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Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 4 of 37

  1. Interleukin (IL)-26 is abundant in human airways and this cytokine is involved in the local immune response to a bacterial stimulus in vivo. Specifically, local exposure to the toll-like receptor (TLR) 4 agoni...

    Authors: Karlhans Fru Che, Riitta Kaarteenaho, Elisa Lappi-Blanco, Bettina Levänen, Jitong Sun, Åsa Wheelock, Lena Palmberg, C. Magnus Sköld and Anders Lindén

    Citation: Molecular Medicine 2017 23:2301247

    Content type: Research Article

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  2. Adoptive immunotherapy with cytokine induced killer (CIK) cells has shown antitumor activity against several kinds of cancer in preclinical models and clinical trials. CIK cells are a subset of ex vivo expanded T...

    Authors: Giulia Mesiano, Roberta Zini, Giulia Montagner, Nicoletta Bianchi, Rossella Manfredini, Antonella Chillemi, Massimo Aglietta, Giovanni Grignani, Ilaria Lampronti, Erika Fiorino, Fabio Malavasi, Dario Sangiolo, Roberto Gambari and Davide Ferrari

    Citation: Molecular Medicine 2017 23:2301235

    Content type: Research Article

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  3. Heme oxygenase-1 (HO-1) is reported to protect against liver injury, but little Is known about its effect on the intestinal barrier in cholestatic liver injury. In this study, we investigated the effects of HO...

    Authors: Lijing Zhang, Zhenling Zhang, Bojia Liu, Yanling Jin, Yan Tian, Yi Xin and Zhijun Duan

    Citation: Molecular Medicine 2017 23:2301215

    Content type: Research Article

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  4. Previously, we showed that an oligodeoxynucleotide (ODN) with AAAG repeats (AAAG ODN) rescued mice from fatal acute lung injury (ALI) induced by influenza virus and inhibited production of tumor necrosis facto...

    Authors: Yue Xiao, Wenting Lu, Xin Li, Peiyan Zhao, Yun Yao, Xiaohong Wang, Ying Wang, Zhipeng Lin, Yongli Yu, Shucheng Hua and Liying Wang

    Citation: Molecular Medicine 2017 23:2301166

    Content type: Research Article

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  5. Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have bee...

    Authors: Anju M. Philip, Youdong Wang, Antonio Mauro, Suzan El-Rass, John C. Marshall, Warren L. Lee, Arthur S. Slutsky, Claudia C. dos Santos and Xiao-Yan Wen

    Citation: Molecular Medicine 2017 23:2301134

    Content type: Research Article

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  6. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer tumors. Comparisons between TNBC and non-triple-negative breast cancer (nTNBC) may help to differentiate key components involved i...

    Authors: Sandra K. Santuario-Facio, Servando Cardona-Huerta, Yadira X. Perez-Paramo, Victor Trevino, Francisco Hernandez-Cabrera, Augusto Rojas-Martinez, Grecia Uscanga-Perales, Jorge L. Martinez-Rodriguez, Lizeth Martinez-Jacobo, Gerardo Padilla-Rivas, Gerardo Muñoz-Maldonado, Juan Francisco Gonzalez-Guerrero, Javier Valero-Gomez, Ana L. Vazquez-Guerrero, Herminia G. Martinez-Rodriguez, Alvaro Barboza-Quintana…

    Citation: Molecular Medicine 2017 23:2301101

    Content type: Research Article

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  7. Osteoporosis is a global public health problem affecting more than 200 million people worldwide. We previously showed that treatment with α-1 antitrypsin (AAT), a multifunctional protein with antiinflammatory ...

    Authors: Mohammad Ahsanul Akbar, David Nardo, Mong-Jen Chen, Ahmed S. Elshikha, Rubina Ahamed, Eslam M. Elsayed, Claire Bigot, L. Shannon Holliday and Sihong Song

    Citation: Molecular Medicine 2017 23:2301057

    Content type: Research Article

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  8. The inflammatory pathways that drive the development of intimai hyperplasia (IH) following arterial injury are not fully understood. We hypothesized that the lysosomal cysteine protease cathepsin L activates p...

    Authors: Jingjing Cai, Hua Zhong, Jinze Wu, Rui-Fang Chen, Huan Yang, Yousef Al-Abed, Ying Li, Xiaohui Li, Weihong Jiang, Marcelo F. Montenegro, Hong Yuan, Timothy R. Billiar and Alex F. Chen

    Citation: Molecular Medicine 2017 23:2301092

    Content type: Research Article

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  9. Pancreatic cancer is one of the most lethal solid malignancies, with few treatment options. We have recently shown that expression of protease activated receptor (PAR)-1 in the tumor microenvironment drives th...

    Authors: Kun Shi, Helene Damhofer, Joost Daalhuisen, Marieke ten Brink, Dick J. Richel and C. Arnold Spek

    Citation: Molecular Medicine 2017 23:2301013

    Content type: Research Article

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  10. miR-155 has been shown to participate in host response to infection and neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell function. We hypothesized that miR-155 may co...

    Authors: Kevin R. Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, Andrea L. Conroy, Michael Hawkes, Henry S. Cheng, Makon-Sébastien Njock, Jason E. Fish, John M. Harlan, Jose A. López, W. Conrad Liles and Kevin C. Kain

    Citation: Molecular Medicine 2017 23:2301024

    Content type: Research Article

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  11. Sepsis survivors suffer from additional morbidities, including higher risk of readmissions, nervous system disturbances and cognitive dysfunction, and increased mortality, even several years after the initial ...

    Authors: Naara Mendes Oliveira, Ester C S Rios, Thais Martins de Lima, Vanessa Jacob Victorino, Hermes Barbeiro, Fabiano Pinheiro da Silva, Csaba Szabo and Francisco Garcia Soriano

    Citation: Molecular Medicine 2016 22:2201886

    Content type: Research Article

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  12. Strategies aimed at reducing cerebral accumulation of the amyloid-β (Aβ) peptides have therapeutic potential in Alzheimer’s disease (AD). Aβ immunization has proven to be effective at promoting Aβ clearance in...

    Authors: Valérie Vingtdeux, Haitian Zhao, Pallavi Chandakkar, Christopher M Acker, Peter Davies and Philippe Marambaud

    Citation: Molecular Medicine 2016 22:2201841

    Content type: Research Article

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  13. The absence of early outcome biomarkers for pediatric acute liver failure (PALF) hinders medical and liver transplant decisions. We sought to define dynamic interactions among circulating inflammatory mediator...

    Authors: Ruben Zamora, Yoram Vodovotz, Qi Mi, Derek Barclay, Jinling Yin, Simon Horslen, David Rudnick, Kathleen M Loomes and Robert H Squires

    Citation: Molecular Medicine 2016 22:2201821

    Content type: Research Article

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  14. Long-term sepsis survivors sustain cryptic brain injury that leads to cognitive impairment, emotional imbalance and Increased disability burden. Suitable animal models of sepsis, such as cecal ligation and pun...

    Authors: Patricio T Huerta, Sergio Robbiati, Tomás S Huerta, Anchal Sabharwal, Roseann Berlin, Maya Frankfurt and Bruce T Volpe

    Citation: Molecular Medicine 2016 22:2201789

    Content type: Research Article

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  15. Obesity and its accompanying metabolic syndrome are strongly associated with heightened morbidity and mortality in older adults. In our review of more than 20 epidemiologic studies of major infectious diseases...

    Authors: Jesse Roth, Navneet Sahota, Priya Patel, Syed F Mehdi, Mohammad M Wiese, Hafiz B Mahboob, Michelle Bravo, Daniel J Eden, Muhammad A Bashir, Amrat Kumar, Farah Alsaati, Irwin J Kurland, Wunnie Brima, Ann Danoff, Alessandra L Szulc, Valentin A Pavlov…

    Citation: Molecular Medicine 2016 22:2201873

    Content type: Review Article

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  16. After several decades of Alzheimer’s disease (AD) research and failed clinical trials, one can speculate that targeting a single pathway is not sufficient. However, a cocktail of novel therapeutics will consti...

    Authors: Roman Sankowski, Arne Herring, Kathy Keyvani, Kathrin Frenzel, Jinyu Wu, Stephan Röskam, Carmen Noelker, Michael Bacher and Yousef Al-Abed

    Citation: Molecular Medicine 2016 22:2201776

    Content type: Research Article

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  17. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to...

    Authors: Tak Mak

    Citation: Molecular Medicine 2016 22:2201675

    Content type: Research Article

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  18. Human myeloma cells express CD38 at high levels and grow in hypoxic niches inside the bone marrow. Myeloma cells respond to hypoxia with metabolic changes leading to aerobic glycolysis, thus reducing adenosine...

    Authors: Alberto L Horenstein, Valeria Quarona, Denise Toscani, Federica Costa, Antonella Chillemi, Vito Pistoia, Nicola Giuliani and Fabio Malavasi

    Citation: Molecular Medicine 2016 22:2201694

    Content type: Research Article

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  19. MicroRNAs (miRNAs) are well preserved in every animal. These pygmy-sized (21–23 nt) noncoding RNAs scattered in the genome are responsible for micromanaging versatile gene regulation. There is involvement of m...

    Authors: Utpal Bhadra, Pradipta Patra, Jagamohan Chhatai and Manika Pal-Bhadra

    Citation: Molecular Medicine 2016 22:2201759

    Content type: Review Article

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  20. Stem cell transcriptional signature activation is an essential event in the development of cancer. This study aimed to investigate the differential expression profiles of three pluripotency-associated genes, OCT4...

    Authors: Eman A Toraih, Manal S Fawzy, Abdullah I El-Falouji, Elham O Hamed, Nader A Nemr, Mohammad H Hussein and Noha M Abd El Fadeal

    Citation: Molecular Medicine 2016 22:2201653

    Content type: Original Articles

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  21. Albert Dahan, Ann Dunne, Maarten Swartjes, Paolo L Proto, Lara Heij, Oscar Vogels, Monique van Velzen, Elise Sarton, Marieke Niesters, Martijn R Tannemaat, Anthony Cerami, and Michael Brines. (2013) ARA 290 Im...

    Authors: Albert Dahan, Ann Dunne, Maarten Swartjes, Paolo L. Proto, Lara Heij, Oscar Vogels, Monique van Velzen, Elise Sarton, Marieke Niesters, Martijn R. Tannemaat, Anthony Cerami and Michael Brines

    Citation: Molecular Medicine 2016 22:2201674

    Content type: Erratum

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    The original article was published in Molecular Medicine 2013 19:1901334

  22. Cancer is a highly complex disease that has become one of the leading causes of death globally. Metastasis, a major cause of cancer deaths, requires two crucial events, adhesion and invasion. The 37kDa/67kDa l...

    Authors: Leila Vania, Carryn J Chetty, Eloise Ferreira and Stefan F T Weiss

    Citation: Molecular Medicine 2016 22:2201664

    Content type: Research Article

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  23. Severe malarial anemia (SMA; hemoglobin [Hb] <5.0 g/dL) is a leading global cause of morbidity and mortality among children residing in Plasmodium falciparum transmission regions. Exploration of molecular pathway...

    Authors: Prakasha Kempaiah, Karol Dokladny, Zachary Karim, Evans Raballah, John M Ong’echa, Pope L Moseley and Douglas J Perkins

    Citation: Molecular Medicine 2016 22:2201570

    Content type: Original Articles

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  24. Acute pancreatitis is characterized by zymogen preactivation. Severe inflammation caused by zymogen activation can eventually lead to multiple organ dysfunctions which contribute to the high mortality rate of ...

    Authors: Juan Xiao, Xueping Feng, Xiao-Ying Huang, Zhongshi Huang, Yanqiang Huang, Chaogan Li, Genliang Li, Song Nong, Ruoshi Wu, Yongzhi Huang and Xi-Dai Long

    Citation: Molecular Medicine 2016 22:2201643

    Content type: Research Article

    Published on:

  25. OBJECTIVE: In rheumatoid arthritis (RA) several recent efforts have sought to discover means of predicting which patients would benefit from treatment. However, results have been discrepant with few successful...

    Authors: Lasse Folkersen, Boel Brynedal, Lina Marcela Diaz-Gallo, Daniel Ramsköld, Klementy Shchetynsky, Helga Westerlind, Yvonne Sundström, Danika Schepis, Aase Hensvold, Nancy Vivar, Maija-Leena Eloranta, Lars Rönnblom, Søren Brunak, Vivianne Malmström, Anca Catrina, Ulrik G W Moerch…

    Citation: Molecular Medicine 2016 22:2201322

    Content type: Research Article

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  26. During exercise, cardiac oxygen consumption increases and the resulting low oxygen level in the myocardium triggers coronary vasodilation. This response to hypoxia is controlled notably by the vasodilator aden...

    Authors: Jean Ruf, Franck Paganelli, Laurent Bonello, Nathalie Kipson, Giovanna Mottola, Julien Fromonot, Jocelyne Condo, Alain Boussuges, Laurie Bruzzese, François Kerbaul, Yves Jammes, Vlad Gariboldi, Frédéric Franceschi, Emmanuel Fenouillet and Régis Guieu

    Citation: Molecular Medicine 2016 22:2201530

    Content type: Research Article

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  27. Sickle cell disease (SCD) patients have low serum hemopexin (Hpx) levels due to chronic hemolysis. We hypothesized that in SCD mice, hepatic overexpression of hemopexin would scavenge the proximal mediator of ...

    Authors: Gregory M Vercellotti, Ping Zhang, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Phong Nguyen, Carlos Nowotny, Clifford J Steer, Ann Smith and John D Belcher

    Citation: Molecular Medicine 2016 22:2201437

    Content type: Research Article

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  28. Although current vaccination strategies have been successful at preventing a variety of human diseases, attempts at vaccinating against some pathogens such as AIDS and tuberculosis (TB) have been more problema...

    Authors: Rui Li, Nan Zhang, Miaomiao Tian, Zihan Ran, Mingjun Zhu, Haiyan Zhu, Fangting Han, Juan Yin and Jiang Zhong

    Citation: Molecular Medicine 2016 22:2201497

    Content type: Research Article

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  29. The identification of HMGB1 as a late mediator in sepsis has highlighted HMGB1 as a promising therapeutic target for sepsis treatment. Recent studies have revealed that annexin A5, a 35 kDa Ca2+-dependent phospho...

    Authors: Jung Hwa Park, Jong-Hwa Jang, Eun Jung Choi, Young Seob Kim, Eun Ji Lee, In Duk Jung, Hee Dong Han, T-C Wu, Chien-Fu Hung, Tae Heung Kang and Yeong-Min Park

    Citation: Molecular Medicine 2016 22:2201424

    Content type: Research Article

    Published on:

  30. The ratio of the longer (Aβ42/Aβ43) to shorter (Aβ40) species is a critical factor determining amyloid fibril formation, neurotoxicity and progression of the amyloid pathology in Alzheimer’s disease. The relat...

    Authors: Katarzyna Marta Zoltowska, Masato Maesako and Oksana Berezovska

    Citation: Molecular Medicine 2016 22:2201329

    Content type: Research Article

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  31. Previous in vivo work showed that resveratrol has beneficial effects in Alzheimer’s disease (AD) pathology, resulting in increased expression of transthyretin (TTR). TTR binds amyloid-beta (Aβ) peptide, avoiding ...

    Authors: Luís Miguel Santos, Daniela Rodrigues, Mobina Alemi, Sara Costa Silva, Carlos Alexandre Ribeiro and Isabel Cardoso

    Citation: Molecular Medicine 2016 22:2201597

    Content type: Research Article

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  32. A 55–200 expansion of the CGG nucleotide repeat in the 5′-UTR of the fragile X mental retardation 1 gene (FMR1) is the hallmark of the triplet nucleotide disease known as the “premutation” as opposed to those ...

    Authors: Gyu Song, Eleonora Napoli, Sarah Wong, Randi Hagerman, Siming Liu, Flora Tassone and Cecilia Giulivi

    Citation: Molecular Medicine 2016 22:2201548

    Content type: Original Articles

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  33. Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen in pneumonia associated with severe lung damage. Tissue injury causes release of damage-associated molecular patterns (DAMPs), which may...

    Authors: Anne Jan van der Meer, Achmed Achouiti, Arie van der Ende, Aicha Ait Soussan, Sandrine Florquin, Alex de Vos, Sacha S Zeerleder and Tom van der Poll

    Citation: Molecular Medicine 2016 22:2201292

    Content type: Research Article

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  34. The pathophysiology of sepsis involves activation of acid sphingomyelinase (SMPD1) with subsequent generation of the bioactive mediator ceramide. We herein evaluate the hypothesis that the enzyme exerts biolog...

    Authors: Ha-Yeun Chung, Daniel C Hupe, Gordon P Otto, Marcel Sprenger, Alexander C Bunck, Michael J Dorer, Clemens L Bockmeyer, Hans-Peter Deigner, Markus H Gräler and Ralf A Claus

    Citation: Molecular Medicine 2016 22:2201412

    Content type: Research Article

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  35. Esophageal adenocarcinoma (EAC) has a poor prognosis and is increasing in incidence in many Western populations. Neoadjuvant chemoradiation therapy (CRT) followed by surgery is increasingly the standard of car...

    Authors: Niamh Lynam-Lennon, Becky A S Bibby, Ann Marie Mongan, Laure Marignol, Christian N Paxton, Katherine Geiersbach, Mary P Bronner, Jacintha O’Sullivan, John V Reynolds and Stephen G Maher

    Citation: Molecular Medicine 2016 22:2201388

    Content type: Research Article

    Published on:

  36. Acute emotionally reactive mental stress (MS) can provoke prognostically relevant deficits in cardiac function and myocardial perfusion, and chronic inflammation increases risk for this ischemic phenomenon. We...

    Authors: Robert Soufer, Antonio B Fernandez, Judith Meadows, Dorothea Collins and Matthew M Burg

    Citation: Molecular Medicine 2016 22:2201286

    Content type: Research Article

    Published on:

  37. The tumor-node-metastasis (TNM) system fails to accurately predict disease recurrence in a considerable number of patients. Although node-negative (stage II) colon cancer is considered to have an overall good ...

    Authors: Martin M Watson and Kjetil Søreide

    Citation: Molecular Medicine 2016 22:2201271

    Content type: Invited Commentary

    Published on:

  38. Alzheimer’s disease (AD) is a devastating neurodegenerative disorder, characterized by extensive loss of neurons and deposition of amyloid β (Aβ) in the form of extracellular plaques. Aβ is considered to have ...

    Authors: Vijay K Sonkar, Paresh P Kulkarni, Susheel N Chaurasia, Ayusman Dash, Abhishek Jauhari, Devendra Parmar, Sanjay Yadav and Debabrata Dash

    Citation: Molecular Medicine 2016 22:2201224

    Content type: Research Article

    Published on:

    The Correction to this article has been published in Molecular Medicine 2019 25:34

  39. Emerging evidence demonstrates association of depression with both immune malfunctioning and worsened course of diverse aging-related diseases, but there is no explanation for the pathway(s) controlling this d...

    Authors: Shani Shenhar-Tsarfaty, Sharon Joker, Itzhak Shapira, Ori Rogowski, Shlomo Berliner, Yaacov Ritov and Hermona Soreq

    Citation: Molecular Medicine 2016 22:2201156

    Content type: Invited Research Article

    Published on:

  40. Endothelial cell (EC) dysfunction is a critical mediator of the acute respiratory distress syndrome (ARDS). Recent studies have demonstrated that stromal cell-derived factor 1α (SDF-1α) promotes EC barrier int...

    Authors: Changrun Guo, Andrew Goodwin, Joy N Jones Buie, James Cook, Perry Halushka, Kelley Argraves, Basilia Zingarelli, Xian Zhang, Liping Wang and Hongkuan Fan

    Citation: Molecular Medicine 2016 22:2201115

    Content type: Research Article

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  41. Sepsis is characterized by dysregulated systemic inflammation with release of early (for example, Interleukin (IL)-1β) and late (for example, HMGB1) proinflammatory mediators from macrophages. Plumbagin, a med...

    Authors: Zhaoxia Zhang, Wenjun Deng, Rui Kang, Min Xie, Timothy Billiar, Haichao Wang, Lizhi Cao and Daolin Tang

    Citation: Molecular Medicine 2016 22:2201162

    Content type: Research Article

    Published on:

  42. β-Arrestin2 (βarr2) is an adaptor protein that interacts with numerous signaling molecules and regulates insulin sensitivity. We reported previously that βarr2 was abundantly expressed in mouse pancreatic β-ce...

    Authors: Ziwei Lin, Yu Zhao, Lige Song, Kaida Mu, Mingliang Zhang, Hongxia Liu, Xiaowen Li, Jian Zhao, Chen Wang and Weiping Jia

    Citation: Molecular Medicine 2016 22:2201074

    Content type: Research Article

    Published on:

  43. Prostate cancer cells are responsive to adrenergic and thyroid stimuli. It is well established that β-adrenergic activation (protein kinase A [PKA]/cAMP response element binding protein [CREB]) promotes cancer...

    Authors: Evangelina Delgado-González, Ana Alicia Sánchez-Tusie, Giapsy Morales, Carmen Aceves and Brenda Anguiano

    Citation: Molecular Medicine 2016 22:2201001

    Content type: Research Article

    Published on:

  44. The goal of this study was to determine how B-cell-activating factor of the TNF family (BAFF) availability influences selection of the autoreactive B-cell repertoire in NZB/W and NZW/BXSB lupus-prone mice bear...

    Authors: Alexis Boneparth, Megan Woods, Weiqing Huang, Meredith Akerman, Martin Lesser and Anne Davidson

    Citation: Molecular Medicine 2016 22:2201173

    Content type: Research Article

    Published on:

  45. Sepsis is a major healthcare concern, especially in the elderly population. The use of an animal model closely resembling clinical conditions in this population may provide a better prediction in translating b...

    Authors: Weng-Lang Yang, Gaifeng Ma, Mian Zhou, Monowar Aziz, Hao-Ting Yen, Spyros A Marvropoulos, Kaie Ojamaa and Ping Wang

    Citation: Molecular Medicine 2016 22:2201124

    Content type: Research Article

    Published on:

  46. Cardiac hypertrophy can be broadly classified as either physiological or pathological. Physiological stimuli such as exercise cause adaptive cardiac hypertrophy and normal heart function. Pathological stimuli ...

    Authors: Jun Xie, Guixin He, Qinhua Chen, Jiayin Sun, Qin Dai, Jianrong Lu, Guannan Li, Han Wu, Ran Li, Jianzhou Chen, Wei Xu and Biao Xu

    Citation: Molecular Medicine 2016 22:2201192

    Content type: Research Article

    Published on:

  47. Sequence alterations in the pendrin gene (SLC26A4) leading to functionally affected protein variants are frequently involved in the pathogenesis of syndromic and nonsyndromic deafness. Considering the high number...

    Authors: Vanessa C S de Moraes, Emanuele Bernardinelli, Nathalia Zocal, Jhonathan A Fernandez, Charity Nofziger, Arthur M Castilho, Edi L Sartorato, Markus Paulmichl and Silvia Dossena

    Citation: Molecular Medicine 2016 22:2201041

    Content type: Research Article

    Published on:

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