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  1. Curcumin is a polyphenolic compound derived from turmeric that has potential beneficial properties for cardiovascular and renal diseases and is relatively safe and inexpensive. However, the application of curc...

    Authors: Mitko Mladenov, Jane Bogdanov, Bogdan Bogdanov, Nikola Hadzi-Petrushev, Andre Kamkin, Radoslav Stojchevski and Dimiter Avtanski
    Citation: Molecular Medicine 2022 28:129
  2. Intestinal barrier dysfunction, which is associated with reactive enteric glia cells (EGCs), is not only a result of early sepsis but also a cause of multiple organ dysfunction syndrome. Inhibition of platelet...

    Authors: Bo Cheng, Mengyu Du, Shuxuan He, Lan Yang, Xi Wang, Hui Gao, Haiqing Chang, Wei Gao, Yan Li, Qiang Wang and Yansong Li
    Citation: Molecular Medicine 2022 28:127

    The Correction to this article has been published in Molecular Medicine 2022 28:149

  3. Pyroptosis is a form of programmed cell death involved in the pathophysiological progression of hypoxic pulmonary hypertension (HPH). Emerging evidence suggests that N6-methyladenosine (m6A)-modified transcrip...

    Authors: Xiaoying Wang, Qian Li, Siyu He, June Bai, Cui Ma, Lixin Zhang, Xiaoyu Guan, Hao Yuan, Yiying Li, Xiangrui Zhu, Jian Mei, Feng Gao and Daling Zhu
    Citation: Molecular Medicine 2022 28:126
  4. Oxidative stress-caused damage to the retinal pigment epithelium (RPE) underlies the onset and progression of age-related macular degeneration (AMD). Impaired mitochondrial biogenesis sensitizes RPE cells to m...

    Authors: Xiaonan Zhuang, Jun Ma, Gezhi Xu and Zhongcui Sun
    Citation: Molecular Medicine 2022 28:125
  5. Uncoupling protein 2 (UCP2), activated by excessive reactive oxygen species (ROS) in vivo, has the dual effect of reducing ROS to protect against oxidative stress and reducing ATP production to regulate cellul...

    Authors: Chunli Zhao, Zijing Yang, Zhongrui Chen, Wenqi Liang, Shusheng Gong and Zhengde Du
    Citation: Molecular Medicine 2022 28:124
  6. Our previous data demonstrated that miR-19b expression was increased in human lung microvascular endothelial cells in-vitro-, in-vivo and in patients with hemorrhagic shock, leading to a decrease in syndecan-1 mR...

    Authors: Feng Wu, Jian-Ying Wang, Brooke Dorman, Ahmad Zeineddin and Rosemary Ann Kozar
    Citation: Molecular Medicine 2022 28:123
  7. Long-COVID is characterized by prolonged, diffuse symptoms months after acute COVID-19. Accurate diagnosis and targeted therapies for Long-COVID are lacking. We investigated vascular transformation biomarkers ...

    Authors: Maitray A. Patel, Michael J. Knauer, Michael Nicholson, Mark Daley, Logan R. Van Nynatten, Claudio Martin, Eric K. Patterson, Gediminas Cepinskas, Shannon L. Seney, Verena Dobretzberger, Markus Miholits, Brian Webb and Douglas D. Fraser
    Citation: Molecular Medicine 2022 28:122
  8. Stent implantation-induced neointima formation is a dominant culprit in coronary artery disease treatment failure after percutaneous coronary intervention. Ferroptosis, an iron-dependent regulated cell death, ...

    Authors: Shunchi Zhang, Yanrou Bei, Yueling Huang, Yimin Huang, Lianjie Hou, Xi-Long Zheng, Yiming Xu, Shaoguo Wu and Xiaoyan Dai
    Citation: Molecular Medicine 2022 28:121
  9. The miR-351 gene is significantly upregulated in diabetic mice with atherosclerosis. However, the mechanism by which its presence is important for the overall disease has not been elucidated. Therefore, this s...

    Authors: Hong Li, Dan Song, Qihui Liu, Linlin Li, Xiaoshi Sun, Jiamei Guo, Dianlian Li and Ping Li
    Citation: Molecular Medicine 2022 28:120
  10. Spinal cord injury (SCI) is a devastating neurological state causing physical disability, psychological stress and financial burden. SCI global rate is estimated between 250,000 and 500,000 individuals every y...

    Authors: Amir Mohammad Malvandi, Seyed Hamidreza Rastegar-moghaddam, Saeede Ebrahimzadeh-Bideskan, Giovanni Lombardi, Alireza Ebrahimzadeh-Bideskan and Abbas Mohammadipour
    Citation: Molecular Medicine 2022 28:118
  11. Lipid accumulation in tubular cells plays a key role in diabetic kidney disease (DKD). Targeting lipid metabolism disorders has clinical value in delaying the progression of DKD, but the precise mechanism by w...

    Authors: Chanyue Zhao, Li Li, Chenrui Li, Chengyuan Tang, Juan Cai, Yu Liu, Jinfei Yang, Yiyun Xi, Ming Yang, Na Jiang, Yachun Han, Yan Liu, Shilu Luo, Li Xiao and Lin Sun
    Citation: Molecular Medicine 2022 28:117
  12. Cataracts are the leading cause of blindness and a common ocular complication of diabetes. The epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) and altered autophagic activity occur duri...

    Authors: Jiyuan Ma, Wei Ye, Yunshu Yang, Tong Wu, Yafen Wang, Ji Li, Rui Pei, Mengmei He, Luning Zhang and Jian Zhou
    Citation: Molecular Medicine 2022 28:116
  13. O-linked β-d-N-acetylglucosamine (O-GlcNAc) is an important post-translational modification of serine or threonine residues on thousands of proteins in the nucleus and cytoplasm of all animals and plants. In euka...

    Authors: Qingsong Lu, Xiaozhen Zhang, Tingbo Liang and Xueli Bai
    Citation: Molecular Medicine 2022 28:115
  14. Immunoglobulin G (IgG) N-glycans have been shown to be associated with the risk of type 2 diabetes (T2D) and its risk factors. However, whether these associations reflect causal effects remain unclear. Further...

    Authors: Biyan Wang, Di Liu, Manshu Song, Wei Wang, Bo Guo and Youxin Wang
    Citation: Molecular Medicine 2022 28:114
  15. HNF1A-MODY is a monogenic form of diabetes caused by variants in the HNF1A gene. Different HNF1A variants are associated with differences in age of disease onset, but other factors are postulated to influence thi...

    Authors: Agnieszka H. Ludwig-Słomczyńska, Michał T. Seweryn, Piotr Radkowski, Przemysław Kapusta, Julita Machlowska, Stepanka Pruhova, Daniela Gasperikova, Christine Bellanne-Chantelot, Andrew Hattersley, Balamurugan Kandasamy, Lisa Letourneau-Freiberg, Louis Philipson, Alessandro Doria, Paweł P. Wołkow, Maciej T. Małecki and Tomasz Klupa
    Citation: Molecular Medicine 2022 28:113
  16. Long non-coding RNAs (lncRNAs) have emerged as regulators of human malignancies, including ovarian cancer (OC). LncRNA KCNQ1OT1 could promote OC progression, and EIF2B5 was associated with development of sever...

    Authors: Si-Li He, Ya-Ling Chen, Qi-Hua Chen, Qi Tian and Shui-Jing Yi
    Citation: Molecular Medicine 2022 28:112
  17. Breast cancer has become the most frequently diagnosed cancer worldwide. Increasing evidence indicated that zinc finger proteins (ZNFs), the largest family of transcription factors, contribute to cancer develo...

    Authors: Qing-Xiang Meng, Ke-Nie Wang, Jun-Hui Li, Hui Zhang, Zhao-Hui Chen, Xue-Jie Zhou, Xu-Chen Cao, Ping Wang and Yue Yu
    Citation: Molecular Medicine 2022 28:111
  18. Targeting ribosome biogenesis to activate p53 has recently emerged as a therapeutic strategy in human cancer. Among various ribosomal proteins, RPL11 centralizes the nucleolar stress-sensing pathway by binding...

    Authors: Bingwu Wang, Jian Gao, Zhongjun Zhao, Xuefei Zhong, Hao Cui, Hui Hou, Yanping Zhang, Junnian Zheng, Jiehui Di and Yong Liu
    Citation: Molecular Medicine 2022 28:109
  19. High-mobility group box 1 protein (HMGB1) is an ubiquitous nuclear protein that once released in the extracellular space acts as a Damage Associated Molecular Pattern and promotes inflammation. HMGB1 is signif...

    Authors: Federica De Leo, Alice Rossi, Francesco De Marchis, Cristina Cigana, Medede Melessike, Giacomo Quilici, Ida De Fino, Malisa Vittoria Mantonico, Chantal Fabris, Alessandra Bragonzi, Marco Emilio Bianchi and Giovanna Musco
    Citation: Molecular Medicine 2022 28:108
  20. Acute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no specific treatment available. Premature trypsinogen activation could initiate...

    Authors: Juan Xiao, Wenying Zeng, Pengcheng Zhang, Yuan Zhou and Qiangqiang Fang
    Citation: Molecular Medicine 2022 28:106
  21. The etiology and most risk factors for a sporadic first primary neoplasm in childhood or subsequent second primary neoplasms are still unknown. One established causal factor for therapy-associated second prima...

    Authors: Caine Lucas Grandt, Lara Kim Brackmann, Alicia Poplawski, Heike Schwarz, Willempje Hummel-Bartenschlager, Thomas Hankeln, Christiane Kraemer, Federico Marini, Sebastian Zahnreich, Iris Schmitt, Philipp Drees, Johanna Mirsch, Desiree Grabow, Heinz Schmidberger, Harald Binder, Moritz Hess…
    Citation: Molecular Medicine 2022 28:105
  22. Inflammatory bowel disease (IBD) is a common chronic remitting disease with no satisfactory treatment. The aim of this study was to investigate the protective effect of α7 nicotinic acetylcholine receptor (α7n...

    Authors: Wenyuan Pu, Zhenzi Su, Junaid Wazir, Chen Zhao, Lulu Wei, Ranran Wang, Qiyi Chen, Saifang Zheng, Shaoyi Zhang and Hongwei Wang
    Citation: Molecular Medicine 2022 28:104
  23. Acute kidney injury (AKI) is still a critical problem in clinical practice, with a heavy burden for national health system around the world. It is notable that sepsis is the predominant cause of AKI for patien...

    Authors: Xianzhi Li, Xiaojun Zhou, Xigao Liu, Xiaoyun Li, Xianzhou Jiang, Benkang Shi and Shuo Wang
    Citation: Molecular Medicine 2022 28:103
  24. It is well-known that both macrophages and osteocytes are critical regulators of osteogenesis and osteoclastogenesis, yet there is limited understanding of the macrophage-osteocyte interaction, and how their c...

    Authors: Shengfang Wang, Lan Xiao, Indira Prasadam, Ross Crawford, Yinghong Zhou and Yin Xiao
    Citation: Molecular Medicine 2022 28:102
  25. Deregulated translation initiation is implicated extensively in cancer initiation and progression. It is actively pursued as a viable target that circumvents the dependency on oncogenic signaling, a significan...

    Authors: Forum Kayastha, Noah B. Herrington, Bandish Kapadia, Anirban Roychowdhury, Nahid Nanaji, Glen E. Kellogg and Ronald B. Gartenhaus
    Citation: Molecular Medicine 2022 28:101
  26. Deficient endometrial decidualization has been associated with URSA. However, the underlying mechanism is poorly understood. This study aimed to investigate the temporal cytokine changes and the involvement of...

    Authors: Zhuo Chang, Hai-xue Kuang, Xueming Zhou, Hui Zhu, Yang Zhang, Yin Fu, Qiang Fu, Bei Jiang, Wei Wang, Sha Jiang, Li Ren, Lei Ma, Xue Pan and Xiao-ling Feng
    Citation: Molecular Medicine 2022 28:100
  27. Sepsis is defined as a state of multisystem organ dysfunction secondary to a dysregulated host response to infection and causes millions of deaths worldwide annually. Novel ways to counteract this disease are ...

    Authors: Amanda Formosa, Paul Turgeon and Claudia C. dos Santos
    Citation: Molecular Medicine 2022 28:99
  28. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystemic condition associated with post-infectious onset, impaired natural killer (NK) cell cytotoxicity and impaired ion channel fu...

    Authors: Etianne Martini Sasso, Katsuhiko Muraki, Natalie Eaton-Fitch, Peter Smith, Olivia Ly Lesslar, Gary Deed and Sonya Marshall-Gradisnik
    Citation: Molecular Medicine 2022 28:98
  29. Neural tissue has limited regenerative ability. To cope with that, in recent years a diverse set of novel tools has been used to tailor neurostimulation therapies and promote functional regeneration after axon...

    Authors: Francina Mesquida-Veny, Sara Martínez-Torres, José Antonio Del Río and Arnau Hervera
    Citation: Molecular Medicine 2022 28:97
  30. Albuminuria is a hallmark of diabetic kidney disease (DKD) that promotes its progression, leading to renal fibrosis. Renal macrophage function is complex and influenced by macrophage metabolic status. However,...

    Authors: Yijie Jia, Jiaqi Chen, Zhikang Zheng, Yuan Tao, Shuting Zhang, Meina Zou, Yanlin Yang, Meng Xue, Fang Hu, Yang Li, Qian Zhang, Yaoming Xue and Zongji Zheng
    Citation: Molecular Medicine 2022 28:95
  31. The proliferation ability and autophagy level of pulmonary artery endothelial cells (PAECs) play an important role in promoting the development of pulmonary artery hypertension (PAH), and there is still no eff...

    Authors: Tingting Jin, Jiangting Lu, Qingbo Lv, Yingchao Gong, Zhaojin Feng, Hangying Ying, Meihui Wang, Guosheng Fu and Dongmei Jiang
    Citation: Molecular Medicine 2022 28:94
  32. Diffuse large B cell lymphoma (DLBCL) is an aggressive and molecularly heterogeneous non-Hodgkin’s lymphoma. The B cell receptor (BCR) signaling pathway in DLBCL emerges as a new drug target. Protein phosphata...

    Authors: Ji-Lin Chen, Pei-Yi Chu, Chun-Teng Huang, Tzu-Ting Huang, Wan-Lun Wang, Yu-Hsuan Lee, Yuan-Ya Chang, Ming-Shen Dai, Chung-Wai Shiau and Chun-Yu Liu
    Citation: Molecular Medicine 2022 28:93
  33. The forkhead box O3a protein (FoxO3a) has been reported to be involved in the migration and invasion of trophoblast, but its underlying mechanisms unknown. In this study, we aim to explore the transcriptional ...

    Authors: Hao Chen, Shi-Han Wang, Chang Chen, Xin-Yang Yu, Jia-Nan Zhu, Toby Mansell, Boris Novakovic, Richard Saffery, Philip N. Baker, Ting-Li Han and Hua Zhang
    Citation: Molecular Medicine 2022 28:92
  34. Neutrophils are the most abundant innate immune cells in the circulating blood, and they act as the first responder against bacterial and fungal infection. However, accumulation of activated neutrophils can ca...

    Authors: Satoshi Takizawa, Yongchan Lee, Asha Jacob, Monowar Aziz and Ping Wang
    Citation: Molecular Medicine 2022 28:91
  35. Myoclonus, Epilepsy and Ragged-Red-Fibers (MERRF) is a mitochondrial encephalomyopathy due to heteroplasmic mutations in mitochondrial DNA (mtDNA) most frequently affecting the tRNALys gene at position m.8344A > ...

    Authors: Mariantonietta Capristo, Valentina Del Dotto, Concetta Valentina Tropeano, Claudio Fiorini, Leonardo Caporali, Chiara La Morgia, Maria Lucia Valentino, Monica Montopoli, Valerio Carelli and Alessandra Maresca
    Citation: Molecular Medicine 2022 28:90
  36. Kidney stones are composed of approximately 70–80% calcium oxalate. However, the exact mechanism of formation of calcium oxalate kidney stones remains unclear. In this study, we investigated the roles of endop...

    Authors: Shaoxiong Ming, Jia Tian, Ke Ma, Chengbin Pei, Ling Li, Zeyu Wang, Ziyu Fang, Min Liu, Hao Dong, Weijian Li, Jianwen Zeng, Yonghan Peng and Xiaofeng Gao
    Citation: Molecular Medicine 2022 28:88
  37. Angiogenesis plays a critical role on post-infarction heart failure (PIHF), the presence of which facilitates additional blood supply to maintain the survival of residual cardiomyocytes. The sigma-1 receptor (...

    Authors: Xin Zhao, Xin Liu, Xiuhuan Chen, Xueyu Han, Yazhou Sun, Yuhong Fo, Xiukun Wang, Chuan Qu and Bo Yang
    Citation: Molecular Medicine 2022 28:87
  38. Regardless of improvements in controlling the COVID-19 pandemic, the lack of comprehensive insight into SARS-COV-2 pathogenesis is still a sophisticated challenge. In order to deal with this challenge, we util...

    Authors: Samaneh Maleknia, Mohammad Javad Tavassolifar, Faezeh Mottaghitalab, Mohammad Reza Zali and Anna Meyfour
    Citation: Molecular Medicine 2022 28:86
  39. Uncontrolled inflammation is an important factor in the occurrence and development of acute lung injury (ALI). Fibroblast growth factor-inducible 14 (Fn14), a plasma membrane-anchored receptor, takes part in t...

    Authors: Xin-Xin Guan, Hui-Hui Yang, Wen-Jing Zhong, Jia-Xi Duan, Chen-Yu Zhang, Hui-Ling Jiang, Yang Xiang, Yong Zhou and Cha-Xiang Guan
    Citation: Molecular Medicine 2022 28:85
  40. Liver failure is a life-threatening complication of infections restricting the host's response to infection. The pivotal role of the liver in metabolic, synthetic, and immunological pathways enforces limits th...

    Authors: Dustin Beyer, Jessica Hoff, Oliver Sommerfeld, Alexander Zipprich, Nikolaus Gaßler and Adrian T. Press
    Citation: Molecular Medicine 2022 28:84
  41. Exposure to anesthesia in the elderly might increase the risk of dementia. Although the mechanism underlying the association is uncertain, anesthesia has been shown to induce acute tau hyperphosphorylation in ...

    Authors: John David Eun, Heidy Jimenez, Leslie Adrien, Adam Wolin, Philippe Marambaud, Peter Davies and Jeremy L. Koppel
    Citation: Molecular Medicine 2022 28:83
  42. Metastasis of malignant tumors accelerates systemic failure and hastens the deaths of pancreatic cancer patients. During the metastatic process, the physical translocation of cancer cells from the primary lesi...

    Authors: Zhongbo Zhang and Yuanhong Xu
    Citation: Molecular Medicine 2022 28:82
  43. Liver fibrosis is a progressive liver injury response. Transforming growth factor β1 (TGF-β1) is oversecreted during liver fibrosis and promotes the development of liver fibrosis. Therapeutic approaches target...

    Authors: Xudong Song, Jiayi Shi, Jieting Liu, Yong Liu, Yang Yu, Yufei Qiu, Zhiqin Cao, Yu Pan, Xiaohuan Yuan, Yanhui Chu and Dan Wu
    Citation: Molecular Medicine 2022 28:80

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