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  2. Diet-induced obesity can result in the development of a diverse spectrum of cardiovascular and metabolic diseases, including type 2 diabetes, dyslipidemia, non-alcoholic liver steatosis and atherosclerotic dis...

    Authors: Christian Smolka, Delia Schlösser, Catherine Hohnloser, Xavier Bemtgen, Caterina Jänich, Laura Schneider, Julien Martin, Dietmar Pfeifer, Martin Moser, Peter Hasselblatt, Christoph Bode, Sebastian Grundmann and Franziska Pankratz
    Citation: Molecular Medicine 2021 27:101
    Content type: Research article Published on:

  3. Oxidative stress is an important factor involved in the progress of heart failure. The current study was performed to investigate whether pinocembrin was able to ameliorate post-infarct heart failure (PIHF) an...

    Authors: Xiuhuan Chen, Weiguo Wan, Yan Guo, Tianxin Ye, Yuhong Fo, Yazhou Sun, Chuan Qu, Bo Yang and Cui Zhang
    Citation: Molecular Medicine 2021 27:100
    Content type: Research article Published on:

  4. We have found disruption of expression of major transcriptional regulators of circadian rhythm in the kidneys of several mouse models of lupus nephritis. Here we define the consequence of this disturbance with...

    Authors: Rakesh Mishra, Ramalingam Bethunaickan, Celine C. Berthier, Zhengzi Yi, Joshua J. Strohl, Patricio T. Huerta, Weijia Zhang and Anne Davidson
    Citation: Molecular Medicine 2021 27:99
    Content type: Research article Published on:

  5. Authors: Mao Wang, Alex G. Gauthier, Thomas P. Kennedy, Haichao Wang, Uday Kiran Velagapudi, Tanaji T. Talele, Mosi Lin, Jiaqi Wu, LeeAnne Daley, Xiaojing Yang, Vivek Patel, Sung Soo Mun, Charles R. Ashby Jr. and Lin L. Mantell
    Citation: Molecular Medicine 2021 27:98
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2021 27:79

  6. N-Acetylcysteine (NAC) demonstrates applications in the prevention of exacerbation of chronic obstructive pulmonary disease (COPD). COPD is often characterized by fibrosis of the small airways. This study aims .....

    Authors: Lanlan Zhu, Fei Xu, Xiuhua Kang, Jing Zhou, Qinqin Yao, Yang Lin and Wei Zhang
    Citation: Molecular Medicine 2021 27:97
    Content type: Research article Published on:

  7. Apoptosis of chondrocyte is involved in osteoarthritis (OA) pathogenesis, and mechanical stress plays a key role in this process by activation of Piezo1. However, the negative regulation of signal conduction m...

    Authors: Yi Sun, Ping Leng, Pengcheng Guo, Huanshen Gao, Yikai Liu, Chenkai Li, Zhenghui Li and Haining Zhang
    Citation: Molecular Medicine 2021 27:96
    Content type: Research article Published on:

  8. Long noncoding RNAs (lncRNAs), a type of pervasive genes that regulates various biological processes, are differentially expressed in different types of malignant tumors. The role of lncRNAs in the carcinogene...

    Authors: Jinglei Li, Hanxing Tong, Dongping Li, Qiuyu Jiang, Yong Zhang, Wenqing Tang, Dayong Jin, She Chen, Xinyu Qin, Si Zhang and Ruyi Xue
    Citation: Molecular Medicine 2021 27:95
    Content type: Research article Published on:

  9. Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), have a covalently closed circular structure resulting from pre-mRNA back splicing via spliceosome and ribozymes. They can be classified diffe...

    Authors: Mei Tao, Ming Zheng, Yanhua Xu, Shuo Ma, Weiwei Zhang and Shaoqing Ju
    Citation: Molecular Medicine 2021 27:94
    Content type: Review Published on:

  11. Nucleus pulposus cell (NPC) degeneration is widely accepted as one of the major causes of intervertebral disc (IVD) degeneration (IVDD). The pathogenesis of IVDD is complex and consists of inflammation, oxidat...

    Authors: Xiaoqiang Cheng, Jiayi Lin, Zhanghuan Chen, Yubo Mao, Xiexin Wu, Congxin Xu, Jiacheng Du, Zhongchen Dong, Huilin Yang, Feng Zhou and Dechun Geng
    Citation: Molecular Medicine 2021 27:92
    Content type: Research article Published on:

  12. Intervertebral disc degeneration (IVDD) is the breakdown of the discs supporting the vertebrae. It is one of the most frequent causes of back pain worldwide. Currently, the clinical interventions for IVDD are ...

    Authors: Xiaoqiu Yuan, Tiefeng Li, Lei Shi, Jinhao Miao, Yongfei Guo and Yu Chen
    Citation: Molecular Medicine 2021 27:91
    Content type: Research article Published on:

  13. It is known that increased gastrin concentration is negatively correlated with cardiovascular mortality, and plasma gastrin levels are increased in patients after myocardial infarction (MI). However, whether g...

    Authors: Jinjuan Fu, Yuanjuan Tang, Zhen Zhang, Lin Tong, Rongchuan Yue and Lin Cai
    Citation: Molecular Medicine 2021 27:90
    Content type: Research article Published on:

  15. Atherosclerosis is recognized as a chronic immuno-inflammatory disease that is characterized by the accumulation of immune cells and lipids in the vascular wall. In this review, we focus on the latest advance ...

    Authors: Jin-Wen Luo, Yuan Hu, Jian Liu, Huan Yang and Peng Huang
    Citation: Molecular Medicine 2021 27:88
    Content type: Review Published on:

  18. Tongue squamous cell carcinoma (TSCC) ranks as the most prevalent malignancy in the oral cavity. TSCC patients with occult lymph node metastasis (OLNM) are thought to be at risk of worse outcome. However, regu...

    Authors: Bo Zhou, Yue Zhou, Ying Liu, Hailin Zhang, Huangxing Mao, Mingjing Peng, Anji Xu, Zan Li, Hui Wang, Haolei Tan, Huayi Ren, Xiao Zhou and Ying Long
    Citation: Molecular Medicine 2021 27:85
    Content type: Research article Published on:

  19. Fetal docosahexaenoic acid (DHA) supply relies on preferential transplacental transfer, which is regulated by placental DHA lipid metabolism. Maternal hyperglycemia and obesity associate with higher birthweigh...

    Authors: Oliver C. Watkins, Preben Selvam, Reshma Appukuttan Pillai, Victoria K. B. Cracknell-Hazra, Hannah E. J. Yong, Neha Sharma, Amaury Cazenave-Gassiot, Anne K. Bendt, Keith M. Godfrey, Rohan M. Lewis, Markus R. Wenk and Shiao-Yng Chan
    Citation: Molecular Medicine 2021 27:84
    Content type: Research article Published on:

  20. Heterogeneity in colorectal cancer (CRC) patients provides novel strategies in clinical decision-making. Identifying distinctive subgroups in patients can improve the screening of CRC and reduce the cost of te...

    Authors: Yongqu Lu, Wendong Wang, Zhenzhen Liu, Junren Ma, Xin Zhou and Wei Fu
    Citation: Molecular Medicine 2021 27:83
    Content type: Research article Published on:

  21. Numerous studies have confirmed the correlation of microRNAs (miRNAs) with human disease, yet few have explored the role of miR-135 in preeclampsia (PE). This study intends to discuss miR-135’s function in inf...

    Authors: Xiaolan Zhao, Xun Zhang, Zhao Wu, Jie Mei, Lingling Li and Yujue Wang
    Citation: Molecular Medicine 2021 27:82
    Content type: Research article Published on:

  22. Fibrous dysplasia (FD) is a bone marrow stromal cell (BMSC) disease caused by activating mutations of guanine nucleotide-binding protein alpha-stimulating activity polypeptide (GNAS) and is characterized by in...

    Authors: Yu Fu, Zhili Xin, Ziji Ling, Hanyu Xie, Tao Xiao, Xin Shen, Jialin Lin, Ling Xu and Hongbing Jiang
    Citation: Molecular Medicine 2021 27:81
    Content type: Research article Published on:

  23. Osteoarthritis (OA) is the most common inflammatory disease associated with pain and cartilage destruction. Interleukin (IL)-1β is widely used to induce inflammatory response in OA models. This study aimed to ...

    Authors: Zhixian Xu, Tie Ke, Yongfa Zhang, Licheng Guo, Feng Chen and Wubing He
    Citation: Molecular Medicine 2021 27:80
    Content type: Research article Published on:

  24. High mobility group box 1 protein (HMGB1) is an alarmin following its release by immune cells upon cellular activation or stress. High levels of extracellular HMGB1 play a critical role in impairing the cleara...

    Authors: Mao Wang, Alex G. Gauthier, Thomas P. Kennedy, Haichao Wang, Uday Kiran Velagapudi, Tanaji T. Talele, Mosi Lin, Jiaqi Wu, LeeAnne Daley, Xiaojing Yang, Vivek Patel, Sung Soo Mun, Charles R. Ashby Jr. and Lin L. Mantell
    Citation: Molecular Medicine 2021 27:79
    Content type: Research article Published on:

    The Correction to this article has been published in Molecular Medicine 2021 27:98

  25. Extracellular vesicles (EVs) derived from tumor cells are implicated in the progression of malignancies through the transfer of molecular cargo microRNAs (miRNAs or miRs). We aimed to explore the role of EVs d...

    Authors: Chong Lu, Yu Zhao, Jing Wang, Wei Shi, Fang Dong, Yue Xin, Xiangwang Zhao and Chunping Liu
    Citation: Molecular Medicine 2021 27:78
    Content type: Research article Published on:

  26. Propofol, an intravenous anesthetic, was proven to protect against lung ischemia/reperfusion (I/R) injury. However, the detailed mechanism of Propofol in lung I/R injury is still elusive. This study was design...

    Authors: Jian-Ping Zhang, Wei-Jing Zhang, Miao Yang and Hua Fang
    Citation: Molecular Medicine 2021 27:77
    Content type: Research article Published on:

  27. Tuberculosis (TB) is an infectious disease. During TB, regulatory T cells (Treg) are related to poor prognosis. However, information about conventional and unconventional Treg (cTreg and uTreg, respectively) i...

    Authors: Norma A. Téllez-Navarrete, Lucero A. Ramon-Luing, Marcela Muñoz-Torrico, Mario Preciado-García, Karen Medina-Quero, Rogelio Hernandez-Pando and Leslie Chavez-Galan
    Citation: Molecular Medicine 2021 27:76
    Content type: Research article Published on:

  29. Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. The endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells has been reported to play a cruci...

    Authors: Lihong Lu, Ziwen Zhong, Jiahui Gu, Ke Nan, Minmin Zhu and Changhong Miao
    Citation: Molecular Medicine 2021 27:74
    Content type: Research article Published on:

  31. Although miR-125b plays a crucial role in many human cancers. However, its function in heart failure (HF) remains unclear. Our study aimed to investigate its involvement in heart failure.

    Authors: Bei Zhang, Shanyong Mao, Xingde Liu, Sha Li, Haiyan Zhou, Ying Gu, Wupeng Liu, Lei Fu, Chunyan Liao and Pengzhen Wang
    Citation: Molecular Medicine 2021 27:72
    Content type: Research article Published on:

  33. Maternally Expressed Gene 3 (MEG3) is expressed at low levels in placental villi during preeclampsia; however, its roles in unexplained recurrent spontaneous abortion (URSA) remain unclear. In this study, we aime...

    Authors: Jun Zhang, Xinqiong Liu and Yali Gao
    Citation: Molecular Medicine 2021 27:70
    Content type: Research article Published on:

  34. Several studies have reported that hypoxia plays a pathological role in severe asthma and tissue fibrosis. Our previous study showed that hypoxia induces A disintegrin and metalloproteinase 17 (ADAM17) express...

    Authors: Wun-Hao Cheng, Chia-Ling Chen, Jing-Yun Chen, Chien-Huang Lin and Bing-Chang Chen
    Citation: Molecular Medicine 2021 27:69
    Content type: Research article Published on:

  35. The aim of this study was to investigate the clinical value of liquid biopsy as a primary source for variant analysis in lung cancer. In addition, we sought to characterize liquid biopsy variants and to correl...

    Authors: Alvida Qvick, Bianca Stenmark, Jessica Carlsson, Johan Isaksson, Christina Karlsson and Gisela Helenius
    Citation: Molecular Medicine 2021 27:68
    Content type: Research article Published on:

  36. This study aimed to explore the role of mesenchymal stromal cells (MSCs)-derived exosomes (MSCs-Exo) in the cerebral ischemia–reperfusion (I/R) injury.

    Authors: Chang Cheng, Xiuying Chen, Yuhan Wang, Wenchao Cheng, Xuzheng Zuo, Weiju Tang and Wen Huang
    Citation: Molecular Medicine 2021 27:67
    Content type: Research article Published on:

  37. Previous studies showed that doxorubicin could lead to osteoarthritis (OA) by inducing chondrocyte inflammation and apoptosis. Besides, it is reported that platelet-rich plasma (PRP) could suppress the activat...

    Authors: Haijun Zhao, Weijie Zhu, Wude Mao and Chengkai Shen
    Citation: Molecular Medicine 2021 27:66
    Content type: Research article Published on:

  38. Bacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response.

    Authors: Ruben Zamora, Sangeeta Chavan, Theodoros Zanos, Richard L. Simmons, Timothy R. Billiar and Yoram Vodovotz
    Citation: Molecular Medicine 2021 27:65
    Content type: Research article Published on:

  39. The present study aimed to determine the functional role of miR-206 in T helper 17 (Th17)/regulatory T (Treg) cell differentiation during the development of osteoarthritis (OA).

    Authors: Xiguang Ye, Qilin Lu, Aofei Yang, Jun Rao, Wei Xie, Chengjian He, Weijun Wang, Hao Li and Zhiwen Zhang
    Citation: Molecular Medicine 2021 27:64
    Content type: Research article Published on:

  40. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine...

    Authors: Steven A. Rosenberg
    Citation: Molecular Medicine 2021 27:63
    Content type: Editorial Published on:

    The Correction to this article has been published in Molecular Medicine 2021 27:140

  41. Pancreatic adenocarcinoma (PAAD) is one of the most challenging cancers with high morbidity and mortality. KRAS mutations could occur as an early event in PAAD. The present study aimed to identify the differen...

    Authors: Chengming Tian, Xiyao Li and Chunlin Ge
    Citation: Molecular Medicine 2021 27:62
    Content type: Research article Published on:

  42. Systemic lupus erythematosus (SLE) is a representative systemic autoimmune disease. LncRNA H19 has been identified to participate in various biological processes in human diseases. However, the role of H19 in ...

    Authors: Xinpeng Chen, Xiuxia Luo, Yazhi Wei, Hualin Sun, Liping Dai, Yidou Tangzhou, Huijie Jin and Zhihua Yin
    Citation: Molecular Medicine 2021 27:61
    Content type: Research article Published on:

  43. Endocervical adenocarcinoma (ECA) is further classified as human papillomavirus (HPV)-associated (HPVA) or non-HPVA (NHPVA), per the International Endocervical Adenocarcinoma Criteria and Classification (IECC)...

    Authors: Yan-Lin Wen, Shu-Mei Yan, Wei Wei, Xia Yang, Shi-Wen Zhang, Jing-Ping Yun, Li-Li Liu and Rong-Zhen Luo
    Citation: Molecular Medicine 2021 27:60
    Content type: Research article Published on:

  44. During sepsis or sterile tissue injury, the nuclear protein high mobility group box 1 (HMGB1) can be released to the extracellular space and ultimately into systemic circulation, where it mediates systemic inf...

    Authors: Takaaki Totoki, Takashi Ito, Shingo Yamada, Goichi Honda, Tsuyoshi Hattori and Ikuro Maruyama
    Citation: Molecular Medicine 2021 27:59
    Content type: Research article Published on:

  45. High mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine activity. It is passively released during cell death and secreted by activated cells of many lineages. HMGB1 cont...

    Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson and Kevin J. Tracey
    Citation: Molecular Medicine 2021 27:58
    Content type: Research article Published on:

  46. Acetaminophen (APAP) overdose causes hepatotoxicity and even acute liver failure. Recent studies indicate that sterile inflammation and innate immune cells may play important roles in damage-induced hepatocyte...

    Authors: Chen Zhang, Xiao Shi, Zhongping Su, Chao Hu, Xianmin Mu, Jinshun Pan, Mengjing Li, Fengmeng Teng, Tao Ling, Ting Zhao, Che Xu, Guozhong Ji and Qiang You
    Citation: Molecular Medicine 2021 27:57
    Content type: Research article Published on:

  47. Hyaluronan (HA) metabolism by chondrocytes is important for cartilage development and homeostasis. However, information about the function of circular RNAs (circRNAs) in HA metabolism is limited. We therefore ...

    Authors: Hong-Xing Liao, Zhi-Hui Zhang, Hui-Lin Chen, Ying-Mei Huang, Zhan-Liang Liu and Jian Huang
    Citation: Molecular Medicine 2021 27:56
    Content type: Research article Published on:

  48. Sepsis is a life-threatening disease syndrome caused by a dysregulated host response to infection and injury. Extracellular cold-inducible RNA-binding protein (eCIRP) acts as a damage-associated molecular patt...

    Authors: William Royster, Hui Jin, Ping Wang and Monowar Aziz
    Citation: Molecular Medicine 2021 27:55
    Content type: Research article Published on:

  50. Chronic obstructive pulmonary disease (COPD) is characterized by airway obstruction and progressive lung inflammation. As the primary ingredient of a traditional Chinese medical herb, Baicalin has been previou...

    Authors: Dexun Hao, Yanshuang Li, Jiang Shi and Junguang Jiang
    Citation: Molecular Medicine 2021 27:53
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658