Skip to main content


Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 10 of 44

  1. Sepsis morbidity and mortality are aggravated by acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Mouse B-1a cells are a phenotypically and functionally unique sub-population of B cells, ...

    Authors: Monowar Aziz, Yasumasa Ode, Mian Zhou, Mahendar Ochani, Nichol E. Holodick, Thomas L. Rothstein and Ping Wang
    Citation: Molecular Medicine 2018 24:26
  2. Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect termination of translation and generation of non-functional, truncated proteins. Translational readthrough of PTCs induce...

    Authors: Maciej Dabrowski, Zuzanna Bukowy-Bieryllo and Ewa Zietkiewicz
    Citation: Molecular Medicine 2018 24:25
  3. Stratified human keratinocytes (SHKs) are an essential part of mucosal innate immune response that modulates adaptive immunity to microbes encountered in the environment. The importance of these SHKs in mucosa...

    Authors: Mohd Israr, David Rosenthal, Lidia Frejo-Navarro, James DeVoti, Craig Meyers and Vincent R. Bonagura
    Citation: Molecular Medicine 2018 24:23
  4. Endothelial injury is an early and enduring feature of cardiovascular disease. Inflammation and hypoxia may be responsible for this, and are often associated with the up-regulation of several transcriptional f...

    Authors: Lamia Heikal, Pietro Ghezzi, Manuela Mengozzi and Gordon Ferns
    Citation: Molecular Medicine 2018 24:22

    The Correction to this article has been published in Molecular Medicine 2020 26:61

  5. High Mobility Group Box 1 (HMGB1) was first identified as a nonhistone chromatin-binding protein that functions as a pro-inflammatory cytokine and a Damage-Associated Molecular Pattern molecule when released f...

    Authors: Mingzhu He, Marco E. Bianchi, Tom R. Coleman, Kevin J. Tracey and Yousef Al-Abed
    Citation: Molecular Medicine 2018 24:21

    The Correction to this article has been published in Molecular Medicine 2018 24:31

  6. Implant failure remains a major obstacle to successful treatment via TJA. Periprosthetic osteolysis and aseptic loosening are considered as proof of wear debris-induced disruption of local regulatory mechanism...

    Authors: Zhao Yan, Xiaoxi Tian, Jinyu Zhu, Zifan Lu, Lifeng Yu, Dawei Zhang, Yanwu Liu, Chongfei Yang, Qingsheng Zhu and Xiaorui Cao
    Citation: Molecular Medicine 2018 24:20
  7. High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. HMGB1 interacts with toll-like receptors (TLRs) but c...

    Authors: Hannah Aucott, Agnieszka Sowinska, Helena Erlandsson Harris and Peter Lundback
    Citation: Molecular Medicine 2018 24:19
  8. As a form of dementia primarily affecting the elderly, vascular dementia (VD) is characterized by changes in the supply of blood to the brain, resulting in cognitive impairment. The aim of the present study wa...

    Authors: Xin-Rui Han, Xin Wen, Yong-Jian Wang, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu and Yuan-Lin Zheng
    Citation: Molecular Medicine 2018 24:18
  9. Dendritic cells (DC) induce adaptive responses against foreign antigens, and play an essential role in maintaining peripheral tolerance to self-antigens. Therefore they are involved in preventing fatal autoimm...

    Authors: Inna Tabansky, Derin B. Keskin, Deepika Watts, Cathleen Petzold, Michael Funaro, Warren Sands, Paul Wright, Edmond J. Yunis, Souhel Najjar, Betty Diamond, Yonghao Cao, David Mooney, Karsten Kretschmer and Joel N. H. Stern
    Citation: Molecular Medicine 2018 24:17
  10. Radiotherapy remains one of the corner stones in the treatment of various malignancies and often leads to an improvement in overall survival. Nonetheless, pre-clinical evidence indicates that radiation can ent...

    Authors: Nora Sundahl, Fréderic Duprez, Piet Ost, Wilfried De Neve and Marc Mareel
    Citation: Molecular Medicine 2018 24:16
  11. Parathyroid hormone (PTH) is one of the principal regulators of calcium homeostasis. Although serum PTH level is mostly accounted by genetic factors, genetic background underlying PTH level is insufficiently k...

    Authors: Antonela Matana, Dubravka Brdar, Vesela Torlak, Thibaud Boutin, Marijana Popović, Ivana Gunjača, Ivana Kolčić, Vesna Boraska Perica, Ante Punda, Ozren Polašek, Maja Barbalić, Caroline Hayward and Tatijana Zemunik
    Citation: Molecular Medicine 2018 24:15
  12. Fetal sex determination is useful for families at risk of X-linked disorders, such as Duchenne muscular dystrophy, adrenal hypoplasia, hemophilia. At first, this could be obtained through invasive procedures s...

    Authors: Elisabetta D’Aversa, Giulia Breveglieri, Patrizia Pellegatti, Giovanni Guerra, Roberto Gambari and Monica Borgatti
    Citation: Molecular Medicine 2018 24:14
  13. Atherosclerosis has been recognized as an inflammatory disease involving the vascular wall. MicroRNAs are a group of small noncoding RNAs to regulate gene expression at the transcriptional level through mRNA d...

    Authors: Heng Li, Xin-Ping Ouyang, Ting Jiang, Xi-Long Zheng, Ping-Ping He and Guo-Jun Zhao
    Citation: Molecular Medicine 2018 24:12
  14. Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases (CVDs). Stachydrine (STA) is an active component in Chinese motherwort Leonurus heterophyllus sweet, which has been widely use...

    Authors: Xinya Xie, Zihui Zhang, Xinfeng Wang, Zhenyu Luo, Baochang Lai, Lei Xiao and Nanping Wang
    Citation: Molecular Medicine 2018 24:10
  15. Endometriosis is a chronic and underdiagnosed disease which affects 5–10% of women of childbearing age and is characterized by growth of endometrial tissue outside of the uterus, most often in the peritoneal c...

    Authors: Laura A. Warren, Andrew Shih, Susana Marquez Renteira, Tamer Seckin, Brandon Blau, Kim Simpfendorfer, Annette Lee, Christine N. Metz and Peter K. Gregersen
    Citation: Molecular Medicine 2018 24:1
  16. Chronic lymphocytic leukemia (CLL), the most frequent type of leukemia in western countries, is characterized by the progressive accumulation in blood, bone marrow and lymphoid tissues of monoclonal B lymphocy...

    Authors: Gerardo Ferrer and Emili Montserrat
    Citation: Molecular Medicine 2018 24:9
  17. The NLRP3 inflammasome, a cytosolic complex that mediates the maturation of IL-1β and IL-18 as well as the release of high mobility group box 1 (HMGB1), contributes to the lethality of endotoxic shock. Ethyl p...

    Authors: Sujun Li, Fang Liang, Kevin Kwan, Yiting Tang, Xiangyu Wang, Youzhou Tang, Jianhua Li, Huan Yang, Sangeeta S. Chavan, Haichao Wang, Ulf Andersson, Ben Lu and Kevin J. Tracey
    Citation: Molecular Medicine 2018 24:8
  18. In order to retrieve episodic past events, the missing information needs to be reconstructed using information stored in semantic memory. Failures in these reconstructive processes are expressed as false memor...

    Authors: Armin Zlomuzica, Friederike Preusser, Susanna Roberts, Marcella L. Woud, Kathryn J. Lester, Ekrem Dere, Thalia C. Eley and Jürgen Margraf
    Citation: Molecular Medicine 2018 24:7
  19. Ec peptide (PEc), resulting from the proteolytic cleavage of the IGF-1Ec isoform, is involved in prostate cancer progression and metastasis, whereas in muscle tissue, it is associated with the mobilization of ...

    Authors: A. Armakolas, A. Dimakakos, C. Loukogiannaki, N. Armakolas, A. Antonopoulos, C. Florou, P. Tsioli, E. Papageorgiou, T. P. Alexandrou, M. Stathaki, D. Spinos, D. Pektasides, E. Patsouris and M. Koutsilieris
    Citation: Molecular Medicine 2018 24:6
  20. Necrotizing Enterocolitis (NEC) is one of the most devastating gastrointestinal diseases in neonates, particularly among preterm infants in whom surgical NEC is the leading cause of morbidity. NEC pathophysiol...

    Authors: Naomi-Liza Denning and Jose M. Prince
    Citation: Molecular Medicine 2018 24:4
  21. Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a red...

    Authors: Natasha Fillmore, Jody L. Levasseur, Arata Fukushima, Cory S. Wagg, Wei Wang, Jason R. B. Dyck and Gary D. Lopaschuk
    Citation: Molecular Medicine 2018 24:3
  22. Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is highly complex with constant features, such a...

    Authors: Antonella Izzo, Nunzia Mollo, Maria Nitti, Simona Paladino, Gaetano Calì, Rita Genesio, Ferdinando Bonfiglio, Rita Cicatiello, Maria Barbato, Viviana Sarnataro, Anna Conti and Lucio Nitsch
    Citation: Molecular Medicine 2018 24:2
  23. Epidemiological studies have suggested a link between cumulative diabetic exposure and cancer. The interaction of advanced glycation end products (AGEs) with their receptor (RAGE) may contribute to the phenome...

    Authors: Nobutaka Nakamara, Takanori Matsui, Yuji Ishibashi, Ami Sotokawauchi, Kei Fukami, Yuichiro Higashimoto and Sho-ichi Yamagishi
    Citation: Molecular Medicine 2017 23:2301295
  24. Sirtuin-6 (Sirt6) is a critical epigenetic regulator, but its function in the gut is unknown. Here, we studied the role of intestinal epithelial Sirt6 in colitis-associated intestinal epithelial injury. We fou...

    Authors: Fangyi Liu, Heng-Fu Bu, Hua Geng, Isabelle G. De Plaen, Chao Gao, Peng Wang, Xiao Wang, Jacob A. Kurowski, Hong Yang, Jiaming Qian and Xiao-Di Tan
    Citation: Molecular Medicine 2017 23:2301272
  25. The kidney is vulnerable to hypoxia-induced injury. One of the mechanisms underlying this phenomenon is cell apoptosis triggered by hypoxia-inducible factor-1- α (HIF-1α) activation. MicroRNA-210 (miR-210) is ...

    Authors: Li-Li Liu, Dahu Li, Yun-Ling He, Yan-Zhao Zhou, Sheng-Hui Gong, Li-Ying Wu, Yong-Qi Zhao, Xin Huang, Tong Zhao, Lun Xu, Kui-Wu Wu, Ming-Gao Li, Ling-Ling Zhu and Ming Fan
    Citation: Molecular Medicine 2017 23:2301258
  26. BD750, a novel JAK3/STAT5 inhibitor, can inhibit T cell proliferation. This study aims to evaluate whether BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune enc...

    Authors: Yan Zhou, Xiao Leng, Hua Li, Shuxia Yang, Tai Yang, Limei Li, Ying Xiong, Qiang Zou, Yang Liu and Yantang Wang
    Citation: Molecular Medicine 2017 23:2301204
  27. Biobanks and national registries represent a powerful tool for genomic discovery, but rely on diagnostic codes that can be unreliable and fail to capture relationships between related diagnoses. We developed a...

    Authors: Thomas H. McCoy Jr, Victor M. Castro, Leslie A. Snapper, Kamber L. Hart and Roy H. Perlis
    Citation: Molecular Medicine 2017 23:2301285
  28. Interleukin (IL)-26 is abundant in human airways and this cytokine is involved in the local immune response to a bacterial stimulus in vivo. Specifically, local exposure to the toll-like receptor (TLR) 4 agoni...

    Authors: Karlhans Fru Che, Riitta Kaarteenaho, Elisa Lappi-Blanco, Bettina Levänen, Jitong Sun, Åsa Wheelock, Lena Palmberg, C. Magnus Sköld and Anders Lindén
    Citation: Molecular Medicine 2017 23:2301247
  29. Coiled-coil domain-containing 80 (CCDC80) is an adipocyte-secreted protein that modulates glucose homeostasis in response to diet-induced obesity in mice. The objective of this study was to analyze the link be...

    Authors: Óscar Osorio-Conles, María Guitart, José María Moreno-Navarrete, Xavier Escoté, Xavier Duran, José Manuel Fernandez-Real, Anna María Gómez-Foix, Sonia Fernández-Veledo and Joan Vendrell
    Citation: Molecular Medicine 2017 23:2301225
  30. Adoptive immunotherapy with cytokine induced killer (CIK) cells has shown antitumor activity against several kinds of cancer in preclinical models and clinical trials. CIK cells are a subset of ex vivo expanded T...

    Authors: Giulia Mesiano, Roberta Zini, Giulia Montagner, Nicoletta Bianchi, Rossella Manfredini, Antonella Chillemi, Massimo Aglietta, Giovanni Grignani, Ilaria Lampronti, Erika Fiorino, Fabio Malavasi, Dario Sangiolo, Roberto Gambari and Davide Ferrari
    Citation: Molecular Medicine 2017 23:2301235
  31. Heme oxygenase-1 (HO-1) is reported to protect against liver injury, but little Is known about its effect on the intestinal barrier in cholestatic liver injury. In this study, we investigated the effects of HO...

    Authors: Lijing Zhang, Zhenling Zhang, Bojia Liu, Yanling Jin, Yan Tian, Yi Xin and Zhijun Duan
    Citation: Molecular Medicine 2017 23:2301215
  32. Histone modifications play a critical role In the pathological processes of dilated cardiomyopathy (DCM), while the role and expression pattern of histone methyltransferases (HMTs), especially mixed lineage le...

    Authors: Ding-Sheng Jiang, Xin Yi, Rui Li, Yun-Shu Su, Jing Wang, Min-Lai Chen, Li-Gang Liu, Min Hu, Cai Cheng, Ping Zheng, Xue-Hai Zhu and Xiang Wei
    Citation: Molecular Medicine 2017 23:2301196
  33. Inflammation plays a significant role in protecting hosts against pathogens. Inflammation induced by noninfectious endogenous agents can be detrimental and, if excessive, can result in organ and tissue damage....

    Authors: Qian Sun, Jie Fan, Timothy R. Billiar and Melanie J. Scott
    Citation: Molecular Medicine 2017 23:2301188
  34. More than 100 risk loci for rheumatoid arthritis (RA) have been identified in individuals of European and Asian descent, but the genetic basis for RA in African Americans is less well understood. We genotyped ...

    Authors: Maria I. Danila, Vincent A. Laufer, Richard J. Reynolds, Qi Yan, Nianjun Liu, Peter K. Gregersen, Annette Lee, Marlena Kern, Carl D. Langefeld, Donna K. Arnett and S. Louis Bridges Jr.
    Citation: Molecular Medicine 2017 23:2301177
  35. Previously, we showed that an oligodeoxynucleotide (ODN) with AAAG repeats (AAAG ODN) rescued mice from fatal acute lung injury (ALI) induced by influenza virus and inhibited production of tumor necrosis facto...

    Authors: Yue Xiao, Wenting Lu, Xin Li, Peiyan Zhao, Yun Yao, Xiaohong Wang, Ying Wang, Zhipeng Lin, Yongli Yu, Shucheng Hua and Liying Wang
    Citation: Molecular Medicine 2017 23:2301166
  36. Reperfusion injury following acute myocardial infarction is associated with significant morbidity. Activation of neuronal or non-neuronal cholinergic pathways in the heart has been shown to reduce ischemic inj...

    Authors: Spyros A. Mavropoulos, Nayaab S. Khan, Asaph C. J. Levy, Bradley T. Faliks, Cristina P. Sison, Valentin A. Pavlov, Youhua Zhang and Kaie Ojamaa
    Citation: Molecular Medicine 2017 23:2301120
  37. Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the perijunctional actin-myosin ring. Myosin light chain kinase (MLCK) p...

    Authors: C. Adam Lorentz, Zhe Liang, Mei Meng, Ching-Wen Chen, Benyam P. Yoseph, Elise R. Breed, Rohit Mittal, Nathan J. Klingensmith, Alton B. Farris, Eileen M. Burd, Michael Koval, Mandy L. Ford and Craig M. Coopersmith
    Citation: Molecular Medicine 2017 23:2301155
  38. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to...

    Authors: Paul Nurse
    Citation: Molecular Medicine 2017 23:2301112
  39. Congenital lipoid adrenal hyperplasia (CLAH) is the most severe form of congenital adrenal hyperplasia, caused by defects in the steroidogenic acute regulatory protein (STAR). The STAR p.Q258* mutation is the mos...

    Authors: Eungu Kang, Yoon-Myung Kim, Gu-Hwan Kim, Beom Hee Lee, Han-Wook Yoo and Jin-Ho Choi
    Citation: Molecular Medicine 2017 23:2301149
  40. The microtubule inhibitor vincristine is currently used to treat a variety of brain tumors, including low-grade glioma and anaplastic oligodendroglioma. Vincristine, however, does not penetrate well into brain...

    Authors: Michelle De Witt, Alexander Gamble, Derek Hanson, Daniel Markowitz, Caitlin Powell, Saleh Al Dimassi, Mark Atlas, John Boockvar, Rosamaria Ruggieri and Marc Symons
    Citation: Molecular Medicine 2017 23:2301050
  41. Calcific aortic valve disease (CAVD) is common among the elderly, and aortic valve interstitial cells (AVICs) exhibit unique inflammatory and osteogenic responses to proinflammatory stimulation, which plays an...

    Authors: Qiong Zhan, Qingchun Zeng, Rui Song, Yufeng Zhai, Dingli Xu, David A. Fullerton, Charles A. Dinarello and Xianzhong Meng
    Citation: Molecular Medicine 2017 23:2301083
  42. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of ...

    Authors: Janin Henkel, Charles Dominic Coleman, Anne Schraplau, Korinna Jöhrens, Daniela Weber, José Pedro Castro, Martin Hugo, Tim Julius Schulz, Stephanie Krämer, Annette Schürmann and Gerhard Paul Püschel
    Citation: Molecular Medicine 2017 23:2301070
  43. Osteoporosis is a global public health problem affecting more than 200 million people worldwide. We previously showed that treatment with α-1 antitrypsin (AAT), a multifunctional protein with antiinflammatory ...

    Authors: Mohammad Ahsanul Akbar, David Nardo, Mong-Jen Chen, Ahmed S. Elshikha, Rubina Ahamed, Eslam M. Elsayed, Claire Bigot, L. Shannon Holliday and Sihong Song
    Citation: Molecular Medicine 2017 23:2301057
  44. α7 nicotinic acetylcholine receptor (α7 nAChR, coded by Chrna7) is indispensable in dampening proinflammatory responses. However, whether α7 nAChR plays a role in regulating bleomycin (BLM)-induced lung fibrosis ...

    Authors: Peiyu Sun, Ling Li, Caiqi Zhao, Mengyao Pan, Zhikang Qian and Xiao Su
    Citation: Molecular Medicine 2017 23:2301034
  45. Pancreatic cancer is one of the most lethal solid malignancies, with few treatment options. We have recently shown that expression of protease activated receptor (PAR)-1 in the tumor microenvironment drives th...

    Authors: Kun Shi, Helene Damhofer, Joost Daalhuisen, Marieke ten Brink, Dick J. Richel and C. Arnold Spek
    Citation: Molecular Medicine 2017 23:2301013
  46. miR-155 has been shown to participate in host response to infection and neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell function. We hypothesized that miR-155 may co...

    Authors: Kevin R. Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, Andrea L. Conroy, Michael Hawkes, Henry S. Cheng, Makon-Sébastien Njock, Jason E. Fish, John M. Harlan, Jose A. López, W. Conrad Liles and Kevin C. Kain
    Citation: Molecular Medicine 2017 23:2301024
  47. Amino acid replacement mutations in certain chronic lymphocytic leukemia (CLL) stereotyped B cell receptor (BCR) immunoglobulins (IGs) at defined positions within antigen-binding sites strongly imply antigen s...

    Authors: Rosa Catera, Yun Liu, Chao Gao, Xiao-Jie Yan, Amanda Magli, Steven L. Allen, Jonathan E. Kolitz, Kanti R. Rai, Charles C. Chu, Ten Feizi, Kostas Stamatopoulos and Nicholas Chiorazzi
    Citation: Molecular Medicine 2017 23:2301001

Annual Journal Metrics

  • Speed
    8 days to first decision for all manuscripts
    43 days to first decision for reviewed manuscripts only
    128 days from submission to acceptance
    24 days from acceptance to publication

    Citation Impact
    6.354 - 2-year Impact Factor
    5.230 - 5-year Impact Factor

    694,801 downloads (2021)
    204 Altmetric mentions