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Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 36 of 36

  1. Content type: OriginalPaper

    The monocyte-derived cytokine, tumor necrosis factor α (TNFα), is essential for host immunity, but overproduction of this cytokine may have serious pathologic consequences. Excess TNFα produced in pulmonary tu...

    Authors: Jane M. Tramontana, Utaiwan Utaipat, Anthony Molloy, Pasakorn Akarasewi, Margaret Burroughs, Sanit Makonkawkeyoon, Barbara Johnson, Jeffrey D. Klausner, William Rom and Gilla Kaplan

    Citation: Molecular Medicine 1995 1:BF03401576

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  2. Content type: Original Articles

    The carboxy-terminus of the merozoite surface protein-1 (MSP1) of Plasmodium falciparum has been implicated as a target of protective immunity.

    Authors: Sanjai Kumar, Anjali Yadava, David B. Keister, Jing Hui Tian, Michael Ohl, Kathy A. Perdue-Greenfield, Louis H. Miller and David C. Kaslow

    Citation: Molecular Medicine 1995 1:BF03401557

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  3. Content type: Original Articles

    Mutations in the ligand-binding domain of the thyroid hormone receptor β (TRβ) gene cause the syndrome of resistance to thyroid hormone (RTH). The clinical phenotype results from the antagonism of the normal TRα ...

    Authors: Rosemary Wong, Xu-Guang Zhu, Mark A. Pineda, Sheue-yann Cheng and Bruce D. Weintraub

    Citation: Molecular Medicine 1995 1:BF03401555

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  4. Content type: Original Articles

    Understanding the mechanism of developmental regulation of hemoglobin switching has scientific as well as clinical relevance because of the influence of fetal hemoglobin (HbF) production in adulthood on the cl...

    Authors: E. Rena Bacon, Nava Dalyot, Dvora Filon, Letizia Schreiber, Eliezer A. Rachmilewitz and Arieila Oppenheim

    Citation: Molecular Medicine 1995 1:BF03401554

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  5. Content type: Original Articles

    Sarcoidosis is a granulomatous disease characterized by the accumulation of activated T cells in the lungs. We previously showed that sarcoidosis patients expressing the HLA haplotype DR3(17), DQ2 had increased n...

    Authors: Johan Grunewald, Thomas Hultman, Anders Bucht, Anders Eklund and Hans Wigzell

    Citation: Molecular Medicine 1995 1:BF03401553

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  6. Content type: Original Articles

    H2-histamine receptors mediate a wide range of physiological functions extending from stimulation of gastric acid secretion to induction of human promyelocyte differentiation. We have previously cloned the H2-...

    Authors: John DelValle, Ira Gantz, Lidong Wang, Yi-Jun Guo, Gerd Munzert, Takao Tashiro, Yoshitaka Konda and Tadataka Yamada

    Citation: Molecular Medicine 1995 1:BF03401552

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  7. Content type: Original Articles

    The Ity/Lsh/Bcg gene on mouse chromosome 1 regulates priming/activation of macrophages for antimicrobial and tumouricidal activity. A candidate gene expressed in macrophages has been identified by positional clon...

    Authors: C. Howard Barton, Simon H. Whitehead and Jenefer M. Blackwell

    Citation: Molecular Medicine 1995 1:BF03401551

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  8. Content type: Original Articles

    Nitric oxide (NO), a small effector molecule produced enzymatically from L-arginine by nitric oxide synthase (NOS), is a mediator not only of important homeostatic mechanisms (e.g., blood vessel tone and tissu...

    Authors: Marina Bianchi, Peter Ulrich, Ona Bloom, Malcolm Meistrell III, Gary A. Zimmerman, Helena Schmidtmayerova, Michael Bukrinsky, Thomas Donnelley, Richard Bucala, Barbara Sherry, Kirk R. Manogue, Anthony J. Tortolani, Anthony Cerami and Kevin J. Tracey

    Citation: Molecular Medicine 1995 1:BF03401550

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  9. Content type: Original Articles

    Paraneoplastic syndromes are “remote” complications of cancer characterized clinically by neurological disease. The sera and cerebrospinal fluid (CSF) from patients with paraneoplastic neurological syndromes (...

    Authors: Lorise C. Gahring, Roy E. Twyman, John E. Greenlee and Scott W. Rogers

    Citation: Molecular Medicine 1995 1:BF03401549

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  10. Content type: Original Articles

    Human immunodeficiency virus type 1 (HIV-1) is a lentivirus and shares with other members of this retroviral subfamily the ability to replicate in nondividing cells, in particular, cells of the monocyte/macrop...

    Authors: Larisa Dubrovsky, Peter Ulrich, Gerard J. Nuovo, Kirk R. Manogue, Anthony Cerami and Michael Bukrinsky

    Citation: Molecular Medicine 1995 1:BF03401569

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  11. Content type: Original Articles

    Several immunotoxins in which antibodies are coupled to plant or bacterial toxins are now in clinical trials for the treatment of cancer. One of these is B3-LysPE38 in which MAb B3 which reacts with many human...

    Authors: Ulrich Brinkmann, Elisabeth Brinkmann and Ira Pastan

    Citation: Molecular Medicine 1995 1:BF03401568

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  12. Content type: Original Articles

    Murine Nramp is a candidate for the macrophage resistance gene Ity/Lsh/Bcg. Sequence analysis of human NRAMP was undertaken to determine its role in man.

    Authors: Jenefer M. Blackwell, C. Howard Barton, Jacqueline K. White, Susan Searle, Anne-Marie Baker, Hazel Williams and Marie-Anne Shaw

    Citation: Molecular Medicine 1995 1:BF03401567

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  13. Content type: Original Articles

    New vessel growth is often associated with ischemia, and hypoxic tissue has been identified as a potential source of angiogenic factors. In particular, ischemia is associated with the development of neovascula...

    Authors: David T. Shima, Anthony P. Adamis, Napoleone Ferrara, Kiang-Teck Yeo, Tet-Kin Yeo, Rapheal Allende, Judah Folkman and Patricia A. D’Amore

    Citation: Molecular Medicine 1995 1:BF03401566

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  14. Content type: Original Articles

    Vascular smooth muscle cell (VSMC) proliferation following arterial injury plays a critical role in a variety of vascular proliferative disorders, including atherosclerosis and restenosis after balloon angiopl...

    Authors: Mark W. Chang, Takeshi Ohno, David Gordon, Min Min Lu, Gary J. Nabel, Elizabeth G. Nabel and Jeffrey M. Leiden

    Citation: Molecular Medicine 1995 1:BF03401565

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  15. Content type: Original Articles

    Cervical intraepithelial neoplasia (CIN) and cervical cancer have been shown to be strongly associated with infection by human papillomavirus (HPV). However, other factors may be contributory in the progressio...

    Authors: Kunle Odunsi, George Terry, Linda Ho, John Bell, Jack Cuzick and Trivadi S. Ganesan

    Citation: Molecular Medicine 1995 1:BF03401564

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  16. Content type: Original Articles

    The identification of transcripts encoding putative olfactory receptors in mammalian germ cells (1) has generated the hypothesis that olfactory receptors may serve a chemosensory role in sperm Chemotaxis during f...

    Authors: Loren D. Walensky, A. Jane Roskams, Robert J. Lefkowitz, Solomon H. Snyder and Gabriele V. Ronnett

    Citation: Molecular Medicine 1995 1:BF03401561

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  17. Content type: Original Articles

    Angiotensin converting enzyme inhibitor (ACEi) therapy delays the onset of renal failure in diabetic nephropathy and inhibits or delays the onset of proteinuria in several animal models.

    Authors: Emmanuel P. Peten, Liliane J. Striker, Agnes Fogo, Iekuni Ichikawa, Aneeta Patel and Gary E. Striker

    Citation: Molecular Medicine 1994 1:BF03403536

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  18. Content type: Original Articles

    Lipopolysaccharide (LPS) is known to activate macrophages, causing the release of toxic cytokines that may provoke inflammation and shock. One of the most important and best studied of these cytokines is tumor...

    Authors: Thomas D. Geppert, Charles E. Whitehurst, Patricia Thompson and Bruce Beutler

    Citation: Molecular Medicine 1994 1:BF03403535

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  19. Content type: Original Articles

    Thirty-six mutations that cause Gaucher disease, the most common glycolipid storage disorder, are known. Although both alleles of most patients with the disease contain one of these mutations, in a few patient...

    Authors: Ernest Beutler, Anna Demina and Terri Gelbart

    Citation: Molecular Medicine 1994 1:BF03403534

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  20. Content type: Original Articles

    The host response to tissue injury requires a complex interplay of diverse cellular, humoral, and connective tissue elements. Fibroblasts participate in this process by proliferating within injured sites and c...

    Authors: Richard Bucala, Lori A. Spiegel, Jason Chesney, Margaret Hogan and Anthony Cerami

    Citation: Molecular Medicine 1994 1:BF03403533

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  21. Content type: Original Articles

    Monozygotic (MZ) twinning is a poorly understood phenomenon that may result in subtle biologic differences between twins, despite their identical inheritance. These differences may in part account for discorda...

    Authors: Velia Trejo, Catherine Derom, Robert Vlietinck, William Ollier, Alan Silman, George Ebers, Robert Derom and Peter K. Gregersen

    Citation: Molecular Medicine 1994 1:BF03403532

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  22. Content type: Original Articles

    Common variable immunodeficiency (CVID) is defined by hypogammaglobulinemia and increased susceptibility to infections. The gene defect responsible for CVID remains unknown.

    Authors: Monika Belickova, Harry W. Schroeder Jr., Y. L. Guan, Joseph Brierre, Seth Berney, Max D. Cooper and Josef T. Prchal

    Citation: Molecular Medicine 1994 1:BF03403531

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  23. Content type: Original Articles

    Reactive arthritis (ReA) is a T cell mediated inflammatory process. The immune response is primarily directed against a triggering organism, although autoimmunity has been invoked in long-lasting, antibiotic-r...

    Authors: Andreas K. H. Mertz, Angelika Daser, Mikael Skurnik, Karl-Heinz Wiesmüller, Jürgen Braun, Heiner Appel, Steven Batsford, Peihua Wu, Armin Distler and Joachim Sieper

    Citation: Molecular Medicine 1994 1:BF03403530

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  24. Content type: Original Articles

    This investigation deals with the molecular mechanism of anti-human immunodeficiency virus type 1 (HIV-1) action of pentoxifylline (PTX) [1-(5′-oxohexyl)-3,7-dimethylxanthine] a drug widely used for the treatm...

    Authors: Debajit K. Biswas, Christoph M. Ahlers, Bruce J. Dezube and Arthur B. Pardee

    Citation: Molecular Medicine 1994 1:BF03403529

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  25. Content type: Original Articles

    It has been proposed that the prion, the infectious agent of transmissible spongiform encephalopathies, is PrPSc, a post-translationally modified form of the normal host protein PrPC. We showed previously that mi...

    Authors: Hansruedi Büeler, Alex Raeber, Andreas Sailer, Marek Fischer, Adriano Aguzzi and Charles Weissmann

    Citation: Molecular Medicine 1994 1:BF03403528

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  26. Content type: Original Articles

    Major symptoms and death from systemic Bacillus anthracis infections are mediated by the action of the pathogen’s lethal toxin on host macrophages. High levels of the toxin are cytolytic to macrophages, whereas l...

    Authors: Philip C. Hanna, Benjamin A. Kruskal, R. Allen B. Ezekowitz, Barry R. Bloom and R. John Collier

    Citation: Molecular Medicine 1994 1:BF03403527

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