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  1. Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage destruction and inflammation. CC chemokine receptor 1 (CCR1), a member of the chemokine family and its receptor family, plays a ro...

    Authors: Hanqing Xu, Sheng Chen, Cheng Meng, Yi He, Xiao-jian Huang and Hong-bo You
    Citation: Molecular Medicine 2024 30:74
    Content type: Research article Published on:

  2. Human malignant pleural mesothelioma (hMPM) is an aggressive, rare disease with a poor prognosis. Histologically, MPM is categorized into epithelioid, biphasic, and sarcomatoid subtypes, with the epithelioid s...

    Authors: James Mei-Lin Chan, Yuan-Ching Chang, Hua-Chen Chan, Hsiu-Chuan Chan, Wei-Chin Chang, Liu-Fang Wang, Tung-Hu Tsai, Yu-Jen Chen and Wen-Chien Huang
    Citation: Molecular Medicine 2024 30:73
    Content type: Research article Published on:

  3. 8-Oxoguanine DNA glycosylase (OGG1), a well-known DNA repair enzyme, has been demonstrated to promote lung fibrosis, while the specific regulatory mechanism of OGG1 during pulmonary fibrosis remains unclarified.

    Authors: Wenjuan Wu, Hongxia Jia, Song Chen, Xinran Ma, Shuai Zhou, Lingxiao Qiu, Xinhui Wu, Ping Li, Heying Chu and Guojun Zhang
    Citation: Molecular Medicine 2024 30:72
    Content type: Research article Published on:

  4. Diabetes mellitus, a chronic metabolic disease, often leads to numerous chronic complications, significantly contributing to global morbidity and mortality rates. High glucose levels trigger epigenetic modific...

    Authors: Tongyue Yang, Feng Qi, Feng Guo, Mingwei Shao, Yi Song, Gaofei Ren, Zhao Linlin, Guijun Qin and Yanyan Zhao
    Citation: Molecular Medicine 2024 30:71
    Content type: Review Published on:

  5. The development of pulmonary fibrosis involves a cascade of events, in which inflammation mediated by immune cells plays a pivotal role. Chemotherapeutic drugs have been shown to have dual effects on fibrosis,...

    Authors: Ting Zhou, Lan lin, Yawen Zhan, Ziyao Zhang, Ying Jiang, Mi Wu, Dan Xue, Limin Chen, Xiufang Weng and Zhenghui Huang
    Citation: Molecular Medicine 2024 30:70
    Content type: Research article Published on:

  6. The Enoyl-CoA hydratase/isomerase family plays a crucial role in the metabolism of tumors, being crucial for maintaining the energy balance and biosynthetic needs of cancer cells. However, the enzymes within t...

    Authors: Jiancheng He, Jianfeng Yi, Li Ji, Lingchen Dai, Yu Chen and Wanjiang Xue
    Citation: Molecular Medicine 2024 30:69
    Content type: Research article Published on:

  7. Acute respiratory distress syndrome (ARDS) is characterized by alveolar edema that can progress to septal fibrosis. Mechanical ventilation can augment lung injury, termed ventilator-induced lung injury (VILI)....

    Authors: Charissa E. van den Brom, Caitlin Bozic, Chantal A. Polet, Annabel Bongers, Anita M. Tuip-de Boer, Roselique Ibelings, Joris J. T. H. Roelofs and Nicole P. Juffermans
    Citation: Molecular Medicine 2024 30:68
    Content type: Research article Published on:

  10. Catalpol (CAT) has various pharmacological activities and plays a protective role in cerebral ischemia. It has been reported that CAT played a protective role in cerebral ischemia by upregulaing NRF1 expressio...

    Authors: Kan Liu, Xinyan Yao, Jun Gao, Jinxi Wang and Jing Qi
    Citation: Molecular Medicine 2024 30:65
    Content type: Research article Published on:

  11. Insulin like growth factor II mRNA binding protein 3 (IGF2BP3) has been implicated in numerous inflammatory and cancerous conditions. However, its precise molecular mechanisms in endometriosis (EMs) remains un...

    Authors: Honglin Wang, Yingying Cao, Yanling Gou, Hao Wang, Zongwen Liang, Qiong Wu, Jiahuan Tan, Jinming Liu, Zhi Li, Jing Cui, Huiyan Zhang and Zongfeng Zhang
    Citation: Molecular Medicine 2024 30:64
    Content type: Research article Published on:

  12. Diabetic wounds are one of the long-term complications of diabetes, with a disordered microenvironment, diabetic wounds can easily develop into chronic non-healing wounds, which can impose a significant burden...

    Authors: Mengqian Liu, Xuerong Wei, Zijun Zheng, Erlian Xie, Qiuyi Yu, Yanbin Gao, Jun Ma and Lei Yang
    Citation: Molecular Medicine 2024 30:63
    Content type: Research article Published on:

  14. Triple negative breast cancer (TNBC) is a heterogeneous and aggressive disease characterized by a high risk of mortality and poor prognosis. It has been reported that Laminin γ2 (LAMC2) is highly expressed in ...

    Authors: Ding Wang, Kailibinuer Keyoumu, Rongji Yu, Doudou Wen, Hao Jiang, Xinchun Liu, Xiaotang Di and Shubing Zhang
    Citation: Molecular Medicine 2024 30:61
    Content type: Research article Published on:

  15. Severe acute pancreatitis (SAP) begins with premature activation of enzymes, promoted by the immune system, triggering a potential systemic inflammatory response that leads to organ failure with increased mort...

    Authors: Hongli Yang, Ruofan Cao, Feifei Zhou, Ben Wang, Qianqian Xu, Rui Li, ChunHua Zhang and Hongwei Xu
    Citation: Molecular Medicine 2024 30:60
    Content type: Review Published on:

  16. Microglial activation and polarization play a central role in poststroke inflammation and neuronal damage. Modulating microglial polarization from pro-inflammatory to anti-inflammatory phenotype is a promising...

    Authors: Chunyang Kang, Qiuling Sang, Dingxi Liu, Libo Wang, Jia Li and Xiaoyang Liu
    Citation: Molecular Medicine 2024 30:59
    Content type: Research article Published on:

  17. Vascular calcification (VC) is a complication in diabetes mellitus (DM) patients. Osteogenic phenotype switching of vascular smooth muscle cells (VSMCs) plays a critical role in diabetes-related VC. Mitophagy ...

    Authors: Kui Chen, Hao-jie Jin, Zi-heng Wu, Bao-fu Zhang, Jun Wu, Zi-yi Huang, Ying-peng Huang, Xin-wu Lu and Xiang-tao Zheng
    Citation: Molecular Medicine 2024 30:58
    Content type: Research article Published on:

  18. Ossification of the posterior longitudinal ligament (OPLL), an emerging heterotopic ossification disease, causes spinal cord compression, resulting in motor and sensory dysfunction. The etiology of OPLL remain...

    Authors: Xiangwu Geng, Yifan Tang, Changjiang Gu, Junkai Zeng, Yin Zhao, Quanwei Zhou, Lianshun Jia, Shengyuan Zhou and Xiongsheng Chen
    Citation: Molecular Medicine 2024 30:57
    Content type: Research article Published on:

  19. Ginsenoside Rh2 (G-Rh2), a steroidal compound extracted from roots of ginseng, has been extensively studied in tumor therapy. However, its specific regulatory mechanism in non-small cell lung cancer (NSCLC) is...

    Authors: Xiyu Liu, Jingjing Li, Qingqing Huang, Mingming Jin and Gang Huang
    Citation: Molecular Medicine 2024 30:56
    Content type: Research article Published on:

  20. Osteoarthritis (OA), the most common joint disease, is linked with chondrocyte apoptosis and extracellular matrix (ECM) degradation. Charged multivesicular body protein 5 (CHMP5), a member of the multivesicula...

    Authors: Weilu Gao, Rui Liu, Keke Huang, Wenhan Fu, Anquan Wang, Gongwen Du, Hao Tang, Li Yin and Zongsheng S. Yin
    Citation: Molecular Medicine 2024 30:55
    Content type: Research article Published on:

  21. Bleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA damage and senescence in alveolar epithelial cells (AECs) is considered a ...

    Authors: Fuqiang Chen, Wenna Zhao, Chenghong Du, Zihan Chen, Jie Du and Meijuan Zhou
    Citation: Molecular Medicine 2024 30:54
    Content type: Research article Published on:

  23. Skin fibrosis affects the normal function of the skin. TGF-β1 is a key cytokine that affects organ fibrosis. The latency-associated peptide (LAP) is essential for TGF-β1 activation. We previously constructed a...

    Authors: Zhiqin Cao, Keke Zhang, Jingruo Liu, Yu Pan, Jiayi Shi, Luxin Li, Xiaocan Sun, Shiqi Li, Xiaohuan Yuan and Dan Wu
    Citation: Molecular Medicine 2024 30:52
    Content type: Research article Published on:

  24. The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct treatment protocol. Distinguishing MIS-C from SARS-CoV-2 negative sepsis ...

    Authors: Maitray A. Patel, Douglas D. Fraser, Mark Daley, Gediminas Cepinskas, Noemi Veraldi and Serge Grazioli
    Citation: Molecular Medicine 2024 30:51
    Content type: Research article Published on:

  27. Immune-mediated arthritis is a group of autoinflammatory diseases, where the patient’s own immune system attacks and destroys synovial joints. Sustained remission is not always achieved with available immunosu...

    Authors: Dipabarna Bhattacharya, Jason Theodoropoulos, Katariina Nurmi, Timo Juutilainen, Kari K. Eklund, Riitta Koivuniemi, Tiina Kelkka, Satu Mustjoki and Tapio Lönnberg
    Citation: Molecular Medicine 2024 30:48
    Content type: Short report Published on:

  28. RASopathies are genetic syndromes affecting development and having variable cancer predisposition. These disorders are clinically related and are caused by germline mutations affecting key players and regulato...

    Authors: Giulia Fasano, Stefania Petrini, Valeria Bonavolontà, Graziamaria Paradisi, Catia Pedalino, Marco Tartaglia and Antonella Lauri
    Citation: Molecular Medicine 2024 30:47
    Content type: Research article Published on:

  29. Effective therapeutic targets and early diagnosis are major challenges in the treatment of gastrointestinal tract (GIT) cancers. SALL4 is a well-known transcription factor that is involved in organogenesis dur...

    Authors: Tairan Wang, Yan Jin, Mengyao Wang, Boya Chen, Jinyu Sun, Jiaying Zhang, Hui Yang, Xinyao Deng, Xingyue Cao, Lidong Wang and Yuanyuan Tang
    Citation: Molecular Medicine 2024 30:46
    Content type: Review Published on:

  32. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory and non-inflammatory diseases, including liver injury induced by acetaminophen (APAP) ov...

    Authors: Joshua Bloom, Georgios Pantouris, Mingzhu He, Bayan Aljabari, Lopa Mishra, Ramu Manjula, Andrew Parkins, Elias J. Lolis and Yousef Al-Abed
    Citation: Molecular Medicine 2024 30:43
    Content type: Research article Published on:

  33. The formation and accumulation of cholesterol crystals (CC) at the lesion site is a hallmark of atherosclerosis. Although studies have shown the importance of vascular smooth muscle cells (VSMCs) in the diseas...

    Authors: Jishamol Thazhathveettil, Ashok Kumar Kumawat, Isak Demirel, Allan Sirsjö and Geena Varghese Paramel
    Citation: Molecular Medicine 2024 30:42
    Content type: Research article Published on:

  34. Benign prostatic hyperplasia (BPH) is a prevalent disease affecting elderly men, with chronic inflammation being a critical factor in its development. Omentin-1, also known as intelectin-1 (ITLN-1), is an anti...

    Authors: Yi-Yi Wang, Guo-Qiang Zhu, Kun Xia, Hong-Bo Zeng, Yun-Hui He, Hui Xie, Zhen-Xing Wang and Ran Xu
    Citation: Molecular Medicine 2024 30:41
    Content type: Research article Published on:

  35. The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER), due to genetic determinants and extrinsic environmental factors, leads to endoplasmic reticulum stress (ER stress). As ...

    Authors: Siqi Yuan, Dan She, Shangming Jiang, Nan Deng, Jiayi Peng and Ling Ma
    Citation: Molecular Medicine 2024 30:40
    Content type: Review Published on:

  36. Anesthetics have been linked to cognitive alterations, particularly in the elderly. The current research delineates how Fibroblast Growth Factor 2 (Fgf2) modulates tau protein phosphorylation, contributing to ...

    Authors: Xin Xie, Xiaomin Zhang, Songze Li and Wei Du
    Citation: Molecular Medicine 2024 30:39
    Content type: Research article Published on:

  37. Macrophage-derived extracellular vesicle (macrophage-EV) is highly studied for its regulatory role in atherosclerosis (AS). Our current study tried to elucidate the possible role of macrophage-EV loaded with s...

    Authors: Weijie Liang, Ruibin Wei, Xingxing Zhu, Jinliang Li, Aiwen Lin, Jun Chen, Wen Wu and Qiang Jie
    Citation: Molecular Medicine 2024 30:38
    Content type: Research article Published on:

  39. The disease-causing mutation in Huntington disease (HD) is a CAG trinucleotide expansion in the huntingtin (HTT) gene. The mutated CAG tract results in the production of a small RNA, HTT1a, coding for only exon 1...

    Authors: Franziska Hoschek, Julia Natan, Maximilian Wagner, Kirupa Sathasivam, Alshaimaa Abdelmoez, Björn von Einem, Gillian P. Bates, G. Bernhard Landwehrmeyer and Andreas Neueder
    Citation: Molecular Medicine 2024 30:36
    Content type: Research article Published on:

    The Correction to this article has been published in Molecular Medicine 2024 30:49

  40. Neuronal ferroptosis plays a critical role in the pathogenesis of cognitive deficits. The present study explored whether artemisinin protected type 2 diabetes mellitus (T2DM) mice from cognitive impairments by...

    Authors: Bo Wang, Sheng Zhu, Miao Guo, Run-Dong Ma, Ya-Ling Tang, Ya-Xiong Nie and Hong-Feng Gu
    Citation: Molecular Medicine 2024 30:35
    Content type: Research article Published on:

  41. Imbalance in energy regulation is a major cause of insulin resistance and diabetes. Melanocortin-4 receptor (MC4R) signaling at specific sites in the central nervous system has synergistic but non-overlapping ...

    Authors: Hengru Guo, Ying Xin, Saifei Wang, Xiaoning Zhang, Yanqi Ren, Bo Qiao, Hongjiang Li, Jing Wu, Xiao Hao, Lijun Xu, Yushan Yan and Haohao Zhang
    Citation: Molecular Medicine 2024 30:34
    Content type: Research article Published on:

  42. Loss of dopaminergic neurons underlies the motor symptoms of Parkinson’s disease (PD). However stereotypical PD symptoms only manifest after approximately 80% of dopamine neurons have died making dopamine-rela...

    Authors: Anna Marie Buchanan, Sergio Mena, Iman Choukari, Aditya Vasa, Jesseca N. Crawford, Jim Fadel, Nick Maxwell, Lawrence Reagan, Allie Cruikshank, Janet Best, H. Fred Nijhout, Michael Reed and Parastoo Hashemi
    Citation: Molecular Medicine 2024 30:33
    Content type: Research article Published on:

  43. Endothelial-to-Mesenchymal Transformation (EndMT) plays key roles in endothelial dysfunction during the pathological progression of atherosclerosis; however, its detailed mechanism remains unclear. Herein, we ...

    Authors: Zhiwen Zhang, Quan Guo, Chao Ma, Zhenzhou Zhao, Qingbo Shi, Haosen Yu, Lixin Rao and Muwei Li
    Citation: Molecular Medicine 2024 30:32
    Content type: Research article Published on:

  44. Reperfusion is the most effective strategy for myocardial infarct, but induces additional injury. WD repeat and SOCS box containing protein 1 (WSB1) plays a protective role in ischemic cells. This study aims t...

    Authors: Lini Fang, Yang Tao, Guoying Che, Yongzi Yun, Min Ren and Yujie Liu
    Citation: Molecular Medicine 2024 30:31
    Content type: Research article Published on:

  45. Sepsis is a systemic inflammatory response which is frequently associated with acute lung injury (ALI). Activating transcription factor 3 (ATF3) promotes M2 polarization, however, the biological effects of ATF...

    Authors: Wei Wang, Rongli Xu, Ping He, Yuqing Xiong, Haomiao Zhao, Xuewei Fu, Jie Lin and Lijiao Ye
    Citation: Molecular Medicine 2024 30:30
    Content type: Research article Published on:

  46. The escalating challenge of Carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospital-acquired pneumonia (HAP) is closely linked to the blaNDM-1 gene. This study explores the regulatory mechanisms of blaNDM-1...

    Authors: Liang Ding, Zheng Yang and Baier Sun
    Citation: Molecular Medicine 2024 30:29
    Content type: Research article Published on:

  47. Lung cancer is the leading cause of cancer-related death worldwide. The sex differences in the occurrence and fatality rates of non-small cell lung cancer (NSCLC), along with its association with estrogen depe...

    Authors: Jiaping Chen, Rong Zhao, Yangwei Wang, Han Xiao, Wei Lin, Mingxin Diao, Shiwen He, Peiyuan Mei and Yongde Liao
    Citation: Molecular Medicine 2024 30:28
    Content type: Research article Published on:

  48. Isoorientin (ISO) is a glycosylated flavonoid with antitumor, anti-inflammatory, and antioxidant properties. However, its effects on bone metabolism remain largely unknown.

    Authors: Bo Zhang, Zechao Qu, Hua Hui, Baorong He, Dong Wang, Yong Zhang, Yiwei Zhao, Jingjun Zhang and Liang Yan
    Citation: Molecular Medicine 2024 30:27
    Content type: Research article Published on:

  49. Chronic Human Papilloma Virus (HPV) infection is supplanting alcohol and tobacco intoxications as the leading cause of oropharyngeal cancer in developed countries. HPV-related squamous cell carcinomas of the o...

    Authors: Robin Baudouin, Eric Tartour, Cécile Badoual and Stéphane Hans
    Citation: Molecular Medicine 2024 30:26
    Content type: Hypothesis Published on:

  50. Scleral extracellular matrix (ECM) remodeling plays a crucial role in the development of myopia, particularly in ocular axial elongation. Thrombospondin-1 (THBS1), also known as TSP-1, is a significant cellula...

    Authors: Junhan Chen, Shin-ichi Ikeda, Yajing Yang, Yan Zhang, Ziyan Ma, Yifan Liang, Kazuno Negishi, Kazuo Tsubota and Toshihide Kurihara
    Citation: Molecular Medicine 2024 30:25
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658