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  1. Approximately 400 million people throughout the world suffer from a rare disease. Although advances in whole exome and whole genome sequencing have greatly facilitated rare disease diagnosis, overall diagnosti...

    Authors: Samantha N. Hartin, John C. Means, Joseph T. Alaimo and Scott T. Younger
    Citation: Molecular Medicine 2020 26:117
  2. MicroRNAs (miRNAs) have been identified as important participants in the development of atherosclerosis (AS). The present study explored the role of miR-128-3p in the dysfunction of vascular smooth muscle cell...

    Authors: Chuan Qu, Xin Liu, Yan Guo, Yuhong Fo, Xiuhuan Chen, Jining Zhou and Bo Yang
    Citation: Molecular Medicine 2020 26:116
  3. Circulating high-mobility group box 1 (HMGB1) plays important roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Intracellular HMGB1 is critical for the biology of hepatocytes. However, the...

    Authors: Minjie Lin, Jungke Long, Wenbo Li, Chenxuan Yang, Patricia Loughran, Robert O’Doherty, Timothy R. Billiar, Meihong Deng and Melanie J. Scott
    Citation: Molecular Medicine 2020 26:115
  4. Long non-coding RNAs (lncRNAs) are biomarkers participating in multiple disease development including acute myeloid leukemia (AML). Here, we investigated molecular mechanism of X Inactive-Specific Transcript (...

    Authors: Chong Wang, Lingling Li, Mengya Li, Weiqiong Wang, Yanfang Liu and Shujuan Wang
    Citation: Molecular Medicine 2020 26:114
  5. Postherpetic neuralgia (PHN) is the most common complication of herpes zoster, but the mechanism of PHN is still unclear. Activation of spinal astrocytes is involved in PHN. Our study aims to explore whether l...

    Authors: Cunlong Kong, Jie Du, Huilian Bu, Chen Huang, Fuxing Xu and Huan Ren
    Citation: Molecular Medicine 2020 26:113
  6. The oncogenic role of the newly identified lncRNA LUADT1 has been revealed in lung adenocarcinoma. It was reported that LUADT1 plays a critical role in multiple human diseases. This study was carried out to in...

    Authors: Zhimin Zhang, Mingzhu Lv, Xiang Wang, Zheng Zhao, Daolong Jiang and Lihua Wang
    Citation: Molecular Medicine 2020 26:112
  7. Myocardial infarction (MI) is the leading cause of death from cardiovascular disease (CVD). Currently, the efficacy for MI treatment remains unsatisfactory. Therefore, it is urgent to develop a novel therapeut...

    Authors: Qiuting Feng, Xing Li, Xian Qin, Cheng Yu, Yan Jin and Xiaojun Qian
    Citation: Molecular Medicine 2020 26:111
  8. Posttraumatic stress disorder (PTSD) is a psychiatric disorder accompanied by chronic peripheral inflammation. What triggers inflammation in PTSD is currently unclear. In the present study, we identified poten...

    Authors: Marpe Bam, Xiaoming Yang, Brandon P. Busbee, Allison E. Aiello, Monica Uddin, Jay P. Ginsberg, Sandro Galea, Prakash S. Nagarkatti and Mitzi Nagarkatti
    Citation: Molecular Medicine 2020 26:110
  9. Breast cancer (BC) is a common malignant tumor with poor prognosis. Angiogenesis is related to the growth and progression of solid tumors and associated with prognosis. ZLM-7, SP1, VEGFA and miR-212-3p were as...

    Authors: Xuan Li, Zi-Zheng Zou, Min Wen, Yuan-Zhu Xie, Kun-Jian Peng, Tiao Luo, Su-You Liu, Qin Gu, Ji-Jia Li and Zhi-Yong Luo
    Citation: Molecular Medicine 2020 26:109
  10. Acute lung injury (ALI), which is induced by numerous pathogenic factors, especially sepsis, can generate alveolar damage, pulmonary edema and vascular hyper-permeability ultimately leading to severe hypoxemia...

    Authors: Xiaojun Pan, Shunyao Xu, Zhen Zhou, Fen Wang, Lingjie Mao, Hao Li, Caixia Wu, Junfeng Wang, Yueyue Huang, Dequan Li, Cong Wang and Jingye Pan
    Citation: Molecular Medicine 2020 26:108
  11. The expression of SIN3A is closely correlated with electroacupuncture (EA) treatment efficacy of scopolamine-induced amnesia (SIA), but its underlying mechanisms remain to be further explored.

    Authors: Fan Ye, Shiming Tian, Huimin Hu and Zhengwen Yu
    Citation: Molecular Medicine 2020 26:107
  12. Recent studies have demonstrated that long non-coding RNAs (LncRNAs) can influence bone cell differentiation and formation. However, it is unclear whether lncRNA HCG18 is involved in osteoporosis (OP). This st...

    Authors: Mingxue Che, Weiquan Gong, Yao Zhao and Mingxi Liu
    Citation: Molecular Medicine 2020 26:106
  13. Acupuncture treatment possesses the neuroprotection potential to attenuate cerebral ischemia–reperfusion (I/R) injury. Endoplasmic reticulum (ER) stress has been suggested to be involved in the pathogenic mech...

    Authors: Xiaowei Sun, Hao Liu, Zhongren Sun, Beng Zhang, Xinyu Wang, Tingting Liu, Tingting Pan, Ying Gao, Xicheng Jiang and Hongtao Li
    Citation: Molecular Medicine 2020 26:105
  14. Neuropathic pain belongs to chronic pain and is caused by the primary dysfunction of the somatosensory nervous system. Long noncoding RNAs (lncRNAs) have been reported to regulate neuronal functions and play s...

    Authors: Zhen Li, Aiyuan Li, Liping Yan, Tian Yang, Wei Xu and Pengju Fan
    Citation: Molecular Medicine 2020 26:104
  15. The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune...

    Authors: Betty Diamond, Bruce T. Volpe, Sonya VanPatten and Yousef Al Abed
    Citation: Molecular Medicine 2020 26:103
  16. The most popular miRNA quantitation technique is RQ-PCR with relative gene expression method that requires an endogenous control (EC) gene for data normalization. However, there are insufficient data and selec...

    Authors: Daina Pamedytyte, Enrika Leipute, Birute Zilaitiene, Valdas Sarauskas, Dalia Dauksiene, Albertas Dauksa and Aurelija Zvirbliene
    Citation: Molecular Medicine 2020 26:100
  17. The incidence of bronchopulmonary dysplasia (BPD), a chronic lung disease of newborns, has been paradoxically rising despite medical advances. Histone deacetylase 3 (Hdac3) has been reported to be a crucial re...

    Authors: Di Wang, Hui Hong, Xiao-Xia Li, Jing Li and Zhi-Qun Zhang
    Citation: Molecular Medicine 2020 26:99
  18. Mechanical ventilation, in combination with supraphysiological concentrations of oxygen (i.e., hyperoxia), is routinely used to treat patients with respiratory distress, such as COVID-19. However, prolonged ex...

    Authors: Ravikumar A. Sitapara, Alex G. Gauthier, Vivek S. Patel, Mosi Lin, Michelle Zur, Charles R. Ashby Jr. and Lin L. Mantell
    Citation: Molecular Medicine 2020 26:98

    The Correction to this article has been published in Molecular Medicine 2021 27:93

  19. COVID-19 is a viral respiratory disease caused by the severe acute respiratory syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this disease may be more prone to venous or arterial thrombosis because of...

    Authors: Yu Chen, Jinglan Wang, Chenxi Liu, Longxiang Su, Dong Zhang, Junping Fan, Yanli Yang, Meng Xiao, Jing Xie, Yingchun Xu, Yongzhe Li and Shuyang Zhang
    Citation: Molecular Medicine 2020 26:97
  20. Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian ca...

    Authors: Lei Du, Cong-Rong Li, Qi-Feng He, Xiao-Hua Li, Lin-Fei Yang, Yuan Zou, Zhi-Xia Yang, Dong Zhang and Xiao-Wei Xing
    Citation: Molecular Medicine 2020 26:96
  21. Neonatal sepsis remains an important cause of morbidity and mortality. The ability to quickly and accurately diagnose neonatal sepsis based on clinical assessments and laboratory blood tests remains difficult,...

    Authors: Ahlam Fatmi, Sid Ahmed Rebiahi, Nafissa Chabni, Hanane Zerrouki, Hafsa Azzaoui, Yamina Elhabiri, Souheila Benmansour, José Santiago Ibáñez-Cabellos, Mohammed Chems-Eddine Smahi, Mourad Aribi, José Luis García-Giménez and Federico V. Pallardó
    Citation: Molecular Medicine 2020 26:94

    The Correction to this article has been published in Molecular Medicine 2020 26:129

  22. Epigenetics can contribute to lipid disorders in obesity. The DNA methylation pattern can be the cause or consequence of high blood lipids. The aim of the study was to investigate the DNA methylation profile i...

    Authors: Teresa Płatek, Anna Polus, Joanna Góralska, Urszula Raźny, Anna Gruca, Beata Kieć-Wilk, Piotr Zabielski, Maria Kapusta, Krystyna Słowińska-Solnica, Bogdan Solnica, Małgorzata Malczewska-Malec and Aldona Dembińska-Kieć
    Citation: Molecular Medicine 2020 26:93
  23. Current blood-based tests for rheumatoid arthritis (RA) have inherent limitations, necessitating the need for additional new biomarkers for its diagnosis and monitoring disease activity and responsiveness to t...

    Authors: Mohamed Taha, Olfat Gamil Shaker, Enas Abdelsalam and Noha Taha
    Citation: Molecular Medicine 2020 26:92
  24. Mechanically ventilated patients with COVID-19 have a mortality of 24–53%, in part due to distal mucopurulent secretions interfering with ventilation. DNA from neutrophil extracellular traps (NETs) contribute ...

    Authors: Andrew G. Weber, Alice S. Chau, Mikala Egeblad, Betsy J. Barnes and Tobias Janowitz
    Citation: Molecular Medicine 2020 26:91
  25. Hypovolemic shock and septic challenge are two major causes of acute kidney injury (AKI) in the clinic setting. Src homology 2 domain-containing phosphatase 2 (SHP2) is one of the major protein phosphatase tyr...

    Authors: Jihong Jiang, Baoji Hu, Chun-Shiang Chung, Yaping Chen, Yunhe Zhang, Elizabeth W. Tindal, Jinbao Li and Alfred Ayala
    Citation: Molecular Medicine 2020 26:89
  26. Patients newly diagnosed with lung adenocarcinoma with bone metastases (LABM) have poor survival rates after treatment with conventional therapies. To improve outcomes, we retrospectively investigated whether ...

    Authors: Long Huang, Xiao-Liu Jiang, Hong-Bin Liang, Jian-Cheng Li, Li-Han Chin, Jian-Ping Wei, Rui-Ru Wang, Jing Cai, Qiang Xiong, Lien-Tu Wang, David S. Cram and An-Wen Liu
    Citation: Molecular Medicine 2020 26:88
  27. Phenotypic transformation of vascular smooth muscle cells is a key element in vascular remodeling and aortic aneurysm growth. Previously, deletion of several inflammasome components decreased formation of aort...

    Authors: Markus Wortmann, Muhammad Arshad, Maani Hakimi, Dittmar Böckler and Susanne Dihlmann
    Citation: Molecular Medicine 2020 26:87
  28. Exposure to ionizing radiation induces complex stress responses in cells, which can lead to adverse health effects such as cancer. Although a variety of studies investigated gene expression and affected pathwa...

    Authors: Lara Kim Brackmann, Alicia Poplawski, Caine Lucas Grandt, Heike Schwarz, Thomas Hankeln, Steffen Rapp, Sebastian Zahnreich, Danuta Galetzka, Iris Schmitt, Christian Grad, Lukas Eckhard, Johanna Mirsch, Maria Blettner, Peter Scholz-Kreisel, Moritz Hess, Harald Binder…
    Citation: Molecular Medicine 2020 26:85
  29. Gender-affirming hormone therapy has been hypothesized to reduce the patient’s reproductive potential in transmen, although the exact long-term effects on future fertility are unknown.

    Authors: Julian Marschalek, Detlef Pietrowski, Sabine Dekan, Marie-Louise Marschalek, Maximilian Brandstetter and Johannes Ott
    Citation: Molecular Medicine 2020 26:83
  30. Chorioamnionitis, inflammation of the chorion and amnion, which often results from intrauterine infection, is associated with premature birth and contributes to significant neonatal morbidity and mortality, in...

    Authors: C. Heymans, I. H. de Lange, K. Lenaerts, L. C. G. A. Kessels, M. Hadfoune, G. Rademakers, V. Melotte, W. Boesmans, B. W. Kramer, A. H. Jobe, M. Saito, M. W. Kemp, W. G. van Gemert and T. G. A. M. Wolfs
    Citation: Molecular Medicine 2020 26:82
  31. Activation of hepatic stellate cells (HSCs) is a prominent driver of liver fibrosis. We previously demonstrated that exosomes derived from natural killer (NK) cells (NK-Exo) attenuated TGF-β1-induced HSC activ...

    Authors: Ling Wang, Yinghao Wang and Jun Quan
    Citation: Molecular Medicine 2020 26:81
  32. Patients with advanced non-small cell lung cancer (NSCLC) benefit from treatment with immune checkpoint inhibitors (ICIs). Biomarkers such as programmed death-ligand 1 (PD-L1), the tumor mutational burden (TMB...

    Authors: Dantong Sun, Lu Tian, Yan Zhu, Yang Wo, Qiaoling Liu, Shihai Liu, Hong Li and Helei Hou
    Citation: Molecular Medicine 2020 26:78
  33. Little is known about the correlation between the melanocortin 4 receptor gene (MC4R) single nucleotide polymorphisms (SNPs) and the risk of obesity. This research sought to test the MC4R rs17782313, rs476828 and...

    Authors: Bi-Liu Wei, Rui-Xing Yin, Chun-Xiao Liu, Guo-Xiong Deng, Yao-Zong Guan and Peng-Fei Zheng
    Citation: Molecular Medicine 2020 26:77
  34. Diabetes during pregnancy affects placental mitochondrial content and function, which has the potential to impact fetal development and the long-term health of offspring. Resistin is a peptide hormone original...

    Authors: Shaoning Jiang, April M. Teague, Jeanie B. Tryggestad, Timothy J. Lyons and Steven D. Chernausek
    Citation: Molecular Medicine 2020 26:76
  35. Therapeutic lymphangiogenesis in an orthotopic lung transplant model has been shown to improve acute allograft rejection that is mediated at least in part through hyaluronan drainage. Lymphatic vessel endothel...

    Authors: Shikshya Shrestha, Woohyun Cho, Benjamin Stump, Jewel Imani, Anthony M. Lamattina, Pierce H. Louis, James Pazzanese, Ivan O. Rosas, Gary Visner, Mark A. Perrella and Souheil El-Chemaly
    Citation: Molecular Medicine 2020 26:75
  36. Studies have demonstrated that long noncoding RNAs (lncRNAs) have essential impacts on the development of atherosclerosis (AS). This study aimed to identify the role and functional mechanism of lncRNA CASC2 in...

    Authors: Chenjing Wang, Jin Zhao, Xiaodong Nan, Zhong Guo, Shuangsheng Huang, Xiaokun Wang, Feng Sun and Shijie Ma
    Citation: Molecular Medicine 2020 26:74
  37. Electroacupuncture (EA), a treatment derived from traditional Chinese medicine, can effectively improve hyperandrogenism and insulin resistance in patients with polycystic ovary syndrome (PCOS), however, its u...

    Authors: Yan Peng, Liyuan Guo, Anxin Gu, Beibei Shi, Yukun Ren, Jing Cong and Xinming Yang
    Citation: Molecular Medicine 2020 26:73
  38. Atherosclerosis (AS) is widely accepted to be a multistep pathophysiological process associated with several other processes such as angiogenesis and inflammatory response. Long non-coding RNAs (lncRNAs) are n...

    Authors: Xian Shi, Ya-Ting Wei, Heng Li, Ting Jiang, Xi-Long Zheng, Kai Yin and Guo-Jun Zhao
    Citation: Molecular Medicine 2020 26:72
  39. Co-administration of human ghrelin and growth hormone (GH) reverse immunosuppression in septic aged animals, but the mechanism remains elusive. Here, we hypothesize that ghrelin and GH co-treatment restores th...

    Authors: Mian Zhou, Monowar Aziz, Mahendar Ochani and Ping Wang
    Citation: Molecular Medicine 2020 26:71
  40. Ovarian cancer is one of the most common gynecologic cancers and has high mortality rate due to the lack of early diagnosis method and efficient therapeutic agents. circCELSR1 is up-regulated in ovarian cancer...

    Authors: Xiang-Yang Zeng, Jing Yuan, Chen Wang, Da Zeng, Jia-Hui Yong, Xiao-Yan Jiang, Hua Lan and Song-Shu Xiao
    Citation: Molecular Medicine 2020 26:70
  41. We previously showed that the autophagy inhibitor chloroquine (CQ) increases inflammatory cleaved caspase-1 activity in myocytes, and that caspase-1/11 is protective in sterile liver injury. However, the role ...

    Authors: Ulka Sachdev, Ricardo Ferrari, Xiangdong Cui, Abish Pius, Amrita Sahu, Michael Reynolds, Hong Liao, Ping Sun, Sunita Shinde, Fabrisia Ambrosio, Sruti Shiva, Patricia Loughran and Melanie Scott
    Citation: Molecular Medicine 2020 26:69
  42. Apoptosis and oxidative stress are the main etiology of age related cataract (ARC). This article aims to investigate the role of WRN in lens epithelial cells (LECs).

    Authors: Shengqun Jiang and Jiansu Chen
    Citation: Molecular Medicine 2020 26:68

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