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Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 4 of 37

  1. Sepsis survivors suffer from additional morbidities, including higher risk of readmissions, nervous system disturbances and cognitive dysfunction, and increased mortality, even several years after the initial ...

    Authors: Naara Mendes Oliveira, Ester C S Rios, Thais Martins de Lima, Vanessa Jacob Victorino, Hermes Barbeiro, Fabiano Pinheiro da Silva, Csaba Szabo and Francisco Garcia Soriano

    Citation: Molecular Medicine 2016 22:2201886

    Content type: Research Article

    Published on:

  2. Strategies aimed at reducing cerebral accumulation of the amyloid-β (Aβ) peptides have therapeutic potential in Alzheimer’s disease (AD). Aβ immunization has proven to be effective at promoting Aβ clearance in...

    Authors: Valérie Vingtdeux, Haitian Zhao, Pallavi Chandakkar, Christopher M Acker, Peter Davies and Philippe Marambaud

    Citation: Molecular Medicine 2016 22:2201841

    Content type: Research Article

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  3. The absence of early outcome biomarkers for pediatric acute liver failure (PALF) hinders medical and liver transplant decisions. We sought to define dynamic interactions among circulating inflammatory mediator...

    Authors: Ruben Zamora, Yoram Vodovotz, Qi Mi, Derek Barclay, Jinling Yin, Simon Horslen, David Rudnick, Kathleen M Loomes and Robert H Squires

    Citation: Molecular Medicine 2016 22:2201821

    Content type: Research Article

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  4. Long-term sepsis survivors sustain cryptic brain injury that leads to cognitive impairment, emotional imbalance and Increased disability burden. Suitable animal models of sepsis, such as cecal ligation and pun...

    Authors: Patricio T Huerta, Sergio Robbiati, Tomás S Huerta, Anchal Sabharwal, Roseann Berlin, Maya Frankfurt and Bruce T Volpe

    Citation: Molecular Medicine 2016 22:2201789

    Content type: Research Article

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  5. Obesity and its accompanying metabolic syndrome are strongly associated with heightened morbidity and mortality in older adults. In our review of more than 20 epidemiologic studies of major infectious diseases...

    Authors: Jesse Roth, Navneet Sahota, Priya Patel, Syed F Mehdi, Mohammad M Wiese, Hafiz B Mahboob, Michelle Bravo, Daniel J Eden, Muhammad A Bashir, Amrat Kumar, Farah Alsaati, Irwin J Kurland, Wunnie Brima, Ann Danoff, Alessandra L Szulc, Valentin A Pavlov…

    Citation: Molecular Medicine 2016 22:2201873

    Content type: Review Article

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  6. After several decades of Alzheimer’s disease (AD) research and failed clinical trials, one can speculate that targeting a single pathway is not sufficient. However, a cocktail of novel therapeutics will consti...

    Authors: Roman Sankowski, Arne Herring, Kathy Keyvani, Kathrin Frenzel, Jinyu Wu, Stephan Röskam, Carmen Noelker, Michael Bacher and Yousef Al-Abed

    Citation: Molecular Medicine 2016 22:2201776

    Content type: Research Article

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  7. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to...

    Authors: Tak Mak

    Citation: Molecular Medicine 2016 22:2201675

    Content type: Research Article

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  8. Studies imply that intestinal barrier dysfunction is a key contributor to morbid events associated with sepsis. Recently, the co-inhibitory molecule programmed death-ligand1 (PD-L1) has been shown to be involv...

    Authors: Youping Wu, Chun-Shiang Chung, Yaping Chen, Sean Farrell Monaghan, Sima Patel, Xin Huang, Daithi Seamus Heffernan and Alfred Ayala

    Citation: Molecular Medicine 2016 22:2201830

    Content type: Research Article

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  9. Previously, we have shown that N,N-dimethylacetamide (DMA) prevents inflammation-induced preterm birth in a murine model, inhibits lipopolysaccharide (LPS)-induced increases in placental proinflammatory cytoki...

    Authors: Ryan Pekson, Vladimir Poltoratsky, Samir Gorasiya, Sruthi Sundaram, Charles R. Ashby Jr., Ivana Vancurova and Sandra E. Reznik

    Citation: Molecular Medicine 2016 22:2201747

    Content type: Research Article

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  10. Pregnancy requires adaptation of maternal energy metabolism, including expansion and functional modifications of adipose tissue. Insulin resistance (IR), predominantly during late gestation, is a physiological...

    Authors: Yurena Vivas, Monica Díez-Hochleitner, Adriana Izquierdo-Lahuerta, Patricia Corrales, Daniel Horrillo, Ismael Velasco, Cristina Martínez-García, Mark Campbell, Julio Sevillano, Mercedes Ricote, Manuel Ros, Maria Pilar Ramos and Gema Medina-Gomez

    Citation: Molecular Medicine 2016 22:2201724

    Content type: Research Article

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  11. Human myeloma cells express CD38 at high levels and grow in hypoxic niches inside the bone marrow. Myeloma cells respond to hypoxia with metabolic changes leading to aerobic glycolysis, thus reducing adenosine...

    Authors: Alberto L Horenstein, Valeria Quarona, Denise Toscani, Federica Costa, Antonella Chillemi, Vito Pistoia, Nicola Giuliani and Fabio Malavasi

    Citation: Molecular Medicine 2016 22:2201694

    Content type: Research Article

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  12. MicroRNAs (miRNAs) are well preserved in every animal. These pygmy-sized (21–23 nt) noncoding RNAs scattered in the genome are responsible for micromanaging versatile gene regulation. There is involvement of m...

    Authors: Utpal Bhadra, Pradipta Patra, Jagamohan Chhatai and Manika Pal-Bhadra

    Citation: Molecular Medicine 2016 22:2201759

    Content type: Review Article

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  13. Stem cell transcriptional signature activation is an essential event in the development of cancer. This study aimed to investigate the differential expression profiles of three pluripotency-associated genes, OCT4...

    Authors: Eman A Toraih, Manal S Fawzy, Abdullah I El-Falouji, Elham O Hamed, Nader A Nemr, Mohammad H Hussein and Noha M Abd El Fadeal

    Citation: Molecular Medicine 2016 22:2201653

    Content type: Original Articles

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  14. Cancer is a highly complex disease that has become one of the leading causes of death globally. Metastasis, a major cause of cancer deaths, requires two crucial events, adhesion and invasion. The 37kDa/67kDa l...

    Authors: Leila Vania, Carryn J Chetty, Eloise Ferreira and Stefan F T Weiss

    Citation: Molecular Medicine 2016 22:2201664

    Content type: Research Article

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  15. Severe malarial anemia (SMA; hemoglobin [Hb] <5.0 g/dL) is a leading global cause of morbidity and mortality among children residing in Plasmodium falciparum transmission regions. Exploration of molecular pathway...

    Authors: Prakasha Kempaiah, Karol Dokladny, Zachary Karim, Evans Raballah, John M Ong’echa, Pope L Moseley and Douglas J Perkins

    Citation: Molecular Medicine 2016 22:2201570

    Content type: Original Articles

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  16. Acute pancreatitis is characterized by zymogen preactivation. Severe inflammation caused by zymogen activation can eventually lead to multiple organ dysfunctions which contribute to the high mortality rate of ...

    Authors: Juan Xiao, Xueping Feng, Xiao-Ying Huang, Zhongshi Huang, Yanqiang Huang, Chaogan Li, Genliang Li, Song Nong, Ruoshi Wu, Yongzhi Huang and Xi-Dai Long

    Citation: Molecular Medicine 2016 22:2201643

    Content type: Research Article

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  17. OBJECTIVE: In rheumatoid arthritis (RA) several recent efforts have sought to discover means of predicting which patients would benefit from treatment. However, results have been discrepant with few successful...

    Authors: Lasse Folkersen, Boel Brynedal, Lina Marcela Diaz-Gallo, Daniel Ramsköld, Klementy Shchetynsky, Helga Westerlind, Yvonne Sundström, Danika Schepis, Aase Hensvold, Nancy Vivar, Maija-Leena Eloranta, Lars Rönnblom, Søren Brunak, Vivianne Malmström, Anca Catrina, Ulrik G W Moerch…

    Citation: Molecular Medicine 2016 22:2201322

    Content type: Research Article

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  18. Idiopathic trigeminal neuralgia (TN) is a debilitating pain disorder characterized by episodic unilateral facial pain along the territory of branches of the trigeminal nerve. Human pain disorders, but not TN, ...

    Authors: Brian S Tanaka, Peng Zhao, Fadia B Dib-Hajj, Valerie Morisset, Simon Tate, Stephen G Waxman and Sulayman D Dib-Hajj

    Citation: Molecular Medicine 2016 22:2201338

    Content type: Research Article

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  19. During exercise, cardiac oxygen consumption increases and the resulting low oxygen level in the myocardium triggers coronary vasodilation. This response to hypoxia is controlled notably by the vasodilator aden...

    Authors: Jean Ruf, Franck Paganelli, Laurent Bonello, Nathalie Kipson, Giovanna Mottola, Julien Fromonot, Jocelyne Condo, Alain Boussuges, Laurie Bruzzese, François Kerbaul, Yves Jammes, Vlad Gariboldi, Frédéric Franceschi, Emmanuel Fenouillet and Régis Guieu

    Citation: Molecular Medicine 2016 22:2201530

    Content type: Research Article

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  20. Sickle cell disease (SCD) patients have low serum hemopexin (Hpx) levels due to chronic hemolysis. We hypothesized that in SCD mice, hepatic overexpression of hemopexin would scavenge the proximal mediator of ...

    Authors: Gregory M Vercellotti, Ping Zhang, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Phong Nguyen, Carlos Nowotny, Clifford J Steer, Ann Smith and John D Belcher

    Citation: Molecular Medicine 2016 22:2201437

    Content type: Research Article

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  21. Congenital diaphragmatic hernia (CDH) causes severe pulmonary hypoplasia from herniation of abdominal contents into the thorax. Tracheal occlusion (TO) for human CDH improves survival, but morbidity and mortal...

    Authors: Brian M Varisco, Lourenco Sbragia, Jing Chen, Federico Scorletti, Rashika Joshi, Hector R Wong, Rebeca Lopes-Figueira, Marc Oria and Jose Peiro

    Citation: Molecular Medicine 2016 22:2201398

    Content type: Research Article

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  22. Neutrophils constitute the early innate immune response to perceived infectious and sterile threats. Neutrophil extracellular traps (NETs) are a novel mechanism to counter pathogenic invasion and sequelae of i...

    Authors: Ahmed B Al-Khafaji, Samer Tohme, Hamza Obaid Yazdani, David Miller, Hai Huang and Allan Tsung

    Citation: Molecular Medicine 2016 22:2201621

    Content type: Research Article

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  23. Alphal-antitrypsin (A1AT, SERPINA1), a major circulating inhibitor of neutrophil elastase (NE) and protelnase-3 (PR3), has been proposed to reduce the processing and release of IL-1β. Since the antiinflammator...

    Authors: Nupur Aggarwal, Elena Korenbaum, Ravi Mahadeva, Stephan Immenschuh, Veronika Grau, Charles A Dinarello, Tobias Welte and Sabina Janciauskiene

    Citation: Molecular Medicine 2016 22:2201680

    Content type: Original Articles

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  24. Although current vaccination strategies have been successful at preventing a variety of human diseases, attempts at vaccinating against some pathogens such as AIDS and tuberculosis (TB) have been more problema...

    Authors: Rui Li, Nan Zhang, Miaomiao Tian, Zihan Ran, Mingjun Zhu, Haiyan Zhu, Fangting Han, Juan Yin and Jiang Zhong

    Citation: Molecular Medicine 2016 22:2201497

    Content type: Research Article

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  25. The identification of HMGB1 as a late mediator in sepsis has highlighted HMGB1 as a promising therapeutic target for sepsis treatment. Recent studies have revealed that annexin A5, a 35 kDa Ca2+-dependent phospho...

    Authors: Jung Hwa Park, Jong-Hwa Jang, Eun Jung Choi, Young Seob Kim, Eun Ji Lee, In Duk Jung, Hee Dong Han, T-C Wu, Chien-Fu Hung, Tae Heung Kang and Yeong-Min Park

    Citation: Molecular Medicine 2016 22:2201424

    Content type: Research Article

    Published on:

  26. The ratio of the longer (Aβ42/Aβ43) to shorter (Aβ40) species is a critical factor determining amyloid fibril formation, neurotoxicity and progression of the amyloid pathology in Alzheimer’s disease. The relat...

    Authors: Katarzyna Marta Zoltowska, Masato Maesako and Oksana Berezovska

    Citation: Molecular Medicine 2016 22:2201329

    Content type: Research Article

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  27. Previous in vivo work showed that resveratrol has beneficial effects in Alzheimer’s disease (AD) pathology, resulting in increased expression of transthyretin (TTR). TTR binds amyloid-beta (Aβ) peptide, avoiding ...

    Authors: Luís Miguel Santos, Daniela Rodrigues, Mobina Alemi, Sara Costa Silva, Carlos Alexandre Ribeiro and Isabel Cardoso

    Citation: Molecular Medicine 2016 22:2201597

    Content type: Research Article

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  28. A 55–200 expansion of the CGG nucleotide repeat in the 5′-UTR of the fragile X mental retardation 1 gene (FMR1) is the hallmark of the triplet nucleotide disease known as the “premutation” as opposed to those ...

    Authors: Gyu Song, Eleonora Napoli, Sarah Wong, Randi Hagerman, Siming Liu, Flora Tassone and Cecilia Giulivi

    Citation: Molecular Medicine 2016 22:2201548

    Content type: Original Articles

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  29. The pathophysiology of sepsis involves activation of acid sphingomyelinase (SMPD1) with subsequent generation of the bioactive mediator ceramide. We herein evaluate the hypothesis that the enzyme exerts biolog...

    Authors: Ha-Yeun Chung, Daniel C Hupe, Gordon P Otto, Marcel Sprenger, Alexander C Bunck, Michael J Dorer, Clemens L Bockmeyer, Hans-Peter Deigner, Markus H Gräler and Ralf A Claus

    Citation: Molecular Medicine 2016 22:2201412

    Content type: Research Article

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  30. Mutations in the SLC13A5 gene that codes for the Na+/citrate cotransporter, NaCT, are associated with early onset epilepsy, developmental delay and tooth dysplasia in children. In this study, we identify addition...

    Authors: Jenna Klotz, Brenda E Porter, Claire Colas, Avner Schlessinger and Ana M Pajor

    Citation: Molecular Medicine 2016 22:2201310

    Content type: Research Article

    Published on:

  31. Esophageal adenocarcinoma (EAC) has a poor prognosis and is increasing in incidence in many Western populations. Neoadjuvant chemoradiation therapy (CRT) followed by surgery is increasingly the standard of car...

    Authors: Niamh Lynam-Lennon, Becky A S Bibby, Ann Marie Mongan, Laure Marignol, Christian N Paxton, Katherine Geiersbach, Mary P Bronner, Jacintha O’Sullivan, John V Reynolds and Stephen G Maher

    Citation: Molecular Medicine 2016 22:2201388

    Content type: Research Article

    Published on:

  32. Alzheimer’s disease (AD) is a devastating neurodegenerative disorder, characterized by extensive loss of neurons and deposition of amyloid β (Aβ) in the form of extracellular plaques. Aβ is considered to have ...

    Authors: Vijay K Sonkar, Paresh P Kulkarni, Susheel N Chaurasia, Ayusman Dash, Abhishek Jauhari, Devendra Parmar, Sanjay Yadav and Debabrata Dash

    Citation: Molecular Medicine 2016 22:2201224

    Content type: Research Article

    Published on:

    The Correction to this article has been published in Molecular Medicine 2019 25:34

  33. Lung epithelial cell apoptosis is an important feature of hyperoxia-induced lung injury. The death receptor-associated extrinsic pathway and mitochondria-associated intrinsic pathway both mediate the developme...

    Authors: Yong Cao, Duo Zhang, Hyung-Geun Moon, Heedoo Lee, Jeffrey A Haspel, Kebin Hu, Lixin Xie and Yang Jin

    Citation: Molecular Medicine 2016 22:2201233

    Content type: Research Article

    Published on:

  34. Perinatal asphyxia, a condition of impaired gas exchange during birth, leads to fetal hypoxia-ischemia (HI) and is associated with postnatal adverse outcomes including intestinal dysmotility and necrotizing en...

    Authors: Maria Nikiforou, Carolin Willburger, Anja E de Jong, Nico Kloosterboer, Reint K Jellema, Daan R M G Ophelders, Harry W M Steinbusch, Boris W Kramer and Tim G A M Wolfs

    Citation: Molecular Medicine 2016 22:2201244

    Content type: Research Article

    Published on:

  35. Sepsis is characterized by dysregulated systemic inflammation with release of early (for example, Interleukin (IL)-1β) and late (for example, HMGB1) proinflammatory mediators from macrophages. Plumbagin, a med...

    Authors: Zhaoxia Zhang, Wenjun Deng, Rui Kang, Min Xie, Timothy Billiar, Haichao Wang, Lizhi Cao and Daolin Tang

    Citation: Molecular Medicine 2016 22:2201162

    Content type: Research Article

    Published on:

  36. β-Arrestin2 (βarr2) is an adaptor protein that interacts with numerous signaling molecules and regulates insulin sensitivity. We reported previously that βarr2 was abundantly expressed in mouse pancreatic β-ce...

    Authors: Ziwei Lin, Yu Zhao, Lige Song, Kaida Mu, Mingliang Zhang, Hongxia Liu, Xiaowen Li, Jian Zhao, Chen Wang and Weiping Jia

    Citation: Molecular Medicine 2016 22:2201074

    Content type: Research Article

    Published on:

  37. The ABCA3 gene encodes a lipid transporter in type II pneumocytes critical for survival and normal respiratory function. The frequent ABCA3 variant R288K increases the risk for neonatal respiratory distress syndr...

    Authors: Thomas Wittmann, Sabrina Frixel, Stefanie Höppner, Ulrike Schindlbeck, Andrea Schams, Matthias Kappler, Jan Hegermann, Christoph Wrede, Gerhard Liebisch, Anne Vierzig, Angela Zacharasiewicz, Matthias Volkmar Kopp, Christian F Poets, Winfried Baden, Dominik Hartl, Anton H van Kaam…

    Citation: Molecular Medicine 2016 22:2201183

    Content type: Research Article

    Published on:

  38. Prostate cancer cells are responsive to adrenergic and thyroid stimuli. It is well established that β-adrenergic activation (protein kinase A [PKA]/cAMP response element binding protein [CREB]) promotes cancer...

    Authors: Evangelina Delgado-González, Ana Alicia Sánchez-Tusie, Giapsy Morales, Carmen Aceves and Brenda Anguiano

    Citation: Molecular Medicine 2016 22:2201001

    Content type: Research Article

    Published on:

  39. Methionine adenosyltransferase (MAT) I/III deficiency can be Inherited as autosomal dominant (AD) or as recessive (AR) traits in which mono- or biallelic MAT1A mutations have been identified, respectively. Althou...

    Authors: Yoo-Mi Kim, Ja Hye Kim, Jin-Ho Choi, Gu-Hwan Kim, Jae-Min Kim, Minji Kang, In-Hee Choi, Chong Kun Cheon, Young Bae Sohn, Marco Maccarana, Han-Wook Yoo and Beom Hee Lee

    Citation: Molecular Medicine 2016 22:2201147

    Content type: Research Article

    Published on:

  40. The goal of this study was to determine how B-cell-activating factor of the TNF family (BAFF) availability influences selection of the autoreactive B-cell repertoire in NZB/W and NZW/BXSB lupus-prone mice bear...

    Authors: Alexis Boneparth, Megan Woods, Weiqing Huang, Meredith Akerman, Martin Lesser and Anne Davidson

    Citation: Molecular Medicine 2016 22:2201173

    Content type: Research Article

    Published on:

  41. Sepsis is a major healthcare concern, especially in the elderly population. The use of an animal model closely resembling clinical conditions in this population may provide a better prediction in translating b...

    Authors: Weng-Lang Yang, Gaifeng Ma, Mian Zhou, Monowar Aziz, Hao-Ting Yen, Spyros A Marvropoulos, Kaie Ojamaa and Ping Wang

    Citation: Molecular Medicine 2016 22:2201124

    Content type: Research Article

    Published on:

  42. Cardiac hypertrophy can be broadly classified as either physiological or pathological. Physiological stimuli such as exercise cause adaptive cardiac hypertrophy and normal heart function. Pathological stimuli ...

    Authors: Jun Xie, Guixin He, Qinhua Chen, Jiayin Sun, Qin Dai, Jianrong Lu, Guannan Li, Han Wu, Ran Li, Jianzhou Chen, Wei Xu and Biao Xu

    Citation: Molecular Medicine 2016 22:2201192

    Content type: Research Article

    Published on:

  43. Our understanding of the process of metastatic progression has improved markedly over the past decades, yet metastasis remains the most enigmatic component of cancer pathogenesis. This lack of knowledge has se...

    Authors: Jagoda K Wrobel and Michal Toborek

    Citation: Molecular Medicine 2016 22:2201032

    Content type: Review Article

    Published on:

  44. Myocarditis is a major cause of heart failure and sudden cardiac death in young adults and adolescents. Many cases of myocarditis are associated with autoimmune processes in which cardiac myosin is a major aut...

    Authors: Wen-Shin Lee, Katalin Erdelyi, Csaba Matyas, Partha Mukhopadhyay, Zoltan V Varga, Lucas Liaudet, György Haskó, Daniela Čiháková, Raphael Mechoulam and Pal Pacher

    Citation: Molecular Medicine 2016 22:2201136

    Content type: Research Article

    Published on:

  45. Sequence alterations in the pendrin gene (SLC26A4) leading to functionally affected protein variants are frequently involved in the pathogenesis of syndromic and nonsyndromic deafness. Considering the high number...

    Authors: Vanessa C S de Moraes, Emanuele Bernardinelli, Nathalia Zocal, Jhonathan A Fernandez, Charity Nofziger, Arthur M Castilho, Edi L Sartorato, Markus Paulmichl and Silvia Dossena

    Citation: Molecular Medicine 2016 22:2201041

    Content type: Research Article

    Published on:

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