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  1. Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) embedded in a bio-compatible matrix has been demonstrated as a promising strategy for the treatment of bone defects. This study was desig...

    Authors: Zhongliu Cao, Yanfeng Wu, Lingling Yu, Lingfeng Zou, Liu Yang, Sijian Lin, Jue Wang, Zhen Yuan and Jianghua Dai
    Citation: Molecular Medicine 2021 27:20
  2. Hepatic ischemia/reperfusion (I/R) injury can be a major complication following liver surgery contributing to post-operative liver dysfunction. Maresin 1 (MaR1), a pro-resolving lipid mediator, has been shown ...

    Authors: Da Tang, Guang Fu, Wenbo Li, Ping Sun, Patricia A. Loughran, Meihong Deng, Melanie J. Scott and Timothy R. Billiar
    Citation: Molecular Medicine 2021 27:18
  3. Parkinson’s disease (PD) is the second more common neurodegenerative disease with increasing incidence worldwide associated to the population ageing. Despite increasing awareness and significant research advan...

    Authors: Theodora Ntetsika, Paraskevi-Evita Papathoma and Ioanna Markaki
    Citation: Molecular Medicine 2021 27:17
  4. Cytokeratin 18 (CK18) is an intermediate filament protein of the cytokeratin acidic type I group and is primarily expressed in single-layered or “simple” epithelial tissues and carcinomas of different origin.

    Authors: Anne Menz, Timo Weitbrecht, Natalia Gorbokon, Franziska Büscheck, Andreas M. Luebke, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Sören Weidemann, Christoph Fraune, Katharina Möller, Christian Bernreuther, Patrick Lebok, Till Clauditz, Guido Sauter…
    Citation: Molecular Medicine 2021 27:16
  5. Cyclin-dependent kinases 2/4/6 (CDK2/4/6) play critical roles in cell cycle progression, and their deregulations are hallmarks of hepatocellular carcinoma (HCC).

    Authors: Ying Zhu, Kun-Bin Ke, Zhong-Kun Xia, Hong-Jian Li, Rong Su, Chao Dong, Feng-Mei Zhou, Lin Wang, Rong Chen, Shi-Guo Wu, Hui Zhao, Peng Gu, Kwong-Sak Leung, Man-Hon Wong, Gang Lu, Jian-Ying Zhang…
    Citation: Molecular Medicine 2021 27:15
  6. Myocardial ischemia is the most common form of cardiovascular disease and the leading cause of morbidity and mortality. Understanding the mechanisms is very crucial for the development of effective therapy. Th...

    Authors: Hui-Yong Chen, Ze-Zhou Xiao, Xiao Ling, Rong-Ning Xu, Peng Zhu and Shao-Yi Zheng
    Citation: Molecular Medicine 2021 27:14
  7. Gestational diabetes mellitus is a risk factor for congenital heart defects. The article aimed to investigate the expression and roles of MST1, YAP1, Last1/2 and Survivin in modulating HG-induced cardiomyocyte...

    Authors: Dongmei Su, Yanhua Li, Lina Guan, Qian Li, Cuige Shi, Xu Ma and Yonghui Song
    Citation: Molecular Medicine 2021 27:13
  8. Osteoarthritis (OA) is the most common articular disorder, leading to joint malfunction and disability. Although the incidence of OA is increasing globally, the treatment of OA is very limited. LncRNA CIR has ...

    Authors: Feng Liu, De-Ye Song, Jun Huang, Hong-Qi Yang, Di You and Jiang-Dong Ni
    Citation: Molecular Medicine 2021 27:12
  9. House dust mite (HDM) inhalation can cause airway epithelial damage which is implicated in the process of airway inflammation in asthma. High mobility group box 1 (HMGB1) is critically required for cellular da...

    Authors: Meixuan Liu, Jingjing Lu, Qian Zhang, Yunxuan Zhang and Zhongliang Guo
    Citation: Molecular Medicine 2021 27:11
  10. LncRNA can regulate gene at various levels such as apparent genetics, alternative splicing, and regulation of mRNA degradation. However, the molecular mechanism of LncRNA in cholangiocarcinoma is still unclear...

    Authors: Hao Ji, Juan Wang, Binbin Lu, Juan Li, Jing Zhou, Li Wang, Shufen Xu, Peng Peng, Xuezhen Hu and Keming Wang
    Citation: Molecular Medicine 2021 27:10
  11. Reprogrammed glucose metabolism of enhanced Warburg effect (or aerobic glycolysis) is considered as a hallmark of cancer. Long non-coding RNAs (lncRNAs) have been certified to play a crucial role in tumor prog...

    Authors: Peng Deng, Kai Li, Feng Gu, Tao Zhang, Wenyan Zhao, Ming Sun and Bin Hou
    Citation: Molecular Medicine 2021 27:9
  12. Alzheimer's disease is a neurodegenerative disease. Previous study has reported that caspase-1/IL-1β is closely associated with Alzheimer's disease. However, the biological role of caspase-1/IL-1β in Alzheimer...

    Authors: Xunhu Gu, Hanjun Wu, Yuqin Xie, Lijun Xu, Xu Liu and Wei Wang
    Citation: Molecular Medicine 2021 27:8
  13. Malignant glioma exerts a metabolic shift from oxidative phosphorylation (OXPHOs) to aerobic glycolysis, with suppressed mitochondrial functions. This phenomenon offers a proliferation advantage to tumor cells...

    Authors: Qiuyun Yuan, Wanchun Yang, Shuxin Zhang, Tengfei Li, Mingrong Zuo, Xingwang Zhou, Junhong Li, Mao Li, Xiaoqiang Xia, Mina Chen and Yanhui Liu
    Citation: Molecular Medicine 2021 27:7
  14. Clinical data suggest that BMI and gestational weight gain (GWG) are strongly interconnected phenotypes; however, the genetic basis of the latter is rather unclear. Here we aim to find genes and genetic varian...

    Authors: Agnieszka H. Ludwig-Słomczyńska, Michał T. Seweryn, Przemysław Kapusta, Ewelina Pitera, Urszula Mantaj, Katarzyna Cyganek, Paweł Gutaj, Łucja Dobrucka, Ewa Wender-Ożegowska, Maciej T. Małecki and Paweł P. Wołkow
    Citation: Molecular Medicine 2021 27:6
  15. Osteoarthritis (OA) is a chronic inflammatory disease that is associated with articular cartilage destruction, subchondral bone alterations, synovitis, and even joint deformity and the loss of joint function. ...

    Authors: Jinshuo Tang, Tong Liu, Xinggui Wen, Zhongsheng Zhou, Jingtong Yan, Jianpeng Gao and Jianlin Zuo
    Citation: Molecular Medicine 2021 27:5
  16. Vascular cognitive impairment (VCI) is a common cognitive disorder caused by cerebrovascular disease, ranging from mild cognitive impairment to dementia. Studies have shown that aerobic exercise might alleviat...

    Authors: Yali Niu, Chunxiao Wan, Jing Zhang, Shu Zhang, Zilong Zhao, Leshan Zhu, Xiaodong Wang, Xiaodong Ren, Jing Wang and Ping Lei
    Citation: Molecular Medicine 2021 27:4
  17. Fetal growth restriction (FGR) is associated with increased risks for complications before, during, and after birth, in addition to risk of disease through to adulthood. Although placental insufficiency, failu...

    Authors: Giulia F. Del Gobbo, Yue Yin, Sanaa Choufani, Emma A. Butcher, John Wei, Evica Rajcan-Separovic, Hayley Bos, Peter von Dadelszen, Rosanna Weksberg, Wendy P. Robinson and Ryan K. C. Yuen
    Citation: Molecular Medicine 2021 27:3
  18. Although large artery atherosclerosis (LAA) is the most common type of cerebral infarction, non-LAA is not uncommon. The purpose of this paper is to investigate the prognosis of patients with non-LAA and to es...

    Authors: Ya-Ying Zeng, Wen-Bo Zhang, Lin Cheng, Li Wang, Dan-Dan Geng, Wen-Jie Tang, Jin-Cai He and Bin-Bin Deng
    Citation: Molecular Medicine 2021 27:2
  19. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s10020-020-00264-1

    Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson, Kevin J. Tracey and Daniel J. Antoine
    Citation: Molecular Medicine 2020 26:133

    The original article was published in Molecular Medicine 2011 18:Art13

  20. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s10020-020-00265-0

    Authors: Ravikumar A. Sitapara, Daniel J. Antoine, Lokesh Sharma, Vivek S. Patel, Charles R. Ashby Jr, Samir Gorasiya, Huan Yang, Michelle Zur and Lin L. Mantell
    Citation: Molecular Medicine 2020 26:132

    The original article was published in Molecular Medicine 2014 20:Art25

  21. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s10020-020-00263-2

    Authors: Karin Palmblad, Hanna Schierbeck, Erik Sundberg, Anna-Carin Horne, Helena Erlandsson Harris, Jan-Inge Henter, Daniel J. Antoine and Ulf Andersson
    Citation: Molecular Medicine 2020 26:131

    The original article was published in Molecular Medicine 2014 20:Art57

  22. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s10020-020-00262-3

    Authors: Daniel James Antoine, Dominic P. Williams, Anja Kipar, Hugh Laverty and B. Kevin Park
    Citation: Molecular Medicine 2020 26:130

    The original article was published in Molecular Medicine 2010 16:Art4

  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ahlam Fatmi, Sid Ahmed Rebiahi, Nafissa Chabni, Hanane Zerrouki, Hafsa Azzaoui, Yamina Elhabiri, Souheila Benmansour, José Santiago Ibáñez-Cabellos, Mohammed Chems-Eddine Smahi, Mourad Aribi, José Luis García-Giménez and Federico V. Pallardó
    Citation: Molecular Medicine 2020 26:129

    The original article was published in Molecular Medicine 2020 26:94

  24. Autosomal dominant polycystic kidney disease (ADPKD) is an inherited chronic kidney disorder (CKD) that is characterized by the development of numerous fluid-filled cysts in kidneys. It is caused either due to...

    Authors: Aryendu Kumar Saini, Rakesh Saini and Shubham Singh
    Citation: Molecular Medicine 2020 26:128
  25. Innervation of adipose tissue is essential for the proper function of this critical metabolic organ. Numerous surgical and chemical denervation studies have demonstrated how maintenance of brain-adipose commun...

    Authors: Magdalena Blaszkiewicz, Elizabeth Wood, Sigi Koizar, Jake Willows, Ryan Anderson, Yu-Hua Tseng, James Godwin and Kristy L. Townsend
    Citation: Molecular Medicine 2020 26:126
  26. Hepatocellular carcinoma (HCC) is a common malignant primary cancer with high mortality. Previous studies have demonstrated that RNA binding proteins (RBPs) are involved in the biological processes of cancers,...

    Authors: Li Wang, Na Zhou, Jialin Qu, Man Jiang and Xiaochun Zhang
    Citation: Molecular Medicine 2020 26:125
  27. Age-related cataract (ARC) is a serious visual impairment disease, and its pathogenesis is unclear. This article aims to investigate the role of ROCK1 in the apoptosis of lens epithelial cells (LECs) in age-re...

    Authors: Shanshan Hu, Dongmei Su, Lei Sun, Zhongying Wang, Lina Guan, Shanhe Liu, Baowen Zhao, Yong Liu, Cuige Shi, Jianbo Yu and Xu Ma
    Citation: Molecular Medicine 2020 26:124
  28. FINCA disease is a pediatric cerebropulmonary disease caused by variants in the NHL repeat-containing 2 (NHLRC2) gene. Neurological symptoms are among the first manifestations of FINCA disease, but the consequenc...

    Authors: Anniina E. Hiltunen, Salla M. Kangas, Steffen Ohlmeier, Ilkka Pietilä, Jori Hiltunen, Heikki Tanila, Colin McKerlie, Subashika Govindan, Hannu Tuominen, Riitta Kaarteenaho, Mikko Hallman, Johanna Uusimaa and Reetta Hinttala
    Citation: Molecular Medicine 2020 26:123
  29. As a common ocular complication of diabetes mellitus, diabetic cataract is becoming a leading cause of visual impairment. The progression of diabetic cataract progression involves epithelial-to-mesenchymal tra...

    Authors: Xin Liu, Qiaoyun Gong, Longfei Yang, Min Liu, Lingzhi Niu and Lufei Wang
    Citation: Molecular Medicine 2020 26:122
  30. Neonatal sepsis and the associated myocardial dysfunction remain a leading cause of infant mortality. Extracellular cold-inducible RNA-binding protein (eCIRP) acts as a ligand of triggering receptor expressed ...

    Authors: Naomi-Liza Denning, Monowar Aziz, Li Diao, Jose M. Prince and Ping Wang
    Citation: Molecular Medicine 2020 26:121
  31. At present, the early diagnosis of femoral head necrosis mainly relies on Magnetic resonance imaging (MRI), and most early patients are difficult to make an accurate diagnosis. Therefore, to investigate the ea...

    Authors: Xiaolong Wang, Jianbo Li, Da Man, Rui Liu and Jianmin Zhao
    Citation: Molecular Medicine 2020 26:120
  32. Increasing number of studies provide evidence that the vagus nerve stimulation (VNS) dampens inflammation in peripheral visceral organs. However, the effects of afferent fibers of the vagus nerve (AFVN) on ant...

    Authors: Byung Gon Jo, Seung-Hyung Kim and Uk Namgung
    Citation: Molecular Medicine 2020 26:119
  33. Approximately 400 million people throughout the world suffer from a rare disease. Although advances in whole exome and whole genome sequencing have greatly facilitated rare disease diagnosis, overall diagnosti...

    Authors: Samantha N. Hartin, John C. Means, Joseph T. Alaimo and Scott T. Younger
    Citation: Molecular Medicine 2020 26:117
  34. MicroRNAs (miRNAs) have been identified as important participants in the development of atherosclerosis (AS). The present study explored the role of miR-128-3p in the dysfunction of vascular smooth muscle cell...

    Authors: Chuan Qu, Xin Liu, Yan Guo, Yuhong Fo, Xiuhuan Chen, Jining Zhou and Bo Yang
    Citation: Molecular Medicine 2020 26:116
  35. Circulating high-mobility group box 1 (HMGB1) plays important roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Intracellular HMGB1 is critical for the biology of hepatocytes. However, the...

    Authors: Minjie Lin, Jungke Long, Wenbo Li, Chenxuan Yang, Patricia Loughran, Robert O’Doherty, Timothy R. Billiar, Meihong Deng and Melanie J. Scott
    Citation: Molecular Medicine 2020 26:115
  36. Long non-coding RNAs (lncRNAs) are biomarkers participating in multiple disease development including acute myeloid leukemia (AML). Here, we investigated molecular mechanism of X Inactive-Specific Transcript (...

    Authors: Chong Wang, Lingling Li, Mengya Li, Weiqiong Wang, Yanfang Liu and Shujuan Wang
    Citation: Molecular Medicine 2020 26:114
  37. Postherpetic neuralgia (PHN) is the most common complication of herpes zoster, but the mechanism of PHN is still unclear. Activation of spinal astrocytes is involved in PHN. Our study aims to explore whether l...

    Authors: Cunlong Kong, Jie Du, Huilian Bu, Chen Huang, Fuxing Xu and Huan Ren
    Citation: Molecular Medicine 2020 26:113
  38. The oncogenic role of the newly identified lncRNA LUADT1 has been revealed in lung adenocarcinoma. It was reported that LUADT1 plays a critical role in multiple human diseases. This study was carried out to in...

    Authors: Zhimin Zhang, Mingzhu Lv, Xiang Wang, Zheng Zhao, Daolong Jiang and Lihua Wang
    Citation: Molecular Medicine 2020 26:112
  39. Myocardial infarction (MI) is the leading cause of death from cardiovascular disease (CVD). Currently, the efficacy for MI treatment remains unsatisfactory. Therefore, it is urgent to develop a novel therapeut...

    Authors: Qiuting Feng, Xing Li, Xian Qin, Cheng Yu, Yan Jin and Xiaojun Qian
    Citation: Molecular Medicine 2020 26:111
  40. Posttraumatic stress disorder (PTSD) is a psychiatric disorder accompanied by chronic peripheral inflammation. What triggers inflammation in PTSD is currently unclear. In the present study, we identified poten...

    Authors: Marpe Bam, Xiaoming Yang, Brandon P. Busbee, Allison E. Aiello, Monica Uddin, Jay P. Ginsberg, Sandro Galea, Prakash S. Nagarkatti and Mitzi Nagarkatti
    Citation: Molecular Medicine 2020 26:110
  41. Breast cancer (BC) is a common malignant tumor with poor prognosis. Angiogenesis is related to the growth and progression of solid tumors and associated with prognosis. ZLM-7, SP1, VEGFA and miR-212-3p were as...

    Authors: Xuan Li, Zi-Zheng Zou, Min Wen, Yuan-Zhu Xie, Kun-Jian Peng, Tiao Luo, Su-You Liu, Qin Gu, Ji-Jia Li and Zhi-Yong Luo
    Citation: Molecular Medicine 2020 26:109
  42. Acute lung injury (ALI), which is induced by numerous pathogenic factors, especially sepsis, can generate alveolar damage, pulmonary edema and vascular hyper-permeability ultimately leading to severe hypoxemia...

    Authors: Xiaojun Pan, Shunyao Xu, Zhen Zhou, Fen Wang, Lingjie Mao, Hao Li, Caixia Wu, Junfeng Wang, Yueyue Huang, Dequan Li, Cong Wang and Jingye Pan
    Citation: Molecular Medicine 2020 26:108
  43. The expression of SIN3A is closely correlated with electroacupuncture (EA) treatment efficacy of scopolamine-induced amnesia (SIA), but its underlying mechanisms remain to be further explored.

    Authors: Fan Ye, Shiming Tian, Huimin Hu and Zhengwen Yu
    Citation: Molecular Medicine 2020 26:107
  44. Recent studies have demonstrated that long non-coding RNAs (LncRNAs) can influence bone cell differentiation and formation. However, it is unclear whether lncRNA HCG18 is involved in osteoporosis (OP). This st...

    Authors: Mingxue Che, Weiquan Gong, Yao Zhao and Mingxi Liu
    Citation: Molecular Medicine 2020 26:106
  45. Acupuncture treatment possesses the neuroprotection potential to attenuate cerebral ischemia–reperfusion (I/R) injury. Endoplasmic reticulum (ER) stress has been suggested to be involved in the pathogenic mech...

    Authors: Xiaowei Sun, Hao Liu, Zhongren Sun, Beng Zhang, Xinyu Wang, Tingting Liu, Tingting Pan, Ying Gao, Xicheng Jiang and Hongtao Li
    Citation: Molecular Medicine 2020 26:105
  46. Neuropathic pain belongs to chronic pain and is caused by the primary dysfunction of the somatosensory nervous system. Long noncoding RNAs (lncRNAs) have been reported to regulate neuronal functions and play s...

    Authors: Zhen Li, Aiyuan Li, Liping Yan, Tian Yang, Wei Xu and Pengju Fan
    Citation: Molecular Medicine 2020 26:104

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