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  1. Hypovolemic shock and septic challenge are two major causes of acute kidney injury (AKI) in the clinic setting. Src homology 2 domain-containing phosphatase 2 (SHP2) is one of the major protein phosphatase tyr...

    Authors: Jihong Jiang, Baoji Hu, Chun-Shiang Chung, Yaping Chen, Yunhe Zhang, Elizabeth W. Tindal, Jinbao Li and Alfred Ayala
    Citation: Molecular Medicine 2020 26:89
  2. Patients newly diagnosed with lung adenocarcinoma with bone metastases (LABM) have poor survival rates after treatment with conventional therapies. To improve outcomes, we retrospectively investigated whether ...

    Authors: Long Huang, Xiao-Liu Jiang, Hong-Bin Liang, Jian-Cheng Li, Li-Han Chin, Jian-Ping Wei, Rui-Ru Wang, Jing Cai, Qiang Xiong, Lien-Tu Wang, David S. Cram and An-Wen Liu
    Citation: Molecular Medicine 2020 26:88
  3. Phenotypic transformation of vascular smooth muscle cells is a key element in vascular remodeling and aortic aneurysm growth. Previously, deletion of several inflammasome components decreased formation of aort...

    Authors: Markus Wortmann, Muhammad Arshad, Maani Hakimi, Dittmar Böckler and Susanne Dihlmann
    Citation: Molecular Medicine 2020 26:87
  4. Exposure to ionizing radiation induces complex stress responses in cells, which can lead to adverse health effects such as cancer. Although a variety of studies investigated gene expression and affected pathwa...

    Authors: Lara Kim Brackmann, Alicia Poplawski, Caine Lucas Grandt, Heike Schwarz, Thomas Hankeln, Steffen Rapp, Sebastian Zahnreich, Danuta Galetzka, Iris Schmitt, Christian Grad, Lukas Eckhard, Johanna Mirsch, Maria Blettner, Peter Scholz-Kreisel, Moritz Hess, Harald Binder…
    Citation: Molecular Medicine 2020 26:85
  5. Gender-affirming hormone therapy has been hypothesized to reduce the patient’s reproductive potential in transmen, although the exact long-term effects on future fertility are unknown.

    Authors: Julian Marschalek, Detlef Pietrowski, Sabine Dekan, Marie-Louise Marschalek, Maximilian Brandstetter and Johannes Ott
    Citation: Molecular Medicine 2020 26:83
  6. Chorioamnionitis, inflammation of the chorion and amnion, which often results from intrauterine infection, is associated with premature birth and contributes to significant neonatal morbidity and mortality, in...

    Authors: C. Heymans, I. H. de Lange, K. Lenaerts, L. C. G. A. Kessels, M. Hadfoune, G. Rademakers, V. Melotte, W. Boesmans, B. W. Kramer, A. H. Jobe, M. Saito, M. W. Kemp, W. G. van Gemert and T. G. A. M. Wolfs
    Citation: Molecular Medicine 2020 26:82
  7. Activation of hepatic stellate cells (HSCs) is a prominent driver of liver fibrosis. We previously demonstrated that exosomes derived from natural killer (NK) cells (NK-Exo) attenuated TGF-β1-induced HSC activ...

    Authors: Ling Wang, Yinghao Wang and Jun Quan
    Citation: Molecular Medicine 2020 26:81
  8. Patients with advanced non-small cell lung cancer (NSCLC) benefit from treatment with immune checkpoint inhibitors (ICIs). Biomarkers such as programmed death-ligand 1 (PD-L1), the tumor mutational burden (TMB...

    Authors: Dantong Sun, Lu Tian, Yan Zhu, Yang Wo, Qiaoling Liu, Shihai Liu, Hong Li and Helei Hou
    Citation: Molecular Medicine 2020 26:78
  9. Little is known about the correlation between the melanocortin 4 receptor gene (MC4R) single nucleotide polymorphisms (SNPs) and the risk of obesity. This research sought to test the MC4R rs17782313, rs476828 and...

    Authors: Bi-Liu Wei, Rui-Xing Yin, Chun-Xiao Liu, Guo-Xiong Deng, Yao-Zong Guan and Peng-Fei Zheng
    Citation: Molecular Medicine 2020 26:77
  10. Diabetes during pregnancy affects placental mitochondrial content and function, which has the potential to impact fetal development and the long-term health of offspring. Resistin is a peptide hormone original...

    Authors: Shaoning Jiang, April M. Teague, Jeanie B. Tryggestad, Timothy J. Lyons and Steven D. Chernausek
    Citation: Molecular Medicine 2020 26:76
  11. Therapeutic lymphangiogenesis in an orthotopic lung transplant model has been shown to improve acute allograft rejection that is mediated at least in part through hyaluronan drainage. Lymphatic vessel endothel...

    Authors: Shikshya Shrestha, Woohyun Cho, Benjamin Stump, Jewel Imani, Anthony M. Lamattina, Pierce H. Louis, James Pazzanese, Ivan O. Rosas, Gary Visner, Mark A. Perrella and Souheil El-Chemaly
    Citation: Molecular Medicine 2020 26:75
  12. Studies have demonstrated that long noncoding RNAs (lncRNAs) have essential impacts on the development of atherosclerosis (AS). This study aimed to identify the role and functional mechanism of lncRNA CASC2 in...

    Authors: Chenjing Wang, Jin Zhao, Xiaodong Nan, Zhong Guo, Shuangsheng Huang, Xiaokun Wang, Feng Sun and Shijie Ma
    Citation: Molecular Medicine 2020 26:74
  13. Electroacupuncture (EA), a treatment derived from traditional Chinese medicine, can effectively improve hyperandrogenism and insulin resistance in patients with polycystic ovary syndrome (PCOS), however, its u...

    Authors: Yan Peng, Liyuan Guo, Anxin Gu, Beibei Shi, Yukun Ren, Jing Cong and Xinming Yang
    Citation: Molecular Medicine 2020 26:73
  14. Atherosclerosis (AS) is widely accepted to be a multistep pathophysiological process associated with several other processes such as angiogenesis and inflammatory response. Long non-coding RNAs (lncRNAs) are n...

    Authors: Xian Shi, Ya-Ting Wei, Heng Li, Ting Jiang, Xi-Long Zheng, Kai Yin and Guo-Jun Zhao
    Citation: Molecular Medicine 2020 26:72
  15. Co-administration of human ghrelin and growth hormone (GH) reverse immunosuppression in septic aged animals, but the mechanism remains elusive. Here, we hypothesize that ghrelin and GH co-treatment restores th...

    Authors: Mian Zhou, Monowar Aziz, Mahendar Ochani and Ping Wang
    Citation: Molecular Medicine 2020 26:71
  16. Ovarian cancer is one of the most common gynecologic cancers and has high mortality rate due to the lack of early diagnosis method and efficient therapeutic agents. circCELSR1 is up-regulated in ovarian cancer...

    Authors: Xiang-Yang Zeng, Jing Yuan, Chen Wang, Da Zeng, Jia-Hui Yong, Xiao-Yan Jiang, Hua Lan and Song-Shu Xiao
    Citation: Molecular Medicine 2020 26:70
  17. We previously showed that the autophagy inhibitor chloroquine (CQ) increases inflammatory cleaved caspase-1 activity in myocytes, and that caspase-1/11 is protective in sterile liver injury. However, the role ...

    Authors: Ulka Sachdev, Ricardo Ferrari, Xiangdong Cui, Abish Pius, Amrita Sahu, Michael Reynolds, Hong Liao, Ping Sun, Sunita Shinde, Fabrisia Ambrosio, Sruti Shiva, Patricia Loughran and Melanie Scott
    Citation: Molecular Medicine 2020 26:69
  18. Apoptosis and oxidative stress are the main etiology of age related cataract (ARC). This article aims to investigate the role of WRN in lens epithelial cells (LECs).

    Authors: Shengqun Jiang and Jiansu Chen
    Citation: Molecular Medicine 2020 26:68
  19. Adipose derived stem cells (ADSCs) are clinically widely used somatic stem cells obtained from white adipose tissue. They are characterized by ability to differentiate e.g. into osteoblasts and might successfu...

    Authors: Aleksandra Skubis-Sikora, Bartosz Sikora, Agnieszka Witkowska, Urszula Mazurek and Joanna Gola
    Citation: Molecular Medicine 2020 26:67
  20. Targeted therapy for NSCLC is rapidly evolving. EGFR-TKIs benefit NSCLC patients with sensitive EGFR mutations and significantly prolong survival. However, 20–30% of patients demonstrate primary resistance to ...

    Authors: Dantong Sun, Yan Zhu, Jingjuan Zhu, Junyan Tao, Xiaojuan Wei, Yang Wo and Helei Hou
    Citation: Molecular Medicine 2020 26:66
  21. Oxygen therapy, using supraphysiological concentrations of oxygen (hyperoxia), is routinely administered to patients who require respiratory support including mechanical ventilation (MV). However, prolonged ex...

    Authors: Ravikumar A. Sitapara, Alex G. Gauthier, Sergio I. Valdés-Ferrer, Mosi Lin, Vivek Patel, Mao Wang, Ashley T. Martino, Jeanette C. Perron, Charles R. Ashby Jr, Kevin J. Tracey, Valentin A. Pavlov and Lin L. Mantell
    Citation: Molecular Medicine 2020 26:63

    The Commentary to this article has been published in Molecular Medicine 2020 26:64

  22. Hepatocarcinogenesis is reportedly correlated with abnormal m6A modifications; however, it is unknown whether m6A RNA methylation regulators facilitate the occurrence of hepatitis B virus (HBV)-related hepatoc...

    Authors: Qiongxuan Fang and Hongsong Chen
    Citation: Molecular Medicine 2020 26:60
  23. Pancreatic Ductal Adenocarcinoma (PDAC) is a cancer of the exocrine pancreas and 5-year survival rates remain constant at 7%. Along with PDAC, Periampullary Adenocarcinoma (PAC) accounts for 0.5–2% of all gast...

    Authors: Gourab Saha, Richa Singh, Argha Mandal, Subrata Das, Esita Chattopadhyay, Prasun Panja, Paromita Roy, Navonil DeSarkar, Sumit Gulati, Supriyo Ghatak, Shibajyoti Ghosh, Sudeep Banerjee, Bidyut Roy, Saurabh Ghosh, Dipankar Chaudhuri, Neeraj Arora…
    Citation: Molecular Medicine 2020 26:59
  24. In light of the present therapeutic situation in COVID-19, any measure to improve course and outcome of seriously affected individuals is of utmost importance. We recap here evidence that supports the use of h...

    Authors: Hannelore Ehrenreich, Karin Weissenborn, Martin Begemann, Markus Busch, Eduard Vieta and Kamilla W. Miskowiak
    Citation: Molecular Medicine 2020 26:58
  25. Esophageal cancer (EC) is one of the most common human cancers, with a particularly aggressive behavior and increased incidence worldwide. The aim of this study was to assess the associations of single-nucleot...

    Authors: Ruimin Zhao, Xin Chen, Wanli Ren, Hao Dai, Huajing Li, Honghui Li, Ai Jia, Yue Wu, Peng Han and Yuan Shao
    Citation: Molecular Medicine 2020 26:57
  26. Ischemia and reperfusion (I/R) induces cytokines, and up-regulates inducible nitric oxide synthase (iNOS), interferon regulatory factor-1(IRF1) and p53 up-regulated modulator of apoptosis (PUMA), which contrib...

    Authors: Qiang Du, Jing Luo, Mu-Qing Yang, Quan Liu, Caroline Heres, Yi-He Yan, Donna Stolz and David A. Geller
    Citation: Molecular Medicine 2020 26:56
  27. With the advance of antibiotics and life support therapy, the mortality of sepsis has been decreasing in recent years. However, the incidence of sepsis-associated encephalopathy (SAE), a common complication of...

    Authors: Xiaoli Zhong, Lingli Xie, Xiaolong Yang, Fang Liang, Yanliang Yang, Jianbin Tong, Yanjun Zhong, Kai Zhao, Yiting Tang and Chuang Yuan
    Citation: Molecular Medicine 2020 26:55
  28. Our objective was to investigate the efficacy of the beta-3 adrenergic receptor (β3-AR) agonist BRL37344 for the prevention of liver steatosis and inflammation associated with nonalcoholic fatty liver disease ...

    Authors: Ziwen Wang, Shanshan Li, Ruifeng Wang, Liansheng Guo, Dan Xu, Tieyuan Zhang, Yifan Xu, Wenlong Wang, Min Wang, Zhongwei Gan and Xiaobing Wang
    Citation: Molecular Medicine 2020 26:54
  29. The majority of patients with chronic fatigue have a risk of comorbidity with depression. Pinocembrin (PB) is a kind of flavonoid molecule isolated from honey and propolis and has antimicrobial, anti-inflammat...

    Authors: Wei Wang, Lili Zheng, Lijun Xu, Jianglong Tu and Xunhu Gu
    Citation: Molecular Medicine 2020 26:53
  30. Fibrosis is an integral component of the pathogenesis of acute lung injury and is associated with poor outcomes in patients with acute respiratory distress syndrome (ARDS). Fibrocytes are bone marrow-derived c...

    Authors: Christine M. Lin, Abdullah Alrbiaan, John Odackal, Zhimin Zhang, Yogesh Scindia, Sun-Sang J. Sung, Marie D. Burdick and Borna Mehrad
    Citation: Molecular Medicine 2020 26:52
  31. The hereditary aspect of obesity is a major focus of modern medical genetics. The genetic background is known to determine a higher-than-average prevalence of obesity in certain regions, like Oceania. There is...

    Authors: Anna E. Pravednikova, Sergey Y. Shevchenko, Victor V. Kerchev, Manana R. Skhirtladze, Svetlana N. Larina, Zaur M. Kachaev, Alexander D. Egorov and Yulii V. Shidlovskii
    Citation: Molecular Medicine 2020 26:51
  32. Pirfenidone (PFD) is effective for pulmonary fibrosis (PF), but its action mechanism has not been fully explained. This study explored the signaling pathways involved in anti-fibrosis role of PFD, thus laying ...

    Authors: Qun Lv, Jianjun Wang, Changqing Xu, Xuqing Huang, Zhaoyang Ruan and Yifan Dai
    Citation: Molecular Medicine 2020 26:49
  33. Molecular mechanism of lung squamous cell carcinoma (LUSC) remains poorly understood, hampering effective targeted therapies or precision diagnosis about LUSC. We devised an integrative framework to investigat...

    Authors: Zongang Liu, Meiyan Deng, Lin Wu and Suning Zhang
    Citation: Molecular Medicine 2020 26:48
  34. Fibulins are a family of secreted glycoproteins, which play an important role in regulating multiple cellular functions such as adhesion, growth, motility, and survival. Fibulin7 (Fbln7) is expressed in develo...

    Authors: Papiya Chakraborty, Shiba Prasad Dash and Pranita P. Sarangi
    Citation: Molecular Medicine 2020 26:47
  35. MicroRNAs control gene expression by post-transcriptional inhibition. Dysregulation of the expressions of miR-199a/214 cluster has been linked to cardiovascular diseases. This study aimed at identifying potent...

    Authors: Yi-Ling Chen, Jiunn-Jye Sheu, Cheuk-Kwan Sun, Tien-Hung Huang, Yuan-Ping Lin and Hon-Kan Yip
    Citation: Molecular Medicine 2020 26:46
  36. This study is aimed to explore the role of miR-543 in non-small cell lung cancer (NSCLC), and verify whether miR-543 targets metastasis associated protein 1 (MTA1) to affect tumorigenesis and angiogenesis in N...

    Authors: Dawei Wang, Li Cai, Xudong Tian and Wenjun Li
    Citation: Molecular Medicine 2020 26:44
  37. Radiation therapy is the primary method of treatment for glioblastoma (GBM). Therefore, the suppression of radioresistance in GBM cells is of enormous significance. Ribophorin II (RPN2), a protein component of...

    Authors: Changyu Li, Haonan Ran, Shaojun Song, Weisong Liu, Wenhui Zou, Bei Jiang, Hongmei Zhao and Bin Shao
    Citation: Molecular Medicine 2020 26:43

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