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  1. We previously have communicated our discovery that the amyloid associated with calcifying epithelial odontogenic tumors is composed of N-terminal fragments of the structurally novel odontogenic ameloblast-asso...

    Authors: Daniel P. Kestler, James S. Foster, Sallie D. Macy, Charles L. Murphy, Deborah T. Weiss and Alan Solomon
    Citation: Molecular Medicine 2008 14:1405318
    Content type: Research Article Published on:

  2. The rTg4510 mouse is a tauopathy model, characterized by massive neurodegeneration in Alzheimer’s disease (AD)-relevant cortical and limbic structures, deficits in spatial reference memory, and progression of ...

    Authors: Rita M. Ramalho, Ricardo J. S. Viana, Rui E. Castro, Clifford J. Steer, Walter C. Low and Cecília M. P. Rodrigues
    Citation: Molecular Medicine 2008 14:1405309
    Content type: Research Article Published on:

  4. Septic shock is the most severe form of sepsis. It is widely accepted that cytokines play pivotal roles in the pathophysiology of septic shock. We reported previously that continuous hemodiafiltration (CHDF) u...

    Authors: Taka-aki Nakada, Shigeto Oda, Ken-ichi Matsuda, Tomohito Sadahiro, Masataka Nakamura, Ryuzo Abe and Hiroyuki Hirasawa
    Citation: Molecular Medicine 2008 14:1405257
    Content type: Research Article Published on:

  5. Insulin resistance (IR) plays a key role in the pathophysiology of obesity-related diseases such as type 2 diabetes and nonalcoholic fatty liver disease. It has been demonstrated that IR is associated with a s...

    Authors: Herbert Tilg and Alexander R. Moschen
    Citation: Molecular Medicine 2008 14:14030222
    Content type: Review Article Published on:

  6. Trauma-hemorrhage leads to prolonged immune suppression, sepsis, and multiple organ failure. The condition affects all compartments of the immune system, and extensive studies have been carried out elucidating...

    Authors: Raghavan Raju, Kirby I. Bland and Irshad H. Chaudry
    Citation: Molecular Medicine 2008 14:14030213
    Content type: Review Article Published on:

  7. This review describes the current knowledge of the pathogenesis of acute Lyme neuroborreliosis (LNB), from invasion to inflammation of the central nervous system. Borrelia burgdorferi (B.b.) enters the host throu...

    Authors: Tobias A. Rupprecht, Uwe Koedel, Volker Fingerle and Hans-Walter Pfister
    Citation: Molecular Medicine 2008 14:14030205
    Content type: Review Article Published on:

  8. It is well established that catecholamines (CAs), which regulate immune and inflammatory responses, derive from the adrenal medulla and from presynaptic neurons. Recent studies reveal that T cells also can syn...

    Authors: Michael A. Flierl, Daniel Rittirsch, Markus Huber-Lang, J. Vidya Sarma and Peter A. Ward
    Citation: Molecular Medicine 2008 14:14030204
    Content type: Review Article Published on:

  9. Presenilin (PS) mutations enhance the production of the Aβ42 peptide that is derived from the amyloid precursor protein (APP). The pathway(s) by which the Aβ42 species is preferentially produced has not been e...

    Authors: Gregory D. Van Vickle, Chera L. Esh, Tyler A. Kokjohn, R. Lyle Patton, Walter M. Kalback, Dean C. Luehrs, Thomas G. Beach, Amanda J. Newel, Francisco Lopera, Bernardino Ghetti, Ruben Vidal, Eduardo M. Castaño and Alex E. Roher
    Citation: Molecular Medicine 2008 14:14030184
    Content type: Review Article Published on:

  10. α-Lipoic acid (LA) has been found previously to accelerate wound repair in patients affected by chronic wounds who underwent hyperbaric oxygen (HBO) therapy. Because proteinases are important in wound repair, ...

    Authors: Renata Alleva, Marco Tomasetti, Davide Sartini, Monica Emanuelli, Emanuele Nasole, Ferruccio Di Donato, Battista Borghi, Lory Santarelli and Jiri Neuzil
    Citation: Molecular Medicine 2008 14:14030175
    Content type: Research Article Published on:

  11. Fanconi anemia (FA) predisposes to hematopoietic failure, birth defects, leukemia, and squamous cell carcinoma of the head and neck (HNSCC) and cervix. The FA/BRCA pathway includes 8 members of a core complex ...

    Authors: Kazuhiko Yamamoto, Abdallah Nihrane, Jason Aglipay, Juan Sironi, Steven Arkin, Jeffrey M. Lipton, Toru Ouchi and Johnson M. Liu
    Citation: Molecular Medicine 2008 14:14030167
    Content type: Research Article Published on:

  12. Meniscal tears are attributed to either trauma or degeneration processes. Clinical data suggest that meniscal degeneration (MD) is associated with knee osteoarthritis; however, the molecular events underpinnin...

    Authors: Dionysios J. Papachristou, Eugenia Papadakou, Efthimia K. Basdra, Panagiotis Baltopoulos, Elias Panagiotopoulos and Athanasios G. Papavassiliou
    Citation: Molecular Medicine 2008 14:14030160
    Content type: Research Article Published on:

  13. In osteoarthritis (OA), cartilage destruction is associated not only with an Imbalance of anabolic and catabolic processes but also with alterations of the cytoskeletal organization in chondrocytes, although t...

    Authors: Helga Joos, Wolfgang Albrecht, Stefan Laufer, Heiko Reichel and Rolf E. Brenner
    Citation: Molecular Medicine 2008 14:14030150
    Content type: Research Article Published on:

  14. Nitric oxide (NO) signaling is important for the regulation of hematopoiesis. However, the role of Individual NO synthase (NOS) isoforms is unclear. Our results indicate that the neuronal NOS isoform (nNOS) re...

    Authors: Peter Krasnov, Tatyana Michurina, Michael A. Packer, Yuri Stasiv, Naoki Nakaya, Kateri A. Moore, Kenneth E. Drazan and Grigori Enikolopov
    Citation: Molecular Medicine 2008 14:14030141
    Content type: Research Article Published on:

  15. The mechanism mediating the development of ventricular arrhythmia (VA) after acute myocardial Infarction (AMI) Is still uncertain. Thrombin receptor (TR) activation has been proven to be arrhythmogenic in many...

    Authors: Lilong Tang, Chunyu Deng, Ming Long, Anli Tang, Shulin Wu, Yugang Dong, Louis D. Saravolatz and Julius M. Gardin
    Citation: Molecular Medicine 2008 14:14030131
    Content type: Research Article Published on:

  16. Macrophage migration inhibitory factor (MIF), a proinflammatory mediator, has been shown to be elevated following heart surgery in adults and may be associated with several postoperative complications, includi...

    Authors: Sanah Merchant, Sumekala Nadaraj, Devyani Chowdhury, Vincent A. Parnell, Cristina Sison, Edmund J. Miller and Kaie Ojamaa
    Citation: Molecular Medicine 2008 14:14030124
    Content type: Research Article Published on:

  17. Whole body exposure of wild type control littermates and A2A adenosine receptor (A2AR) gene deleted mice to low oxygen containing inspired gas mixture allowed the investigation of the mechanism that controls i...

    Authors: Alexander Choukèr, Manfred Thiel, Dmitriy Lukashev, Jerrold M. Ward, Ines Kaufmann, Sergey Apasov, Michail V. Sitkovsky and Akio Ohta
    Citation: Molecular Medicine 2008 14:14030116
    Content type: Research Article Published on:

  18. Chronic kidney disease (CKD) is associated with inflammation and malnutrition and carries a markedly increased risk of cardiovascular disease (CVD). High Mobility Group Box Protein-1 (HMGB-1) is a 30-kDa nucle...

    Authors: Annette Bruchfeld, Abdul Rashid Qureshi, Bengt Lindholm, Peter Barany, LiHong Yang, Peter Stenvinkel and Kevin J. Tracey
    Citation: Molecular Medicine 2008 14:14030109
    Content type: Research Article Published on:

  19. Previous phenotyping of glucose homeostasis and insulin secretion in a mouse model of hereditary hemochromatosis (Hfe−/−) and iron overload suggested mitochondrial dysfunction. Mitochondria from Hfe−/− mouse live...

    Authors: Hani A. Jouihan, Paul A. Cobine, Robert C. Cooksey, Emily A. Hoagland, Sihem Boudina, E. Dale Abel, Dennis R. Winge and Donald A. McClain
    Citation: Molecular Medicine 2008 14:14030098
    Content type: Research Article Published on:

  20. Plasmodium falciparum malaria causes 1–2 million deaths per year. Most deaths occur as a result of complications such as severe anemia and cerebral malaria (CM) (coma). Red cells of children with severe malaria-a...

    Authors: Boaz O. Owuor, Collins O. Odhiambo, Walter O. Otieno, Christine Adhiambo, Dominic W. Makawiti and José A. Stoute
    Citation: Molecular Medicine 2008 14:14030089
    Content type: Research Article Published on:

  21. Endothelial progenitor cells (EPCs) have been shown to be involved in vascular regeneration and angiogenesis in experimental diabetes. Because insulin therapy mobilizes circulating progenitor cells, we studied...

    Authors: Per M. Humpert, Zdenka Djuric, Ulf Zeuge, Dimitrios Oikonomou, Yuri Seregin, Klaus Laine, Volker Eckstein, Peter P. Nawroth and Angelika Bierhaus
    Citation: Molecular Medicine 2008 14:1405301
    Content type: Research Article Published on:

  22. Isolated growth hormone deficiency (IGHD) may be of genetic origin. One of the few genes involved in that condition encodes the growth hormone releasing hormone receptor (GHRHR) that, through its ligand (GHRH)...

    Authors: Latifa Hilal, Yassir Hajaji, Marie-Pierre Vie-Luton, Zeina Ajaltouni, Bouchra Benazzouz, Maha Chana, Adelmajid Chraïbi, Abdelkrim Kadiri, Serge Amselem and Marie-Laure Sobrier
    Citation: Molecular Medicine 2008 14:1405286
    Content type: Research Article Published on:

  23. The development of immunosuppression during polymicrobial sepsis is associated with the failure of dendritic cells (DC) to promote the polarization of T helper (Th) cells toward a protective Th1 type. The aim ...

    Authors: Stefanie B. Flohé, Hemant Agrawal, Sascha Flohé, Meenakshi Rani, Jörg M. Bangen and F. Ulrich Schade
    Citation: Molecular Medicine 2008 14:1405247
    Content type: Research Article Published on:

  25. Recent evidence suggests that additional risk loci for RA are present in the major histocompatibility complex (MHC), independent of the class II HLA-DRB1 locus. We have now tested a total of 1,769 SNPs across ...

    Authors: Hye-Soon Lee, Annette T. Lee, Lindsey A. Criswell, Michael F. Seldin, Christopher I. Amos, John P. Carulli, Cristina Navarrete, Elaine F. Remmers, Daniel L. Kastner, Robert M. Plenge, Wentian Li and Peter K. Gregersen
    Citation: Molecular Medicine 2008 14:1405293
    Content type: Research Article Published on:

  26. Loss of kidney graft function with tubular atrophy (TA) and interstitial fibrosis (IF) causes most kidney allograft losses. We aimed to identify the molecular pathways involved in IF/TA progression. Kidney bio...

    Authors: Daniel G. Maluf, Valeria R. Mas, Kellie J. Archer, Kenneth Yanek, Eric M. Gibney, Anne L. King, Adrian Cotterell, Robert A. Fisher and Marc P. Posner
    Citation: Molecular Medicine 2008 14:1405276
    Content type: Research Article Published on:

  27. Septic cardiomyopathy is a well-described complication of severe sepsis and septic shock. However, the interplay of its underlying mechanisms remains enigmatic. Consequently, we constantly add to our pathophys...

    Authors: Michael A. Flierl, Daniel Rittirsch, Markus S. Huber-Lang, J. Vidya Sarma and Peter A. Ward
    Citation: Molecular Medicine 2008 14:1405327
    Content type: Review Article Published on:

  28. Uterine leiomyomas (fibroids) are benign tumors that are prevalent in women of reproductive age. Research suggests that activated receptor tyrosine kinases (RTKs) play an important role in the enhanced prolife...

    Authors: Linda Yu, Katrin Saile, Carol D. Swartz, Hong He, Xiaolin Zheng, Grace E. Kissling, Xudong Di, Shantelle Lucas, Stanley J. Robboy and Darlene Dixon
    Citation: Molecular Medicine 2008 14:1405264
    Content type: Research Article Published on:

  29. We have recently demonstrated that oxidants can activate monocytes via an action on Toll-like receptor (TLR) 2; however, it is unclear what functional consequence this has on immune surveillance for Gram-negat...

    Authors: Mark J. Paul-Clark, Rosalinda Sorrentino, Lucy K. Bailey, Shiranee Sriskandan and Jane A. Mitchell
    Citation: Molecular Medicine 2008 14:1405238
    Content type: Research Article Published on:

  30. Therapeutic angiogenesis and myogenesis restore perfusion of ischemic myocardium and improve left ventricular contractility. These therapeutic modalities must be considered as complementary rather than competi...

    Authors: Husnain K. Haider, Ibrahim Elmadbouh, Michel Jean-Baptiste and Muhammad Ashraf
    Citation: Molecular Medicine 2008 14:14010079
    Content type: Review Article Published on:

  31. Septic syndromes represent a major although largely underrecognized healthcare problem worldwide, accounting for thousands of deaths every year. It is now agreed that sepsis deeply perturbs immune homeostasis ...

    Authors: Guillaume Monneret, Fabienne Venet, Alexandre Pachot and Alain Lepape
    Citation: Molecular Medicine 2008 14:14010064
    Content type: Review Article Published on:

  32. Interleukin-1 (IL-1) is a potent regulator of cell proliferation, inflammation, and contraction of cardiovascular cells. It has been proposed that the IL-1/IL-1ra (IL-1 receptor antagonist) ratio influences th...

    Authors: Elena Westphal, Susanne Rohrbach, Michael Buerke, Hagen Behr, Dorothea Darmer, Rolf-Edgar Silber, Karl Werdan and Harald Loppnow
    Citation: Molecular Medicine 2008 14:14010055
    Content type: Research Article Published on:

  33. Early detection and accurate staging of gastrointestinal (GI) cancers are difficult. The aim of this study was to evaluate whether telomerase activity (TA) in exfoliated/disseminated epithelial cells could be ...

    Authors: Inna L. Botchkina, David E. Rivadeneira, Kevin Watkins, Martin S. Karpeh and Galina I. Botchkina
    Citation: Molecular Medicine 2008 14:14010045
    Content type: Research Article Published on:

  34. We compared gene expression in blood neutrophils (polymorphonuclear leukocytes, or PMNs) collected from healthy subjects with those of cystic fibrosis (CF) patients devoid of bacterial colonization. Macroarray...

    Authors: Minou Adib-Conquy, Thierry Pedron, Anne-France Petit-Bertron, Olivier Tabary, Harriet Corvol, Jacky Jacquot, Annick Clément and Jean-Marc Cavaillon
    Citation: Molecular Medicine 2008 14:14010036
    Content type: Research Article Published on:

  35. The antithrombotic effect of angiotensin(Ang)-(1-7) has been reported, but the mechanism of this effect is not known. We investigated the participation of platelets and receptor Mas-related mechanisms in this ...

    Authors: Rodrigo Araújo Fraga-Silva, Sergio Veloso Brant Pinheiro, Andrey Christian Costa Gonçalves, Nathalia Alenina, Michael Bader and Robson Augusto Souza Santos
    Citation: Molecular Medicine 2008 14:14010028
    Content type: Research Article Published on:

  36. Chronic lymphocytic leukemia (CLL) is one of the most common leukemias in adults in the developed world. Despite significant advances in the treatment of cancer, CLL remains incurable. The main feature of the ...

    Authors: Imke Bokelmann and Ulrich Mahlknecht
    Citation: Molecular Medicine 2008 14:14010020
    Content type: Research Article Published on:

  37. Hepatic homeostasis is essential for survival in critically ill and burned patients. Insulin administration improves survival and decreases infections in these patients. To determine the molecular mechanisms, ...

    Authors: Marc G. Jeschke, Dagmar Klein, Wolfgang E. Thasler, Ulrich Bolder, Hans-Jürgen Schlitt, Karl-Walter Jauch and Thomas S. Weiss
    Citation: Molecular Medicine 2008 14:14010011
    Content type: Research Article Published on:

  38. Human small airway epithelial cells (SAECs) previously immortalized with human telomerase reverse transcriptase (h-TERT) were continuously treated with sodium arsenite at a dose of 0.5 µg/mL in culture for up ...

    Authors: Gengyun Wen, Gloria M. Calaf, Michael A. Partridge, Carlos Echiburú-Chau, Yongliang Zhao, Sarah Huang, Yunfei Chai, Bingyan Li, Burong Hu and Tom K. Hei
    Citation: Molecular Medicine 2008 14:14010002
    Content type: Research Article Published on:

  39. Authors: Margot Gallowitsch-Puerta
    Citation: Molecular Medicine 2008 14:BF03402219
    Content type: EditorialNotes Published on:

  41. A number of Lys-Pro-containing short peptides have been described as possessing a variety of biological activities in vitro. Because of limited metabolic stability, however, their efficacy in vivo is uncertain...

    Authors: Silvia Bertuglia, Hideo Ichimura, Gianluca Fossati, Kaushik Parthasarathi, Flavio Leoni, Daniela Modena, Piero Cremonesi, Jahar Bhattacharya and Paolo Mascagni
    Citation: Molecular Medicine 2007 13:130110615
    Content type: Research Article Published on:

  42. The induction of proinflammatory cytokines in stressed myocardium is considered an innate immune response, but the role of β-adrenergic signaling in this proinflammatory response and the mechanisms of cardiopr...

    Authors: Susanne Rohrbach, Stefan Engelhardt, Martin J. Lohse, Karl Werdan, Juergen Holtz and Ursula Muller-Werdan
    Citation: Molecular Medicine 2007 13:130110605
    Content type: Research Article Published on:

  43. Sepsis, which is the product of a poorly controlled inflammatory response, is a major health problem. Adequate therapies for sepsis are unavailable, and patient care is mainly supportive. Statins, widely used ...

    Authors: Tiffany Frey and Antonio De Maio
    Citation: Molecular Medicine 2007 13:130110592
    Content type: Research Article Published on:

  44. The identification of specific biomarkers provides opportunities to develop early diagnostic parameters, monitor disease progression, and test drug efficiency in clinical trials. We previously demonstrated tha...

    Authors: Bárbara Macedo, Ana Rita Batista, José Barbas do Amaral and Maria João Saraiva
    Citation: Molecular Medicine 2007 13:130110584
    Content type: Research Article Published on:

  45. Pregnancy-induced hypertension (PIH), also known as preeclampsia, Is one of the major causes of maternal and fetal death. While the precise cause of PIH is not known, aberrant cytokine production and placenta ...

    Authors: Oonagh Dowling, Burton Rochelson, Kathleen Way, Yousef Al-Abed and Christine N. Metz
    Citation: Molecular Medicine 2007 13:130110576
    Content type: Research Article Published on:

  46. Stathmin (Oncoprotein18), a signal transduction regulatory factor, plays an Important role In cell division and malignant tumor development. Stathmin is a ubiquitous intracellular phosphoprotein that is overexpre...

    Authors: Rui Wang, Ke Dong, Fang Lin, Xi Wang, Ping Gao, San-Hua Wei, Shi-Yin Cheng and Hui-Zhong Zhang
    Citation: Molecular Medicine 2007 13:130110567
    Content type: Research Article Published on:

  47. FOXO forkhead transcription factors play an important role in controlling lymphocyte activation and proliferation. To evaluate the possibility that FOXO transcriptional expression is dysregulated in systemic l...

    Authors: Chia-Chen Kuo and Shih-Chang Lin
    Citation: Molecular Medicine 2007 13:130110561
    Content type: Research Article Published on:

  48. Clearance of apoptotic cells is crucial to maintain cellular function under normal and pathological conditions. We have recently shown that administration of immature dendritic cell-derived exosomes to septic ...

    Authors: Michael Miksa, Dhruv Amin, Rongqian Wu, Weifeng Dong, Thanjavur S. Ravikumar and Ping Wang
    Citation: Molecular Medicine 2007 13:130110553
    Content type: Research Article Published on:

  49. Downregulation of vascular endothelial constitutive nitric oxide synthase (ecNOS) contributes to the vascular hyporesponsiveness in sepsis. Although coadministration of the potent vasodilatory peptide adrenome...

    Authors: Mian Zhou, Subir R. Maitra and Ping Wang
    Citation: Molecular Medicine 2007 13:1309488
    Content type: Research Article Published on:

  50. A recent study in the North American White population has documented the association of a common STAT4 haplotype (tagged by rs7574865) with risk for rheumatoid arthritis (RA) and systemic lupus erythematosus. ...

    Authors: Hye-Soon Lee, Elaine F. Remmers, Julie M. Le, Daniel L. Kastner, Sang-Cheol Bae and Peter K. Gregersen
    Citation: Molecular Medicine 2007 13:1309455
    Content type: Research Article Published on:
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    Citation Impact 2023
    Journal Impact Factor: 6.0
    5-year Journal Impact Factor: 6.0
    Source Normalized Impact per Paper (SNIP): 0.907
    SCImago Journal Rank (SJR): 1.446

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Molecular Medicine

ISSN: 1528-3658