue macrophages (ATMs) are the main so...

    Authors: Huaying Huang, Heye Chen, Yu Yao and Xueyong Lou
    Citation: Molecular Medicine 2024 30:149
    Content type: Research article Published on:

  9. Ventilator-induced lung injury (VILI) is one of the severe complications in the clinic concerning mechanical ventilation (MV). Capsaicin (CAP) has anti-inflammatory and inhibitory effects on oxidative stress, ...

    Authors: Jinyuan Lin, Huajin Ou, Bijun Luo, Maoyao Ling, Fei Lin, Liming Cen, Zhaokun Hu, Liu Ye and Linghui Pan
    Citation: Molecular Medicine 2024 30:148
    Content type: Research article Published on:

  10. The complex interplay between Sirtuin 1 (SIRT1) and FOXO3 in endometrial cancer (EC) remains understudied. This research aims to unravel the interactions of deacetylase SIRT1 and transcription factor FOXO3 in ...

    Authors: Xuehua Wei, Xiangpeng Xiong, Pingping Wang, Shufang Zhang and Dongxian Peng
    Citation: Molecular Medicine 2024 30:147
    Content type: Research article Published on:

  11. At present, hepatic ischemia-reperfusion injury (IRI) is an important complication of partial hepatectomy and liver transplantation, and it is an important cause of poor prognosis. Spleen tyrosine kinase(SYK) ...

    Authors: Xuejiao Chen, Chuanwei Jiang, Minhao Chen, Xiangdong Li, Wenjie Yu, Aigang Qiu, Linfeng Sun, Liyong Pu and Yuhua Shi
    Citation: Molecular Medicine 2024 30:146
    Content type: Research Published on:

  12. Ionizing radiation (IR), including radiotherapy, can exert lasting harm on living organisms. While liposaccharide (LPS) offers resistance to radiation damage, it also induces toxic responses. Thankfully, an LP...

    Authors: Zhihua Li, Yatong Wu, Jicong Du, Wen Qian, Sinian Wang, Fengsheng Li, Suhe Dong and Shunchang Jiao
    Citation: Molecular Medicine 2024 30:145
    Content type: Research Published on:

  13. Idiopathic pulmonary fibrosis (IPF) is a special kind of chronic interstitial lung disease with insidious onset. Previous studies have revealed that mutations in ZCCHC8 may lead to IPF. The aim of this study i...

    Authors: Chen-Yu Wang, Si-Hua Chang, Cheng-Feng Hu, Yi-Qiao Hu, Hong Luo, Lv Liu and Liang-Liang Fan
    Citation: Molecular Medicine 2024 30:144
    Content type: Short report Published on:

  14. Targeting the tumor microenvironment represents an emerging therapeutic strategy for cancer. Macrophages are an essential part of the tumor microenvironment. Macrophage polarization is modulated by mitochondri...

    Authors: Sung Woo Lee, Soyoon Kim, Bokyung Kim, Jung Bae Seong, Young-Ho Park, Hong Jun Lee, Dong Kyu Choi, Eunbyul Yeom and Dong-Seok Lee
    Citation: Molecular Medicine 2024 30:143
    Content type: Research article Published on:

  15. Oxidative damage to human retinal pigment epithelial (RPE) cells is the main cause of age-related macular degeneration (AMD), in our previous work, we showed that ghrelin has an antioxidative effect on human l...

    Authors: Jie Bai, Yanqing Wang, Yanze Li, Yan Liu and Shan Wang
    Citation: Molecular Medicine 2024 30:142
    Content type: Research article Published on:

  16. Advanced glycation end products (AGEs) are a diverse range of compounds that are formed when free amino groups of proteins, lipids, and nucleic acids are carbonylated by reactive carbonyl species or glycosylat...

    Authors: Yanchi Chen, Zihan Meng, Yong Li, Shibo Liu, Pei Hu and En Luo
    Citation: Molecular Medicine 2024 30:141
    Content type: Review Published on:

  17. Sepsis-induced pulmonary injury (SPI) is a common complication of sepsis with a high rate of mortality. N4-acetylcytidine (ac4C) is mediated by the ac4C “writer”, N-acetyltransferase (NAT)10, to regulate the stab...

    Authors: Pengcheng Xing, Minjie Zhou, Jian Sun, Donglian Wang, Weipeng Huang and Peng An
    Citation: Molecular Medicine 2024 30:140
    Content type: Research article Published on:

  18. Myocardial ischemia/reperfusion (I/R) injury is a common pathological process in clinical practice. Developing effective therapeutic strategies to reduce or prevent this injury is crucial. The article aimed to...

    Authors: Haibin Dong, Wenjuan Jia, Chunxiao Wang, Da Teng, Bowen Xu, Xiaoning Ding, Jun Yang, Lin Zhong and Lei Gong
    Citation: Molecular Medicine 2024 30:139
    Content type: Research article Published on:

  19. Premature rupture of the membranes (PROM) is a key cause of preterm birth and represents a major cause of neonatal mortality and morbidity. Natural products N-acetyl-d-galactosamine (GalNAc), which are basic b...

    Authors: Jia-Le Chen, Lou Liu, Xin-Rui Peng, Yan Wang, Xiang Xiang, Yu Chen, De-Xiang Xu and Dao-Zhen Chen
    Citation: Molecular Medicine 2024 30:138
    Content type: Research article Published on:

  23. Epidermal remodeling and hypertrophy are hallmarks of skin fibrotic disorders, and keratinocyte to mesenchymal (EMT)-like transformations drive epidermis alteration in skin fibrosis such as keloids and hypertr...

    Authors: Javier Milara, Pilar Ribera, Severiano Marín, Paula Montero, Inés Roger and Julio Cortijo
    Citation: Molecular Medicine 2024 30:134
    Content type: Research article Published on:

  24. Renal ischemia/reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), which is associated with high incidence and mortality. AST-120 is an oral carbonaceous adsorbent that can alleviate kidney...

    Authors: Jinmeng Zhou, Jinbao Zhang, Feng Xu, Haijin Gao, Lei Wang, Yutong Zhao and Ke Li
    Citation: Molecular Medicine 2024 30:133
    Content type: Research article Published on:

  25. Cell-based therapeutic strategies have been proposed as an alternative for brain and blood vessels repair after stroke, but their clinical application is hampered by potential adverse effects. We therefore tes...

    Authors: Rodrigo Azevedo Loiola, Johan Hachani, Sophie Duban-Deweer, Emmanuel Sevin, Paulina Bugno, Agnieszka Kowalska, Eleonora Rizzi, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Mazurek and Fabien Gosselet
    Citation: Molecular Medicine 2024 30:132
    Content type: Research article Published on:

  26. The severe course of COVID-19 causes cardiovascular injuries, although the mechanisms involved are still not fully recognized, linked, and understood. Their characterization is of great importance with the est...

    Authors: Maciej Suski, Agnieszka Olszanecka, Aneta Stachowicz, Anna Kiepura, Michał Terlecki, Józef Madej, Marek Rajzer and Rafał Olszanecki
    Citation: Molecular Medicine 2024 30:131
    Content type: Research Published on:

  27. Vascular calcification is a common vascular lesion associated with high morbidity and mortality from cardiovascular events. Antibiotics can disrupt the gut microbiota (GM) and have been shown to exacerbate or ...

    Authors: Shi-Yu Zeng, Yi-Fu Liu, Zhao-Lin Zeng, Zhi-Bo Zhao, Xi-Lin Yan, Jie Zheng, Wen-Hang Chen, Zhen-Xing Wang, Hui Xie and Jiang-Hua Liu
    Citation: Molecular Medicine 2024 30:130
    Content type: Research article Published on:

  28. Mitochondria, responsible for cellular energy synthesis and signal transduction, intricately regulate diverse metabolic processes, mediating fundamental biological phenomena such as cell growth, aging, and apo...

    Authors: Quanling Zhou, Tingping Cao, Fujun Li, Ming Zhang, Xiaohui Li, Hailong Zhao and Ya Zhou
    Citation: Molecular Medicine 2024 30:129
    Content type: Review Published on:

  30. Cognitive dysfunction caused by infection frequently emerges as a complication in sepsis survivor patients. However, a comprehensive understanding of its pathogenesis remains elusive.

    Authors: Ni Liang, Yi Li, Chuang Yuan, Xiaoli Zhong, Yanliang Yang, Fang Liang, Kai Zhao, Fangfang Yuan, Jian Shi, Erhua Wang, Yanjun Zhong, Guixiang Tian, Ben Lu and Yiting Tang
    Citation: Molecular Medicine 2024 30:127
    Content type: Research article Published on:

  31. Bone marrow mesenchymal stem cells (BMMSCs) are commonly used for cell transplantation to treat refractory diseases. However, the presence of inflammatory factors, such as tumour necrosis factor-alpha (TNF-α),...

    Authors: Xudong Wang, Yong Liu, Shiyong Zhang, Linli Zheng, Yunze Kang, Puyi Sheng and Ziji Zhang
    Citation: Molecular Medicine 2024 30:126
    Content type: Research article Published on:

  32. Epimedin A (EA) has been shown to suppress extensive osteoclastogenesis and bone resorption, but the effects of EA remain incompletely understood. The aim of our study was to investigate the effects of EA on o...

    Authors: Jun Li, Jia J. Wei, Cen H. Wu, Tao Zou, Hong Zhao, Tian Q. Huo, Cheng J. Wei and Ting Yang
    Citation: Molecular Medicine 2024 30:125
    Content type: Research article Published on:

  33. Obesity is well-established as a significant contributor to the development of insulin resistance (IR) and diabetes, partially due to elevated plasma saturated free fatty acids like palmitic acid (PA). Grb10-i...

    Authors: Ziwei Lv, Yuanyuan Ren, Yang Li, Fanglin Niu, Zhuozhuo Li, Man Li, Xiaofang Li, Qinhua Li, Deqing Huang, Yi Yu, Yuyan Xiong and Lu Qian
    Citation: Molecular Medicine 2024 30:124
    Content type: Research Published on:

  34. Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease associated with high morbidity and mortality worldwide. Oxidative injury and mitochondrial dysfunction in the airway epitheli...

    Authors: Bin Xie, Qiong Chen, Ziyu Dai, Chen Jiang and Xi Chen
    Citation: Molecular Medicine 2024 30:123
    Content type: Research article Published on:

  36. Inflammatory diseases are often initiated by the activation of inflammasomes triggered by pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs), which media...

    Authors: Xuying Zhao, Wenyu Ni, Wenjie Zheng, Wenkai Ni, Chunfeng Sun, Yunjuan Gu and Zhifeng Gu
    Citation: Molecular Medicine 2024 30:121
    Content type: Research article Published on:

  37. Asthma is a heterogeneous, inflammatory disease with several phenotypes and endotypes. Severe asthmatics often exhibit mixed granulocytosis with reduced corticosteroid sensitivity. Bronchom is a newly develope...

    Authors: Acharya Balkrishna, Sandeep Sinha, Anupam Pandey, Surjeet Singh, Monali Joshi, Rani Singh and Anurag Varshney
    Citation: Molecular Medicine 2024 30:120
    Content type: Research Published on:

  38. AGTPBP1 is a cytosolic carboxypeptidase that cleaves poly-glutamic acids from the C terminus or side chains of α/β tubulins. Although its dysregulated expression has been linked to the development of non-small...

    Authors: Ding-zhong Li, Zhe-yu Yang, Asi leng, Qian Zhang, Xiao-dong Zhang, Yan-chao Bian, Rui Xiao and Jian-jun Ren
    Citation: Molecular Medicine 2024 30:119
    Content type: Research article Published on:

  39. Cell subsets differentially modulate host immune responses to Mycobacterium tuberculosis (MTB) infection. However, the nature and functions of these subsets against osteoarticular tuberculosis (OTB) are unclear. ...

    Authors: Ying Jiang, Xinqiang Zhang, Bo Wang, Liping Tang, Xin Liu, Xiudong Ding, Yueming Dong, Hong Lei, Di Wang and Huicheng Feng
    Citation: Molecular Medicine 2024 30:118
    Content type: Research article Published on:

  40. Lipid metabolism disorders are associated with degeneration of multiple tissues and organs, but the mechanism of crosstalk between lipid metabolism disorder and intervertebral disc degeneration (IDD) has not b...

    Authors: Tan Bing, Xiang Shanlin, Wang Jisheng, Hao Jie, Cao Ruichao, Zhang Zhiwei, Yu Bin, Ma Zhaoxin, Hu Zhenming and Zhou Nian
    Citation: Molecular Medicine 2024 30:117
    Content type: Research article Published on:

  41. CD74 is ectopically expressed in many tumors and can regulate tumor immunity. However, there are many gaps in the study of the prognostic value of CD74 expression and immune infiltration in hepatocellular carc...

    Authors: Jianghong Cheng, Junyang Li, Xinjie Jiang, Xi Ma, Bixuan Li, Han Zhai, Xianyang Luo, Yi Zhou, Junhua Wu, Zhiming Zhang, Shuai Chen and Yang Wang
    Citation: Molecular Medicine 2024 30:116
    Content type: Research article Published on:

  42. Pancreatic fibrosis is an early diagnostic feature of the common inherited disorder cystic fibrosis (CF). Many people with CF (pwCF) are pancreatic insufficient from birth and the replacement of acinar tissue ...

    Authors: Shih-Hsing Leir, Svyatoslav Tkachenko, Alekh Paranjapye, Frederick Meckler, Arnaud J. Van Wettere, Jenny L. Kerschner, Elizabeth Kuznetsov, Makayla Schacht, Pulak Gillurkar, Misha Regouski, Iuri Viotti Perisse, Cheyenne M. Marriott, Ying Liu, Ian Bunderson, Kenneth L. White, Irina A. Polejaeva…
    Citation: Molecular Medicine 2024 30:115
    Content type: Research article Published on:

  43. Glucose transporter 5 (GLUT5) overexpression has gained increasing attention due to its profound implications for tumorigenesis. This manuscript provides a comprehensive overview of the key findings and implic...

    Authors: Nikola Hadzi-Petrushev, Radoslav Stojchevski, Anastasija Jakimovska, Mimoza Stamenkovska, Slavica Josifovska, Aleksandar Stamatoski, Iliyana Sazdova, Ramadan Sopi, Andre Kamkin, Hristo Gagov, Mitko Mladenov and Dimiter Avtanski
    Citation: Molecular Medicine 2024 30:114
    Content type: Review Published on:

  45. Patients with type 2 diabetes often face early tubular injury, necessitating effective treatment strategies. This study aimed to evaluate the impact of the SGLT2 inhibitor empagliflozin on early tubular injury...

    Authors: Chuangbiao Zhang, Weiwei Ren, Xiaohua Lu, Lie Feng, Jiaying Li and Beibei Zhu
    Citation: Molecular Medicine 2024 30:112
    Content type: Research article Published on:

  46. Osteoclast hyperactivation due to the pathological overproduction of reactive oxygen species (ROS) stimulated by glucocorticoids (GCs) is one of the key drivers behind glucocorticoid-induced osteonecrosis of t...

    Authors: Tao Yuan, Haojue Wang, Yi Wang, Shankun Dong, Jianxun Ge, Ziqing Li and Shui Sun
    Citation: Molecular Medicine 2024 30:111
    Content type: Research article Published on:

  47. Inflammation is initiates the propagation phase of aortic valve calcification. The activation of NLRP3 signaling in macrophages plays a crucial role in the progression of calcific aortic valve stenosis (CAVS)....

    Authors: Jing Lu, Jiaming meng, Gang Wu, Wulong Wei, Huabao Xie and Yanli Liu
    Citation: Molecular Medicine 2024 30:110
    Content type: Research article Published on:

  48. Primary cilia are sensory organelles that extend from the cellular membrane and are found in a wide range of cell types. Cilia possess a plethora of vital components that enable the detection and transmission ...

    Authors: Xiaonan Liu, Anna Pacwa, Giorgia Bresciani, Marta Swierczynska, Mariola Dorecka and Adrian Smedowski
    Citation: Molecular Medicine 2024 30:109
    Content type: Review Published on:

  49. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of the digestive system, and the exact mechanism of HCC is still unclear. Transcription factor 7 like 2 (TCF7L2) plays a pivotal role i...

    Authors: Linsong Tang, Shengjun Xu, Rongli Wei, Guanghan Fan, Junbin Zhou, Xuyong Wei and Xiao Xu
    Citation: Molecular Medicine 2024 30:108
    Content type: Research article Published on:

  50. Aging is associated with an increased risk of myocardial ischemia/reperfusion injury (IRI). With an increasing prevalence of cardiovascular diseases such as coronary arteriosclerosis in older people, there has...

    Authors: Ji Zhang, Yuanyuan Zhao and Nianqiao Gong
    Citation: Molecular Medicine 2024 30:107
    Content type: Review Published on:
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    Journal Impact Factor: 6.0
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    Source Normalized Impact per Paper (SNIP): 0.907
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Molecular Medicine

ISSN: 1528-3658