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  1. Tongue squamous cell carcinoma (TSCC) ranks as the most prevalent malignancy in the oral cavity. TSCC patients with occult lymph node metastasis (OLNM) are thought to be at risk of worse outcome. However, regu...

    Authors: Bo Zhou, Yue Zhou, Ying Liu, Hailin Zhang, Huangxing Mao, Mingjing Peng, Anji Xu, Zan Li, Hui Wang, Haolei Tan, Huayi Ren, Xiao Zhou and Ying Long
    Citation: Molecular Medicine 2021 27:85
  2. Heterogeneity in colorectal cancer (CRC) patients provides novel strategies in clinical decision-making. Identifying distinctive subgroups in patients can improve the screening of CRC and reduce the cost of te...

    Authors: Yongqu Lu, Wendong Wang, Zhenzhen Liu, Junren Ma, Xin Zhou and Wei Fu
    Citation: Molecular Medicine 2021 27:83
  3. Numerous studies have confirmed the correlation of microRNAs (miRNAs) with human disease, yet few have explored the role of miR-135 in preeclampsia (PE). This study intends to discuss miR-135’s function in inf...

    Authors: Xiaolan Zhao, Xun Zhang, Zhao Wu, Jie Mei, Lingling Li and Yujue Wang
    Citation: Molecular Medicine 2021 27:82
  4. Fibrous dysplasia (FD) is a bone marrow stromal cell (BMSC) disease caused by activating mutations of guanine nucleotide-binding protein alpha-stimulating activity polypeptide (GNAS) and is characterized by in...

    Authors: Yu Fu, Zhili Xin, Ziji Ling, Hanyu Xie, Tao Xiao, Xin Shen, Jialin Lin, Ling Xu and Hongbing Jiang
    Citation: Molecular Medicine 2021 27:81
  5. Osteoarthritis (OA) is the most common inflammatory disease associated with pain and cartilage destruction. Interleukin (IL)-1β is widely used to induce inflammatory response in OA models. This study aimed to ...

    Authors: Zhixian Xu, Tie Ke, Yongfa Zhang, Licheng Guo, Feng Chen and Wubing He
    Citation: Molecular Medicine 2021 27:80
  6. High mobility group box 1 protein (HMGB1) is an alarmin following its release by immune cells upon cellular activation or stress. High levels of extracellular HMGB1 play a critical role in impairing the cleara...

    Authors: Mao Wang, Alex G. Gauthier, Thomas P. Kennedy, Haichao Wang, Uday Kiran Velagapudi, Tanaji T. Talele, Mosi Lin, Jiaqi Wu, LeeAnne Daley, Xiaojing Yang, Vivek Patel, Sung Soo Mun, Charles R. Ashby Jr. and Lin L. Mantell
    Citation: Molecular Medicine 2021 27:79

    The Correction to this article has been published in Molecular Medicine 2021 27:98

  7. Extracellular vesicles (EVs) derived from tumor cells are implicated in the progression of malignancies through the transfer of molecular cargo microRNAs (miRNAs or miRs). We aimed to explore the role of EVs d...

    Authors: Chong Lu, Yu Zhao, Jing Wang, Wei Shi, Fang Dong, Yue Xin, Xiangwang Zhao and Chunping Liu
    Citation: Molecular Medicine 2021 27:78
  8. Propofol, an intravenous anesthetic, was proven to protect against lung ischemia/reperfusion (I/R) injury. However, the detailed mechanism of Propofol in lung I/R injury is still elusive. This study was design...

    Authors: Jian-Ping Zhang, Wei-Jing Zhang, Miao Yang and Hua Fang
    Citation: Molecular Medicine 2021 27:77
  9. Tuberculosis (TB) is an infectious disease. During TB, regulatory T cells (Treg) are related to poor prognosis. However, information about conventional and unconventional Treg (cTreg and uTreg, respectively) i...

    Authors: Norma A. Téllez-Navarrete, Lucero A. Ramon-Luing, Marcela Muñoz-Torrico, Mario Preciado-García, Karen Medina-Quero, Rogelio Hernandez-Pando and Leslie Chavez-Galan
    Citation: Molecular Medicine 2021 27:76
  10. Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. The endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells has been reported to play a cruci...

    Authors: Lihong Lu, Ziwen Zhong, Jiahui Gu, Ke Nan, Minmin Zhu and Changhong Miao
    Citation: Molecular Medicine 2021 27:74
  11. Although miR-125b plays a crucial role in many human cancers. However, its function in heart failure (HF) remains unclear. Our study aimed to investigate its involvement in heart failure.

    Authors: Bei Zhang, Shanyong Mao, Xingde Liu, Sha Li, Haiyan Zhou, Ying Gu, Wupeng Liu, Lei Fu, Chunyan Liao and Pengzhen Wang
    Citation: Molecular Medicine 2021 27:72
  12. Maternally Expressed Gene 3 (MEG3) is expressed at low levels in placental villi during preeclampsia; however, its roles in unexplained recurrent spontaneous abortion (URSA) remain unclear. In this study, we aime...

    Authors: Jun Zhang, Xinqiong Liu and Yali Gao
    Citation: Molecular Medicine 2021 27:70
  13. Several studies have reported that hypoxia plays a pathological role in severe asthma and tissue fibrosis. Our previous study showed that hypoxia induces A disintegrin and metalloproteinase 17 (ADAM17) express...

    Authors: Wun-Hao Cheng, Chia-Ling Chen, Jing-Yun Chen, Chien-Huang Lin and Bing-Chang Chen
    Citation: Molecular Medicine 2021 27:69
  14. The aim of this study was to investigate the clinical value of liquid biopsy as a primary source for variant analysis in lung cancer. In addition, we sought to characterize liquid biopsy variants and to correl...

    Authors: Alvida Qvick, Bianca Stenmark, Jessica Carlsson, Johan Isaksson, Christina Karlsson and Gisela Helenius
    Citation: Molecular Medicine 2021 27:68
  15. This study aimed to explore the role of mesenchymal stromal cells (MSCs)-derived exosomes (MSCs-Exo) in the cerebral ischemia–reperfusion (I/R) injury.

    Authors: Chang Cheng, Xiuying Chen, Yuhan Wang, Wenchao Cheng, Xuzheng Zuo, Weiju Tang and Wen Huang
    Citation: Molecular Medicine 2021 27:67
  16. Previous studies showed that doxorubicin could lead to osteoarthritis (OA) by inducing chondrocyte inflammation and apoptosis. Besides, it is reported that platelet-rich plasma (PRP) could suppress the activat...

    Authors: Haijun Zhao, Weijie Zhu, Wude Mao and Chengkai Shen
    Citation: Molecular Medicine 2021 27:66
  17. Bacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response.

    Authors: Ruben Zamora, Sangeeta Chavan, Theodoros Zanos, Richard L. Simmons, Timothy R. Billiar and Yoram Vodovotz
    Citation: Molecular Medicine 2021 27:65
  18. The present study aimed to determine the functional role of miR-206 in T helper 17 (Th17)/regulatory T (Treg) cell differentiation during the development of osteoarthritis (OA).

    Authors: Xiguang Ye, Qilin Lu, Aofei Yang, Jun Rao, Wei Xie, Chengjian He, Weijun Wang, Hao Li and Zhiwen Zhang
    Citation: Molecular Medicine 2021 27:64
  19. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine...

    Authors: Steven A. Rosenberg
    Citation: Molecular Medicine 2021 27:63

    The Correction to this article has been published in Molecular Medicine 2021 27:140

  20. Pancreatic adenocarcinoma (PAAD) is one of the most challenging cancers with high morbidity and mortality. KRAS mutations could occur as an early event in PAAD. The present study aimed to identify the differen...

    Authors: Chengming Tian, Xiyao Li and Chunlin Ge
    Citation: Molecular Medicine 2021 27:62
  21. Systemic lupus erythematosus (SLE) is a representative systemic autoimmune disease. LncRNA H19 has been identified to participate in various biological processes in human diseases. However, the role of H19 in ...

    Authors: Xinpeng Chen, Xiuxia Luo, Yazhi Wei, Hualin Sun, Liping Dai, Yidou Tangzhou, Huijie Jin and Zhihua Yin
    Citation: Molecular Medicine 2021 27:61
  22. Endocervical adenocarcinoma (ECA) is further classified as human papillomavirus (HPV)-associated (HPVA) or non-HPVA (NHPVA), per the International Endocervical Adenocarcinoma Criteria and Classification (IECC)...

    Authors: Yan-Lin Wen, Shu-Mei Yan, Wei Wei, Xia Yang, Shi-Wen Zhang, Jing-Ping Yun, Li-Li Liu and Rong-Zhen Luo
    Citation: Molecular Medicine 2021 27:60
  23. During sepsis or sterile tissue injury, the nuclear protein high mobility group box 1 (HMGB1) can be released to the extracellular space and ultimately into systemic circulation, where it mediates systemic inf...

    Authors: Takaaki Totoki, Takashi Ito, Shingo Yamada, Goichi Honda, Tsuyoshi Hattori and Ikuro Maruyama
    Citation: Molecular Medicine 2021 27:59
  24. High mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine activity. It is passively released during cell death and secreted by activated cells of many lineages. HMGB1 cont...

    Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson and Kevin J. Tracey
    Citation: Molecular Medicine 2021 27:58
  25. Acetaminophen (APAP) overdose causes hepatotoxicity and even acute liver failure. Recent studies indicate that sterile inflammation and innate immune cells may play important roles in damage-induced hepatocyte...

    Authors: Chen Zhang, Xiao Shi, Zhongping Su, Chao Hu, Xianmin Mu, Jinshun Pan, Mengjing Li, Fengmeng Teng, Tao Ling, Ting Zhao, Che Xu, Guozhong Ji and Qiang You
    Citation: Molecular Medicine 2021 27:57
  26. Hyaluronan (HA) metabolism by chondrocytes is important for cartilage development and homeostasis. However, information about the function of circular RNAs (circRNAs) in HA metabolism is limited. We therefore ...

    Authors: Hong-Xing Liao, Zhi-Hui Zhang, Hui-Lin Chen, Ying-Mei Huang, Zhan-Liang Liu and Jian Huang
    Citation: Molecular Medicine 2021 27:56
  27. Sepsis is a life-threatening disease syndrome caused by a dysregulated host response to infection and injury. Extracellular cold-inducible RNA-binding protein (eCIRP) acts as a damage-associated molecular patt...

    Authors: William Royster, Hui Jin, Ping Wang and Monowar Aziz
    Citation: Molecular Medicine 2021 27:55
  28. Chronic obstructive pulmonary disease (COPD) is characterized by airway obstruction and progressive lung inflammation. As the primary ingredient of a traditional Chinese medical herb, Baicalin has been previou...

    Authors: Dexun Hao, Yanshuang Li, Jiang Shi and Junguang Jiang
    Citation: Molecular Medicine 2021 27:53
  29. XRCC2, a homologous recombination-related gene, has been reported to be associated with a variety of cancers. However, its role in glioma has not been reported. This study aimed to find out the role of XRCC2 in g...

    Authors: Zhendong Liu, Wang Zhang, Xingbo Cheng, Hongbo Wang, Lu Bian, Jialin Wang, Zhibin Han, Yanbiao Wang, Xiaoyu Lian, Binfeng Liu, Zhishuai Ren, Bo Zhang, Zhenfeng Jiang, Zhiguo Lin and Yanzheng Gao
    Citation: Molecular Medicine 2021 27:52
  30. Long non-coding RNAs (lncRNAs) are a group of non-protein coding RNAs with a length of more than 200 bp. The lncRNA taurine up-regulated gene 1 (TUG1) is abnormally expressed in many human malignant cancers, wher...

    Authors: Miao Da, Jing Zhuang, Yani Zhou, Quan Qi and Shuwen Han
    Citation: Molecular Medicine 2021 27:51
  31. To evaluate the taxonomic composition of the gut microbiome in gout patients with and without tophi formation, and predict bacterial functions that might have an impact on urate metabolism.

    Authors: Eder Orlando Méndez-Salazar, Janitzia Vázquez-Mellado, Carlos S. Casimiro-Soriguer, Joaquin Dopazo, Cankut Çubuk, Yessica Zamudio-Cuevas, Adriana Francisco-Balderas, Karina Martínez-Flores, Javier Fernández-Torres, Carlos Lozada-Pérez, Carlos Pineda, Austreberto Sánchez-González, Luis H. Silveira, Ana I. Burguete-García, Citlalli Orbe-Orihuela, Alfredo Lagunas-Martínez…
    Citation: Molecular Medicine 2021 27:50
  32. Macrophage activation syndrome (MAS) is a potentially fatal complication of systemic inflammation. HMGB1 is a nuclear protein released extracellularly during proinflammatory lytic cell death or secreted by act...

    Authors: Karin Palmblad, Hanna Schierbeck, Erik Sundberg, Anna-Carin Horne, Helena Erlandsson Harris, Jan-Inge Henter and Ulf Andersson
    Citation: Molecular Medicine 2021 27:48
  33. Despite recent advances in diagnostic and therapeutic approaches for gastric cancer (GC), the survival of patients with advanced GC remains very low. Islet-1 (ISL1) is a LIM-homeodomain transcription factor, w...

    Authors: Qiong Shi, Xiaomei Ni, Ming Lei, Quansong Xia, Yan Dong, Qiao Zhang and Weiping Wang
    Citation: Molecular Medicine 2021 27:47
  34. Antibody drug conjugates (ADCs) represent one of the most promising approaches in the current immuno-oncology research. The precise delivery of cytotoxic drugs to the cancer cells using ADCs specific for tumor...

    Authors: Marta Poźniak, Natalia Porębska, Mateusz Adam Krzyścik, Aleksandra Sokołowska-Wędzina, Kamil Jastrzębski, Martyna Sochacka, Jakub Szymczyk, Małgorzata Zakrzewska, Jacek Otlewski and Łukasz Opaliński
    Citation: Molecular Medicine 2021 27:46
  35. Circular RNA hsa_circ_0008305 (circPTK2), miR-181c-5p and High mobility group box-1 (HMGB1) had a targeted regulatory relationship through bioinformatics analysis. This study explained the effects of these gen...

    Authors: Min Li, Junwen Hu, Yucong Peng, Jingbo Li and Reng Ren
    Citation: Molecular Medicine 2021 27:45
  36. Leucine rich repeat containing 4 (LRRC4), also known as netrin-G ligand-2 (NGL-2), belongs to the superfamily of LRR proteins and serves as a receptor for netrin-G2. LRRC4 regulates the formation of excitatory...

    Authors: Yan Zhang, Di Li, Qiuming Zeng, Jianbo Feng, Haijuan Fu, Zhaohui Luo, Bo Xiao, Huan Yang and Minghua Wu
    Citation: Molecular Medicine 2021 27:44
  37. Osteoporosis seriously disturbs the life of people. Meanwhile, inhibition or weakening of osteogenic differentiation is one of the important factors in the pathogenesis of osteoporosis. It was reported that mi...

    Authors: Li-Rong Ren, Ru-Bin Yao, Shi-Yong Wang, Xiang-Dong Gong, Ji-Tao Xu and Kai-Shun Yang
    Citation: Molecular Medicine 2021 27:43
  38. Long non-coding RNA (lncRNA) XIST has been implicated in the progression of a variety of tumor diseases. The purpose of this study was to explore the molecular role of lncRNA XIST in human hepatitis B virus (H...

    Authors: Jiancheng Wang, Gang Yin, Hu Bian, Jiangli Yang, Pengcheng Zhou, Kai Yan, Cheng Liu, Pei Chen, Jun Zhu, Zhi Li and Tongqing Xue
    Citation: Molecular Medicine 2021 27:41
  39. Targeted inhibition of inflammatory response can reduce diabetic cerebral ischemia–reperfusion (I/R) injure. Pyroptosis is characterized by caspase-1 dependence and the release of a large number of pro-inflamm...

    Authors: Li-Qing Wang, Yue-Ying Zheng, Heng-Jun Zhou, Xiong-Xin Zhang, Pin Wu and Sheng-Mei Zhu
    Citation: Molecular Medicine 2021 27:39
  40. Gemcitabine (GEM) resistance remains a significant clinical challenge in pancreatic cancer treatment. Here, we investigated the therapeutic utility of everolimus (Evr), an inhibitor of mammalian target of rapa...

    Authors: Jing Cui, Yao Guo, Heshui Wu, Jiongxin Xiong and Tao Peng
    Citation: Molecular Medicine 2021 27:38
  41. Ovarian tumour domain deubiquitinase with linear linkage specificity (OTULIN) is a potent negative regulator of the nuclear factor-κB (NF-κB) signalling pathway, and it plays a strong neuroprotective role foll...

    Authors: Hongbei Xu, You Wang and Yong Luo
    Citation: Molecular Medicine 2021 27:37
  42. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, and its 5-year survival rate is less than 20%, despite various treatments being available. Increasing evidence indicates ...

    Authors: Shanshan Yu, Luya Cai, Chuan Liu, Ruihong Gu, Lingyi Cai and Leying Zhuo
    Citation: Molecular Medicine 2021 27:36
  43. Complement activation is a central mechanism in systemic inflammation and remote organ dysfunction following major trauma. Data on temporal changes of complement activation early after injury is largely missin...

    Authors: Ingrid Nygren Rognes, Søren Erik Pischke, William Ottestad, Jo Røislien, Jens Petter Berg, Christina Johnson, Torsten Eken and Tom Eirik Mollnes
    Citation: Molecular Medicine 2021 27:35

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