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  1. It has been demonstrated recently that coagulation factor XIII (FXIII) plays an extraordinary role in myocardial healing after infarction, improving survival in a mouse model. Common FXIII gene variants (i.e. ...

    Authors: Donato Gemmati, Federica Federici, Gianluca Campo, Silvia Tognazzo, Maria L. Serino, Monica De Mattei, Marco Valgimigli, Patrizia Malagutti, Gabriele Guardigli, Paolo Ferraresi, Francesco Bernardi, Roberto Ferrari, Gian L. Scapoli and Linda Catozzi
    Citation: Molecular Medicine 2007 13:1301112
    Content type: Research Article Published on:

  2. Several markers have been used to detect circulating tumor cells (CTC) in the peripheral blood of patients with breast cancer. However, analysis of activated signaling kinases in CTC implicated in cellular tra...

    Authors: Galatea Kallergi, Dimitris Mavroudis, Vassilis Georgoulias and Christos Stournaras
    Citation: Molecular Medicine 2007 13:1301079
    Content type: Research Article Published on:

  3. Diindolylmethane (DIM), a biologically active congener of indole-3-carbinol (I3C) derived from cruciferous vegetables, is a promising agent for the prevention of estrogen-sensitive cancers. Both DIM and estrog...

    Authors: Laura Mulvey, Alamelu Chandrasekaran, Kai Liu, Sarah Lombardi, Xue-Ping Wang, Karen J. Auborn and Leslie Goodwin
    Citation: Molecular Medicine 2007 13:1301069
    Content type: Research Article Published on:

  4. Recent studies have shown increased expression of interferon (IFN)-regulated genes in the peripheral blood cells of patients with systemic lupus erythematosus. A similar interferon signature has been observed ...

    Authors: Emily C. Baechler, Jason W. Bauer, Catherine A. Slattery, Ward A. Ortmann, Karl J. Espe, Jill Novitzke, Steven R. Ytterberg, Peter K. Gregersen, Timothy W. Behrens and Ann M. Reed
    Citation: Molecular Medicine 2007 13:1301059
    Content type: Research Article Published on:

  5. Rheumatoid arthritis (RA) is a chronic inflammatory arthritis. Currently, diagnosis of RA may take several weeks, and factors used to predict a poor prognosis are not always reliable. Gene expression in RA may...

    Authors: Christopher J. Edwards, Jeffrey L. Feldman, Jonathan Beech, Kathleen M. Shields, Jennifer A. Stover, William L. Trepicchio, Glenn Larsen, Brian M. J. Foxwell, Fionula M. Brennan, Marc Feldmann and Debra D. Pittman
    Citation: Molecular Medicine 2007 13:1301040
    Content type: Research Article Published on:

  6. Patients with temporal lobe epilepsy (TLE) often have a shrunken hippocampus that is known to be the location in which seizures originate. The role of the sclerotic hippocampus in the causation and maintenance...

    Authors: Tih-Shih Lee, Shrikant Mane, Tore Eid, Hongyu Zhao, Aiping Lin, Zhong Guan, Jung H. Kim, Jeffrey Schweitzer, David King-Stevens, Peter Weber, Susan S. Spencer, Dennis D. Spencer and Nihal C. de Lanerolle
    Citation: Molecular Medicine 2007 13:1301001
    Content type: Research Article Published on:

  7. The cytochrome P-450 (CYP) isoenzymes, a superfamily of heme proteins which are the terminal oxidases of the mixed function oxidases system, metabolize more than 70% of all clinically approved drugs. The highl...

    Authors: Jimena V. Lavandera, Victoria E. Parera, Alcira Batlle and Ana María Buzaleh
    Citation: Molecular Medicine 2006 12:1209259
    Content type: Research Article Published on:

  8. Multiple older studies report that immunoglobulin directed to rough mutant bacteria, such as E. coli J5, provides broad protection against challenge with heterologous strains of Gram-negative bacteria. This prote...

    Authors: Catherine H. Valentine, Judith Hellman, Laura K. Beasley-Topliffe, Aranya Bagchi and H. Shaw Warren
    Citation: Molecular Medicine 2006 12:1209252
    Content type: Research Article Published on:

  9. Lesch-Nyhan syndrome (LNS) is an X-linked genetic disorder resulting in hyperuricemia, choreoathetosis, mental retardation, and self-injurious behavior. It is caused by loss of activity of the ubiquitous enzym...

    Authors: Cristina Lapucci, Diego Pomarè Montin, Massimo Pandolfo and Matteo Bertelli
    Citation: Molecular Medicine 2006 12:1209246
    Content type: Research Article Published on:

  10. During embryogenesis, a complex interplay between extracellular matrix (ECM) molecules, regulatory molecules, and growth factors mediates morphogenetic processes involved in palatogenesis. Transforming growth ...

    Authors: Tiziano Baroni, Catia Bellucci, Cinzia Lilli, Furio Pezzetti, Francesco Carinci, Ennio Becchetti, Paolo Carinci, Giordano Stabellini, Mario Calvitti, Eleonora Lumare and Maria Bodo
    Citation: Molecular Medicine 2006 12:1209237
    Content type: Research Article Published on:

  11. A new chimeric IgG1 antibody hCAb which could be specifically directed against a cell surface-associated glycoprotein of colorectal cancer cells was prepared by genetic engineering technology in our lab. In th...

    Authors: Hua Xiong, Ling Li, Qin-Chuan Liang, Hui-Jie Bian, Juan Tang, Qin Zhang, Li Mi and Zhi-Nan Chen
    Citation: Molecular Medicine 2006 12:1209229
    Content type: Research Article Published on:

  12. Reactive free radical and oxidant production leads to DNA damage during myocardial Ischemia/reperfusion. Consequent overactivation of poly(ADP-ribose) polymerase (PARP) promotes cellular energy deficit and nec...

    Authors: Emese Tóth-Zsámboki, Eszter Horváth, Katarina Vargova, Eszter Pankotai, Kanneganti Murthy, Zsuzsanna Zsengellér, Tamás Bárány, Tamás Pék, Katalin Fekete, Róbert Gábor Kiss, István Préda, Zsombor Lacza, Domokos Gerö and Csaba Szabó
    Citation: Molecular Medicine 2006 12:1209221
    Content type: Research Article Published on:

  13. Our previous study showed that CD151 promotes neovascularization and improves blood perfusion in a rat hindlimb ischemia model. In this study, we investigated whether CD151 promotes neovascularization and impr...

    Authors: Zhenzhong Zheng and Zhengxiang Liu
    Citation: Molecular Medicine 2006 12:1209214
    Content type: Research Article Published on:

  14. Chemokines activate and recruit specific leukocyte subpopulations. We sought to determine whether neutrophil migration, which can contribute to the development of ischemia-reperfusion injury, correlates with l...

    Authors: Shin Hirayama, Takeshi Shiraishi, Takayuki Shirakusa, Takao Higuchi and Edmund J. Miller
    Citation: Molecular Medicine 2006 12:1209208
    Content type: Research Article Published on:

  15. The adenoviral transfer of therapeutic genes into epidermal and dermal cells is an interesting approach to treat skin diseases and to promote wound healing. The aim of this study was to assess the in vitro and...

    Authors: Tobias Hirsch, Sebastian von Peter, Grzegorz Dubin, Dominik Mittler, Frank Jacobsen, Markus Lehnhardt, Elof Eriksson, Hans-Ulrich Steinau and Lars Steinstraesser
    Citation: Molecular Medicine 2006 12:1209199
    Content type: Research Article Published on:

  16. Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Liver transplantation (LT) represents a curative treatment for “small” HCC. Preoperative staging is critical in selecting optimal ca...

    Authors: Valeria R. Mas, Daniel G. Maluf, Kellie J. Archer, Kenneth Yanek, Bridgette Williams and Robert A. Fisher
    Citation: Molecular Medicine 2006 12:12040097
    Content type: Research Article Published on:

  17. Gamma knife radiosurgery is an attractive noninvasive treatment of brain tumors and vascular malformations that minimizes collateral tissue damage. However, exposure of normal tissue to even low-dose radiation...

    Authors: Serhat Erbayraktar, Nihal de Lanerolle, Alain de Lotbinière, Jonathan P. S. Knisely, Zubeyde Erbayraktar, Osman Yilmaz, Anthony Cerami, Thomas R. Coleman and Michael Brines
    Citation: Molecular Medicine 2006 12:12040074
    Content type: Research Article Published on:

  18. ADAMs (a disintegrin and metalloprotease) constitute a family of cell surface proteins containing disintegrin and metalloprotease domains which associate features of adhesion molecules and proteases. ADAMTSs (a d

    Authors: Geneviève Paulissen, Natacha Rocks, Florence Quesada-Calvo, Philippe Gosset, Jean-Michel Foidart, Agnès Noel, Renaud Louis and Didier D. Cataldo
    Citation: Molecular Medicine 2006 12:1207171
    Content type: Research Article Published on:

  19. The use of quantitative gene expression analysis for the diagnosis, prognosis, and monitoring of disease requires the ability to distinguish pathophysiological changes from natural variations. To characterize ...

    Authors: Kevin McLoughlin, Ken Turteltaub, Danute Bankaitis-Davis, Richard Gerren, Lisa Siconolfi, Kathleen Storm, John Cheronis, David Trollinger, Dennis Macejak, Victor Tryon and Michael Bevilacqua
    Citation: Molecular Medicine 2006 12:1207185
    Content type: Research Article Published on:

  20. Advanced glycation end products (AGEs) are senescent macroprotein derivatives that are formed at an accelerated rate in patients with chronic renal failure (CRF). AGE formation and accumulation in plasma and v...

    Authors: Seiji Ueda, Sho-ichi Yamagishi, Masayoshi Takeuchi, Keisuke Kohno, Ryo Shibata, Yuriko Matsumoto, Utako Kaneyuki, Toshiko Fujimura, Ayako Hayashida and Seiya Okuda
    Citation: Molecular Medicine 2006 12:1207180
    Content type: Research Article Published on:

  21. The brain is a common metastatic site for various types of cancers, especially lung cancer. Patients with brain metastases have a poor prognosis in spite of radiotherapy and/or chemotherapy. It is postulated t...

    Authors: Bei Ping He, Jian Jun Wang, Xian Zhang, Yan Wu, Miao Wang, Boon-Huat Bay and Alex Yuang-Chi Chang
    Citation: Molecular Medicine 2006 12:1207161
    Content type: Research Article Published on:

  22. Chronic treatment with asialo erythropoietin (ASIALO-EPO) or carbamylated erythropoietin (CEPO) improved motor behavior and reduced motoneuron loss and astrocyte and microglia activation in the cervical spinal...

    Authors: Tiziana Mennini, Massimiliano De Paola, Paolo Bigini, Cristina Mastrotto, Elena Fumagalli, Sara Barbera, Manuela Mengozzi, Barbara Viviani, Emanuela Corsini, Marina Marinovich, Lars Torup, Johan Van Beek, Marcel Leist, Michael Brines, Antony Cerami and Pietro Ghezzi
    Citation: Molecular Medicine 2006 12:1207153
    Content type: Research Article Published on:

  23. Poly(ADP-ribose) polymerase (PARP) activation has been implicated in the pathogenesis of acute and chronic myocardial dysfunction and heart failure. The goal of the present study was to investigate PARP activa...

    Authors: Andrea Molnár, Attila Tóth, Zsolt Bagi, Zoltán Papp, István Édes, Miklós Vaszily, Zoltán Galajda, Julius Gy. Papp, András Varró, Viktória Szüts, Zsombor Lacza, Domokos Gerö and Csaba Szabó
    Citation: Molecular Medicine 2006 12:1207143
    Content type: Research Article Published on:

  24. Missense mutations reduce protein levels through several molecular mechanisms. Among them, altered targeting to endoplasmic reticulum (ER) and its relationship with clinical phenotypes in patients have been po...

    Authors: Lara Rizzotto, Mirko Pinotti, Paolo Pinton, Rosario Rizzuto and Francesco Bernardi
    Citation: Molecular Medicine 2006 12:1207137
    Content type: Research Article Published on:

  25. Vascular endothelial growth factor (VEGF) plays an important role in normal and pathological angiogenesis. VEGF receptors (VEGFRs, including VEGFR-1, VEGFR-2, and VEGFR-3) and neuropilins (NRPs, including NRP-...

    Authors: Xiao-Yong Man, Xiao-Hong Yang, Sui-Qing Cai, Yong-Gang Yao and Min Zheng
    Citation: Molecular Medicine 2006 12:1207127
    Content type: Research Article Published on:

  26. Hepatitis B virus (HBV) is one of the major etiological factors responsible for the development of hepatocellular carcinoma (HCC). We used a transgenic mouse, containing HBV sequences, as a model system to unr...

    Authors: Michele Barone, Daniela Spano, Maria D’Apolito, Marta Centra, Carla Lasalandra, Mario Capasso, Alfredo Di Leo, Stefano Volinia, Diego Arcelli, Natalia Rosso, Antonio Franavilla, Claudio Tiribelli and Achille Iolascon
    Citation: Molecular Medicine 2006 12:12040115
    Content type: Research Article Published on:

  27. Intestinal barrier dysfunction occurs following hemorrhagic shock and resuscitation (HS/R). High-mobility group B1 (HMGB1) has been shown to increase the permeability of Caco-2 human enterocyte-like epithelial...

    Authors: Runkuan Yang, Tomoyuki Harada, Kevin P. Mollen, Jose M. Prince, Ryan M. Levy, Joshua A. Englert, Margot Gallowitsch-Puerta, LiHong Yang, Huan Yang, Kevin J. Tracey, Brian G. Harbrecht, Timothy R. Billiar and Mitchell P. Fink
    Citation: Molecular Medicine 2006 12:12040105
    Content type: Research Article Published on:

  28. The inflammatory phenotype of genetically modified mice is complex, and the role of Gram-negative lipopolysaccharide (LPS) In acute inflammation induced by surgical cannulation trauma, alone or in combination ...

    Authors: Jose M. Prince, Ryan M. Levy, John Bartels, Arie Baratt, John M. Kane III, Claudio Lagoa, Jonathan Rubin, Judy Day, Joyce Wei, Mitchell P. Fink, Sanna M. Goyert, Gilles Clermont, Timothy R. Billiar and Yoram Vodovotz
    Citation: Molecular Medicine 2006 12:12040088
    Content type: Research Article Published on:

  29. Hepatocellular carcinoma (HCC), one of the most common and malignant tumors worldwide, is unresponsive to any of the available therapies. Using intact HCC cells as therapeutic targets, we isolated a novel pept...

    Authors: Yong-Qiang Jiang, Hai-Rong Wang, Han-Ping Li, Huai-Jie Hao, Yu-Ling Zheng and Jun Gu
    Citation: Molecular Medicine 2006 12:12040081
    Content type: Research Article Published on:

  30. Hypoxia produces sex dimorphic immune responses in males and proestrus females. Because Kupffer cells are the major source of proinflammatory cytokines, studies were conducted to discern IL-6 production in mou...

    Authors: Rui Zheng, George Pan, Bjoern M. Thobe, Mashkoor A. Choudhry, Takeshi Matsutani, T. S. Anantha Samy, Shih-Ching Kang, Kirby I. Bland and Irshad H. Chaudry
    Citation: Molecular Medicine 2006 12:12040065
    Content type: Research Article Published on:

  31. Hepatitis C virus (HCV) core protein features many intriguing properties and plays a pivotal role in cellular immunity, cell growth, apoptosis, cell transformation, and eventually in tumor development. However...

    Authors: Chuan-ging Wu, Anuradha Budhu, Sheng Chen, Xiaoling Zhou, Nicholas C. Popescu, Kristoffer Valerie and Xin Wei Wang
    Citation: Molecular Medicine 2006 12:12010047
    Content type: Research Article Published on:

  32. Embryonic stem (ES) cells have been investigated in repair of the CNS following neuronal injury and disease; however, the efficacy of these cells in treatment of postinjury pain is far from clear. In this stud...

    Authors: Wesley A. Hendricks, Elena S. Pak, J. Paul Owensby, Kristie J. Menta, Margarita Glazova, Justin Moretto, Sarah Hollis, Kori L. Brewer and Alexander K. Murashov
    Citation: Molecular Medicine 2006 12:12010034
    Content type: Research Article Published on:

  33. Discovering molecular heterogeneities in phenotypically defined disease is of critical importance both for understanding pathogenic mechanisms of complex diseases and for finding efficient treatments. Recently...

    Authors: Jian-zhen Xu, Zheng Guo, Min Zhang, Xia Li, Yong-jin Li and Shao-qi Rao
    Citation: Molecular Medicine 2006 12:12010025
    Content type: Research Article Published on:

  34. The binding of sphingoid bases to peroxisome proliferator-activated receptor (PPAR) has been detected in a solid-phase binding assay. However, sphingoid base-induced changes in PPAR transactivation activity ha...

    Authors: Sujong Kim, Il Hong, Jung Sun Hwang, Jin Kyu Choi, Ho Sik Rho, Duck Hee Kim, Ihseop Chang, Seung Hun Lee, Mi-Ock Lee and Jae Sung Hwang
    Citation: Molecular Medicine 2006 12:12010017
    Content type: Research Article Published on:

  35. The Tie receptors (Tie-1 and Tie-2/Tek) are essential for angiogenesis and vascular remodeling/integrity. Tie receptors are up-regulated in tumor-associated endothelium, and their inhibition disrupts angiogene...

    Authors: Peter W. Hewett, Emma L. Daft, Charles A. Laughton, Shakil Ahmad, Asif Ahmed and J. Clifford Murray
    Citation: Molecular Medicine 2006 12:12010008
    Content type: Research Article Published on:

  36. Matriptase is a type II transmembrane serine protease expressed in most human epithelia, where it is coexpressed with its cognate transmembrane inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1. ...

    Authors: Karin List, Thomas H. Bugge and Roman Szabo
    Citation: Molecular Medicine 2006 12:12010001
    Content type: Research Article Published on:

  37. Indole-3-carbinol (I3C) is a phytochemical (derived from broccoli, cabbage, and other cruciferous vegetables) with proven anticancer efficacy including the reduction of cervical intraepithelial neoplasia (CIN)...

    Authors: Mei Qi, Ann E. Anderson, Da-Zhi Chen, Shishinn Sun and Karen J. Auborn
    Citation: Molecular Medicine 2006 11:1101059
    Content type: Articles Published on:

  38. Immunoglobulin κ (IGK) locus rearrangements were analyzed in parallel on cDNA/genomic DNA in 188 κ- and 103 λ-chronic lymphocytic leukemia (CLL) cases. IGKV-KDE and IGKJ-C-intron-KDE rearrangements were also a...

    Authors: Chrysoula Belessi, Kostas Stamatopoulos, Anastasia Hadzidimitriou, Katerina Hatzi, Tatjana Smilevska, Niki Stavroyianni, Fotini Marantidou, George Paterakis, Athanasios Fassas, Achilles Anagnostopoulos and Nikolaos Laoutaris
    Citation: Molecular Medicine 2006 11:1101052
    Content type: Articles Published on:

  39. We characterized the effect of chronic ochratoxin A (OTA) on rat kidney cortex, analyzing collagen content and collagen turnover and the major markers of epithelial-to-mesenchymal transition (EMT), such as α-s...

    Authors: Nicoletta Gagliano, Carlo Torri, Elena Donetti, Fabio Grizzi, Francesco Costa, Alberto A E Bertelli, Massimiliano Migliori, Cristina Filippi, Marzia Bedoni, Vincenzo Panichi, Luca Giovannini and Magda Gioia
    Citation: Molecular Medicine 2006 11:1101030
    Content type: Articles Published on:

  40. Psoriatic arthritis (PsA) is a chronic and erosive form of arthritis of unknown cause. We aimed to characterize the PsA phenotype using gene expression profiling and comparing it with healthy control subjects ...

    Authors: Franak M. Batliwalla, Wentian Li, Christopher T. Ritchlin, Xiangli Xiao, Max Brenner, Teresina Laragione, Tianmeng Shao, Robert Durham, Sunil Kemshetti, Edward Schwarz, Rodney Coe, Marlena Kern, Emily C. Baechler, Timothy W. Behrens, Peter K. Gregersen and Pércio S. Gulko
    Citation: Molecular Medicine 2006 11:1101021
    Content type: Articles Published on:

  41. Simian virus SV40, an oncogenic virus in rodents, was accidentally transmitted to humans through the Poliovirus vaccine during the years 1955 to 1963. If the vaccination program were the major source of human ...

    Authors: Valentina Paracchini, Seymour Garte, Paola Pedotti, Francesca Poli, Sara Frison and Emanuela Taioli
    Citation: Molecular Medicine 2006 11:1101048
    Content type: Articles Published on:

  42. Obesity is an important risk factor for heart disease, diabetes, and certain cancers, but the molecular basis for obesity is poorly understood. The transcriptional repressor AEBP1, which functions as a negativ...

    Authors: Lei Zhang, Shannon P Reidy, Tara E Nicholson, Hyun-Jeong Lee, Amin Majdalawieh, Chris Webber, Bruce R Stewart, Peter Dolphin and Hyo-Sung Ro
    Citation: Molecular Medicine 2006 11:1101039
    Content type: Articles Published on:

  43. Several chemokines or chemokine receptors are involved in atherogenesis. CCR1 is expressed by macrophages and lymphocytes, two major cell types involved in the progression of atherosclerosis, and binds to lesi...

    Authors: Stéphane Potteaux, Christophe Combadière, Bruno Esposito, Saveria Casanova, Régine Merval, Patrice Ardouin, Ji-Liang Gao, Philip M Murphy, Alain Tedgui and Ziad Mallat
    Citation: Molecular Medicine 2006 11:1101016
    Content type: Articles Published on:

  44. We studied inhibition of histone deacetylases (HDACs), which results in the unraveling of chromatin, facilitating increased gene expression. ITF2357, an orally active, synthetic inhibitor of HDACs, was evaluat...

    Authors: Flavio Leoni, Gianluca Fossati, Eli C Lewis, Jae-Kwon Lee, Giulia Porro, Paolo Pagani, Daniela Modena, Maria Lusia Moras, Pietro Pozzi, Leonid L Reznikov, Britta Siegmund, Giamila Fantuzzi, Charles A Dinarello and Paolo Mascagni
    Citation: Molecular Medicine 2006 11:1101001
    Content type: Articles Published on:
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Molecular Medicine

ISSN: 1528-3658