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Page 5 of 36

  1. Content type: Research Article

    Epidermolysis bullosa acquisita (EBA) is a difficult-to-treat subepidermal autoimmune blistering skin disease (AIBD) with circulating and tissue-bound anti-type VII collagen antibodies. Different reports have ...

    Authors: Misa Hirose, Anika Kasprick, Foteini Beltsiou, Katharina Schulze Dieckhoff, Franziska Sophie Schulze, Unni K J S R L Samavedam, Jennifer E Hundt, Hendri H Pas, Marcel F Jonkman, Enno Schmidt, Kathrin Kalies, Detlef Zillikens, Ralf J Ludwig and Katja Bieber

    Citation: Molecular Medicine 2016 22:2201918

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  2. Content type: Research Article

    Although low-energy shock wave (SW) is adopted to treat ischemic diseases because of its pro-angiogenic properties, the underlying mechanism remains unclear. This study is aimed at testing whether SW-induced a...

    Authors: Tien-Hung Huang, Cheuk-Kwan Sun, Yi-Ling Chen, Ching-Jen Wang, Tsung-Cheng Yin, Mel S Lee and Hon-Kan Yip

    Citation: Molecular Medicine 2016 22:2201850

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  3. Content type: Research Article

    The signals causing resolution of muscle inflammation are only partially characterized. The long pentraxin PTX3, which modulates leukocyte recruitment and activation, could contribute. We analyzed the expressi...

    Authors: Michela Vezzoli, Clara Sciorati, Lara Campana, Antonella Monno, Maria Giulia Doglio, Elena Rigamonti, Gianfranca Corna, Thierry Touvier, Alessandra Castiglioni, Annalisa Capobianco, Alberto Mantovani, Angelo A Manfredi, Cecilia Garlanda and Patrizia Rovere-Querini

    Citation: Molecular Medicine 2016 22:2201809

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  4. Content type: Research Article

    Transforming growth factor (TGF)-β-induced epithelial-mesenchymal transition (EMT) leads to the formation of ocular fibrotic pathologies, such as anterior subcapsular cataract and posterior capsule opacificati...

    Authors: Anna Korol, Aftab Taiyab and Judith A West-Mays

    Citation: Molecular Medicine 2016 22:2201713

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  5. Content type: Research Article

    Circulating γδ T cells In healthy Individuals rapidly respond to bacterial and viral pathogens. Many studies have demonstrated that γδ T cells are activated and expanded by Listeria monocytogenes (L. monocytogene...

    Authors: Yuli Zhu, Huaishan Wang, Yi Xu, Yu Hu, Hui Chen, Lianxian Cui, Jianmin Zhang and Wei He

    Citation: Molecular Medicine 2016 22:2201737

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  6. Content type: Research Article

    Rheumatoid arthritis (RA) is a systemic autoimmune disease that results in a chronic and inflammatory disorder. Dynamic balance of helper T cells (Th) 1 and 17 and regulatory T cells (Treg) is broken in RA. Si...

    Authors: Xiaoyin Niu, Shaohua Deng, Shan Li, Yebin Xi, Chengzhen Li, Li Wang, Dongyi He, Zhaojun Wang and Guangjie Chen

    Citation: Molecular Medicine 2016 22:2201608

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  7. Content type: Original Articles

    We investigated the pathophysiology of diet-induced diabetes in the Cohen diabetic rat (CDs/y) from its induction to its chronic phase, using a multilayered integrated genomic approach. We identified by linkag...

    Authors: Yoram Yagil, Barak Markus, Refael Kohen and Chana Yagil

    Citation: Molecular Medicine 2016 22:2201560

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  8. Content type: Research Article

    The exponential rise in molecular and genomic data has generated a vast array of therapeutic targets. Oligonucleotide-based technologies to down regulate these molecular targets have promising therapeutic effi...

    Authors: Noriko Satake, Connie Duong, Sakiko Yoshida, Michael Oestergaard, Cathy Chen, Rachael Peralta, Shuling Guo, Punit P Seth, Yueju Li, Laurel Beckett, Jong Chung, Jan Nolta, Nitin Nitin and Joseph M Tuscano

    Citation: Molecular Medicine 2016 22:2201632

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  9. Content type: Invited Review Article

    Lung cancer is the leading cause of mortality among all cancer types worldwide. The latest available global statistics of the World Health Organization report 1.59 million casualities in 2012. Worldwide, 1 in ...

    Authors: Havva O Kilgoz, Guzide Bender, Joseph M Scandura, Agnes Viale and Bahar Taneri

    Citation: Molecular Medicine 2016 22:2201380

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  10. Content type: Research Article

    Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by β cell destruction, insulin deficiency and hyperglycemia. Activated macrophages and autoimmune T cells play a crucial role in the...

    Authors: LaQueta K Hudson, Meghan E Dancho, Jianhua Li, Johanna B Bruchfeld, Ahmed A Ragab, Mingzhu M He, Meaghan Bragg, Delaney Lenaghan, Michael D Quinn, Jason R Fritz, Matthew V Tanzi, Harold A Silverman, William M Hanes, Yaakov A Levine, Valentin A Pavlov, Peder S Olofsson…

    Citation: Molecular Medicine 2016 22:2201585

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  11. Content type: Research Article

    Genetic features of chronic pancreatitis (CP) have been investigated extensively, mainly by testing genes associated to the trypsinogen activation pathway. However, different molecular pathways involving other...

    Authors: Valentina Maria Sofia, Letizia Da Sacco, Cecilia Surace, Anna Cristina Tomaiuolo, Silvia Genovese, Simona Grotta, Maria Gnazzo, Stefano Petrocchi, Laura Ciocca, Federico Alghisi, Enza Montemitro, Luigi Martemucci, Ausilia Elce, Vincenzina Lucidi, Giuseppe Castaldo and Adriano Angioni

    Citation: Molecular Medicine 2016 22:2201300

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  12. Content type: Review Article

    Single-chain antibodies (scFvs), which contain only the variable domains of full-length antibodies, are relatively small molecules that can be used for selective drug delivery. In this review, we discuss how s...

    Authors: Yaghoub Safdari, Vahideh Ahmadzadeh, Masoumeh Khalili, Hossein Zarei Jaliani, Vahid Zarei and Vahid Erfani-Moghadam

    Citation: Molecular Medicine 2016 22:2201258

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  13. Content type: Research Article

    High mobility group box 1 (HMGB1) is a nuclear DNA binding protein that acts as an alarmin when secreted. HMGB1 is increased in systemic lupus erythematosus and might represent a potential therapeutic target. ...

    Authors: Fleur Schaper, Mirjan M van Timmeren, Arjen Petersen, Gerda Horst, Marc Bijl, Pieter C Limburg, Johanna Westra and Peter Heeringa

    Citation: Molecular Medicine 2016 22:2201012

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  14. Content type: Research Article

    Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible...

    Authors: Tian Lin, Jialin Liu, Feng Huang, Tjitske S R van Engelen, Sujatha R Thundivalappil, Frank E Riley, Michael Super, Alexander L Watters, Ann Smith, Nathan Brinkman, Donald E Ingber and H Shaw Warren

    Citation: Molecular Medicine 2016 22:2201022

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  15. Content type: Research Article

    Extensively burned patients often suffer from sepsis, a complication that enhances postburn hypermetabolism and contributes to increased incidence of multiple organ failure, morbidity and mortality. Despite th...

    Authors: Li Diao, David Patsouris, Ali-Reza Sadri, Xiaojing Dai, Saeid Amini-Nik and Marc G. Jeschke

    Citation: Molecular Medicine 2015 21:2101959

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  16. Content type: Research Article

    Patients surviving sepsis develop anemia, but the molecular mechanism is unknown. Here we observed that mice surviving polymicrobial gram-negative sepsis develop hypochromic, microcytic anemia with reticulocyt...

    Authors: Sergio I. Valdés-Ferrer, Julien Papoin, Meghan E. Dancho, Peder S. Olofsson, Jianhua Li, Jeffrey M. Lipton, Patricia Avancena, Huan Yang, Yong-Rui Zou, Sangeeta S. Chavan, Bruce T. Volpe, Sara Gardenghi, Stefano Rivella, Betty Diamond, Ulf Andersson, Bettie M. Steinberg…

    Citation: Molecular Medicine 2015 21:2101951

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  17. Content type: Research Article

    In the era of personalized cancer medicine, identifying mutations within patient tumors plays an important role in defining high-risk stage II colon cancer patients. The prognostic role of BRAF V600E mutation, mi...

    Authors: F. Jeroen Vogelaar, Felice N. van Erning, Marlies S. Reimers, Hans van der Linden, Hans Pruijt, Adriaan J. C. van den Brule and Koop Bosscha

    Citation: Molecular Medicine 2015 21:21011038

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  18. Content type: Erratum

    The following paragraph was published in: Christoph Ott, Henrik Martens, Imam Hassouna, Bárbara Oliveira, Christian Erck, Maria-Patapia Zafeiriou, Ulla-Kaisa Peteri, Dörte Hesse, Simone Gerhart, Bekir Altas, T...

    Authors: Christoph Ott, Henrik Martens, Imam Hassouna, Barbara Oliveira, Christian Erck, Maria-Patapia Zafeiriou, Ulla-Kaisa Peteri, Dörte Hesse, Simone Gerhart, Bekir Altas, Tekla Kolbow, Herbert Stadler, Hiroshi Kawabe, Wolfram-Hubertus Zimmermann, Klaus-Armin Nave, Walter Schulz-Schaeffer…

    Citation: Molecular Medicine 2015 21:2101816

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    The original article was published in Molecular Medicine 2015 21:2101803

  19. Content type: Erratum

    The following paper had incorrect IC50 values in Table 1; the values should be the same as given in Table 2:

    Authors: Davorka Messmer, Kymmy Lorrain, Karin Stebbins, Yalda Bravo, Nicholas Stock, Geraldine Cabrera, Lucia Correa, Austin Chen, Jason Jacintho, Nicholas Chiorazzi, Xiao Jie Yan, David Spaner, Peppi Prasit and Daniel Lorrain

    Citation: Molecular Medicine 2015 21:2101665

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    The original article was published in Molecular Medicine 2015 21:2101410

  20. Content type: Research Article

    Sepsis remains a major medical issue despite decades of research. Identification of important inflammatory cascades and key molecular mediators are crucial for developing intervention and prevention strategies...

    Authors: Maria Karmella Apaya, Chih-Yu Lin, Ching-Yi Chiou, Chung-Chih Yang, Chen-Yun Ting and Lie-Fen Shyur

    Citation: Molecular Medicine 2015 21:2101988

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  21. Content type: Research Article

    To investigate the genetics of late-onset myasthenia gravis (LOMG), we conducted a genome-wide association study imputation of >6 million single nucleotide polymorphisms (SNPs) in 532 LOMG cases (anti-acetylch...

    Authors: Michael F. Seldin, Omar K. Alkhairy, Annette T. Lee, Janine A. Lamb, Jon Sussman, Ritva Pirskanen-Matell, Fredrik Piehl, Jan J. G. M. Verschuuren, Anna Kostera-Pruszczyk, Piotr Szczudlik, David McKee, Angelina H. Maniaol, Hanne F. Harbo, Benedicte A. Lie, Arthur Melms, Henri-Jean Garchon…

    Citation: Molecular Medicine 2015 21:2101769

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  22. Content type: Research Article

    Sporadic inclusion body myositis (sIBM) is a rare disease that is difficult to diagnose. Muscle biopsy provides three prominent pathological findings: inflammation, mitochondrial abnormalities and fibber degen...

    Authors: Marc Catalán-García, Glòria Garrabou, Constanza Morén, Mariona Guitart-Mampel, Ingrid Gonzalez-Casacuberta, Adriana Hernando, Jose Miquel Gallego-Escuredo, Dèlia Yubero, Francesc Villarroya, Raquel Montero, Albert Selva O-Callaghan, Francesc Cardellach and Josep Maria Grau

    Citation: Molecular Medicine 2015 21:2101817

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  23. Content type: Invited Review Article

    Circulating tumor cells (CTC) may be defined as tumor- or metastasis-derived cells that are present in the bloodstream. The CTC pool in colorectal cancer (CRC) patients may include not only epithelial tumor ce...

    Authors: Jennifer E. Hardingham, Phulwinder Grover, Marnie Winter, Peter J. Hewett, Timothy J. Price and Benjamin Thierry

    Citation: Molecular Medicine 2015 21(Suppl 1):21010025

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    This article is part of a Supplement: Volume 21 Supplement 1

  24. Content type: Invited Review Article

    Twenty-five years ago marked the publication of the first report describing a functional contribution by the cytokine, macrophage migration inhibitory factor (MIF), to tumor-associated angiogenesis and growth....

    Authors: Jason A. Chesney and Robert A. Mitchell

    Citation: Molecular Medicine 2015 21(Suppl 1):21010019

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    This article is part of a Supplement: Volume 21 Supplement 1

  25. Content type: Invited Review Article

    Extensive research has been carried out to decipher the function of the adaptive immune response in atherosclerosis, with the expectation that it will pave the road for the design of immunomodulatory therapies...

    Authors: Marie Le Borgne, Giuseppina Caligiuri and Antonino Nicoletti

    Citation: Molecular Medicine 2015 21(Suppl 1):21010013

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    This article is part of a Supplement: Volume 21 Supplement 1

  26. Content type: Invited Review Article

    High mobility group box protein 1 (HMGB1) is an evolutionary ancient nuclear protein that exerts divergent biological tasks inside and outside of cells. The functions of HMGB1 depend on location, binding partn...

    Authors: Huan Yang, Haichao Wang, Sangeeta S. Chavan and Ulf Andersson

    Citation: Molecular Medicine 2015 21(Suppl 1):21010006

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    This article is part of a Supplement: Volume 21 Supplement 1

  27. Content type: Research Article

    Erythropoietin (EPO) exerts potent neuroprotective, neuroregenerative and procognitive functions. However, unequivocal demonstration of erythropoietin receptor (EPOR) expression in brain cells has remained dif...

    Authors: Christoph Ott, Henrik Martens, Imam Hassouna, Barbara Oliveira, Christian Erck, Maria-Patapia Zafeiriou, Ulla-Kaisa Peteri, Dörte Hesse, Simone Gerhart, Bekir Altas, Tekla Kolbow, Herbert Stadler, Hiroshi Kawabe, Wolfram-Hubertus Zimmermann, Klaus-Armin Nave, Walter Schulz-Schaeffer…

    Citation: Molecular Medicine 2015 21:2101803

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  28. Content type: Research Article

    Erythropoietin (EPO) has both erythropoietic and tissue-protective properties. The EPO analogues carbamylated EPO (CEPO) and pyroglutamate helix B surface peptide (pHBSP) lack the erythropoietic activity of EP...

    Authors: Lamia Heikal, Pietro Ghezzi, Manuela Mengozzi and Gordon Ferns

    Citation: Molecular Medicine 2015 21:2101709

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  29. Content type: Research Article

    Transforming growth factor (TGF)-β1 is a cytokine that participates in a broad range of cellular regulatory processes and is associated with various diseases including aortic aneurysm. Increased TGF-β1 levels ...

    Authors: Ramune Sepetiene, Vaiva Patamsyte, Giedrius Zukovas, Giedre Jariene, Zita Stanioniene, Rimantas Benetis, Abdonas Tamosiunas and Vaiva Lesauskaite

    Citation: Molecular Medicine 2015 21:2101735

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  30. Content type: Research Article

    Simvastatin has been shown to have antiinflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these antiinflammatory effects are mediated have not been ...

    Authors: Lisa Mullen, Jason Ferdjani and Sandra Sacre

    Citation: Molecular Medicine 2015 21:2101726

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  31. Content type: Research Article

    Type 1 diabetes in mice is characterized by autoimmune destruction of insulin-producing pancreatic β-cells. Disease pathogenesis involves invasion of pancreatic islets by immune cells, including macrophages an...

    Authors: William M. Hanes, Peder S. Olofsson, Kevin Kwan, LaQueta K. Hudson, Sangeeta S. Chavan, Valentin A. Pavlov and Kevin J. Tracey

    Citation: Molecular Medicine 2015 21:2101702

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  32. Content type: Research Article

    Defects in intestinal epithelial integrity occur commonly in various pathologies. miR-222 is implicated in many aspects of cellular function and plays an important role in several diseases, but its exact biolo...

    Authors: Hee Kyoung Chung, Yu Chen, Jaladanki N. Rao, Lan Liu, Lan Xiao, Douglas J. Turner, Peixin Yang, Myriam Gorospe and Jian-Ying Wang

    Citation: Molecular Medicine 2015 21:2101676

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  33. Content type: Review Article

    Pulmonary hypertension (PH) is a disease with high morbidity and mortality. The prevalence of idiopathic pulmonary arterial hypertension (IPAH) and hereditary pulmonary arterial hypertension (HPAH) is approxim...

    Authors: Pravin B. Sehgal, Yang-Ming Yang and Edmund J. Miller

    Citation: Molecular Medicine 2015 21:2101688

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  34. Content type: Research Article

    Sepsis and septic shock are enormous public health problems with astronomical financial repercussions on health systems worldwide. The central nervous system (CNS) is closely intertwined in the septic process ...

    Authors: Nikhil Mulchandani, Weng-Lang Yang, Mohammad Moshahid Khan, Fangming Zhang, Philippe Marambaud, Jeffrey Nicastro, Gene F. Coppa and Ping Wang

    Citation: Molecular Medicine 2015 21:2101637

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  35. Content type: Research Article

    Biliary atresia (BA) is a devastating liver disease of unknown etiology affecting children generally within the first 3 months of life. The disease is manifested by inflammation and subsequent obstruction of t...

    Authors: Tatiana Iordanskaia, Miroslav Malesevic, Gunter Fischer, Tatiana Pushkarsky, Michael Bukrinsky and Evan P. Nadler

    Citation: Molecular Medicine 2015 21:2101657

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  36. Content type: Research Article

    MicroRNA (miR)-145 is the most abundant miR in vascular smooth muscle cells (VSMCs). However, the effect of hyperglycemia on the regulation of miR-145 is unknown. We hypothesized that the hyperglycemic conditi...

    Authors: Kou-Gi Shyu, Wen-Ping Cheng and Bao-Wei Wang

    Citation: Molecular Medicine 2015 21:2101616

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  37. Content type: Research Article

    Nuclear factor-kappa B (NF-κB) activation is widely implicated in multiple organ failure (MOF); however, a direct inhibitor of IκB kinase (IKK), which plays a pivotal role in the activation of NF-κB, has not b...

    Authors: Regina Sordi, Fausto Chiazza, Florence L. Johnson, Nimesh S. A. Patel, Karim Brohi, Massimo Collino and Christoph Thiemermann

    Citation: Molecular Medicine 2015 21:2101563

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  38. Content type: Research Article

    Neonates manifest a unique host response to sepsis even among other children. Preterm neonates may experience sepsis soon after birth or during often-protracted birth hospitalizations as they attain physiologi...

    Authors: James L. Wynn, Scott O. Guthrie, Hector R. Wong, Patrick Lahni, Ricardo Ungaro, M. Cecilia Lopez, Henry V. Baker and Lyle L. Moldawer

    Citation: Molecular Medicine 2015 21:2101496

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  39. Content type: Research Article

    The importance of Galectin-3 (Gal-3) in obesity-associated liver pathology is incompletely defined. To dissect the role of Gal-3 in fibrotic nonalcoholic steatohepatitis (NASH), Gal-3-deficient (LGALS3−/−) and wi...

    Authors: Ilija Jeftic, Nemanja Jovicic, Jelena Pantic, Nebojsa Arsenijevic, Miodrag L. Lukic and Nada Pejnovic

    Citation: Molecular Medicine 2015 21:2101453

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  40. Content type: Research Article

    Anti-Thy1 glomerulonephritis is a rat nephritis model closely simulating human mesangial proliferative glomerulonephritis. It affects primarily the mesangium, yet displays substantial proteinuria during the co...

    Authors: Yung-Ming Chen, Wen-Chih Chiang, Yalin Yang, Chun-Fu Lai, Kwan-Dun Wu and Shuei-Liong Lin

    Citation: Molecular Medicine 2015 21:2101276

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  41. Content type: Research Article

    Hyperthrophic scarring of the skin is caused by excessive activity of skin myofibroblasts after wound healing and often leads to functional and/or aesthetic disturbance with significant impairment of patient q...

    Authors: Christiane Gras, Dominica Ratuszny, Catarina Hadamitzky, Haijiao Zhang, Rainer Blasczyk and Constança Figueiredo

    Citation: Molecular Medicine 2015 21:2101296

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  42. Content type: Research Article

    Sepsis-associated encephalopathy (SAE) is associated with an increased rate of morbidity and mortality. It is not understood what the exact mechanism is for the brain dysfunction that occurs in septic patients...

    Authors: Monique Michels, Lucinéia Gainski Danieslki, Andriele Vieira, Drielly Florentino, Dhébora Dall’Igna, Letícia Galant, Beatriz Sonai, Francieli Vuolo, Franciele Mina, Bruna Pescador, Diogo Dominguini, Tatiana Barichello, Joäo Quevedo, Felipe Dal-Pizzol and Fabrícia Petronilho

    Citation: Molecular Medicine 2015 21:2101219

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  43. Content type: Research Article

    Thoracic X-ray therapy (XRT), used in cancer treatment, is associated with increased risk of heart failure. XRT-mediated injury to the heart induces an inflammatory response leading to cardiomyopathy. The aim ...

    Authors: Eleonora Mezzaroma, Ross B. Mikkelsen, Stefano Toldo, Adolfo G. Mauro, Khushboo Sharma, Carlo Marchetti, Asim Alam, Benjamin W. Van Tassell, David A. Gewirtz and Antonio Abbate

    Citation: Molecular Medicine 2015 21:2101210

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  44. Content type: Research Article

    MicroRNAs (or miRs) play a crucial role in chronic lymphocytic leukemia (CLL) physiopathology and prognosis. In addition, circulating microRNAs in body fluids have been proposed as new biomarkers. We investiga...

    Authors: Basile Stamatopoulos, Michaël Van Damme, Emerence Crompot, Barbara Dessars, Hakim El Housni, Philippe Mineur, Nathalie Meuleman, Dominique Bron and Laurence Lagneaux

    Citation: Molecular Medicine 2015 21:2101123

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  45. Content type: Research Article

    Doxorubicin (DOX) is a widely used, potent chemotherapeutic agent; however, its clinical application is limited because of its dose-dependent cardiotoxicity. DOX’s cardiotoxicity involves increased oxidative/n...

    Authors: Enkui Hao, Partha Mukhopadhyay, Zongxian Cao, Katalin Erdélyi, Eileen Holovac, Lucas Liaudet, Wen-Shin Lee, György Haskó, Raphael Mechoulam and Pál Pacher

    Citation: Molecular Medicine 2015 21:2101038

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