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  1. Radiotherapy remains one of the corner stones in the treatment of various malignancies and often leads to an improvement in overall survival. Nonetheless, pre-clinical evidence indicates that radiation can ent...

    Authors: Nora Sundahl, Fréderic Duprez, Piet Ost, Wilfried De Neve and Marc Mareel

    Citation: Molecular Medicine 2018 24:16

    Content type: Review

    Published on:

  2. Parathyroid hormone (PTH) is one of the principal regulators of calcium homeostasis. Although serum PTH level is mostly accounted by genetic factors, genetic background underlying PTH level is insufficiently k...

    Authors: Antonela Matana, Dubravka Brdar, Vesela Torlak, Thibaud Boutin, Marijana Popović, Ivana Gunjača, Ivana Kolčić, Vesna Boraska Perica, Ante Punda, Ozren Polašek, Maja Barbalić, Caroline Hayward and Tatijana Zemunik

    Citation: Molecular Medicine 2018 24:15

    Content type: Research article

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  3. Fetal sex determination is useful for families at risk of X-linked disorders, such as Duchenne muscular dystrophy, adrenal hypoplasia, hemophilia. At first, this could be obtained through invasive procedures s...

    Authors: Elisabetta D’Aversa, Giulia Breveglieri, Patrizia Pellegatti, Giovanni Guerra, Roberto Gambari and Monica Borgatti

    Citation: Molecular Medicine 2018 24:14

    Content type: Research article

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  5. Atherosclerosis has been recognized as an inflammatory disease involving the vascular wall. MicroRNAs are a group of small noncoding RNAs to regulate gene expression at the transcriptional level through mRNA d...

    Authors: Heng Li, Xin-Ping Ouyang, Ting Jiang, Xi-Long Zheng, Ping-Ping He and Guo-Jun Zhao

    Citation: Molecular Medicine 2018 24:12

    Content type: Review

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  7. Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases (CVDs). Stachydrine (STA) is an active component in Chinese motherwort Leonurus heterophyllus sweet, which has been widely use...

    Authors: Xinya Xie, Zihui Zhang, Xinfeng Wang, Zhenyu Luo, Baochang Lai, Lei Xiao and Nanping Wang

    Citation: Molecular Medicine 2018 24:10

    Content type: Research article

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  8. Endometriosis is a chronic and underdiagnosed disease which affects 5–10% of women of childbearing age and is characterized by growth of endometrial tissue outside of the uterus, most often in the peritoneal c...

    Authors: Laura A. Warren, Andrew Shih, Susana Marquez Renteira, Tamer Seckin, Brandon Blau, Kim Simpfendorfer, Annette Lee, Christine N. Metz and Peter K. Gregersen

    Citation: Molecular Medicine 2018 24:1

    Content type: Research article

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  9. Chronic lymphocytic leukemia (CLL), the most frequent type of leukemia in western countries, is characterized by the progressive accumulation in blood, bone marrow and lymphoid tissues of monoclonal B lymphocy...

    Authors: Gerardo Ferrer and Emili Montserrat

    Citation: Molecular Medicine 2018 24:9

    Content type: Review

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  10. The NLRP3 inflammasome, a cytosolic complex that mediates the maturation of IL-1β and IL-18 as well as the release of high mobility group box 1 (HMGB1), contributes to the lethality of endotoxic shock. Ethyl p...

    Authors: Sujun Li, Fang Liang, Kevin Kwan, Yiting Tang, Xiangyu Wang, Youzhou Tang, Jianhua Li, Huan Yang, Sangeeta S. Chavan, Haichao Wang, Ulf Andersson, Ben Lu and Kevin J. Tracey

    Citation: Molecular Medicine 2018 24:8

    Content type: Research article

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  11. In order to retrieve episodic past events, the missing information needs to be reconstructed using information stored in semantic memory. Failures in these reconstructive processes are expressed as false memor...

    Authors: Armin Zlomuzica, Friederike Preusser, Susanna Roberts, Marcella L. Woud, Kathryn J. Lester, Ekrem Dere, Thalia C. Eley and Jürgen Margraf

    Citation: Molecular Medicine 2018 24:7

    Content type: Research article

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  12. Ec peptide (PEc), resulting from the proteolytic cleavage of the IGF-1Ec isoform, is involved in prostate cancer progression and metastasis, whereas in muscle tissue, it is associated with the mobilization of ...

    Authors: A. Armakolas, A. Dimakakos, C. Loukogiannaki, N. Armakolas, A. Antonopoulos, C. Florou, P. Tsioli, E. Papageorgiou, T. P. Alexandrou, M. Stathaki, D. Spinos, D. Pektasides, E. Patsouris and M. Koutsilieris

    Citation: Molecular Medicine 2018 24:6

    Content type: Research article

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  14. Necrotizing Enterocolitis (NEC) is one of the most devastating gastrointestinal diseases in neonates, particularly among preterm infants in whom surgical NEC is the leading cause of morbidity. NEC pathophysiol...

    Authors: Naomi-Liza Denning and Jose M. Prince

    Citation: Molecular Medicine 2018 24:4

    Content type: Review

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  15. Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a red...

    Authors: Natasha Fillmore, Jody L. Levasseur, Arata Fukushima, Cory S. Wagg, Wei Wang, Jason R. B. Dyck and Gary D. Lopaschuk

    Citation: Molecular Medicine 2018 24:3

    Content type: Research article

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  16. Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is highly complex with constant features, such a...

    Authors: Antonella Izzo, Nunzia Mollo, Maria Nitti, Simona Paladino, Gaetano Calì, Rita Genesio, Ferdinando Bonfiglio, Rita Cicatiello, Maria Barbato, Viviana Sarnataro, Anna Conti and Lucio Nitsch

    Citation: Molecular Medicine 2018 24:2

    Content type: Review

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  17. Epidemiological studies have suggested a link between cumulative diabetic exposure and cancer. The interaction of advanced glycation end products (AGEs) with their receptor (RAGE) may contribute to the phenome...

    Authors: Nobutaka Nakamara, Takanori Matsui, Yuji Ishibashi, Ami Sotokawauchi, Kei Fukami, Yuichiro Higashimoto and Sho-ichi Yamagishi

    Citation: Molecular Medicine 2017 23:2301295

    Content type: Research Article

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  18. Sirtuin-6 (Sirt6) is a critical epigenetic regulator, but its function in the gut is unknown. Here, we studied the role of intestinal epithelial Sirt6 in colitis-associated intestinal epithelial injury. We fou...

    Authors: Fangyi Liu, Heng-Fu Bu, Hua Geng, Isabelle G. De Plaen, Chao Gao, Peng Wang, Xiao Wang, Jacob A. Kurowski, Hong Yang, Jiaming Qian and Xiao-Di Tan

    Citation: Molecular Medicine 2017 23:2301272

    Content type: Research Article

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  19. The kidney is vulnerable to hypoxia-induced injury. One of the mechanisms underlying this phenomenon is cell apoptosis triggered by hypoxia-inducible factor-1- α (HIF-1α) activation. MicroRNA-210 (miR-210) is ...

    Authors: Li-Li Liu, Dahu Li, Yun-Ling He, Yan-Zhao Zhou, Sheng-Hui Gong, Li-Ying Wu, Yong-Qi Zhao, Xin Huang, Tong Zhao, Lun Xu, Kui-Wu Wu, Ming-Gao Li, Ling-Ling Zhu and Ming Fan

    Citation: Molecular Medicine 2017 23:2301258

    Content type: Research Article

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  20. BD750, a novel JAK3/STAT5 inhibitor, can inhibit T cell proliferation. This study aims to evaluate whether BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune enc...

    Authors: Yan Zhou, Xiao Leng, Hua Li, Shuxia Yang, Tai Yang, Limei Li, Ying Xiong, Qiang Zou, Yang Liu and Yantang Wang

    Citation: Molecular Medicine 2017 23:2301204

    Content type: Research Article

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  21. Biobanks and national registries represent a powerful tool for genomic discovery, but rely on diagnostic codes that can be unreliable and fail to capture relationships between related diagnoses. We developed a...

    Authors: Thomas H. McCoy Jr, Victor M. Castro, Leslie A. Snapper, Kamber L. Hart and Roy H. Perlis

    Citation: Molecular Medicine 2017 23:2301285

    Content type: Research Article

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  22. Interleukin (IL)-26 is abundant in human airways and this cytokine is involved in the local immune response to a bacterial stimulus in vivo. Specifically, local exposure to the toll-like receptor (TLR) 4 agoni...

    Authors: Karlhans Fru Che, Riitta Kaarteenaho, Elisa Lappi-Blanco, Bettina Levänen, Jitong Sun, Åsa Wheelock, Lena Palmberg, C. Magnus Sköld and Anders Lindén

    Citation: Molecular Medicine 2017 23:2301247

    Content type: Research Article

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  23. Coiled-coil domain-containing 80 (CCDC80) is an adipocyte-secreted protein that modulates glucose homeostasis in response to diet-induced obesity in mice. The objective of this study was to analyze the link be...

    Authors: Óscar Osorio-Conles, María Guitart, José María Moreno-Navarrete, Xavier Escoté, Xavier Duran, José Manuel Fernandez-Real, Anna María Gómez-Foix, Sonia Fernández-Veledo and Joan Vendrell

    Citation: Molecular Medicine 2017 23:2301225

    Content type: Research Article

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  24. Adoptive immunotherapy with cytokine induced killer (CIK) cells has shown antitumor activity against several kinds of cancer in preclinical models and clinical trials. CIK cells are a subset of ex vivo expanded T...

    Authors: Giulia Mesiano, Roberta Zini, Giulia Montagner, Nicoletta Bianchi, Rossella Manfredini, Antonella Chillemi, Massimo Aglietta, Giovanni Grignani, Ilaria Lampronti, Erika Fiorino, Fabio Malavasi, Dario Sangiolo, Roberto Gambari and Davide Ferrari

    Citation: Molecular Medicine 2017 23:2301235

    Content type: Research Article

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  25. Heme oxygenase-1 (HO-1) is reported to protect against liver injury, but little Is known about its effect on the intestinal barrier in cholestatic liver injury. In this study, we investigated the effects of HO...

    Authors: Lijing Zhang, Zhenling Zhang, Bojia Liu, Yanling Jin, Yan Tian, Yi Xin and Zhijun Duan

    Citation: Molecular Medicine 2017 23:2301215

    Content type: Research Article

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  26. Histone modifications play a critical role In the pathological processes of dilated cardiomyopathy (DCM), while the role and expression pattern of histone methyltransferases (HMTs), especially mixed lineage le...

    Authors: Ding-Sheng Jiang, Xin Yi, Rui Li, Yun-Shu Su, Jing Wang, Min-Lai Chen, Li-Gang Liu, Min Hu, Cai Cheng, Ping Zheng, Xue-Hai Zhu and Xiang Wei

    Citation: Molecular Medicine 2017 23:2301196

    Content type: Research Article

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  27. Inflammation plays a significant role in protecting hosts against pathogens. Inflammation induced by noninfectious endogenous agents can be detrimental and, if excessive, can result in organ and tissue damage....

    Authors: Qian Sun, Jie Fan, Timothy R. Billiar and Melanie J. Scott

    Citation: Molecular Medicine 2017 23:2301188

    Content type: Research Article

    Published on:

  28. More than 100 risk loci for rheumatoid arthritis (RA) have been identified in individuals of European and Asian descent, but the genetic basis for RA in African Americans is less well understood. We genotyped ...

    Authors: Maria I. Danila, Vincent A. Laufer, Richard J. Reynolds, Qi Yan, Nianjun Liu, Peter K. Gregersen, Annette Lee, Marlena Kern, Carl D. Langefeld, Donna K. Arnett and S. Louis Bridges Jr.

    Citation: Molecular Medicine 2017 23:2301177

    Content type: Research Article

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  29. Previously, we showed that an oligodeoxynucleotide (ODN) with AAAG repeats (AAAG ODN) rescued mice from fatal acute lung injury (ALI) induced by influenza virus and inhibited production of tumor necrosis facto...

    Authors: Yue Xiao, Wenting Lu, Xin Li, Peiyan Zhao, Yun Yao, Xiaohong Wang, Ying Wang, Zhipeng Lin, Yongli Yu, Shucheng Hua and Liying Wang

    Citation: Molecular Medicine 2017 23:2301166

    Content type: Research Article

    Published on:

  30. Reperfusion injury following acute myocardial infarction is associated with significant morbidity. Activation of neuronal or non-neuronal cholinergic pathways in the heart has been shown to reduce ischemic inj...

    Authors: Spyros A. Mavropoulos, Nayaab S. Khan, Asaph C. J. Levy, Bradley T. Faliks, Cristina P. Sison, Valentin A. Pavlov, Youhua Zhang and Kaie Ojamaa

    Citation: Molecular Medicine 2017 23:2301120

    Content type: Research Article

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  31. Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the perijunctional actin-myosin ring. Myosin light chain kinase (MLCK) p...

    Authors: C. Adam Lorentz, Zhe Liang, Mei Meng, Ching-Wen Chen, Benyam P. Yoseph, Elise R. Breed, Rohit Mittal, Nathan J. Klingensmith, Alton B. Farris, Eileen M. Burd, Michael Koval, Mandy L. Ford and Craig M. Coopersmith

    Citation: Molecular Medicine 2017 23:2301155

    Content type: Research Article

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  32. Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have bee...

    Authors: Anju M. Philip, Youdong Wang, Antonio Mauro, Suzan El-Rass, John C. Marshall, Warren L. Lee, Arthur S. Slutsky, Claudia C. dos Santos and Xiao-Yan Wen

    Citation: Molecular Medicine 2017 23:2301134

    Content type: Research Article

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  33. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to...

    Authors: Paul Nurse

    Citation: Molecular Medicine 2017 23:2301112

    Content type: Anthony Cerami Award in Translational Medicine

    Published on:

  34. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer tumors. Comparisons between TNBC and non-triple-negative breast cancer (nTNBC) may help to differentiate key components involved i...

    Authors: Sandra K. Santuario-Facio, Servando Cardona-Huerta, Yadira X. Perez-Paramo, Victor Trevino, Francisco Hernandez-Cabrera, Augusto Rojas-Martinez, Grecia Uscanga-Perales, Jorge L. Martinez-Rodriguez, Lizeth Martinez-Jacobo, Gerardo Padilla-Rivas, Gerardo Muñoz-Maldonado, Juan Francisco Gonzalez-Guerrero, Javier Valero-Gomez, Ana L. Vazquez-Guerrero, Herminia G. Martinez-Rodriguez, Alvaro Barboza-Quintana…

    Citation: Molecular Medicine 2017 23:2301101

    Content type: Research Article

    Published on:

  35. Congenital lipoid adrenal hyperplasia (CLAH) is the most severe form of congenital adrenal hyperplasia, caused by defects in the steroidogenic acute regulatory protein (STAR). The STAR p.Q258* mutation is the mos...

    Authors: Eungu Kang, Yoon-Myung Kim, Gu-Hwan Kim, Beom Hee Lee, Han-Wook Yoo and Jin-Ho Choi

    Citation: Molecular Medicine 2017 23:2301149

    Content type: Research Article

    Published on:

  36. The microtubule inhibitor vincristine is currently used to treat a variety of brain tumors, including low-grade glioma and anaplastic oligodendroglioma. Vincristine, however, does not penetrate well into brain...

    Authors: Michelle De Witt, Alexander Gamble, Derek Hanson, Daniel Markowitz, Caitlin Powell, Saleh Al Dimassi, Mark Atlas, John Boockvar, Rosamaria Ruggieri and Marc Symons

    Citation: Molecular Medicine 2017 23:2301050

    Content type: Research Article

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  37. Calcific aortic valve disease (CAVD) is common among the elderly, and aortic valve interstitial cells (AVICs) exhibit unique inflammatory and osteogenic responses to proinflammatory stimulation, which plays an...

    Authors: Qiong Zhan, Qingchun Zeng, Rui Song, Yufeng Zhai, Dingli Xu, David A. Fullerton, Charles A. Dinarello and Xianzhong Meng

    Citation: Molecular Medicine 2017 23:2301083

    Content type: Research Article

    Published on:

  38. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of ...

    Authors: Janin Henkel, Charles Dominic Coleman, Anne Schraplau, Korinna Jöhrens, Daniela Weber, José Pedro Castro, Martin Hugo, Tim Julius Schulz, Stephanie Krämer, Annette Schürmann and Gerhard Paul Püschel

    Citation: Molecular Medicine 2017 23:2301070

    Content type: Research Article

    Published on:

  39. Osteoporosis is a global public health problem affecting more than 200 million people worldwide. We previously showed that treatment with α-1 antitrypsin (AAT), a multifunctional protein with antiinflammatory ...

    Authors: Mohammad Ahsanul Akbar, David Nardo, Mong-Jen Chen, Ahmed S. Elshikha, Rubina Ahamed, Eslam M. Elsayed, Claire Bigot, L. Shannon Holliday and Sihong Song

    Citation: Molecular Medicine 2017 23:2301057

    Content type: Research Article

    Published on:

  40. The inflammatory pathways that drive the development of intimai hyperplasia (IH) following arterial injury are not fully understood. We hypothesized that the lysosomal cysteine protease cathepsin L activates p...

    Authors: Jingjing Cai, Hua Zhong, Jinze Wu, Rui-Fang Chen, Huan Yang, Yousef Al-Abed, Ying Li, Xiaohui Li, Weihong Jiang, Marcelo F. Montenegro, Hong Yuan, Timothy R. Billiar and Alex F. Chen

    Citation: Molecular Medicine 2017 23:2301092

    Content type: Research Article

    Published on:

  41. α7 nicotinic acetylcholine receptor (α7 nAChR, coded by Chrna7) is indispensable in dampening proinflammatory responses. However, whether α7 nAChR plays a role in regulating bleomycin (BLM)-induced lung fibrosis ...

    Authors: Peiyu Sun, Ling Li, Caiqi Zhao, Mengyao Pan, Zhikang Qian and Xiao Su

    Citation: Molecular Medicine 2017 23:2301034

    Content type: Research Article

    Published on:

  42. Pancreatic cancer is one of the most lethal solid malignancies, with few treatment options. We have recently shown that expression of protease activated receptor (PAR)-1 in the tumor microenvironment drives th...

    Authors: Kun Shi, Helene Damhofer, Joost Daalhuisen, Marieke ten Brink, Dick J. Richel and C. Arnold Spek

    Citation: Molecular Medicine 2017 23:2301013

    Content type: Research Article

    Published on:

  43. miR-155 has been shown to participate in host response to infection and neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell function. We hypothesized that miR-155 may co...

    Authors: Kevin R. Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, Andrea L. Conroy, Michael Hawkes, Henry S. Cheng, Makon-Sébastien Njock, Jason E. Fish, John M. Harlan, Jose A. López, W. Conrad Liles and Kevin C. Kain

    Citation: Molecular Medicine 2017 23:2301024

    Content type: Research Article

    Published on:

  44. Amino acid replacement mutations in certain chronic lymphocytic leukemia (CLL) stereotyped B cell receptor (BCR) immunoglobulins (IGs) at defined positions within antigen-binding sites strongly imply antigen s...

    Authors: Rosa Catera, Yun Liu, Chao Gao, Xiao-Jie Yan, Amanda Magli, Steven L. Allen, Jonathan E. Kolitz, Kanti R. Rai, Charles C. Chu, Ten Feizi, Kostas Stamatopoulos and Nicholas Chiorazzi

    Citation: Molecular Medicine 2017 23:2301001

    Content type: Research Article

    Published on:

  45. Albert Dahan, Ann Dunne, Maarten Swartjes, Paolo L Proto, Lara Heij, Oscar Vogels, Monique van Velzen, Elise Sarton, Marieke Niesters, Martijn R Tannemaat, Anthony Cerami, and Michael Brines. (2013) ARA 290 Im...

    Authors: Albert Dahan, Ann Dunne, Maarten Swartjes, Paolo L. Proto, Lara Heij, Oscar Vogels, Monique van Velzen, Elise Sarton, Marieke Niesters, Martijn R. Tannemaat, Anthony Cerami and Michael Brines

    Citation: Molecular Medicine 2016 22:2201674

    Content type: Erratum

    Published on:

    The original article was published in Molecular Medicine 2013 19:1901334

  46. Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen in pneumonia associated with severe lung damage. Tissue injury causes release of damage-associated molecular patterns (DAMPs), which may...

    Authors: Anne Jan van der Meer, Achmed Achouiti, Arie van der Ende, Aicha Ait Soussan, Sandrine Florquin, Alex de Vos, Sacha S Zeerleder and Tom van der Poll

    Citation: Molecular Medicine 2016 22:2201292

    Content type: Research Article

    Published on:

  47. Acute emotionally reactive mental stress (MS) can provoke prognostically relevant deficits in cardiac function and myocardial perfusion, and chronic inflammation increases risk for this ischemic phenomenon. We...

    Authors: Robert Soufer, Antonio B Fernandez, Judith Meadows, Dorothea Collins and Matthew M Burg

    Citation: Molecular Medicine 2016 22:2201286

    Content type: Research Article

    Published on:

  48. The tumor-node-metastasis (TNM) system fails to accurately predict disease recurrence in a considerable number of patients. Although node-negative (stage II) colon cancer is considered to have an overall good ...

    Authors: Martin M Watson and Kjetil Søreide

    Citation: Molecular Medicine 2016 22:2201271

    Content type: Invited Commentary

    Published on:

  49. Emerging evidence demonstrates association of depression with both immune malfunctioning and worsened course of diverse aging-related diseases, but there is no explanation for the pathway(s) controlling this d...

    Authors: Shani Shenhar-Tsarfaty, Sharon Joker, Itzhak Shapira, Ori Rogowski, Shlomo Berliner, Yaacov Ritov and Hermona Soreq

    Citation: Molecular Medicine 2016 22:2201156

    Content type: Invited Research Article

    Published on:

  50. Endothelial cell (EC) dysfunction is a critical mediator of the acute respiratory distress syndrome (ARDS). Recent studies have demonstrated that stromal cell-derived factor 1α (SDF-1α) promotes EC barrier int...

    Authors: Changrun Guo, Andrew Goodwin, Joy N Jones Buie, James Cook, Perry Halushka, Kelley Argraves, Basilia Zingarelli, Xian Zhang, Liping Wang and Hongkuan Fan

    Citation: Molecular Medicine 2016 22:2201115

    Content type: Research Article

    Published on:

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Molecular Medicine

ISSN: 1528-3658