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  1. We have previously shown that the membrane attack complex (MAC) of complement stimulates cell proliferation and that insertion of homologous MAC into the membranes of endothelial cells results in the release o...

    Authors: Juan A. Acosta, Laura R. Benzaquen, Daniel J. Goldstein, Magdalena T. Tosteson and José A. Halperin
    Citation: Molecular Medicine 1996 2:BF03401659
    Content type: Original Articles Published on:

  2. Bm2325, a major IgE-inducing antigen of the filarial parasite Brugia malayi has been implicated in the pathology of tropical pulmonary eosinophilia (TPE), a pulmonary syndrome thought to result from hypersensitiv...

    Authors: Edgar Lobos, Regina Zahn, Niklaus Weiss and Thomas B. Nutman
    Citation: Molecular Medicine 1996 2:BF03401655
    Content type: Original Articles Published on:

  3. Cysteinyl leukotrienes (LT) are mediators involved in inflammatory and allergic disorders. LTC4 synthase catalyzes the first committed step in the synthesis of these inflammatory mediators, and its cellular distr...

    Authors: Timothy D. Bigby, Craig R. Hodulik, Karen C. Arden and Lixia Fu
    Citation: Molecular Medicine 1996 2:BF03401647
    Content type: Original Articles Published on:

  4. Using differential display (DD), we discovered a new member of the serine protease family of protein-cleaving enzymes, named protease M. The gene is most closely related by sequence to the kallikreins, to pros...

    Authors: Anthony Anisowicz, Georgia Sotiropoulou, Goran Stenman, Samuel C. Mok and Ruth Sager
    Citation: Molecular Medicine 1996 2:BF03401646
    Content type: Original Articles Published on:

  5. X-linked agammaglobulinemia (XLA) is a severe, life-threatening disease characterized by failure of B cell differentiation and antibody production and is associated with mutations in Bruton’s tyrosine kinase (Btk

    Authors: Stephen J. Kornfeld, Robert N. Haire, Scott J. Strong, Huayang Tang, Sun-Sang J. Sung, Shu Man Fu and Gary W. Litman
    Citation: Molecular Medicine 1996 2:BF03401645
    Content type: Original Articles Published on:

  6. While oligoclonality of circulating CD4− CD8− and of CD8+ T cells is not uncommon, clonal dominance within the CD4 compartment is not frequently found in healthy individuals. In contrast, the majority of patients...

    Authors: Dorle Schmidt, Peter B. Martens, Cornelia M. Weyand and Jörg J. Goronzy
    Citation: Molecular Medicine 1996 2:BF03401644
    Content type: Original Articles Published on:

  7. Alternative splicing of the transcripts of the human glucocorticoid receptor gene results in two mutually exclusive products, the classic, ligand-binding glucocorticoid receptor (hGRα), and a dominant negative no...

    Authors: Margaret de Castro, Sharon Elliot, Tomoshige Kino, Christoph Bamberger, Michael Karl, Elizabeth Webster and George P. Chrousos
    Citation: Molecular Medicine 1996 2:BF03401643
    Content type: Original Articles Published on:

  8. The mechanism by which aspirin (ASA) acts to protect against human cancer is not yet known. We recently showed that ASA triggers the formation of a new series of potent bioactive eicosanoids, 15-epi-lipoxins (...

    Authors: Joan Clària, Min H. Lee and Charles N. Serhan
    Citation: Molecular Medicine 1996 2:BF03401642
    Content type: Original Articles Published on:

  10. Familial hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease characterized by ventricular hypertrophy, myocellular disarray, arrhythmias, and sudden death. Mutations in several contractile prote...

    Authors: Karen L. Vikstrom, Stephen M. Factor and Leslie A. Leinwand
    Citation: Molecular Medicine 1996 2:BF03401640
    Content type: Original Articles Published on:

  11. A number of tumors express antigens that are recognized by specific cytotoxic T cells. The normal host immune responses, however, are not usually sufficient to cause tumor rejection. Using appropriate immuniza...

    Authors: Hansruedi Büeler and Richard C. Mulligan
    Citation: Molecular Medicine 1996 2:BF03401639
    Content type: Original Articles Published on:

  15. Tumor necrosis factor α (TNFα) is thought to mediate both protective and detrimental manifestations of the inflammatory response. Recently, thalidomide (α-n–phthalimidoglutarimide) was shown to partially inhibit ...

    Authors: Laura G. Corral, George W. Muller, André L. Moreira, Yuxi Chen, Mingdan Wu, David Stirling and Gilla Kaplan
    Citation: Molecular Medicine 1996 2:BF03401909
    Content type: Original Articles Published on:

  16. Epithelial dysfunction and patient symptoms in inflammatory intestinal diseases such as ulcerative colitis and Crohn’s disease correlate with migration of neutrophils (PMN) across the intestinal epithelium. In...

    Authors: Charles A. Parkos, Sean P. Colgan, Michael S. Diamond, Asma Nusrat, Tony W. Liang, Timothy A. Springer and James L. Madara
    Citation: Molecular Medicine 1996 2:BF03401908
    Content type: Original Articles Published on:

  17. Tumor necrosis factor (TNF) production by macrophages plays an important role in the host response to infection. TNF-α gene expression in RAW 264.7 macrophages is predominantly regulated at the translational leve...

    Authors: Cyril Gueydan, Laurent Houzet, Arnaud Marchant, André Sels, Georges Huez and Véronique Kruys
    Citation: Molecular Medicine 1996 2:BF03401907
    Content type: Original Articles Published on:

    The Erratum to this article has been published in Molecular Medicine 1996 2:Art14

  18. The decision for a cell to enter the DNA synthesis (S) phase of the cell cycle or to arrest in quiescence is likely to be determined by genes expressed in the late G1 phase, at the restriction point. Loss of r...

    Authors: Recep S. Alpan, Scott Sparvero and Arthur B. Pardee
    Citation: Molecular Medicine 1996 2:BF03401906
    Content type: Original Articles Published on:

  19. Human immunodeficiency virus type 1 (HIV-1) infection leads to a general exhaustion of the immune system. Prior to this widespread decline of immune functions, however, there is an evident hyperactivation of t...

    Authors: Michael Bukrinsky, Helena Schmidtmayerova, Gabriele Zybarth, Larisa Dubrovsky, Barbara Sherry and Grigori Enikolopov
    Citation: Molecular Medicine 1996 2:BF03401905
    Content type: Original Articles Published on:

  20. The principal symptoms of myasthenia gravis (MG), muscle weakness and fatigue due to impaired neuromuscular transmission, are caused by autoantibodies to the muscle nicotinic acetylcholine receptor (AChR). The...

    Authors: Dulceaydee Gigliotti, Ann-Kari Lefvert, Mahmood Jeddi-Tehrani, Semih Esin, Vida Hodara, Ritva Pirskanen, Hans Wigzell and Roland Andersson
    Citation: Molecular Medicine 1996 2:BF03401904
    Content type: Original Articles Published on:

  21. The cellular mdm2 gene has transforming activity when overexpressed and is amplified in a variety of human tumors. At least part of the transforming ability of the MDM2 protein is due to binding and inactivating ...

    Authors: Brian Elenbaas, Matthias Dobbelstein, Judith Roth, Thomas Shenk and Arnold J. Levine
    Citation: Molecular Medicine 1996 2:BF03401903
    Content type: Original Articles Published on:

  22. Specific inhibition of target proteins by antisense oligodeoxynucleotides is an extensively studied experimental approach. This technique is currently being tested in clinical trials applying phosphorothioate-...

    Authors: Gunther Hartmann, Anne Krug, Kerstin Waller-Fontaine and Stefan Endres
    Citation: Molecular Medicine 1996 2:BF03401902
    Content type: Original Articles Published on:

  23. Studies of human immunodeficiency virus type 1 (HIV-1) associated dementia have shown neuronal loss in discrete areas. The presence and mechanism of neuronal death, however, has remained quite elusive. One mec...

    Authors: D. Cory Adamson, Ted M. Dawson, M. Christine Zink, Janice E. Clements and Valina L. Dawson
    Citation: Molecular Medicine 1996 2:BF03401901
    Content type: Original Articles Published on:

  27. Lipopolysaccharides (LPS), widely used to study the mechanisms of gram-negative sepsis, increase airway resistance by constriction of terminal bronchioles. The role of the cyclooxygenase (COX) isoenzymes and t...

    Authors: Stefan Uhlig, Rolf Nüsing, Alexander von Bethmann, Roland Lewis Featherstone, Thomas Klein, Frank Brasch, Klaus-Michael Müller, Volker Ullrich and Albrecht Wendel
    Citation: Molecular Medicine 1996 2:BF03401635
    Content type: Original Articles Published on:

  28. Adipose and muscle tissues express an insulin-sensitive glucose transporter (GLUT4). This transporter has been shown to translocate from intracellular stores to the plasma membrane following insulin stimulatio...

    Authors: Johanna Gustavsson, Santiago Parpal and Peter Strålfors
    Citation: Molecular Medicine 1996 2:BF03401634
    Content type: Original Articles Published on:

  29. We recently showed that acquired immunodeficiency syndrome (AIDS) dementia is associated with activated infection of microglia, neurons, and astrocytes by HIV-1. However, it is doubtful whether infection per s...

    Authors: Gerard J. Nuovo, Maria Lynn Alfieri and A. Cerami
    Citation: Molecular Medicine 1996 2:BF03401633
    Content type: Original Articles Published on:

  30. Thrombin is a serine protease that elicits a variety of cellular responses. Molecular cloning of a thrombin receptor revealed a G protein-coupled receptor that is activated by a novel proteolytic mechanism. Re...

    Authors: Mark Kahn, Kenji Ishii, Wen-Lin Kuo, Michael Piper, Andrew Connolly, Yu-Ping Shi, Richard Wu, C. C. Lin and Shaun R. Coughlin
    Citation: Molecular Medicine 1996 2:BF03401632
    Content type: Original Articles Published on:

  31. Understanding the processes that control selective eosinophilia is of fundamental importance in a variety of human diseases (e.g., allergies, parasitic infections, malignancy). Interleukin 5, an eosinophil-spe...

    Authors: Marc E. Rothenberg, Robert Ownbey, Paul D. Mehlhop, Paul M. Loiselle, Matthijs van de Rijn, Joseph V. Bonventre, Hans C. Oettgen, Philip Leder and Andrew D. Luster
    Citation: Molecular Medicine 1996 2:BF03401631
    Content type: Original Articles Published on:

  32. The immunophilins are proteins that mediate actions of immunosuppressant drugs such as FK-506 and cyclosporin A by binding to calcineurin, inhibiting its phosphatase activity, and increasing the phosphorylatio...

    Authors: Joseph P. Steiner, Ted M. Dawson, Majid Fotuhi and Solomon H. Snyder
    Citation: Molecular Medicine 1996 2:BF03401630
    Content type: Original Articles Published on:

  33. The genetic factors involved in determining bone mineral density (BMD) have not been fully elucidated. We have begun genetic linkage analysis of seven families in which many members are osteopenic, in order to...

    Authors: Loretta D. Spotila, John Caminis, Marcella Devoto, Koichiro Shimoya, Larisa Sereda, Jürg Ott, Michael P. Whyte, Alan Tenenhouse and Darwin J. Prockop
    Citation: Molecular Medicine 1996 2:BF03401629
    Content type: Original Articles Published on:

  34. CSF-1 expression precedes renal injury in autoimmune MRL-lpr mice and is responsible for macrophage (Mϕ) proliferation and survival in the kidney. By comparison, C3H-lpr mice do not express CSF-1 in the kidney, a...

    Authors: Takero Naito, Hitoshi Yokoyama, Kathryn J. Moore, Glenn Dranoff, Richard C. Mulligan and Vicki Rubin Kelley
    Citation: Molecular Medicine 1996 2:BF03401628
    Content type: Original Articles Published on:

  35. Nitric oxide (NO) has been implicated as a mediator of penile erection, because the neuronal isoform of NO synthase (NOS) is localized to the penile innervation and NOS inhibitors selectively block erections. ...

    Authors: Arthur L. Burnett, Randy J. Nelson, David C. Calvin, Jian-Xiang Liu, Gregory E. Demas, Sabra L. Klein, Lance J. Kriegsfeld, Valina L. Dawso, Ted M. Dawson and Solomon H. Snyder
    Citation: Molecular Medicine 1996 2:BF03401627
    Content type: Original Articles Published on:

  41. Mice with inactivated tumor necrosis factor (TNF) and lymphotoxin α (LTα) genes have profound abnormalities of the immune system including lymphocytosis, lack of lymph nodes, undifferentiated spleen, hypoimmunogl...

    Authors: Matthias Müller, Hans-Pietro Eugster, Michel Le Hir, Alexander Shakhov, Franco Di Padova, Claudine Maurer, Valerie F. J. Quesniaux and Bernhard Ryffel
    Citation: Molecular Medicine 1996 2:BF03401621
    Content type: Original Articles Published on:

  42. Human falciparum malaria, caused by the intracellular protozoa Plasmodium falciparum, results in 1–2 million deaths per year. P. falciparum digests host erythrocyte hemoglobin within its food vacuole, resulting i...

    Authors: James A. Martiney, Anthony Cerami and Andrew F. G. Slater
    Citation: Molecular Medicine 1996 2:BF03401620
    Content type: Original Articles Published on:

  43. Nitric oxide has a wide variety of homeostatic and pathological effects. Control of the production of nitric oxide by the inducible form of the enzyme resides in the 5′ promoter region of the gene. Although co...

    Authors: Sergei V. Spitsin, Hilary Koprowski and Frank H. Michaels
    Citation: Molecular Medicine 1996 2:BF03401619
    Content type: Original Articles Published on:

  44. Parathyroid hormone-related protein (PTHrP) is a ubiquitous and highly conserved vasoactive peptide whose role and regulation in normal physiology remain an enigma. Recently, we demonstrated that low-dose endo...

    Authors: Janet L. Funk, Arthur H. Moser, Gordon J. Strewler, Kenneth R. Feingold and Carl Grünfeld
    Citation: Molecular Medicine 1996 2:BF03401617
    Content type: Original Articles Published on:

  45. Protein tyrosine kinases play an imporH-RYK, an Unusual Receptor Kinase: Isolation and Analysis of Expression in Ovarian Cancertant role in cellular metabolism as key components of signal transduction pathways...

    Authors: Xiao C. Wang, Roy Katso, Robin Butler, Andrew M. Hanby, Richard Poulsom, Tania Jones, Denise Sheer and Trivadi S. Ganesan
    Citation: Molecular Medicine 1996 2:BF03401616
    Content type: Original Articles Published on:

  46. An important issue in autoimmune diseases mediated by T cells, such as experimental allergic encephalomyelitis (EAE), is the affinity of the disease-inducing determinants for MHC class II proteins. Tolerance, ...

    Authors: Lars Fugger, James Liang, Anand Gautam, Jonathan B. Rothbard and Hugh O. McDevitt
    Citation: Molecular Medicine 1996 2:BF03401615
    Content type: Original Articles Published on:

  47. The apolipoprotein E (apoE) type ε4 isoform specifies increased cerebral and cerebrovascular accumulation of amyloid-β protein (Aβ) and contributes to the genetic susceptibility underlying a large proportion (~60...

    Authors: Zhongmin Zhou, Jonathan D. Smith, Paul Greengard and Sam Gandy
    Citation: Molecular Medicine 1996 2:BF03401614
    Content type: Original Articles Published on:
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Molecular Medicine

ISSN: 1528-3658