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  1. The NLRP3 inflammasome, a cytosolic complex that mediates the maturation of IL-1β and IL-18 as well as the release of high mobility group box 1 (HMGB1), contributes to the lethality of endotoxic shock. Ethyl p...

    Authors: Sujun Li, Fang Liang, Kevin Kwan, Yiting Tang, Xiangyu Wang, Youzhou Tang, Jianhua Li, Huan Yang, Sangeeta S. Chavan, Haichao Wang, Ulf Andersson, Ben Lu and Kevin J. Tracey

    Citation: Molecular Medicine 2018 24:8

    Content type: Research article

    Published on:

  3. Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a red...

    Authors: Natasha Fillmore, Jody L. Levasseur, Arata Fukushima, Cory S. Wagg, Wei Wang, Jason R. B. Dyck and Gary D. Lopaschuk

    Citation: Molecular Medicine 2018 24:3

    Content type: Research article

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  4. Epidemiological studies have suggested a link between cumulative diabetic exposure and cancer. The interaction of advanced glycation end products (AGEs) with their receptor (RAGE) may contribute to the phenome...

    Authors: Nobutaka Nakamara, Takanori Matsui, Yuji Ishibashi, Ami Sotokawauchi, Kei Fukami, Yuichiro Higashimoto and Sho-ichi Yamagishi

    Citation: Molecular Medicine 2017 23:2301295

    Content type: Research Article

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  5. Sirtuin-6 (Sirt6) is a critical epigenetic regulator, but its function in the gut is unknown. Here, we studied the role of intestinal epithelial Sirt6 in colitis-associated intestinal epithelial injury. We fou...

    Authors: Fangyi Liu, Heng-Fu Bu, Hua Geng, Isabelle G. De Plaen, Chao Gao, Peng Wang, Xiao Wang, Jacob A. Kurowski, Hong Yang, Jiaming Qian and Xiao-Di Tan

    Citation: Molecular Medicine 2017 23:2301272

    Content type: Research Article

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  6. The kidney is vulnerable to hypoxia-induced injury. One of the mechanisms underlying this phenomenon is cell apoptosis triggered by hypoxia-inducible factor-1- α (HIF-1α) activation. MicroRNA-210 (miR-210) is ...

    Authors: Li-Li Liu, Dahu Li, Yun-Ling He, Yan-Zhao Zhou, Sheng-Hui Gong, Li-Ying Wu, Yong-Qi Zhao, Xin Huang, Tong Zhao, Lun Xu, Kui-Wu Wu, Ming-Gao Li, Ling-Ling Zhu and Ming Fan

    Citation: Molecular Medicine 2017 23:2301258

    Content type: Research Article

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  7. BD750, a novel JAK3/STAT5 inhibitor, can inhibit T cell proliferation. This study aims to evaluate whether BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune enc...

    Authors: Yan Zhou, Xiao Leng, Hua Li, Shuxia Yang, Tai Yang, Limei Li, Ying Xiong, Qiang Zou, Yang Liu and Yantang Wang

    Citation: Molecular Medicine 2017 23:2301204

    Content type: Research Article

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  8. Biobanks and national registries represent a powerful tool for genomic discovery, but rely on diagnostic codes that can be unreliable and fail to capture relationships between related diagnoses. We developed a...

    Authors: Thomas H. McCoy Jr, Victor M. Castro, Leslie A. Snapper, Kamber L. Hart and Roy H. Perlis

    Citation: Molecular Medicine 2017 23:2301285

    Content type: Research Article

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  9. Interleukin (IL)-26 is abundant in human airways and this cytokine is involved in the local immune response to a bacterial stimulus in vivo. Specifically, local exposure to the toll-like receptor (TLR) 4 agoni...

    Authors: Karlhans Fru Che, Riitta Kaarteenaho, Elisa Lappi-Blanco, Bettina Levänen, Jitong Sun, Åsa Wheelock, Lena Palmberg, C. Magnus Sköld and Anders Lindén

    Citation: Molecular Medicine 2017 23:2301247

    Content type: Research Article

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  10. Coiled-coil domain-containing 80 (CCDC80) is an adipocyte-secreted protein that modulates glucose homeostasis in response to diet-induced obesity in mice. The objective of this study was to analyze the link be...

    Authors: Óscar Osorio-Conles, María Guitart, José María Moreno-Navarrete, Xavier Escoté, Xavier Duran, José Manuel Fernandez-Real, Anna María Gómez-Foix, Sonia Fernández-Veledo and Joan Vendrell

    Citation: Molecular Medicine 2017 23:2301225

    Content type: Research Article

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  11. Adoptive immunotherapy with cytokine induced killer (CIK) cells has shown antitumor activity against several kinds of cancer in preclinical models and clinical trials. CIK cells are a subset of ex vivo expanded T...

    Authors: Giulia Mesiano, Roberta Zini, Giulia Montagner, Nicoletta Bianchi, Rossella Manfredini, Antonella Chillemi, Massimo Aglietta, Giovanni Grignani, Ilaria Lampronti, Erika Fiorino, Fabio Malavasi, Dario Sangiolo, Roberto Gambari and Davide Ferrari

    Citation: Molecular Medicine 2017 23:2301235

    Content type: Research Article

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  12. Heme oxygenase-1 (HO-1) is reported to protect against liver injury, but little Is known about its effect on the intestinal barrier in cholestatic liver injury. In this study, we investigated the effects of HO...

    Authors: Lijing Zhang, Zhenling Zhang, Bojia Liu, Yanling Jin, Yan Tian, Yi Xin and Zhijun Duan

    Citation: Molecular Medicine 2017 23:2301215

    Content type: Research Article

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  13. Histone modifications play a critical role In the pathological processes of dilated cardiomyopathy (DCM), while the role and expression pattern of histone methyltransferases (HMTs), especially mixed lineage le...

    Authors: Ding-Sheng Jiang, Xin Yi, Rui Li, Yun-Shu Su, Jing Wang, Min-Lai Chen, Li-Gang Liu, Min Hu, Cai Cheng, Ping Zheng, Xue-Hai Zhu and Xiang Wei

    Citation: Molecular Medicine 2017 23:2301196

    Content type: Research Article

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  14. Inflammation plays a significant role in protecting hosts against pathogens. Inflammation induced by noninfectious endogenous agents can be detrimental and, if excessive, can result in organ and tissue damage....

    Authors: Qian Sun, Jie Fan, Timothy R. Billiar and Melanie J. Scott

    Citation: Molecular Medicine 2017 23:2301188

    Content type: Research Article

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  15. More than 100 risk loci for rheumatoid arthritis (RA) have been identified in individuals of European and Asian descent, but the genetic basis for RA in African Americans is less well understood. We genotyped ...

    Authors: Maria I. Danila, Vincent A. Laufer, Richard J. Reynolds, Qi Yan, Nianjun Liu, Peter K. Gregersen, Annette Lee, Marlena Kern, Carl D. Langefeld, Donna K. Arnett and S. Louis Bridges Jr.

    Citation: Molecular Medicine 2017 23:2301177

    Content type: Research Article

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  16. Previously, we showed that an oligodeoxynucleotide (ODN) with AAAG repeats (AAAG ODN) rescued mice from fatal acute lung injury (ALI) induced by influenza virus and inhibited production of tumor necrosis facto...

    Authors: Yue Xiao, Wenting Lu, Xin Li, Peiyan Zhao, Yun Yao, Xiaohong Wang, Ying Wang, Zhipeng Lin, Yongli Yu, Shucheng Hua and Liying Wang

    Citation: Molecular Medicine 2017 23:2301166

    Content type: Research Article

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  17. Reperfusion injury following acute myocardial infarction is associated with significant morbidity. Activation of neuronal or non-neuronal cholinergic pathways in the heart has been shown to reduce ischemic inj...

    Authors: Spyros A. Mavropoulos, Nayaab S. Khan, Asaph C. J. Levy, Bradley T. Faliks, Cristina P. Sison, Valentin A. Pavlov, Youhua Zhang and Kaie Ojamaa

    Citation: Molecular Medicine 2017 23:2301120

    Content type: Research Article

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  18. Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the perijunctional actin-myosin ring. Myosin light chain kinase (MLCK) p...

    Authors: C. Adam Lorentz, Zhe Liang, Mei Meng, Ching-Wen Chen, Benyam P. Yoseph, Elise R. Breed, Rohit Mittal, Nathan J. Klingensmith, Alton B. Farris, Eileen M. Burd, Michael Koval, Mandy L. Ford and Craig M. Coopersmith

    Citation: Molecular Medicine 2017 23:2301155

    Content type: Research Article

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  19. Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have bee...

    Authors: Anju M. Philip, Youdong Wang, Antonio Mauro, Suzan El-Rass, John C. Marshall, Warren L. Lee, Arthur S. Slutsky, Claudia C. dos Santos and Xiao-Yan Wen

    Citation: Molecular Medicine 2017 23:2301134

    Content type: Research Article

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  20. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to...

    Authors: Paul Nurse

    Citation: Molecular Medicine 2017 23:2301112

    Content type: Anthony Cerami Award in Translational Medicine

    Published on:

  21. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer tumors. Comparisons between TNBC and non-triple-negative breast cancer (nTNBC) may help to differentiate key components involved i...

    Authors: Sandra K. Santuario-Facio, Servando Cardona-Huerta, Yadira X. Perez-Paramo, Victor Trevino, Francisco Hernandez-Cabrera, Augusto Rojas-Martinez, Grecia Uscanga-Perales, Jorge L. Martinez-Rodriguez, Lizeth Martinez-Jacobo, Gerardo Padilla-Rivas, Gerardo Muñoz-Maldonado, Juan Francisco Gonzalez-Guerrero, Javier Valero-Gomez, Ana L. Vazquez-Guerrero, Herminia G. Martinez-Rodriguez, Alvaro Barboza-Quintana…

    Citation: Molecular Medicine 2017 23:2301101

    Content type: Research Article

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  22. Congenital lipoid adrenal hyperplasia (CLAH) is the most severe form of congenital adrenal hyperplasia, caused by defects in the steroidogenic acute regulatory protein (STAR). The STAR p.Q258* mutation is the mos...

    Authors: Eungu Kang, Yoon-Myung Kim, Gu-Hwan Kim, Beom Hee Lee, Han-Wook Yoo and Jin-Ho Choi

    Citation: Molecular Medicine 2017 23:2301149

    Content type: Research Article

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  23. The microtubule inhibitor vincristine is currently used to treat a variety of brain tumors, including low-grade glioma and anaplastic oligodendroglioma. Vincristine, however, does not penetrate well into brain...

    Authors: Michelle De Witt, Alexander Gamble, Derek Hanson, Daniel Markowitz, Caitlin Powell, Saleh Al Dimassi, Mark Atlas, John Boockvar, Rosamaria Ruggieri and Marc Symons

    Citation: Molecular Medicine 2017 23:2301050

    Content type: Research Article

    Published on:

  24. Calcific aortic valve disease (CAVD) is common among the elderly, and aortic valve interstitial cells (AVICs) exhibit unique inflammatory and osteogenic responses to proinflammatory stimulation, which plays an...

    Authors: Qiong Zhan, Qingchun Zeng, Rui Song, Yufeng Zhai, Dingli Xu, David A. Fullerton, Charles A. Dinarello and Xianzhong Meng

    Citation: Molecular Medicine 2017 23:2301083

    Content type: Research Article

    Published on:

  25. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of ...

    Authors: Janin Henkel, Charles Dominic Coleman, Anne Schraplau, Korinna Jöhrens, Daniela Weber, José Pedro Castro, Martin Hugo, Tim Julius Schulz, Stephanie Krämer, Annette Schürmann and Gerhard Paul Püschel

    Citation: Molecular Medicine 2017 23:2301070

    Content type: Research Article

    Published on:

  26. Osteoporosis is a global public health problem affecting more than 200 million people worldwide. We previously showed that treatment with α-1 antitrypsin (AAT), a multifunctional protein with antiinflammatory ...

    Authors: Mohammad Ahsanul Akbar, David Nardo, Mong-Jen Chen, Ahmed S. Elshikha, Rubina Ahamed, Eslam M. Elsayed, Claire Bigot, L. Shannon Holliday and Sihong Song

    Citation: Molecular Medicine 2017 23:2301057

    Content type: Research Article

    Published on:

  27. The inflammatory pathways that drive the development of intimai hyperplasia (IH) following arterial injury are not fully understood. We hypothesized that the lysosomal cysteine protease cathepsin L activates p...

    Authors: Jingjing Cai, Hua Zhong, Jinze Wu, Rui-Fang Chen, Huan Yang, Yousef Al-Abed, Ying Li, Xiaohui Li, Weihong Jiang, Marcelo F. Montenegro, Hong Yuan, Timothy R. Billiar and Alex F. Chen

    Citation: Molecular Medicine 2017 23:2301092

    Content type: Research Article

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  28. α7 nicotinic acetylcholine receptor (α7 nAChR, coded by Chrna7) is indispensable in dampening proinflammatory responses. However, whether α7 nAChR plays a role in regulating bleomycin (BLM)-induced lung fibrosis ...

    Authors: Peiyu Sun, Ling Li, Caiqi Zhao, Mengyao Pan, Zhikang Qian and Xiao Su

    Citation: Molecular Medicine 2017 23:2301034

    Content type: Research Article

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  29. Pancreatic cancer is one of the most lethal solid malignancies, with few treatment options. We have recently shown that expression of protease activated receptor (PAR)-1 in the tumor microenvironment drives th...

    Authors: Kun Shi, Helene Damhofer, Joost Daalhuisen, Marieke ten Brink, Dick J. Richel and C. Arnold Spek

    Citation: Molecular Medicine 2017 23:2301013

    Content type: Research Article

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  30. miR-155 has been shown to participate in host response to infection and neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell function. We hypothesized that miR-155 may co...

    Authors: Kevin R. Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, Andrea L. Conroy, Michael Hawkes, Henry S. Cheng, Makon-Sébastien Njock, Jason E. Fish, John M. Harlan, Jose A. López, W. Conrad Liles and Kevin C. Kain

    Citation: Molecular Medicine 2017 23:2301024

    Content type: Research Article

    Published on:

  31. Amino acid replacement mutations in certain chronic lymphocytic leukemia (CLL) stereotyped B cell receptor (BCR) immunoglobulins (IGs) at defined positions within antigen-binding sites strongly imply antigen s...

    Authors: Rosa Catera, Yun Liu, Chao Gao, Xiao-Jie Yan, Amanda Magli, Steven L. Allen, Jonathan E. Kolitz, Kanti R. Rai, Charles C. Chu, Ten Feizi, Kostas Stamatopoulos and Nicholas Chiorazzi

    Citation: Molecular Medicine 2017 23:2301001

    Content type: Research Article

    Published on:

  32. Sepsis survivors suffer from additional morbidities, including higher risk of readmissions, nervous system disturbances and cognitive dysfunction, and increased mortality, even several years after the initial ...

    Authors: Naara Mendes Oliveira, Ester C S Rios, Thais Martins de Lima, Vanessa Jacob Victorino, Hermes Barbeiro, Fabiano Pinheiro da Silva, Csaba Szabo and Francisco Garcia Soriano

    Citation: Molecular Medicine 2016 22:2201886

    Content type: Research Article

    Published on:

  33. Strategies aimed at reducing cerebral accumulation of the amyloid-β (Aβ) peptides have therapeutic potential in Alzheimer’s disease (AD). Aβ immunization has proven to be effective at promoting Aβ clearance in...

    Authors: Valérie Vingtdeux, Haitian Zhao, Pallavi Chandakkar, Christopher M Acker, Peter Davies and Philippe Marambaud

    Citation: Molecular Medicine 2016 22:2201841

    Content type: Research Article

    Published on:

  34. The absence of early outcome biomarkers for pediatric acute liver failure (PALF) hinders medical and liver transplant decisions. We sought to define dynamic interactions among circulating inflammatory mediator...

    Authors: Ruben Zamora, Yoram Vodovotz, Qi Mi, Derek Barclay, Jinling Yin, Simon Horslen, David Rudnick, Kathleen M Loomes and Robert H Squires

    Citation: Molecular Medicine 2016 22:2201821

    Content type: Research Article

    Published on:

  35. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to...

    Authors: Tak Mak

    Citation: Molecular Medicine 2016 22:2201675

    Content type: Research Article

    Published on:

  36. Albert Dahan, Ann Dunne, Maarten Swartjes, Paolo L Proto, Lara Heij, Oscar Vogels, Monique van Velzen, Elise Sarton, Marieke Niesters, Martijn R Tannemaat, Anthony Cerami, and Michael Brines. (2013) ARA 290 Im...

    Authors: Albert Dahan, Ann Dunne, Maarten Swartjes, Paolo L. Proto, Lara Heij, Oscar Vogels, Monique van Velzen, Elise Sarton, Marieke Niesters, Martijn R. Tannemaat, Anthony Cerami and Michael Brines

    Citation: Molecular Medicine 2016 22:2201674

    Content type: Erratum

    Published on:

    The original article was published in Molecular Medicine 2013 19:Art43

  37. OBJECTIVE: In rheumatoid arthritis (RA) several recent efforts have sought to discover means of predicting which patients would benefit from treatment. However, results have been discrepant with few successful...

    Authors: Lasse Folkersen, Boel Brynedal, Lina Marcela Diaz-Gallo, Daniel Ramsköld, Klementy Shchetynsky, Helga Westerlind, Yvonne Sundström, Danika Schepis, Aase Hensvold, Nancy Vivar, Maija-Leena Eloranta, Lars Rönnblom, Søren Brunak, Vivianne Malmström, Anca Catrina, Ulrik G W Moerch…

    Citation: Molecular Medicine 2016 22:2201322

    Content type: Research Article

    Published on:

  39. During exercise, cardiac oxygen consumption increases and the resulting low oxygen level in the myocardium triggers coronary vasodilation. This response to hypoxia is controlled notably by the vasodilator aden...

    Authors: Jean Ruf, Franck Paganelli, Laurent Bonello, Nathalie Kipson, Giovanna Mottola, Julien Fromonot, Jocelyne Condo, Alain Boussuges, Laurie Bruzzese, François Kerbaul, Yves Jammes, Vlad Gariboldi, Frédéric Franceschi, Emmanuel Fenouillet and Régis Guieu

    Citation: Molecular Medicine 2016 22:2201530

    Content type: Research Article

    Published on:

  40. Although current vaccination strategies have been successful at preventing a variety of human diseases, attempts at vaccinating against some pathogens such as AIDS and tuberculosis (TB) have been more problema...

    Authors: Rui Li, Nan Zhang, Miaomiao Tian, Zihan Ran, Mingjun Zhu, Haiyan Zhu, Fangting Han, Juan Yin and Jiang Zhong

    Citation: Molecular Medicine 2016 22:2201497

    Content type: Research Article

    Published on:

  41. The ratio of the longer (Aβ42/Aβ43) to shorter (Aβ40) species is a critical factor determining amyloid fibril formation, neurotoxicity and progression of the amyloid pathology in Alzheimer’s disease. The relat...

    Authors: Katarzyna Marta Zoltowska, Masato Maesako and Oksana Berezovska

    Citation: Molecular Medicine 2016 22:2201329

    Content type: Research Article

    Published on:

  42. Previous in vivo work showed that resveratrol has beneficial effects in Alzheimer’s disease (AD) pathology, resulting in increased expression of transthyretin (TTR). TTR binds amyloid-beta (Aβ) peptide, avoiding ...

    Authors: Luís Miguel Santos, Daniela Rodrigues, Mobina Alemi, Sara Costa Silva, Carlos Alexandre Ribeiro and Isabel Cardoso

    Citation: Molecular Medicine 2016 22:2201597

    Content type: Research Article

    Published on:

  43. A 55–200 expansion of the CGG nucleotide repeat in the 5′-UTR of the fragile X mental retardation 1 gene (FMR1) is the hallmark of the triplet nucleotide disease known as the “premutation” as opposed to those ...

    Authors: Gyu Song, Eleonora Napoli, Sarah Wong, Randi Hagerman, Siming Liu, Flora Tassone and Cecilia Giulivi

    Citation: Molecular Medicine 2016 22:2201548

    Content type: Original Articles

    Published on:

  44. Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen in pneumonia associated with severe lung damage. Tissue injury causes release of damage-associated molecular patterns (DAMPs), which may...

    Authors: Anne Jan van der Meer, Achmed Achouiti, Arie van der Ende, Aicha Ait Soussan, Sandrine Florquin, Alex de Vos, Sacha S Zeerleder and Tom van der Poll

    Citation: Molecular Medicine 2016 22:2201292

    Content type: Research Article

    Published on:

  45. Acute emotionally reactive mental stress (MS) can provoke prognostically relevant deficits in cardiac function and myocardial perfusion, and chronic inflammation increases risk for this ischemic phenomenon. We...

    Authors: Robert Soufer, Antonio B Fernandez, Judith Meadows, Dorothea Collins and Matthew M Burg

    Citation: Molecular Medicine 2016 22:2201286

    Content type: Research Article

    Published on:

  46. The tumor-node-metastasis (TNM) system fails to accurately predict disease recurrence in a considerable number of patients. Although node-negative (stage II) colon cancer is considered to have an overall good ...

    Authors: Martin M Watson and Kjetil Søreide

    Citation: Molecular Medicine 2016 22:2201271

    Content type: Invited Commentary

    Published on:

  48. Emerging evidence demonstrates association of depression with both immune malfunctioning and worsened course of diverse aging-related diseases, but there is no explanation for the pathway(s) controlling this d...

    Authors: Shani Shenhar-Tsarfaty, Sharon Joker, Itzhak Shapira, Ori Rogowski, Shlomo Berliner, Yaacov Ritov and Hermona Soreq

    Citation: Molecular Medicine 2016 22:2201156

    Content type: Invited Research Article

    Published on:

  49. Endothelial cell (EC) dysfunction is a critical mediator of the acute respiratory distress syndrome (ARDS). Recent studies have demonstrated that stromal cell-derived factor 1α (SDF-1α) promotes EC barrier int...

    Authors: Changrun Guo, Andrew Goodwin, Joy N Jones Buie, James Cook, Perry Halushka, Kelley Argraves, Basilia Zingarelli, Xian Zhang, Liping Wang and Hongkuan Fan

    Citation: Molecular Medicine 2016 22:2201115

    Content type: Research Article

    Published on:

  50. Sepsis is a major healthcare concern, especially in the elderly population. The use of an animal model closely resembling clinical conditions in this population may provide a better prediction in translating b...

    Authors: Weng-Lang Yang, Gaifeng Ma, Mian Zhou, Monowar Aziz, Hao-Ting Yen, Spyros A Marvropoulos, Kaie Ojamaa and Ping Wang

    Citation: Molecular Medicine 2016 22:2201124

    Content type: Research Article

    Published on:

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Molecular Medicine

ISSN: 1528-3658