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Page 4 of 36

  1. Content type: Research Article

    While cardiac functional recovery is attenuated in the elderly following cardiac surgery with obligatory global myocardial ischemia/reperfusion (I/R), the underlying mechanism remains incompletely understood. ...

    Authors: Lihua Ao, Yufeng Zhai, Chunhua Jin, Joseph C Cleveland Jr., David A Fullerton and Xianzhong Meng

    Citation: Molecular Medicine 2016 22:2201863

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  2. Content type: Research Article

    Glucagon-like peptide 1 (GLP-1) can promote islet β cell replication and function, and mesenchymal stem cells (MSCs) can inhibit T cell autoimmunity. The aim of this study was to test the dynamic distribution ...

    Authors: Li-rong Li, Jing Lu, Xiao-lei Jia, Hui Hui, Jie Zhang, Ying Liu, Wei-juan Cui, Qian-yue Xu and Da-long Zhu

    Citation: Molecular Medicine 2016 22:2201800

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  3. Content type: Research Article

    Long-term sepsis survivors sustain cryptic brain injury that leads to cognitive impairment, emotional imbalance and Increased disability burden. Suitable animal models of sepsis, such as cecal ligation and pun...

    Authors: Patricio T Huerta, Sergio Robbiati, Tomás S Huerta, Anchal Sabharwal, Roseann Berlin, Maya Frankfurt and Bruce T Volpe

    Citation: Molecular Medicine 2016 22:2201789

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  4. Content type: Review Article

    Obesity and its accompanying metabolic syndrome are strongly associated with heightened morbidity and mortality in older adults. In our review of more than 20 epidemiologic studies of major infectious diseases...

    Authors: Jesse Roth, Navneet Sahota, Priya Patel, Syed F Mehdi, Mohammad M Wiese, Hafiz B Mahboob, Michelle Bravo, Daniel J Eden, Muhammad A Bashir, Amrat Kumar, Farah Alsaati, Irwin J Kurland, Wunnie Brima, Ann Danoff, Alessandra L Szulc, Valentin A Pavlov…

    Citation: Molecular Medicine 2016 22:2201873

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  5. Content type: Research Article

    Studies imply that intestinal barrier dysfunction is a key contributor to morbid events associated with sepsis. Recently, the co-inhibitory molecule programmed death-ligand1 (PD-L1) has been shown to be involv...

    Authors: Youping Wu, Chun-Shiang Chung, Yaping Chen, Sean Farrell Monaghan, Sima Patel, Xin Huang, Daithi Seamus Heffernan and Alfred Ayala

    Citation: Molecular Medicine 2016 22:2201830

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  6. Content type: Research Article

    Previously, we have shown that N,N-dimethylacetamide (DMA) prevents inflammation-induced preterm birth in a murine model, inhibits lipopolysaccharide (LPS)-induced increases in placental proinflammatory cytoki...

    Authors: Ryan Pekson, Vladimir Poltoratsky, Samir Gorasiya, Sruthi Sundaram, Charles R. Ashby Jr., Ivana Vancurova and Sandra E. Reznik

    Citation: Molecular Medicine 2016 22:2201747

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  7. Content type: Research Article

    Pregnancy requires adaptation of maternal energy metabolism, including expansion and functional modifications of adipose tissue. Insulin resistance (IR), predominantly during late gestation, is a physiological...

    Authors: Yurena Vivas, Monica Díez-Hochleitner, Adriana Izquierdo-Lahuerta, Patricia Corrales, Daniel Horrillo, Ismael Velasco, Cristina Martínez-García, Mark Campbell, Julio Sevillano, Mercedes Ricote, Manuel Ros, Maria Pilar Ramos and Gema Medina-Gomez

    Citation: Molecular Medicine 2016 22:2201724

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  8. Content type: Research Article

    Human myeloma cells express CD38 at high levels and grow in hypoxic niches inside the bone marrow. Myeloma cells respond to hypoxia with metabolic changes leading to aerobic glycolysis, thus reducing adenosine...

    Authors: Alberto L Horenstein, Valeria Quarona, Denise Toscani, Federica Costa, Antonella Chillemi, Vito Pistoia, Nicola Giuliani and Fabio Malavasi

    Citation: Molecular Medicine 2016 22:2201694

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  9. Content type: Review Article

    MicroRNAs (miRNAs) are well preserved in every animal. These pygmy-sized (21–23 nt) noncoding RNAs scattered in the genome are responsible for micromanaging versatile gene regulation. There is involvement of m...

    Authors: Utpal Bhadra, Pradipta Patra, Jagamohan Chhatai and Manika Pal-Bhadra

    Citation: Molecular Medicine 2016 22:2201759

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  10. Content type: Original Articles

    Stem cell transcriptional signature activation is an essential event in the development of cancer. This study aimed to investigate the differential expression profiles of three pluripotency-associated genes, OCT4...

    Authors: Eman A Toraih, Manal S Fawzy, Abdullah I El-Falouji, Elham O Hamed, Nader A Nemr, Mohammad H Hussein and Noha M Abd El Fadeal

    Citation: Molecular Medicine 2016 22:2201653

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  11. Content type: Original Articles

    Severe malarial anemia (SMA; hemoglobin [Hb] <5.0 g/dL) is a leading global cause of morbidity and mortality among children residing in Plasmodium falciparum transmission regions. Exploration of molecular pathway...

    Authors: Prakasha Kempaiah, Karol Dokladny, Zachary Karim, Evans Raballah, John M Ong’echa, Pope L Moseley and Douglas J Perkins

    Citation: Molecular Medicine 2016 22:2201570

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  12. Content type: Research Article

    Acute pancreatitis is characterized by zymogen preactivation. Severe inflammation caused by zymogen activation can eventually lead to multiple organ dysfunctions which contribute to the high mortality rate of ...

    Authors: Juan Xiao, Xueping Feng, Xiao-Ying Huang, Zhongshi Huang, Yanqiang Huang, Chaogan Li, Genliang Li, Song Nong, Ruoshi Wu, Yongzhi Huang and Xi-Dai Long

    Citation: Molecular Medicine 2016 22:2201643

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  13. Content type: Research Article

    The Cadherin 13 (CDH13) gene encodes a cell adhesion molecule likely to influence development and connections of brain circuits that modulate addiction, locomotion and cognition, including those that involve midb...

    Authors: Jana Drgonova, Donna Walther, G. Luke Hartstein, Mohammad O. Bukhari, Michael H. Baumann, Jonathan Katz, F. Scott Hall, Elizabeth R. Arnold, Shaun Flax, Anthony Riley, Olga Rivero, Klaus-Peter Lesch, Juan Troncoso, Barbara Ranscht and George R. Uhl

    Citation: Molecular Medicine 2016 22:2201537

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  14. Content type: Research Article

    Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 (MMP8) improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothe...

    Authors: Sarah J Atkinson, Brian M Varisco, Mary Sandquist, Meghan N Daly, Lindsey Klingbeil, Joshua W Kuethe, Emily F Midura, Kelli Harmon, Amy Opoka, Patrick Lahni, Giovanna Piraino, Paul Hake, Basilia Zingarelli, Joel E Mortensen, James L Wynn and Hector R Wong

    Citation: Molecular Medicine 2016 22:2201455

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  15. Content type: Research Article

    Amyotrophic lateral sclerosis (ALS) is a progressive and lethal neurodegenerative disease characterized by loss of upper and lower motor neurons leading to muscle paralysis in affected individuals. Numerous me...

    Authors: Claudia R Vintilescu, Sana Afreen, Ashlee E Rubino and Adriana Ferreira

    Citation: Molecular Medicine 2016 22:2201477

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  16. Content type: Research Article

    Idiopathic trigeminal neuralgia (TN) is a debilitating pain disorder characterized by episodic unilateral facial pain along the territory of branches of the trigeminal nerve. Human pain disorders, but not TN, ...

    Authors: Brian S Tanaka, Peng Zhao, Fadia B Dib-Hajj, Valerie Morisset, Simon Tate, Stephen G Waxman and Sulayman D Dib-Hajj

    Citation: Molecular Medicine 2016 22:2201338

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  17. Content type: Research Article

    Male sex is a risk factor for abdominal aortic aneurysm (AAA). Within the AAA adventitia, infiltrating leukocytes express high levels of inflammasome components. To further elucidate the role of inflammatory c...

    Authors: Xiaoyu Wu, Sinan Cakmak, Markus Wortmann, Maani Hakimi, Jian Zhang, Dittmar Böckler and Susanne Dihlmann

    Citation: Molecular Medicine 2016 22:2201508

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  18. Content type: Research Article

    T cell engineering with T cell receptors (TCRs) specific for tumors plays an important role in adoptive T cell transfer (ATC) therapy for cancer. Here, we present a novel strategy to redirect peripheral blood-...

    Authors: Kangxia He, Hongqin You, Yuxia Li, Lianxian Cui, Jianmin Zhang and Wei He

    Citation: Molecular Medicine 2016 22:2201519

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  19. Content type: Research Article

    Sickle cell disease (SCD) patients have low serum hemopexin (Hpx) levels due to chronic hemolysis. We hypothesized that in SCD mice, hepatic overexpression of hemopexin would scavenge the proximal mediator of ...

    Authors: Gregory M Vercellotti, Ping Zhang, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Phong Nguyen, Carlos Nowotny, Clifford J Steer, Ann Smith and John D Belcher

    Citation: Molecular Medicine 2016 22:2201437

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  20. Content type: Research Article

    Congenital diaphragmatic hernia (CDH) causes severe pulmonary hypoplasia from herniation of abdominal contents into the thorax. Tracheal occlusion (TO) for human CDH improves survival, but morbidity and mortal...

    Authors: Brian M Varisco, Lourenco Sbragia, Jing Chen, Federico Scorletti, Rashika Joshi, Hector R Wong, Rebeca Lopes-Figueira, Marc Oria and Jose Peiro

    Citation: Molecular Medicine 2016 22:2201398

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  21. Content type: Research Article

    Neutrophils constitute the early innate immune response to perceived infectious and sterile threats. Neutrophil extracellular traps (NETs) are a novel mechanism to counter pathogenic invasion and sequelae of i...

    Authors: Ahmed B Al-Khafaji, Samer Tohme, Hamza Obaid Yazdani, David Miller, Hai Huang and Allan Tsung

    Citation: Molecular Medicine 2016 22:2201621

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  22. Content type: Original Articles

    Alphal-antitrypsin (A1AT, SERPINA1), a major circulating inhibitor of neutrophil elastase (NE) and protelnase-3 (PR3), has been proposed to reduce the processing and release of IL-1β. Since the antiinflammator...

    Authors: Nupur Aggarwal, Elena Korenbaum, Ravi Mahadeva, Stephan Immenschuh, Veronika Grau, Charles A Dinarello, Tobias Welte and Sabina Janciauskiene

    Citation: Molecular Medicine 2016 22:2201680

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  23. Content type: Research Article

    The identification of HMGB1 as a late mediator in sepsis has highlighted HMGB1 as a promising therapeutic target for sepsis treatment. Recent studies have revealed that annexin A5, a 35 kDa Ca2+-dependent phospho...

    Authors: Jung Hwa Park, Jong-Hwa Jang, Eun Jung Choi, Young Seob Kim, Eun Ji Lee, In Duk Jung, Hee Dong Han, T-C Wu, Chien-Fu Hung, Tae Heung Kang and Yeong-Min Park

    Citation: Molecular Medicine 2016 22:2201424

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  24. Content type: Research Article

    Obesity is strongly associated with metabolic syndrome, a combination of risk factors that predisposes to development of the cardiometabolic diseases: atherosclerotic cardiovascular disease and type 2 diabetes...

    Authors: Melina Amor, Veronica Moreno-Viedma, Alisina Sarabi, Nicole G Grün, Bianca Itariu, Lukas Leitner, Irene Steiner, Martin Bilban, Keiichi Kodama, Atul J Butte, Guenther Staffler, Maximilian Zeyda and Thomas M Stulnig

    Citation: Molecular Medicine 2016 22:2201487

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  25. Content type: Research Article

    The pathophysiology of sepsis involves activation of acid sphingomyelinase (SMPD1) with subsequent generation of the bioactive mediator ceramide. We herein evaluate the hypothesis that the enzyme exerts biolog...

    Authors: Ha-Yeun Chung, Daniel C Hupe, Gordon P Otto, Marcel Sprenger, Alexander C Bunck, Michael J Dorer, Clemens L Bockmeyer, Hans-Peter Deigner, Markus H Gräler and Ralf A Claus

    Citation: Molecular Medicine 2016 22:2201412

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  26. Content type: Research Article

    Vagotomy (VGX) increases the susceptibility to develop colitis suggesting a crucial role for the cholinergic anti-inflammatory pathway in the regulation of the immune responses. Since oral tolerance and the ge...

    Authors: Martina Di Giovangiulio, Goele Bosmans, Elisa Meroni, Nathalie Stakenborg, Morgane Florens, Giovanna Farro, Pedro J Gomez-Pinilla, Gianluca Matteoli and Guy E Boeckxstaens

    Citation: Molecular Medicine 2016 22:2201464

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  27. Content type: Research Article

    Mutations in the SLC13A5 gene that codes for the Na+/citrate cotransporter, NaCT, are associated with early onset epilepsy, developmental delay and tooth dysplasia in children. In this study, we identify addition...

    Authors: Jenna Klotz, Brenda E Porter, Claire Colas, Avner Schlessinger and Ana M Pajor

    Citation: Molecular Medicine 2016 22:2201310

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  28. Content type: Research Article

    Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes. In addition to caspase-1, the neutroph...

    Authors: Erik J M Toonen, Andreea-Manuela Mirea, Cees J Tack, Rinke Stienstra, Dov B Ballak, Janna A van Diepen, Anneke Hijmans, Triantafyllos Chavakis, Wim H Dokter, Christine T N Pham, Mihai G Netea, Charles A Dinarello and Leo A B Joosten

    Citation: Molecular Medicine 2016 22:2201202

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  29. Content type: Research Article

    HLA-B*27 is strongly associated with an inflammatory autoimmune disorder, the Ankylosing Spondylitis (AS) and plays a protective role in viral infections. The two aspects might be linked. In this work, we compare...

    Authors: Valentina Tedeschi, Carolina Vitulano, Alberto Cauli, Fabiana Paladini, Matteo Piga, Alessandro Mathieu, Rosa Sorrentino and Maria Teresa Fiorillo

    Citation: Molecular Medicine 2016 22:2201215

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  30. Content type: Research Article

    Colon cancer cells contain high levels of cystathlonlne-β-synthase (CBS). Its product, hydrogen sulfide (H2S), promotes the growth and proliferation of colorectal tumor cells. To improve the antitumor efficacy of...

    Authors: Celia Chao, John R Zatarain, Ye Ding, Ciro Coletta, Amy A Mrazek, Nadiya Druzhyna, Paul Johnson, Haiying Chen, Judy L Hellmich, Antonia Asimakopoulou, Kazunori Yanagi, Gabor Olah, Petra Szoleczky, Gabor Törö, Fredrick J Bohanon, Minal Cheema…

    Citation: Molecular Medicine 2016 22:2201361

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  31. Content type: Research Article

    Platelet (PLT) transfusion is indispensable to maintain homeostasis in thrombocytopenic patients. However, PLT transfusion refractoriness is a common life-threatening condition observed in multitransfused pati...

    Authors: Ann-Kathrin Börger, Dorothee Eicke, Christina Wolf, Christiane Gras, Susanne Aufderbeck, Kai Schulze, Lena Engels, Britta Eiz-Vesper, Axel Schambach, Carlos A Guzman, Nico Lachmann, Thomas Moritz, Ulrich Martin, Rainer Blasczyk and Constança Figueiredo

    Citation: Molecular Medicine 2016 22:2201274

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  32. Content type: Research Article

    Alzheimer’s disease (AD) is a devastating neurodegenerative disorder, characterized by extensive loss of neurons and deposition of amyloid β (Aβ) in the form of extracellular plaques. Aβ is considered to have ...

    Authors: Vijay K Sonkar, Paresh P Kulkarni, Susheel N Chaurasia, Ayusman Dash, Abhishek Jauhari, Devendra Parmar, Sanjay Yadav and Debabrata Dash

    Citation: Molecular Medicine 2016 22:2201224

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  33. Content type: Research Article

    Lung epithelial cell apoptosis is an important feature of hyperoxia-induced lung injury. The death receptor-associated extrinsic pathway and mitochondria-associated intrinsic pathway both mediate the developme...

    Authors: Yong Cao, Duo Zhang, Hyung-Geun Moon, Heedoo Lee, Jeffrey A Haspel, Kebin Hu, Lixin Xie and Yang Jin

    Citation: Molecular Medicine 2016 22:2201233

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  34. Content type: Research Article

    Perinatal asphyxia, a condition of impaired gas exchange during birth, leads to fetal hypoxia-ischemia (HI) and is associated with postnatal adverse outcomes including intestinal dysmotility and necrotizing en...

    Authors: Maria Nikiforou, Carolin Willburger, Anja E de Jong, Nico Kloosterboer, Reint K Jellema, Daan R M G Ophelders, Harry W M Steinbusch, Boris W Kramer and Tim G A M Wolfs

    Citation: Molecular Medicine 2016 22:2201244

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  35. Content type: Research Article

    β-Arrestin2 (βarr2) is an adaptor protein that interacts with numerous signaling molecules and regulates insulin sensitivity. We reported previously that βarr2 was abundantly expressed in mouse pancreatic β-ce...

    Authors: Ziwei Lin, Yu Zhao, Lige Song, Kaida Mu, Mingliang Zhang, Hongxia Liu, Xiaowen Li, Jian Zhao, Chen Wang and Weiping Jia

    Citation: Molecular Medicine 2016 22:2201074

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  36. Content type: Research Article

    The ABCA3 gene encodes a lipid transporter in type II pneumocytes critical for survival and normal respiratory function. The frequent ABCA3 variant R288K increases the risk for neonatal respiratory distress syndr...

    Authors: Thomas Wittmann, Sabrina Frixel, Stefanie Höppner, Ulrike Schindlbeck, Andrea Schams, Matthias Kappler, Jan Hegermann, Christoph Wrede, Gerhard Liebisch, Anne Vierzig, Angela Zacharasiewicz, Matthias Volkmar Kopp, Christian F Poets, Winfried Baden, Dominik Hartl, Anton H van Kaam…

    Citation: Molecular Medicine 2016 22:2201183

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  37. Content type: Research Article

    Prostate cancer cells are responsive to adrenergic and thyroid stimuli. It is well established that β-adrenergic activation (protein kinase A [PKA]/cAMP response element binding protein [CREB]) promotes cancer...

    Authors: Evangelina Delgado-González, Ana Alicia Sánchez-Tusie, Giapsy Morales, Carmen Aceves and Brenda Anguiano

    Citation: Molecular Medicine 2016 22:2201001

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  38. Content type: Research Article

    Methionine adenosyltransferase (MAT) I/III deficiency can be Inherited as autosomal dominant (AD) or as recessive (AR) traits in which mono- or biallelic MAT1A mutations have been identified, respectively. Althou...

    Authors: Yoo-Mi Kim, Ja Hye Kim, Jin-Ho Choi, Gu-Hwan Kim, Jae-Min Kim, Minji Kang, In-Hee Choi, Chong Kun Cheon, Young Bae Sohn, Marco Maccarana, Han-Wook Yoo and Beom Hee Lee

    Citation: Molecular Medicine 2016 22:2201147

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  39. Content type: Research Article

    The goal of this study was to determine how B-cell-activating factor of the TNF family (BAFF) availability influences selection of the autoreactive B-cell repertoire in NZB/W and NZW/BXSB lupus-prone mice bear...

    Authors: Alexis Boneparth, Megan Woods, Weiqing Huang, Meredith Akerman, Martin Lesser and Anne Davidson

    Citation: Molecular Medicine 2016 22:2201173

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  40. Content type: Research Article

    Cardiac hypertrophy can be broadly classified as either physiological or pathological. Physiological stimuli such as exercise cause adaptive cardiac hypertrophy and normal heart function. Pathological stimuli ...

    Authors: Jun Xie, Guixin He, Qinhua Chen, Jiayin Sun, Qin Dai, Jianrong Lu, Guannan Li, Han Wu, Ran Li, Jianzhou Chen, Wei Xu and Biao Xu

    Citation: Molecular Medicine 2016 22:2201192

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  41. Content type: Research Article

    Alternative intravesical agents are required to overcome the side effects currently associated with the treatment of bladder cancer. This study used an orthotopic bladder cancer mouse model to evaluate Guizhi ...

    Authors: Chi-Chen Lu, Cheng-Huang Shen, Chia-Bin Chang, Hsiao-Yen Hsieh, Jiann-Der Wu, Ling-Huei Tseng, Dennis W Hwang, Syue-Yi Chen, Shu-Fen Wu, Michael W Y Chan and Cheng-Da Hsu

    Citation: Molecular Medicine 2016 22:2201064

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  42. Content type: Review Article

    Our understanding of the process of metastatic progression has improved markedly over the past decades, yet metastasis remains the most enigmatic component of cancer pathogenesis. This lack of knowledge has se...

    Authors: Jagoda K Wrobel and Michal Toborek

    Citation: Molecular Medicine 2016 22:2201032

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  43. Content type: Research Article

    Myocarditis is a major cause of heart failure and sudden cardiac death in young adults and adolescents. Many cases of myocarditis are associated with autoimmune processes in which cardiac myosin is a major aut...

    Authors: Wen-Shin Lee, Katalin Erdelyi, Csaba Matyas, Partha Mukhopadhyay, Zoltan V Varga, Lucas Liaudet, György Haskó, Daniela Čiháková, Raphael Mechoulam and Pal Pacher

    Citation: Molecular Medicine 2016 22:2201136

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  44. Content type: Research Article

    Chronic respiratory diseases such as obstructive pulmonary disease (COPD) and oxidative stress may underlie lung cancer (LC). We hypothesized that the profile of oxidative and antioxidant events may differ in ...

    Authors: Mercè Mateu-Jiménez, Albert Sánchez-Font, Alberto Rodríguez-Fuster, Rafael Aguiló, Lara Pijuan, Clara Fermoselle, Joaquim Gea, Víctor Curull and Esther Barreiro

    Citation: Molecular Medicine 2016 22:2201085

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  45. Content type: Research Article

    Mechanical ventilation can improve hypoxemia, but can also cause the so-called ventilator-induced lung injury (VILI). Polyinosinic:polycytidylic acid (poly(I:C)), an analogue of natural double-strand RNA virus...

    Authors: Shuqing Jin, Zhixia Chen, Xibing Ding, Xiang Zhao, Xi Jiang, Yao Tong, Timothy R Billiar and Quan Li

    Citation: Molecular Medicine 2016 22:2201054

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  46. Content type: Research Article

    Sequence alterations in the pendrin gene (SLC26A4) leading to functionally affected protein variants are frequently involved in the pathogenesis of syndromic and nonsyndromic deafness. Considering the high number...

    Authors: Vanessa C S de Moraes, Emanuele Bernardinelli, Nathalia Zocal, Jhonathan A Fernandez, Charity Nofziger, Arthur M Castilho, Edi L Sartorato, Markus Paulmichl and Silvia Dossena

    Citation: Molecular Medicine 2016 22:2201041

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