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  1. New vessel growth is often associated with ischemia, and hypoxic tissue has been identified as a potential source of angiogenic factors. In particular, ischemia is associated with the development of neovascula...

    Authors: David T. Shima, Anthony P. Adamis, Napoleone Ferrara, Kiang-Teck Yeo, Tet-Kin Yeo, Rapheal Allende, Judah Folkman and Patricia A. D’Amore
    Citation: Molecular Medicine 1995 1:BF03401566
    Content type: Original Articles Published on:

  2. Angiotensin converting enzyme inhibitor (ACEi) therapy delays the onset of renal failure in diabetic nephropathy and inhibits or delays the onset of proteinuria in several animal models.

    Authors: Emmanuel P. Peten, Liliane J. Striker, Agnes Fogo, Iekuni Ichikawa, Aneeta Patel and Gary E. Striker
    Citation: Molecular Medicine 1994 1:BF03403536
    Content type: Original Articles Published on:

  3. Lipopolysaccharide (LPS) is known to activate macrophages, causing the release of toxic cytokines that may provoke inflammation and shock. One of the most important and best studied of these cytokines is tumor...

    Authors: Thomas D. Geppert, Charles E. Whitehurst, Patricia Thompson and Bruce Beutler
    Citation: Molecular Medicine 1994 1:BF03403535
    Content type: Original Articles Published on:

  4. Thirty-six mutations that cause Gaucher disease, the most common glycolipid storage disorder, are known. Although both alleles of most patients with the disease contain one of these mutations, in a few patient...

    Authors: Ernest Beutler, Anna Demina and Terri Gelbart
    Citation: Molecular Medicine 1994 1:BF03403534
    Content type: Original Articles Published on:

  5. The host response to tissue injury requires a complex interplay of diverse cellular, humoral, and connective tissue elements. Fibroblasts participate in this process by proliferating within injured sites and c...

    Authors: Richard Bucala, Lori A. Spiegel, Jason Chesney, Margaret Hogan and Anthony Cerami
    Citation: Molecular Medicine 1994 1:BF03403533
    Content type: Original Articles Published on:

  6. Monozygotic (MZ) twinning is a poorly understood phenomenon that may result in subtle biologic differences between twins, despite their identical inheritance. These differences may in part account for discorda...

    Authors: Velia Trejo, Catherine Derom, Robert Vlietinck, William Ollier, Alan Silman, George Ebers, Robert Derom and Peter K. Gregersen
    Citation: Molecular Medicine 1994 1:BF03403532
    Content type: Original Articles Published on:

  7. Common variable immunodeficiency (CVID) is defined by hypogammaglobulinemia and increased susceptibility to infections. The gene defect responsible for CVID remains unknown.

    Authors: Monika Belickova, Harry W. Schroeder Jr., Y. L. Guan, Joseph Brierre, Seth Berney, Max D. Cooper and Josef T. Prchal
    Citation: Molecular Medicine 1994 1:BF03403531
    Content type: Original Articles Published on:

  8. Reactive arthritis (ReA) is a T cell mediated inflammatory process. The immune response is primarily directed against a triggering organism, although autoimmunity has been invoked in long-lasting, antibiotic-r...

    Authors: Andreas K. H. Mertz, Angelika Daser, Mikael Skurnik, Karl-Heinz Wiesmüller, Jürgen Braun, Heiner Appel, Steven Batsford, Peihua Wu, Armin Distler and Joachim Sieper
    Citation: Molecular Medicine 1994 1:BF03403530
    Content type: Original Articles Published on:

  9. This investigation deals with the molecular mechanism of anti-human immunodeficiency virus type 1 (HIV-1) action of pentoxifylline (PTX) [1-(5′-oxohexyl)-3,7-dimethylxanthine] a drug widely used for the treatm...

    Authors: Debajit K. Biswas, Christoph M. Ahlers, Bruce J. Dezube and Arthur B. Pardee
    Citation: Molecular Medicine 1994 1:BF03403529
    Content type: Original Articles Published on:

  10. It has been proposed that the prion, the infectious agent of transmissible spongiform encephalopathies, is PrPSc, a post-translationally modified form of the normal host protein PrPC. We showed previously that mi...

    Authors: Hansruedi Büeler, Alex Raeber, Andreas Sailer, Marek Fischer, Adriano Aguzzi and Charles Weissmann
    Citation: Molecular Medicine 1994 1:BF03403528
    Content type: Original Articles Published on:

  11. Major symptoms and death from systemic Bacillus anthracis infections are mediated by the action of the pathogen’s lethal toxin on host macrophages. High levels of the toxin are cytolytic to macrophages, whereas l...

    Authors: Philip C. Hanna, Benjamin A. Kruskal, R. Allen B. Ezekowitz, Barry R. Bloom and R. John Collier
    Citation: Molecular Medicine 1994 1:BF03403527
    Content type: Original Articles Published on:
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Molecular Medicine

ISSN: 1528-3658