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Page 5 of 37

  1. Epidermolysis bullosa acquisita (EBA) is a difficult-to-treat subepidermal autoimmune blistering skin disease (AIBD) with circulating and tissue-bound anti-type VII collagen antibodies. Different reports have ...

    Authors: Misa Hirose, Anika Kasprick, Foteini Beltsiou, Katharina Schulze Dieckhoff, Franziska Sophie Schulze, Unni K J S R L Samavedam, Jennifer E Hundt, Hendri H Pas, Marcel F Jonkman, Enno Schmidt, Kathrin Kalies, Detlef Zillikens, Ralf J Ludwig and Katja Bieber

    Citation: Molecular Medicine 2016 22:2201918

    Content type: Research Article

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  2. While cardiac functional recovery is attenuated in the elderly following cardiac surgery with obligatory global myocardial ischemia/reperfusion (I/R), the underlying mechanism remains incompletely understood. ...

    Authors: Lihua Ao, Yufeng Zhai, Chunhua Jin, Joseph C Cleveland Jr., David A Fullerton and Xianzhong Meng

    Citation: Molecular Medicine 2016 22:2201863

    Content type: Research Article

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  3. Although low-energy shock wave (SW) is adopted to treat ischemic diseases because of its pro-angiogenic properties, the underlying mechanism remains unclear. This study is aimed at testing whether SW-induced a...

    Authors: Tien-Hung Huang, Cheuk-Kwan Sun, Yi-Ling Chen, Ching-Jen Wang, Tsung-Cheng Yin, Mel S Lee and Hon-Kan Yip

    Citation: Molecular Medicine 2016 22:2201850

    Content type: Research Article

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  4. The signals causing resolution of muscle inflammation are only partially characterized. The long pentraxin PTX3, which modulates leukocyte recruitment and activation, could contribute. We analyzed the expressi...

    Authors: Michela Vezzoli, Clara Sciorati, Lara Campana, Antonella Monno, Maria Giulia Doglio, Elena Rigamonti, Gianfranca Corna, Thierry Touvier, Alessandra Castiglioni, Annalisa Capobianco, Alberto Mantovani, Angelo A Manfredi, Cecilia Garlanda and Patrizia Rovere-Querini

    Citation: Molecular Medicine 2016 22:2201809

    Content type: Research Article

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  5. Glucagon-like peptide 1 (GLP-1) can promote islet β cell replication and function, and mesenchymal stem cells (MSCs) can inhibit T cell autoimmunity. The aim of this study was to test the dynamic distribution ...

    Authors: Li-rong Li, Jing Lu, Xiao-lei Jia, Hui Hui, Jie Zhang, Ying Liu, Wei-juan Cui, Qian-yue Xu and Da-long Zhu

    Citation: Molecular Medicine 2016 22:2201800

    Content type: Research Article

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  6. Transforming growth factor (TGF)-β-induced epithelial-mesenchymal transition (EMT) leads to the formation of ocular fibrotic pathologies, such as anterior subcapsular cataract and posterior capsule opacificati...

    Authors: Anna Korol, Aftab Taiyab and Judith A West-Mays

    Citation: Molecular Medicine 2016 22:2201713

    Content type: Research Article

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  7. Circulating γδ T cells In healthy Individuals rapidly respond to bacterial and viral pathogens. Many studies have demonstrated that γδ T cells are activated and expanded by Listeria monocytogenes (L. monocytogene...

    Authors: Yuli Zhu, Huaishan Wang, Yi Xu, Yu Hu, Hui Chen, Lianxian Cui, Jianmin Zhang and Wei He

    Citation: Molecular Medicine 2016 22:2201737

    Content type: Research Article

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  8. Rheumatoid arthritis (RA) is a systemic autoimmune disease that results in a chronic and inflammatory disorder. Dynamic balance of helper T cells (Th) 1 and 17 and regulatory T cells (Treg) is broken in RA. Si...

    Authors: Xiaoyin Niu, Shaohua Deng, Shan Li, Yebin Xi, Chengzhen Li, Li Wang, Dongyi He, Zhaojun Wang and Guangjie Chen

    Citation: Molecular Medicine 2016 22:2201608

    Content type: Research Article

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  9. The Cadherin 13 (CDH13) gene encodes a cell adhesion molecule likely to influence development and connections of brain circuits that modulate addiction, locomotion and cognition, including those that involve midb...

    Authors: Jana Drgonova, Donna Walther, G. Luke Hartstein, Mohammad O. Bukhari, Michael H. Baumann, Jonathan Katz, F. Scott Hall, Elizabeth R. Arnold, Shaun Flax, Anthony Riley, Olga Rivero, Klaus-Peter Lesch, Juan Troncoso, Barbara Ranscht and George R. Uhl

    Citation: Molecular Medicine 2016 22:2201537

    Content type: Research Article

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  10. Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 (MMP8) improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothe...

    Authors: Sarah J Atkinson, Brian M Varisco, Mary Sandquist, Meghan N Daly, Lindsey Klingbeil, Joshua W Kuethe, Emily F Midura, Kelli Harmon, Amy Opoka, Patrick Lahni, Giovanna Piraino, Paul Hake, Basilia Zingarelli, Joel E Mortensen, James L Wynn and Hector R Wong

    Citation: Molecular Medicine 2016 22:2201455

    Content type: Research Article

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  11. Amyotrophic lateral sclerosis (ALS) is a progressive and lethal neurodegenerative disease characterized by loss of upper and lower motor neurons leading to muscle paralysis in affected individuals. Numerous me...

    Authors: Claudia R Vintilescu, Sana Afreen, Ashlee E Rubino and Adriana Ferreira

    Citation: Molecular Medicine 2016 22:2201477

    Content type: Research Article

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  12. Male sex is a risk factor for abdominal aortic aneurysm (AAA). Within the AAA adventitia, infiltrating leukocytes express high levels of inflammasome components. To further elucidate the role of inflammatory c...

    Authors: Xiaoyu Wu, Sinan Cakmak, Markus Wortmann, Maani Hakimi, Jian Zhang, Dittmar Böckler and Susanne Dihlmann

    Citation: Molecular Medicine 2016 22:2201508

    Content type: Research Article

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  13. We investigated the pathophysiology of diet-induced diabetes in the Cohen diabetic rat (CDs/y) from its induction to its chronic phase, using a multilayered integrated genomic approach. We identified by linkag...

    Authors: Yoram Yagil, Barak Markus, Refael Kohen and Chana Yagil

    Citation: Molecular Medicine 2016 22:2201560

    Content type: Original Articles

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  14. T cell engineering with T cell receptors (TCRs) specific for tumors plays an important role in adoptive T cell transfer (ATC) therapy for cancer. Here, we present a novel strategy to redirect peripheral blood-...

    Authors: Kangxia He, Hongqin You, Yuxia Li, Lianxian Cui, Jianmin Zhang and Wei He

    Citation: Molecular Medicine 2016 22:2201519

    Content type: Research Article

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  15. The exponential rise in molecular and genomic data has generated a vast array of therapeutic targets. Oligonucleotide-based technologies to down regulate these molecular targets have promising therapeutic effi...

    Authors: Noriko Satake, Connie Duong, Sakiko Yoshida, Michael Oestergaard, Cathy Chen, Rachael Peralta, Shuling Guo, Punit P Seth, Yueju Li, Laurel Beckett, Jong Chung, Jan Nolta, Nitin Nitin and Joseph M Tuscano

    Citation: Molecular Medicine 2016 22:2201632

    Content type: Research Article

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  16. Lung cancer is the leading cause of mortality among all cancer types worldwide. The latest available global statistics of the World Health Organization report 1.59 million casualities in 2012. Worldwide, 1 in ...

    Authors: Havva O Kilgoz, Guzide Bender, Joseph M Scandura, Agnes Viale and Bahar Taneri

    Citation: Molecular Medicine 2016 22:2201380

    Content type: Invited Review Article

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  17. Obesity is strongly associated with metabolic syndrome, a combination of risk factors that predisposes to development of the cardiometabolic diseases: atherosclerotic cardiovascular disease and type 2 diabetes...

    Authors: Melina Amor, Veronica Moreno-Viedma, Alisina Sarabi, Nicole G Grün, Bianca Itariu, Lukas Leitner, Irene Steiner, Martin Bilban, Keiichi Kodama, Atul J Butte, Guenther Staffler, Maximilian Zeyda and Thomas M Stulnig

    Citation: Molecular Medicine 2016 22:2201487

    Content type: Research Article

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  18. Vagotomy (VGX) increases the susceptibility to develop colitis suggesting a crucial role for the cholinergic anti-inflammatory pathway in the regulation of the immune responses. Since oral tolerance and the ge...

    Authors: Martina Di Giovangiulio, Goele Bosmans, Elisa Meroni, Nathalie Stakenborg, Morgane Florens, Giovanna Farro, Pedro J Gomez-Pinilla, Gianluca Matteoli and Guy E Boeckxstaens

    Citation: Molecular Medicine 2016 22:2201464

    Content type: Research Article

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  19. Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by β cell destruction, insulin deficiency and hyperglycemia. Activated macrophages and autoimmune T cells play a crucial role in the...

    Authors: LaQueta K Hudson, Meghan E Dancho, Jianhua Li, Johanna B Bruchfeld, Ahmed A Ragab, Mingzhu M He, Meaghan Bragg, Delaney Lenaghan, Michael D Quinn, Jason R Fritz, Matthew V Tanzi, Harold A Silverman, William M Hanes, Yaakov A Levine, Valentin A Pavlov, Peder S Olofsson…

    Citation: Molecular Medicine 2016 22:2201585

    Content type: Research Article

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  20. Genetic features of chronic pancreatitis (CP) have been investigated extensively, mainly by testing genes associated to the trypsinogen activation pathway. However, different molecular pathways involving other...

    Authors: Valentina Maria Sofia, Letizia Da Sacco, Cecilia Surace, Anna Cristina Tomaiuolo, Silvia Genovese, Simona Grotta, Maria Gnazzo, Stefano Petrocchi, Laura Ciocca, Federico Alghisi, Enza Montemitro, Luigi Martemucci, Ausilia Elce, Vincenzina Lucidi, Giuseppe Castaldo and Adriano Angioni

    Citation: Molecular Medicine 2016 22:2201300

    Content type: Research Article

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  21. Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes. In addition to caspase-1, the neutroph...

    Authors: Erik J M Toonen, Andreea-Manuela Mirea, Cees J Tack, Rinke Stienstra, Dov B Ballak, Janna A van Diepen, Anneke Hijmans, Triantafyllos Chavakis, Wim H Dokter, Christine T N Pham, Mihai G Netea, Charles A Dinarello and Leo A B Joosten

    Citation: Molecular Medicine 2016 22:2201202

    Content type: Research Article

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  22. HLA-B*27 is strongly associated with an inflammatory autoimmune disorder, the Ankylosing Spondylitis (AS) and plays a protective role in viral infections. The two aspects might be linked. In this work, we compare...

    Authors: Valentina Tedeschi, Carolina Vitulano, Alberto Cauli, Fabiana Paladini, Matteo Piga, Alessandro Mathieu, Rosa Sorrentino and Maria Teresa Fiorillo

    Citation: Molecular Medicine 2016 22:2201215

    Content type: Research Article

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  23. Colon cancer cells contain high levels of cystathlonlne-β-synthase (CBS). Its product, hydrogen sulfide (H2S), promotes the growth and proliferation of colorectal tumor cells. To improve the antitumor efficacy of...

    Authors: Celia Chao, John R Zatarain, Ye Ding, Ciro Coletta, Amy A Mrazek, Nadiya Druzhyna, Paul Johnson, Haiying Chen, Judy L Hellmich, Antonia Asimakopoulou, Kazunori Yanagi, Gabor Olah, Petra Szoleczky, Gabor Törö, Fredrick J Bohanon, Minal Cheema…

    Citation: Molecular Medicine 2016 22:2201361

    Content type: Research Article

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  24. Platelet (PLT) transfusion is indispensable to maintain homeostasis in thrombocytopenic patients. However, PLT transfusion refractoriness is a common life-threatening condition observed in multitransfused pati...

    Authors: Ann-Kathrin Börger, Dorothee Eicke, Christina Wolf, Christiane Gras, Susanne Aufderbeck, Kai Schulze, Lena Engels, Britta Eiz-Vesper, Axel Schambach, Carlos A Guzman, Nico Lachmann, Thomas Moritz, Ulrich Martin, Rainer Blasczyk and Constança Figueiredo

    Citation: Molecular Medicine 2016 22:2201274

    Content type: Research Article

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  25. Single-chain antibodies (scFvs), which contain only the variable domains of full-length antibodies, are relatively small molecules that can be used for selective drug delivery. In this review, we discuss how s...

    Authors: Yaghoub Safdari, Vahideh Ahmadzadeh, Masoumeh Khalili, Hossein Zarei Jaliani, Vahid Zarei and Vahid Erfani-Moghadam

    Citation: Molecular Medicine 2016 22:2201258

    Content type: Review Article

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  26. Alternative intravesical agents are required to overcome the side effects currently associated with the treatment of bladder cancer. This study used an orthotopic bladder cancer mouse model to evaluate Guizhi ...

    Authors: Chi-Chen Lu, Cheng-Huang Shen, Chia-Bin Chang, Hsiao-Yen Hsieh, Jiann-Der Wu, Ling-Huei Tseng, Dennis W Hwang, Syue-Yi Chen, Shu-Fen Wu, Michael W Y Chan and Cheng-Da Hsu

    Citation: Molecular Medicine 2016 22:2201064

    Content type: Research Article

    Published on:

  27. High mobility group box 1 (HMGB1) is a nuclear DNA binding protein that acts as an alarmin when secreted. HMGB1 is increased in systemic lupus erythematosus and might represent a potential therapeutic target. ...

    Authors: Fleur Schaper, Mirjan M van Timmeren, Arjen Petersen, Gerda Horst, Marc Bijl, Pieter C Limburg, Johanna Westra and Peter Heeringa

    Citation: Molecular Medicine 2016 22:2201012

    Content type: Research Article

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  28. Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible...

    Authors: Tian Lin, Jialin Liu, Feng Huang, Tjitske S R van Engelen, Sujatha R Thundivalappil, Frank E Riley, Michael Super, Alexander L Watters, Ann Smith, Nathan Brinkman, Donald E Ingber and H Shaw Warren

    Citation: Molecular Medicine 2016 22:2201022

    Content type: Research Article

    Published on:

  29. Chronic respiratory diseases such as obstructive pulmonary disease (COPD) and oxidative stress may underlie lung cancer (LC). We hypothesized that the profile of oxidative and antioxidant events may differ in ...

    Authors: Mercè Mateu-Jiménez, Albert Sánchez-Font, Alberto Rodríguez-Fuster, Rafael Aguiló, Lara Pijuan, Clara Fermoselle, Joaquim Gea, Víctor Curull and Esther Barreiro

    Citation: Molecular Medicine 2016 22:2201085

    Content type: Research Article

    Published on:

  30. Mechanical ventilation can improve hypoxemia, but can also cause the so-called ventilator-induced lung injury (VILI). Polyinosinic:polycytidylic acid (poly(I:C)), an analogue of natural double-strand RNA virus...

    Authors: Shuqing Jin, Zhixia Chen, Xibing Ding, Xiang Zhao, Xi Jiang, Yao Tong, Timothy R Billiar and Quan Li

    Citation: Molecular Medicine 2016 22:2201054

    Content type: Research Article

    Published on:

  31. Extensively burned patients often suffer from sepsis, a complication that enhances postburn hypermetabolism and contributes to increased incidence of multiple organ failure, morbidity and mortality. Despite th...

    Authors: Li Diao, David Patsouris, Ali-Reza Sadri, Xiaojing Dai, Saeid Amini-Nik and Marc G. Jeschke

    Citation: Molecular Medicine 2015 21:2101959

    Content type: Research Article

    Published on:

  32. The following paragraph was published in: Christoph Ott, Henrik Martens, Imam Hassouna, Bárbara Oliveira, Christian Erck, Maria-Patapia Zafeiriou, Ulla-Kaisa Peteri, Dörte Hesse, Simone Gerhart, Bekir Altas, T...

    Authors: Christoph Ott, Henrik Martens, Imam Hassouna, Barbara Oliveira, Christian Erck, Maria-Patapia Zafeiriou, Ulla-Kaisa Peteri, Dörte Hesse, Simone Gerhart, Bekir Altas, Tekla Kolbow, Herbert Stadler, Hiroshi Kawabe, Wolfram-Hubertus Zimmermann, Klaus-Armin Nave, Walter Schulz-Schaeffer…

    Citation: Molecular Medicine 2015 21:2101816

    Content type: Erratum

    Published on:

    The original article was published in Molecular Medicine 2015 21:2101803

  33. The following paper had incorrect IC50 values in Table 1; the values should be the same as given in Table 2:

    Authors: Davorka Messmer, Kymmy Lorrain, Karin Stebbins, Yalda Bravo, Nicholas Stock, Geraldine Cabrera, Lucia Correa, Austin Chen, Jason Jacintho, Nicholas Chiorazzi, Xiao Jie Yan, David Spaner, Peppi Prasit and Daniel Lorrain

    Citation: Molecular Medicine 2015 21:2101665

    Content type: Erratum

    Published on:

    The original article was published in Molecular Medicine 2015 21:2101410

  34. Sporadic inclusion body myositis (sIBM) is a rare disease that is difficult to diagnose. Muscle biopsy provides three prominent pathological findings: inflammation, mitochondrial abnormalities and fibber degen...

    Authors: Marc Catalán-García, Glòria Garrabou, Constanza Morén, Mariona Guitart-Mampel, Ingrid Gonzalez-Casacuberta, Adriana Hernando, Jose Miquel Gallego-Escuredo, Dèlia Yubero, Francesc Villarroya, Raquel Montero, Albert Selva O-Callaghan, Francesc Cardellach and Josep Maria Grau

    Citation: Molecular Medicine 2015 21:2101817

    Content type: Research Article

    Published on:

  35. Circulating tumor cells (CTC) may be defined as tumor- or metastasis-derived cells that are present in the bloodstream. The CTC pool in colorectal cancer (CRC) patients may include not only epithelial tumor ce...

    Authors: Jennifer E. Hardingham, Phulwinder Grover, Marnie Winter, Peter J. Hewett, Timothy J. Price and Benjamin Thierry

    Citation: Molecular Medicine 2015 21(Suppl 1):21010025

    Content type: Invited Review Article

    Published on:

    This article is part of a Supplement: Volume 21 Supplement 1

  36. Twenty-five years ago marked the publication of the first report describing a functional contribution by the cytokine, macrophage migration inhibitory factor (MIF), to tumor-associated angiogenesis and growth....

    Authors: Jason A. Chesney and Robert A. Mitchell

    Citation: Molecular Medicine 2015 21(Suppl 1):21010019

    Content type: Invited Review Article

    Published on:

    This article is part of a Supplement: Volume 21 Supplement 1

  37. High mobility group box protein 1 (HMGB1) is an evolutionary ancient nuclear protein that exerts divergent biological tasks inside and outside of cells. The functions of HMGB1 depend on location, binding partn...

    Authors: Huan Yang, Haichao Wang, Sangeeta S. Chavan and Ulf Andersson

    Citation: Molecular Medicine 2015 21(Suppl 1):21010006

    Content type: Invited Review Article

    Published on:

    This article is part of a Supplement: Volume 21 Supplement 1

  38. Erythropoietin (EPO) has both erythropoietic and tissue-protective properties. The EPO analogues carbamylated EPO (CEPO) and pyroglutamate helix B surface peptide (pHBSP) lack the erythropoietic activity of EP...

    Authors: Lamia Heikal, Pietro Ghezzi, Manuela Mengozzi and Gordon Ferns

    Citation: Molecular Medicine 2015 21:2101709

    Content type: Research Article

    Published on:

  39. Simvastatin has been shown to have antiinflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these antiinflammatory effects are mediated have not been ...

    Authors: Lisa Mullen, Jason Ferdjani and Sandra Sacre

    Citation: Molecular Medicine 2015 21:2101726

    Content type: Research Article

    Published on:

  40. Type 1 diabetes in mice is characterized by autoimmune destruction of insulin-producing pancreatic β-cells. Disease pathogenesis involves invasion of pancreatic islets by immune cells, including macrophages an...

    Authors: William M. Hanes, Peder S. Olofsson, Kevin Kwan, LaQueta K. Hudson, Sangeeta S. Chavan, Valentin A. Pavlov and Kevin J. Tracey

    Citation: Molecular Medicine 2015 21:2101702

    Content type: Research Article

    Published on:

  41. Sepsis and septic shock are enormous public health problems with astronomical financial repercussions on health systems worldwide. The central nervous system (CNS) is closely intertwined in the septic process ...

    Authors: Nikhil Mulchandani, Weng-Lang Yang, Mohammad Moshahid Khan, Fangming Zhang, Philippe Marambaud, Jeffrey Nicastro, Gene F. Coppa and Ping Wang

    Citation: Molecular Medicine 2015 21:2101637

    Content type: Research Article

    Published on:

  42. Neonates manifest a unique host response to sepsis even among other children. Preterm neonates may experience sepsis soon after birth or during often-protracted birth hospitalizations as they attain physiologi...

    Authors: James L. Wynn, Scott O. Guthrie, Hector R. Wong, Patrick Lahni, Ricardo Ungaro, M. Cecilia Lopez, Henry V. Baker and Lyle L. Moldawer

    Citation: Molecular Medicine 2015 21:2101496

    Content type: Research Article

    Published on:

  43. Anti-Thy1 glomerulonephritis is a rat nephritis model closely simulating human mesangial proliferative glomerulonephritis. It affects primarily the mesangium, yet displays substantial proteinuria during the co...

    Authors: Yung-Ming Chen, Wen-Chih Chiang, Yalin Yang, Chun-Fu Lai, Kwan-Dun Wu and Shuei-Liong Lin

    Citation: Molecular Medicine 2015 21:2101276

    Content type: Research Article

    Published on:

  44. MicroRNAs (or miRs) play a crucial role in chronic lymphocytic leukemia (CLL) physiopathology and prognosis. In addition, circulating microRNAs in body fluids have been proposed as new biomarkers. We investiga...

    Authors: Basile Stamatopoulos, Michaël Van Damme, Emerence Crompot, Barbara Dessars, Hakim El Housni, Philippe Mineur, Nathalie Meuleman, Dominique Bron and Laurence Lagneaux

    Citation: Molecular Medicine 2015 21:2101123

    Content type: Research Article

    Published on:

  45. Doxorubicin (DOX) is a widely used, potent chemotherapeutic agent; however, its clinical application is limited because of its dose-dependent cardiotoxicity. DOX’s cardiotoxicity involves increased oxidative/n...

    Authors: Enkui Hao, Partha Mukhopadhyay, Zongxian Cao, Katalin Erdélyi, Eileen Holovac, Lucas Liaudet, Wen-Shin Lee, György Haskó, Raphael Mechoulam and Pál Pacher

    Citation: Molecular Medicine 2015 21:2101038

    Content type: Research Article

    Published on:

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