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Page 43 of 44

  1. We previously demonstrated the local production of the pleiotropic cytokine interleukin-6 (IL-6) in the central nervous system (CNS) in experimental autoimmune encephalomyelitis (EAE), an animal model for the ...

    Authors: Koenraad Gijbels, Stefan Brocke, John S. Abrams and Lawrence Steinman
    Citation: Molecular Medicine 1995 1:BF03401894
  2. Hereditary angioneurotic edema (HANE) is an autosomal dominant disease due to genetic alterations at the C1 inhibitor gene. Mutations within the C1 inhibitor gene are responsible for the molecular defect in ty...

    Authors: Javier G. Ocejo-Vinyals, Francisco Leyva-Cobián and José L. Fernández-Luna
    Citation: Molecular Medicine 1995 1:BF03401610
  3. The nervous system has been implicated in several inflammatory skin disorders based on evidence such as the role of stress in inducing lesions, symmetry of lesions, and sparing of denervated skin. Interleukin ...

    Authors: Laurence A. Turka, Richard E. Goodman, J. Lynn Rutkowski, Anders A. F. Sima, Andrew Merry, Raj S. Mitra, Tamara Wrone-Smith, Galen Toews, Robert M. Strieter and Brian J. Nickoloff
    Citation: Molecular Medicine 1995 1:BF03401609
  4. Tyr-Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) and Tyr-Tic-Ala were the first peptides with δ opioid antagonist activity lacking Phe, considered essential for opioid activity based on the N-terminal t...

    Authors: Severo Salvadori, Martti Attila, Giofranco Balboni, Clementina Bianchi, Sharon D. Bryant, Orlando Crescenzi, Remo Guerrini, Delia Picone, Teodorico Tancredi, Piero A. Temussi and Lawrence H. Lazarus
    Citation: Molecular Medicine 1995 1:BF03401608
  5. Cytokines and cytokine antagonists modulate human immunodeficiency virus (HIV) replication in vitro and may be involved in HIV disease pathogenesis. An understanding of these cytokine networks may suggest nove...

    Authors: Eric V. Granowitz, Bradford M. Saget, Monica Z. Wang, Charles A. Dinarello, Paul R. Skolnik and A. S. Fauci
    Citation: Molecular Medicine 1995 1:BF03401607
  6. Protein kinase CK2 (also known as casein kinase 2) is a messenger-independent protein serine/threonine kinase ubiquitously distributed in eukaryotes. CK2 has been found to phosphorylate a wide variety of cytos...

    Authors: Markus Gapany, Russell A. Faust, Sherif Tawfic, Alan Davis, George L. Adams, P. Leder and Khalil Ahmed
    Citation: Molecular Medicine 1995 1:BF03401606
  7. Advanced glycation end products (AGE), the reactive derivatives of nonenzymatic glucose-protein condensation reactions, are implicated in the multiorgan complications of diabetes and aging. An AGE-specific cel...

    Authors: Helen Vlassara, Yong Ming Li, Farhad Imani, Donald Wojciechowicz, Zhi Yang, Fu-Tong Liu and Anthony Cerami
    Citation: Molecular Medicine 1995 1:BF03401604
  8. Insulin (1) and glutamic acid decarboxylase (GAD) (2) are both autoantigens in insulin-dependent diabetes mellitus (IDDM), but no molecular mechanism has been proposed for their association. We have identified a ...

    Authors: George Rudy, Natalie Stone, Leonard C. Harrison, Peter G. Colman, Peter McNair, Vladimir Brusic, Michelle B. French, Margo C. Honeyman, Brian Tait and Andrew M. Lew
    Citation: Molecular Medicine 1995 1:BF03401603
  9. We have previously demonstrated CD8+ T cell clonal dominance using a PCR assay for the CDR3 length of T cell receptors belonging to a limited number of TCRBV segments/families. In this study, we have modified thi...

    Authors: Joanita Monteiro, Ravi Hingorani, In-Hong Choi, Jack Silver, Robert Pergolizzi and Peter K. Gregersen
    Citation: Molecular Medicine 1995 1:BF03401602
  10. Creutzfeldt-Jakob disease (CJD) is a prion disease which is manifest as a sporadic, inherited, and transmissible neurodegenerative disorder. The mean age at onset of CJD is ∼60 years, and as such, many people ...

    Authors: Serena Spudich, James A. Mastrianni, Margaret Wrensch, Ruth Gabizon, Zeev Meiner, Irit Kahana, Hana Rosenmann, Esther Kahana and Stanley B. Prusiner
    Citation: Molecular Medicine 1995 1:BF03401601
  11. Individuals at risk for insulin-dependent diabetes mellitus (IDDM), with an affected first-degree relative, can be identified by the presence of islet cell antibodies (ICA). ICA-positive relatives progress at ...

    Authors: Margo C. Honeyman, Leonard C. Harrison, Bruce Drummond, Peter G. Colman and Brian D. Tait
    Citation: Molecular Medicine 1995 1:BF03401595
  12. The receptor of ciliary neurotrophic factor (CNTF) contains the signal transduction protein gp130, which is also a component of the receptors of cytokines such as interleukin (IL)-6, leukemia-inhibitory factor...

    Authors: Fabio Benigni, Pia Villa, Maria Teresa Demitri, Silvano Sacco, Jean D. Sipe, Laura Lagunowich, Nikos Panayotatos and Pietro Ghezzi
    Citation: Molecular Medicine 1995 1:BF03401594
  13. A problem likely to be encountered in any cancer immunotherapy based on vaccination with a single protein or peptide is variation in the host response. A particularly informative example is provided by the two...

    Authors: Nance Nardi and Nicholas A. Mitchison
    Citation: Molecular Medicine 1995 1:BF03401593
  14. Interactions between γδ T cells and heat shock proteins (HSP) have been proposed as contributing factors in a number of diseases of possible autoimmune etiology but definitive evidence to support this hypothesis ...

    Authors: Luca Battistini, Marco Salvetti, Giovanni Ristori, Marika Falcone, Cedric S. Raine and Celia F. Brosnan
    Citation: Molecular Medicine 1995 1:BF03401592
  15. Human, but not mouse, islet amyloid polypeptide (IAPP) is amyloidogenic. Transgenic mice overexpressing human IAPP in the β cells of the islets of Langerhans should be useful in identifying factors important for ...

    Authors: Gunilla Westermark, Michelle Benig Arora, Niles Fox, Raymond Carroll, Shu Jin Chan, Per Westermark and Donald F. Steiner
    Citation: Molecular Medicine 1995 1:BF03401591
  16. Aberrant metabolism of the Alzheimer amyloid precursor protein (APP) or its amyloidogenic Aβ fragment is thought to be centrally involved in Alzheimer’s disease. Nonamyloidogenic processing of APP involves its cl...

    Authors: Edgar F. da Cruz e Silva, Odete A. B. da Cruz e Silva, Cássia Thais B. V. Zaia and Paul Greengard
    Citation: Molecular Medicine 1995 1:BF03401590
  17. Chronic diabetes causes structural changes in the retinal capillaries of nearly all patients with a disease duration of more than 15 years. Acellular occluded vessels cause hypoxia, which stimulates sight-thre...

    Authors: Hans-Peter Hammes, Howard J. Federoff and Michael Brownlee
    Citation: Molecular Medicine 1995 1:BF03401589
  18. At therapeutic concentrations, the antineoplastic agent taxol selectively perturbs mitotic spindle microtubules. Taxol has recently been shown to induce apoptosis, similar to the mechanism of cell death induce...

    Authors: Catherine M. Woods, Jian Zhu, Patricia A. McQueney, Daniel Bollag and Elias Lazarides
    Citation: Molecular Medicine 1995 1:BF03401588
  19. The developmental stage from which stems the malignant B cell population in Burkitt’s lymphoma (BL) is unclear. An approach to answering this question is provided by the sequence analysis of rearranged immunog...

    Authors: Ulf Klein, George Klein, Barbro Ehlin-Henriksson, Klaus Rajewsky and Ralf Küppers
    Citation: Molecular Medicine 1995 1:BF03401587
  20. Von Hippel-Lindau (VHL) disease is a familial cancer syndrome that has a dominant inherited pattern which predisposes affected individuals to a variety of tumors. The most frequent tumors are hemangioblastomas...

    Authors: Patricia M. Kessler, Sandip P. Vasavada, Raymond R. Rackley, Thomas Stackhouse, Fuh-Mei Duh, Farida Latif, Michael I. Lerman, Berton Zbar and Bryan R. G. Williams
    Citation: Molecular Medicine 1995 1:BF03401583
  21. Reactive glucose-protein intermediates and advanced glycation endproducts (AGEs) are shown to colocalize with atheromatous lesions and to trigger complex chemical and biological responses through interaction w...

    Authors: Helen Vlassara, Hubert Fuh, Thomas Donnelly and Myron Cybulsky
    Citation: Molecular Medicine 1995 1:BF03401582
  22. The marR gene of Escherichia coli encodes a repressor of the marRAB operon, a regulatory locus controlling multiple antibiotic resistance in this organism. Inactivation of marR results in increased expression of

    Authors: Mark C. Sulavik, Laura F. Gambino and Paul F. Miller
    Citation: Molecular Medicine 1995 1:BF03401581
  23. The anti-tumor agent, Taxol, has been shown in murine macrophages to stimulate tumor necrosis factor (TNF), modulate TNF receptors, induce a large panel of immediate-early genes, and induce protein tyrosine ph...

    Authors: Beth E. Henricson, Joan M. Carboni, Anne L. Burkhardt and Stefanie N. Vogel
    Citation: Molecular Medicine 1995 1:BF03401580
  24. Tissue inhibitor of metalloproteinases-3 (TIMP3) is the third member of the TIMP family of proteins, believed to play a significant role in controlling extracellular matrix remodeling.

    Authors: Jennifer A. Byrne, Catherine Tomasetto, Nicolas Rouyer, Jean-Pierre Bellocq, Marie-Christine Rio and Paul Basset
    Citation: Molecular Medicine 1995 1:BF03401579
  25. The antiviral drugs AZT and acyclovir are generally used in the treatment of infections with human immunodeficiency virus (HIV) and herpes simplex virus (HSV). These substances are known to impede virus replic...

    Authors: Martin Gschwentner, Alex Susanna, Ewald Wöll, Markus Ritter, Ulrich O. Nagl, Andreas Schmarda, Andreas Laich, Germar M. Pinggera, Helmut Ellemunter, Hartwig Huemer, Peter Deetjen and Markus Paulmichl
    Citation: Molecular Medicine 1995 1:BF03401578
  26. Clozapine, the classic atypical neuroleptic, exerts therapeutic actions in schizophrenic patients unresponsive to most neuroleptics. Clozapine interacts with numerous neurotransmitter receptors, and selective ...

    Authors: Charles E. Glatt, Adele M. Snowman, David R. Sibley and Solomon H. Snyder
    Citation: Molecular Medicine 1995 1:BF03401577
  27. The monocyte-derived cytokine, tumor necrosis factor α (TNFα), is essential for host immunity, but overproduction of this cytokine may have serious pathologic consequences. Excess TNFα produced in pulmonary tu...

    Authors: Jane M. Tramontana, Utaiwan Utaipat, Anthony Molloy, Pasakorn Akarasewi, Margaret Burroughs, Sanit Makonkawkeyoon, Barbara Johnson, Jeffrey D. Klausner, William Rom and Gilla Kaplan
    Citation: Molecular Medicine 1995 1:BF03401576
  28. An expanded CAG trinucleotide repeat is the genetic trigger of neuronal degeneration in Huntington’s disease (HD), but its mode of action has yet to be discovered. The sequence of the HD gene places the CAG re...

    Authors: Francesca Persichetti, Christine M. Ambrose, Pei Ge, Sandra M. McNeil, Jayalakshmi Srinidhi, Mary Anne Anderson, Barbara Jenkins, Glenn T. Barnes, Mabel P. Duyao, Lisa Kanaley, Nancy S. Wexler, Richard H. Myers, Edward D. Bird, Jean-Paul Vonsattel, Marcy E. MacDonald, James F. Gusella…
    Citation: Molecular Medicine 1995 1:BF03401575
  29. The carboxy-terminus of the merozoite surface protein-1 (MSP1) of Plasmodium falciparum has been implicated as a target of protective immunity.

    Authors: Sanjai Kumar, Anjali Yadava, David B. Keister, Jing Hui Tian, Michael Ohl, Kathy A. Perdue-Greenfield, Louis H. Miller and David C. Kaslow
    Citation: Molecular Medicine 1995 1:BF03401557
  30. Understanding the mechanism of developmental regulation of hemoglobin switching has scientific as well as clinical relevance because of the influence of fetal hemoglobin (HbF) production in adulthood on the cl...

    Authors: E. Rena Bacon, Nava Dalyot, Dvora Filon, Letizia Schreiber, Eliezer A. Rachmilewitz and Arieila Oppenheim
    Citation: Molecular Medicine 1995 1:BF03401554
  31. Sarcoidosis is a granulomatous disease characterized by the accumulation of activated T cells in the lungs. We previously showed that sarcoidosis patients expressing the HLA haplotype DR3(17), DQ2 had increased n...

    Authors: Johan Grunewald, Thomas Hultman, Anders Bucht, Anders Eklund and Hans Wigzell
    Citation: Molecular Medicine 1995 1:BF03401553
  32. H2-histamine receptors mediate a wide range of physiological functions extending from stimulation of gastric acid secretion to induction of human promyelocyte differentiation. We have previously cloned the H2-...

    Authors: John DelValle, Ira Gantz, Lidong Wang, Yi-Jun Guo, Gerd Munzert, Takao Tashiro, Yoshitaka Konda and Tadataka Yamada
    Citation: Molecular Medicine 1995 1:BF03401552
  33. Paraneoplastic syndromes are “remote” complications of cancer characterized clinically by neurological disease. The sera and cerebrospinal fluid (CSF) from patients with paraneoplastic neurological syndromes (...

    Authors: Lorise C. Gahring, Roy E. Twyman, John E. Greenlee and Scott W. Rogers
    Citation: Molecular Medicine 1995 1:BF03401549

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