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  1. Heme oxygenase (HO; EC 1.14.99.3) catalyzes the conversion of heme to biliverdin, which is reduced enzymatically to bilirubin. Since bilirubin is a potent antioxidant and heme a pro-oxidant, HO may protect cel...

    Authors: Tory Prestera, Paul Talalay, Jawed Alam, Young I. Ahn, Patty J. Lee and Augustine M. K. Choi

    Citation: Molecular Medicine 1995 1:BF03401897

    Content type: Original Articles

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  2. T lymphocytes infiltrating airways during the allergic immune response play a fundamental role in recruiting other specialized cells, such as eosinophils, by secreting interleukin 5 (IL-5), and promoting local...

    Authors: Fabrizio Spinozzi, Elisabetta Agea, Onelia Bistoni, Nicola Forenza, Alessandro Monaco, Brunangelo Falini, Gabrio Bassotti, Fernando De Benedictis, Fausto Grignani and Alberto Bertotto

    Citation: Molecular Medicine 1995 1:BF03401896

    Content type: Original Articles

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  3. It has previously been observed that the insulin-producing cells of human pancreatic islets are more resistant to alloxan-, streptozotocin-, nitroprusside-, or cytokine-induced injury than those of mouse and r...

    Authors: Nils Welsh, Boris Margulis, L. A. Håkan Borg, Helena Jernberg Wiklund, Johan Saldeen, Malin Flodström, Maria Alice Mello, Arne Andersson, Daniel G. Pipeleers, Claes Hellerström and Decio L. Eizirik

    Citation: Molecular Medicine 1995 1:BF03401895

    Content type: Original Articles

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  4. We previously demonstrated the local production of the pleiotropic cytokine interleukin-6 (IL-6) in the central nervous system (CNS) in experimental autoimmune encephalomyelitis (EAE), an animal model for the ...

    Authors: Koenraad Gijbels, Stefan Brocke, John S. Abrams and Lawrence Steinman

    Citation: Molecular Medicine 1995 1:BF03401894

    Content type: Original Articles

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  5. Recurrent and metastatic carcinoma of the colorectum remains a major problem, with survival at 5 years post curative resection still only about 50%. Moreover, up to 30% of patients who present with early stage...

    Authors: Jennifer E. Hardingham, Dusan Kotasek, Robert E. Sage, Michael C. Eaton, Vivienne H. Pascoe and Alexander Dobrovic

    Citation: Molecular Medicine 1995 1:BF03401893

    Content type: Original Articles

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  6. Macrophage migration inhibitory factor (MIF) was one of the first lymphokine activities to be discovered and was described almost 30 years ago to be a soluble factor(s) produced by activated T lymphocytes. In ...

    Authors: Toshihiko Nishino, Jürgen Bernhagen, Hideo Shiiki, Thierry Calandra, Kazuhiro Dohi and Richard Bucala

    Citation: Molecular Medicine 1995 1:BF03401892

    Content type: Original Articles

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  7. Rheumatoid factor (RF) is a characteristic but not pathognomic feature in patients with rheumatoid arthritis (RA). It is unknown whether the repertoire of immunoglobulin genes utilized by RF+ B cells of RA patien...

    Authors: Xiaowen He, Jörg J. Goronzy, Wanyun Zhong, Congping Xie and Cornelia M. Weyand

    Citation: Molecular Medicine 1995 1:BF03401891

    Content type: Original Articles

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  8. Therapeutic intervention designed to block expression of human immunodeficiency virus (HIV) at a cellular level may slow the clinical progression of HIV-1 disease.

    Authors: Salvatore T. Butera, Beverly D. Roberts, J. William Critchfield, Guofu Fang, Thomas McQuade, Stephen J. Gracheck and Thomas M. Folks

    Citation: Molecular Medicine 1995 1:BF03401890

    Content type: dh]Original Articles

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  9. We investigated the human immunodeficiency virus (HIV) proviral DNA sequence and copy number in alveolar macrophages (AM) and peripheral blood monocytes (PBM) from 10 HIV-positive patients without any active c...

    Authors: Koh Nakata, Michael Weiden, Timothy Harkin, David Ho and William N. Rom

    Citation: Molecular Medicine 1995 1:BF03401889

    Content type: Original Articles

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  10. The histopathology of multiple sclerosis (MS) is characterized by a loss of myelin and oligodendrocytes, relative preservation of axons, and a modest inflammatory response. The reasons for this selective oligo...

    Authors: Timothy Vartanian, You Li, Meijuan Zhao and Kari Stefansson

    Citation: Molecular Medicine 1995 1:BF03401888

    Content type: Original Articles

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  11. Hereditary angioneurotic edema (HANE) is an autosomal dominant disease due to genetic alterations at the C1 inhibitor gene. Mutations within the C1 inhibitor gene are responsible for the molecular defect in ty...

    Authors: Javier G. Ocejo-Vinyals, Francisco Leyva-Cobián and José L. Fernández-Luna

    Citation: Molecular Medicine 1995 1:BF03401610

    Content type: Original Articles

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  12. The nervous system has been implicated in several inflammatory skin disorders based on evidence such as the role of stress in inducing lesions, symmetry of lesions, and sparing of denervated skin. Interleukin ...

    Authors: Laurence A. Turka, Richard E. Goodman, J. Lynn Rutkowski, Anders A. F. Sima, Andrew Merry, Raj S. Mitra, Tamara Wrone-Smith, Galen Toews, Robert M. Strieter and Brian J. Nickoloff

    Citation: Molecular Medicine 1995 1:BF03401609

    Content type: Original Articles

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  13. Tyr-Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) and Tyr-Tic-Ala were the first peptides with δ opioid antagonist activity lacking Phe, considered essential for opioid activity based on the N-terminal t...

    Authors: Severo Salvadori, Martti Attila, Giofranco Balboni, Clementina Bianchi, Sharon D. Bryant, Orlando Crescenzi, Remo Guerrini, Delia Picone, Teodorico Tancredi, Piero A. Temussi and Lawrence H. Lazarus

    Citation: Molecular Medicine 1995 1:BF03401608

    Content type: Original Articles

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  14. Cytokines and cytokine antagonists modulate human immunodeficiency virus (HIV) replication in vitro and may be involved in HIV disease pathogenesis. An understanding of these cytokine networks may suggest nove...

    Authors: Eric V. Granowitz, Bradford M. Saget, Monica Z. Wang, Charles A. Dinarello, Paul R. Skolnik and A. S. Fauci

    Citation: Molecular Medicine 1995 1:BF03401607

    Content type: Original Articles

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  15. Protein kinase CK2 (also known as casein kinase 2) is a messenger-independent protein serine/threonine kinase ubiquitously distributed in eukaryotes. CK2 has been found to phosphorylate a wide variety of cytos...

    Authors: Markus Gapany, Russell A. Faust, Sherif Tawfic, Alan Davis, George L. Adams, P. Leder and Khalil Ahmed

    Citation: Molecular Medicine 1995 1:BF03401606

    Content type: Original Articles

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  16. Advanced glycation end products (AGE), the reactive derivatives of nonenzymatic glucose-protein condensation reactions, are implicated in the multiorgan complications of diabetes and aging. An AGE-specific cel...

    Authors: Helen Vlassara, Yong Ming Li, Farhad Imani, Donald Wojciechowicz, Zhi Yang, Fu-Tong Liu and Anthony Cerami

    Citation: Molecular Medicine 1995 1:BF03401604

    Content type: Original Articles

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  17. Insulin (1) and glutamic acid decarboxylase (GAD) (2) are both autoantigens in insulin-dependent diabetes mellitus (IDDM), but no molecular mechanism has been proposed for their association. We have identified a ...

    Authors: George Rudy, Natalie Stone, Leonard C. Harrison, Peter G. Colman, Peter McNair, Vladimir Brusic, Michelle B. French, Margo C. Honeyman, Brian Tait and Andrew M. Lew

    Citation: Molecular Medicine 1995 1:BF03401603

    Content type: Original Articles

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  18. We have previously demonstrated CD8+ T cell clonal dominance using a PCR assay for the CDR3 length of T cell receptors belonging to a limited number of TCRBV segments/families. In this study, we have modified thi...

    Authors: Joanita Monteiro, Ravi Hingorani, In-Hong Choi, Jack Silver, Robert Pergolizzi and Peter K. Gregersen

    Citation: Molecular Medicine 1995 1:BF03401602

    Content type: Original Articles

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  19. Creutzfeldt-Jakob disease (CJD) is a prion disease which is manifest as a sporadic, inherited, and transmissible neurodegenerative disorder. The mean age at onset of CJD is ∼60 years, and as such, many people ...

    Authors: Serena Spudich, James A. Mastrianni, Margaret Wrensch, Ruth Gabizon, Zeev Meiner, Irit Kahana, Hana Rosenmann, Esther Kahana and Stanley B. Prusiner

    Citation: Molecular Medicine 1995 1:BF03401601

    Content type: Original Articles

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  20. Individuals at risk for insulin-dependent diabetes mellitus (IDDM), with an affected first-degree relative, can be identified by the presence of islet cell antibodies (ICA). ICA-positive relatives progress at ...

    Authors: Margo C. Honeyman, Leonard C. Harrison, Bruce Drummond, Peter G. Colman and Brian D. Tait

    Citation: Molecular Medicine 1995 1:BF03401595

    Content type: Original Articles

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  21. The receptor of ciliary neurotrophic factor (CNTF) contains the signal transduction protein gp130, which is also a component of the receptors of cytokines such as interleukin (IL)-6, leukemia-inhibitory factor...

    Authors: Fabio Benigni, Pia Villa, Maria Teresa Demitri, Silvano Sacco, Jean D. Sipe, Laura Lagunowich, Nikos Panayotatos and Pietro Ghezzi

    Citation: Molecular Medicine 1995 1:BF03401594

    Content type: Original Articles

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  22. A problem likely to be encountered in any cancer immunotherapy based on vaccination with a single protein or peptide is variation in the host response. A particularly informative example is provided by the two...

    Authors: Nance Nardi and Nicholas A. Mitchison

    Citation: Molecular Medicine 1995 1:BF03401593

    Content type: Original Articles

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  23. Interactions between γδ T cells and heat shock proteins (HSP) have been proposed as contributing factors in a number of diseases of possible autoimmune etiology but definitive evidence to support this hypothesis ...

    Authors: Luca Battistini, Marco Salvetti, Giovanni Ristori, Marika Falcone, Cedric S. Raine and Celia F. Brosnan

    Citation: Molecular Medicine 1995 1:BF03401592

    Content type: Original Articles

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  24. Human, but not mouse, islet amyloid polypeptide (IAPP) is amyloidogenic. Transgenic mice overexpressing human IAPP in the β cells of the islets of Langerhans should be useful in identifying factors important for ...

    Authors: Gunilla Westermark, Michelle Benig Arora, Niles Fox, Raymond Carroll, Shu Jin Chan, Per Westermark and Donald F. Steiner

    Citation: Molecular Medicine 1995 1:BF03401591

    Content type: Original Articles

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  25. Aberrant metabolism of the Alzheimer amyloid precursor protein (APP) or its amyloidogenic Aβ fragment is thought to be centrally involved in Alzheimer’s disease. Nonamyloidogenic processing of APP involves its cl...

    Authors: Edgar F. da Cruz e Silva, Odete A. B. da Cruz e Silva, Cássia Thais B. V. Zaia and Paul Greengard

    Citation: Molecular Medicine 1995 1:BF03401590

    Content type: Original Articles

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  26. Chronic diabetes causes structural changes in the retinal capillaries of nearly all patients with a disease duration of more than 15 years. Acellular occluded vessels cause hypoxia, which stimulates sight-thre...

    Authors: Hans-Peter Hammes, Howard J. Federoff and Michael Brownlee

    Citation: Molecular Medicine 1995 1:BF03401589

    Content type: Original Articles

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  27. At therapeutic concentrations, the antineoplastic agent taxol selectively perturbs mitotic spindle microtubules. Taxol has recently been shown to induce apoptosis, similar to the mechanism of cell death induce...

    Authors: Catherine M. Woods, Jian Zhu, Patricia A. McQueney, Daniel Bollag and Elias Lazarides

    Citation: Molecular Medicine 1995 1:BF03401588

    Content type: Original Articles

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  28. The developmental stage from which stems the malignant B cell population in Burkitt’s lymphoma (BL) is unclear. An approach to answering this question is provided by the sequence analysis of rearranged immunog...

    Authors: Ulf Klein, George Klein, Barbro Ehlin-Henriksson, Klaus Rajewsky and Ralf Küppers

    Citation: Molecular Medicine 1995 1:BF03401587

    Content type: Original Articles

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  29. Von Hippel-Lindau (VHL) disease is a familial cancer syndrome that has a dominant inherited pattern which predisposes affected individuals to a variety of tumors. The most frequent tumors are hemangioblastomas...

    Authors: Patricia M. Kessler, Sandip P. Vasavada, Raymond R. Rackley, Thomas Stackhouse, Fuh-Mei Duh, Farida Latif, Michael I. Lerman, Berton Zbar and Bryan R. G. Williams

    Citation: Molecular Medicine 1995 1:BF03401583

    Content type: OriginalPaper

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  30. Reactive glucose-protein intermediates and advanced glycation endproducts (AGEs) are shown to colocalize with atheromatous lesions and to trigger complex chemical and biological responses through interaction w...

    Authors: Helen Vlassara, Hubert Fuh, Thomas Donnelly and Myron Cybulsky

    Citation: Molecular Medicine 1995 1:BF03401582

    Content type: OriginalPaper

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  31. The marR gene of Escherichia coli encodes a repressor of the marRAB operon, a regulatory locus controlling multiple antibiotic resistance in this organism. Inactivation of marR results in increased expression of

    Authors: Mark C. Sulavik, Laura F. Gambino and Paul F. Miller

    Citation: Molecular Medicine 1995 1:BF03401581

    Content type: OriginalPaper

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  32. The anti-tumor agent, Taxol, has been shown in murine macrophages to stimulate tumor necrosis factor (TNF), modulate TNF receptors, induce a large panel of immediate-early genes, and induce protein tyrosine ph...

    Authors: Beth E. Henricson, Joan M. Carboni, Anne L. Burkhardt and Stefanie N. Vogel

    Citation: Molecular Medicine 1995 1:BF03401580

    Content type: OriginalPaper

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  33. Tissue inhibitor of metalloproteinases-3 (TIMP3) is the third member of the TIMP family of proteins, believed to play a significant role in controlling extracellular matrix remodeling.

    Authors: Jennifer A. Byrne, Catherine Tomasetto, Nicolas Rouyer, Jean-Pierre Bellocq, Marie-Christine Rio and Paul Basset

    Citation: Molecular Medicine 1995 1:BF03401579

    Content type: OriginalPaper

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  34. The antiviral drugs AZT and acyclovir are generally used in the treatment of infections with human immunodeficiency virus (HIV) and herpes simplex virus (HSV). These substances are known to impede virus replic...

    Authors: Martin Gschwentner, Alex Susanna, Ewald Wöll, Markus Ritter, Ulrich O. Nagl, Andreas Schmarda, Andreas Laich, Germar M. Pinggera, Helmut Ellemunter, Hartwig Huemer, Peter Deetjen and Markus Paulmichl

    Citation: Molecular Medicine 1995 1:BF03401578

    Content type: OriginalPaper

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  35. Clozapine, the classic atypical neuroleptic, exerts therapeutic actions in schizophrenic patients unresponsive to most neuroleptics. Clozapine interacts with numerous neurotransmitter receptors, and selective ...

    Authors: Charles E. Glatt, Adele M. Snowman, David R. Sibley and Solomon H. Snyder

    Citation: Molecular Medicine 1995 1:BF03401577

    Content type: OriginalPaper

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  36. An expanded CAG trinucleotide repeat is the genetic trigger of neuronal degeneration in Huntington’s disease (HD), but its mode of action has yet to be discovered. The sequence of the HD gene places the CAG re...

    Authors: Francesca Persichetti, Christine M. Ambrose, Pei Ge, Sandra M. McNeil, Jayalakshmi Srinidhi, Mary Anne Anderson, Barbara Jenkins, Glenn T. Barnes, Mabel P. Duyao, Lisa Kanaley, Nancy S. Wexler, Richard H. Myers, Edward D. Bird, Jean-Paul Vonsattel, Marcy E. MacDonald, James F. Gusella…

    Citation: Molecular Medicine 1995 1:BF03401575

    Content type: OriginalPaper

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    46 days to first decision for reviewed manuscripts only
    28 days to first decision for all manuscripts
    118 days from submission to acceptance
    25 days from acceptance to publication


    Citation Impact
    4.096 - 2-year Impact Factor
    3.929 - 5-year Impact Factor

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