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Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 36 of 37

  1. The receptor of ciliary neurotrophic factor (CNTF) contains the signal transduction protein gp130, which is also a component of the receptors of cytokines such as interleukin (IL)-6, leukemia-inhibitory factor...

    Authors: Fabio Benigni, Pia Villa, Maria Teresa Demitri, Silvano Sacco, Jean D. Sipe, Laura Lagunowich, Nikos Panayotatos and Pietro Ghezzi

    Citation: Molecular Medicine 1995 1:BF03401594

    Content type: Original Articles

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  2. Interactions between γδ T cells and heat shock proteins (HSP) have been proposed as contributing factors in a number of diseases of possible autoimmune etiology but definitive evidence to support this hypothesis ...

    Authors: Luca Battistini, Marco Salvetti, Giovanni Ristori, Marika Falcone, Cedric S. Raine and Celia F. Brosnan

    Citation: Molecular Medicine 1995 1:BF03401592

    Content type: Original Articles

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  3. Human, but not mouse, islet amyloid polypeptide (IAPP) is amyloidogenic. Transgenic mice overexpressing human IAPP in the β cells of the islets of Langerhans should be useful in identifying factors important for ...

    Authors: Gunilla Westermark, Michelle Benig Arora, Niles Fox, Raymond Carroll, Shu Jin Chan, Per Westermark and Donald F. Steiner

    Citation: Molecular Medicine 1995 1:BF03401591

    Content type: Original Articles

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  4. At therapeutic concentrations, the antineoplastic agent taxol selectively perturbs mitotic spindle microtubules. Taxol has recently been shown to induce apoptosis, similar to the mechanism of cell death induce...

    Authors: Catherine M. Woods, Jian Zhu, Patricia A. McQueney, Daniel Bollag and Elias Lazarides

    Citation: Molecular Medicine 1995 1:BF03401588

    Content type: Original Articles

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  5. The developmental stage from which stems the malignant B cell population in Burkitt’s lymphoma (BL) is unclear. An approach to answering this question is provided by the sequence analysis of rearranged immunog...

    Authors: Ulf Klein, George Klein, Barbro Ehlin-Henriksson, Klaus Rajewsky and Ralf Küppers

    Citation: Molecular Medicine 1995 1:BF03401587

    Content type: Original Articles

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  6. Von Hippel-Lindau (VHL) disease is a familial cancer syndrome that has a dominant inherited pattern which predisposes affected individuals to a variety of tumors. The most frequent tumors are hemangioblastomas...

    Authors: Patricia M. Kessler, Sandip P. Vasavada, Raymond R. Rackley, Thomas Stackhouse, Fuh-Mei Duh, Farida Latif, Michael I. Lerman, Berton Zbar and Bryan R. G. Williams

    Citation: Molecular Medicine 1995 1:BF03401583

    Content type: OriginalPaper

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  7. Reactive glucose-protein intermediates and advanced glycation endproducts (AGEs) are shown to colocalize with atheromatous lesions and to trigger complex chemical and biological responses through interaction w...

    Authors: Helen Vlassara, Hubert Fuh, Thomas Donnelly and Myron Cybulsky

    Citation: Molecular Medicine 1995 1:BF03401582

    Content type: OriginalPaper

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  8. The marR gene of Escherichia coli encodes a repressor of the marRAB operon, a regulatory locus controlling multiple antibiotic resistance in this organism. Inactivation of marR results in increased expression of

    Authors: Mark C. Sulavik, Laura F. Gambino and Paul F. Miller

    Citation: Molecular Medicine 1995 1:BF03401581

    Content type: OriginalPaper

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  9. The anti-tumor agent, Taxol, has been shown in murine macrophages to stimulate tumor necrosis factor (TNF), modulate TNF receptors, induce a large panel of immediate-early genes, and induce protein tyrosine ph...

    Authors: Beth E. Henricson, Joan M. Carboni, Anne L. Burkhardt and Stefanie N. Vogel

    Citation: Molecular Medicine 1995 1:BF03401580

    Content type: OriginalPaper

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  10. Tissue inhibitor of metalloproteinases-3 (TIMP3) is the third member of the TIMP family of proteins, believed to play a significant role in controlling extracellular matrix remodeling.

    Authors: Jennifer A. Byrne, Catherine Tomasetto, Nicolas Rouyer, Jean-Pierre Bellocq, Marie-Christine Rio and Paul Basset

    Citation: Molecular Medicine 1995 1:BF03401579

    Content type: OriginalPaper

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  11. The antiviral drugs AZT and acyclovir are generally used in the treatment of infections with human immunodeficiency virus (HIV) and herpes simplex virus (HSV). These substances are known to impede virus replic...

    Authors: Martin Gschwentner, Alex Susanna, Ewald Wöll, Markus Ritter, Ulrich O. Nagl, Andreas Schmarda, Andreas Laich, Germar M. Pinggera, Helmut Ellemunter, Hartwig Huemer, Peter Deetjen and Markus Paulmichl

    Citation: Molecular Medicine 1995 1:BF03401578

    Content type: OriginalPaper

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  12. Clozapine, the classic atypical neuroleptic, exerts therapeutic actions in schizophrenic patients unresponsive to most neuroleptics. Clozapine interacts with numerous neurotransmitter receptors, and selective ...

    Authors: Charles E. Glatt, Adele M. Snowman, David R. Sibley and Solomon H. Snyder

    Citation: Molecular Medicine 1995 1:BF03401577

    Content type: OriginalPaper

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  13. The monocyte-derived cytokine, tumor necrosis factor α (TNFα), is essential for host immunity, but overproduction of this cytokine may have serious pathologic consequences. Excess TNFα produced in pulmonary tu...

    Authors: Jane M. Tramontana, Utaiwan Utaipat, Anthony Molloy, Pasakorn Akarasewi, Margaret Burroughs, Sanit Makonkawkeyoon, Barbara Johnson, Jeffrey D. Klausner, William Rom and Gilla Kaplan

    Citation: Molecular Medicine 1995 1:BF03401576

    Content type: OriginalPaper

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  14. An expanded CAG trinucleotide repeat is the genetic trigger of neuronal degeneration in Huntington’s disease (HD), but its mode of action has yet to be discovered. The sequence of the HD gene places the CAG re...

    Authors: Francesca Persichetti, Christine M. Ambrose, Pei Ge, Sandra M. McNeil, Jayalakshmi Srinidhi, Mary Anne Anderson, Barbara Jenkins, Glenn T. Barnes, Mabel P. Duyao, Lisa Kanaley, Nancy S. Wexler, Richard H. Myers, Edward D. Bird, Jean-Paul Vonsattel, Marcy E. MacDonald, James F. Gusella…

    Citation: Molecular Medicine 1995 1:BF03401575

    Content type: OriginalPaper

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  15. The carboxy-terminus of the merozoite surface protein-1 (MSP1) of Plasmodium falciparum has been implicated as a target of protective immunity.

    Authors: Sanjai Kumar, Anjali Yadava, David B. Keister, Jing Hui Tian, Michael Ohl, Kathy A. Perdue-Greenfield, Louis H. Miller and David C. Kaslow

    Citation: Molecular Medicine 1995 1:BF03401557

    Content type: Original Articles

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  16. Mutations in the ligand-binding domain of the thyroid hormone receptor β (TRβ) gene cause the syndrome of resistance to thyroid hormone (RTH). The clinical phenotype results from the antagonism of the normal TRα ...

    Authors: Rosemary Wong, Xu-Guang Zhu, Mark A. Pineda, Sheue-yann Cheng and Bruce D. Weintraub

    Citation: Molecular Medicine 1995 1:BF03401555

    Content type: Original Articles

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  17. Understanding the mechanism of developmental regulation of hemoglobin switching has scientific as well as clinical relevance because of the influence of fetal hemoglobin (HbF) production in adulthood on the cl...

    Authors: E. Rena Bacon, Nava Dalyot, Dvora Filon, Letizia Schreiber, Eliezer A. Rachmilewitz and Arieila Oppenheim

    Citation: Molecular Medicine 1995 1:BF03401554

    Content type: Original Articles

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  18. Sarcoidosis is a granulomatous disease characterized by the accumulation of activated T cells in the lungs. We previously showed that sarcoidosis patients expressing the HLA haplotype DR3(17), DQ2 had increased n...

    Authors: Johan Grunewald, Thomas Hultman, Anders Bucht, Anders Eklund and Hans Wigzell

    Citation: Molecular Medicine 1995 1:BF03401553

    Content type: Original Articles

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  19. H2-histamine receptors mediate a wide range of physiological functions extending from stimulation of gastric acid secretion to induction of human promyelocyte differentiation. We have previously cloned the H2-...

    Authors: John DelValle, Ira Gantz, Lidong Wang, Yi-Jun Guo, Gerd Munzert, Takao Tashiro, Yoshitaka Konda and Tadataka Yamada

    Citation: Molecular Medicine 1995 1:BF03401552

    Content type: Original Articles

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  20. The Ity/Lsh/Bcg gene on mouse chromosome 1 regulates priming/activation of macrophages for antimicrobial and tumouricidal activity. A candidate gene expressed in macrophages has been identified by positional clon...

    Authors: C. Howard Barton, Simon H. Whitehead and Jenefer M. Blackwell

    Citation: Molecular Medicine 1995 1:BF03401551

    Content type: Original Articles

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  21. Nitric oxide (NO), a small effector molecule produced enzymatically from L-arginine by nitric oxide synthase (NOS), is a mediator not only of important homeostatic mechanisms (e.g., blood vessel tone and tissu...

    Authors: Marina Bianchi, Peter Ulrich, Ona Bloom, Malcolm Meistrell III, Gary A. Zimmerman, Helena Schmidtmayerova, Michael Bukrinsky, Thomas Donnelley, Richard Bucala, Barbara Sherry, Kirk R. Manogue, Anthony J. Tortolani, Anthony Cerami and Kevin J. Tracey

    Citation: Molecular Medicine 1995 1:BF03401550

    Content type: Original Articles

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  22. Paraneoplastic syndromes are “remote” complications of cancer characterized clinically by neurological disease. The sera and cerebrospinal fluid (CSF) from patients with paraneoplastic neurological syndromes (...

    Authors: Lorise C. Gahring, Roy E. Twyman, John E. Greenlee and Scott W. Rogers

    Citation: Molecular Medicine 1995 1:BF03401549

    Content type: Original Articles

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  23. Human immunodeficiency virus type 1 (HIV-1) is a lentivirus and shares with other members of this retroviral subfamily the ability to replicate in nondividing cells, in particular, cells of the monocyte/macrop...

    Authors: Larisa Dubrovsky, Peter Ulrich, Gerard J. Nuovo, Kirk R. Manogue, Anthony Cerami and Michael Bukrinsky

    Citation: Molecular Medicine 1995 1:BF03401569

    Content type: Original Articles

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  24. Several immunotoxins in which antibodies are coupled to plant or bacterial toxins are now in clinical trials for the treatment of cancer. One of these is B3-LysPE38 in which MAb B3 which reacts with many human...

    Authors: Ulrich Brinkmann, Elisabeth Brinkmann and Ira Pastan

    Citation: Molecular Medicine 1995 1:BF03401568

    Content type: Original Articles

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  25. Murine Nramp is a candidate for the macrophage resistance gene Ity/Lsh/Bcg. Sequence analysis of human NRAMP was undertaken to determine its role in man.

    Authors: Jenefer M. Blackwell, C. Howard Barton, Jacqueline K. White, Susan Searle, Anne-Marie Baker, Hazel Williams and Marie-Anne Shaw

    Citation: Molecular Medicine 1995 1:BF03401567

    Content type: Original Articles

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  26. New vessel growth is often associated with ischemia, and hypoxic tissue has been identified as a potential source of angiogenic factors. In particular, ischemia is associated with the development of neovascula...

    Authors: David T. Shima, Anthony P. Adamis, Napoleone Ferrara, Kiang-Teck Yeo, Tet-Kin Yeo, Rapheal Allende, Judah Folkman and Patricia A. D’Amore

    Citation: Molecular Medicine 1995 1:BF03401566

    Content type: Original Articles

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  27. Vascular smooth muscle cell (VSMC) proliferation following arterial injury plays a critical role in a variety of vascular proliferative disorders, including atherosclerosis and restenosis after balloon angiopl...

    Authors: Mark W. Chang, Takeshi Ohno, David Gordon, Min Min Lu, Gary J. Nabel, Elizabeth G. Nabel and Jeffrey M. Leiden

    Citation: Molecular Medicine 1995 1:BF03401565

    Content type: Original Articles

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  28. Cervical intraepithelial neoplasia (CIN) and cervical cancer have been shown to be strongly associated with infection by human papillomavirus (HPV). However, other factors may be contributory in the progressio...

    Authors: Kunle Odunsi, George Terry, Linda Ho, John Bell, Jack Cuzick and Trivadi S. Ganesan

    Citation: Molecular Medicine 1995 1:BF03401564

    Content type: Original Articles

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  29. The identification of transcripts encoding putative olfactory receptors in mammalian germ cells (1) has generated the hypothesis that olfactory receptors may serve a chemosensory role in sperm Chemotaxis during f...

    Authors: Loren D. Walensky, A. Jane Roskams, Robert J. Lefkowitz, Solomon H. Snyder and Gabriele V. Ronnett

    Citation: Molecular Medicine 1995 1:BF03401561

    Content type: Original Articles

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  30. Angiotensin converting enzyme inhibitor (ACEi) therapy delays the onset of renal failure in diabetic nephropathy and inhibits or delays the onset of proteinuria in several animal models.

    Authors: Emmanuel P. Peten, Liliane J. Striker, Agnes Fogo, Iekuni Ichikawa, Aneeta Patel and Gary E. Striker

    Citation: Molecular Medicine 1994 1:BF03403536

    Content type: Original Articles

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  31. Thirty-six mutations that cause Gaucher disease, the most common glycolipid storage disorder, are known. Although both alleles of most patients with the disease contain one of these mutations, in a few patient...

    Authors: Ernest Beutler, Anna Demina and Terri Gelbart

    Citation: Molecular Medicine 1994 1:BF03403534

    Content type: Original Articles

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  32. The host response to tissue injury requires a complex interplay of diverse cellular, humoral, and connective tissue elements. Fibroblasts participate in this process by proliferating within injured sites and c...

    Authors: Richard Bucala, Lori A. Spiegel, Jason Chesney, Margaret Hogan and Anthony Cerami

    Citation: Molecular Medicine 1994 1:BF03403533

    Content type: Original Articles

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  33. Monozygotic (MZ) twinning is a poorly understood phenomenon that may result in subtle biologic differences between twins, despite their identical inheritance. These differences may in part account for discorda...

    Authors: Velia Trejo, Catherine Derom, Robert Vlietinck, William Ollier, Alan Silman, George Ebers, Robert Derom and Peter K. Gregersen

    Citation: Molecular Medicine 1994 1:BF03403532

    Content type: Original Articles

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  34. Common variable immunodeficiency (CVID) is defined by hypogammaglobulinemia and increased susceptibility to infections. The gene defect responsible for CVID remains unknown.

    Authors: Monika Belickova, Harry W. Schroeder Jr., Y. L. Guan, Joseph Brierre, Seth Berney, Max D. Cooper and Josef T. Prchal

    Citation: Molecular Medicine 1994 1:BF03403531

    Content type: Original Articles

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  35. It has been proposed that the prion, the infectious agent of transmissible spongiform encephalopathies, is PrPSc, a post-translationally modified form of the normal host protein PrPC. We showed previously that mi...

    Authors: Hansruedi Büeler, Alex Raeber, Andreas Sailer, Marek Fischer, Adriano Aguzzi and Charles Weissmann

    Citation: Molecular Medicine 1994 1:BF03403528

    Content type: Original Articles

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