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Page 8 of 36

  1. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already caused 6 million deaths worldwide. While asymptomatic individuals are responsible of many potential transmissions, the difficulty to ide...

    Authors: Lucía Beltrán-Camacho, Sara Eslava-Alcón, Marta Rojas-Torres, Daniel Sánchez-Morillo, Mª Pilar Martinez-Nicolás, Victoria Martín-Bermejo, Inés García de la Torre, Esther Berrocoso, Juan Antonio Moreno, Rafael Moreno-Luna and Mª Carmen Durán-Ruiz
    Citation: Molecular Medicine 2022 28:40
    Content type: Research article Published on:

  2. Bladder cancer (BC) has the highest per-patient cost of all cancer types. Hence, we aim to develop a non-invasive, point-of-care tool for the diagnostic and molecular stratification of patients with BC based o...

    Authors: Tudor Moisoiu, Mihnea P. Dragomir, Stefania D. Iancu, Simon Schallenberg, Giovanni Birolo, Giulio Ferrero, Dan Burghelea, Andrei Stefancu, Ramona G. Cozan, Emilia Licarete, Alessandra Allione, Giuseppe Matullo, Gheorghita Iacob, Zoltán Bálint, Radu I. Badea, Alessio Naccarati…
    Citation: Molecular Medicine 2022 28:39
    Content type: Research article Published on:

  3. The diagnostic yield of whole-exome sequencing (WES) varies from 30%–50% among patients with mild to severe neurodevelopmental delay (NDD)/intellectual disability (ID). Routine retrospective reanalysis of undi...

    Authors: Go Hun Seo, Hane Lee, Jungsul Lee, Heonjong Han, You Kyung Cho, Minji Kim, Yunha Choi, Jeongmin Choi, In Hee Choi, Seonkyeong Rhie, Kyu Young Chae, Yoo-Mi Kim, Chong Kun Cheon, Su Jin Kim, Jieun Lee, Eungu Kang…
    Citation: Molecular Medicine 2022 28:38
    Content type: Research article Published on:

  4. Chronic liver injury induces pathological repair, resulting in fibrosis, during which hepatic stellate cells (HSCs) are activated and transform into myofibroblasts. CD248 is mainly expressed on myofibroblasts ...

    Authors: Shaojie Liu, Donghui Han, Chao Xu, Fa Yang, Yu Li, Keying Zhang, Xiaolong Zhao, Jiayu Zhang, Tong Lu, Shiqi Lu, Changhong Shi, Rui Zhang, An-Gang Yang, Aizhi Zhao, Weijun Qin, Bo Yang…
    Citation: Molecular Medicine 2022 28:37
    Content type: Research article Published on:

  5. Over the years, microRNAs (miRNAs) have been involved in the pathogenesis of rheumatoid arthritis (RA). We aim to investigate the role of human umbilical cord mesenchymal stem cells (HUCMSCs)-derived exosomal ...

    Authors: Yijiang Huang, Liang Chen, Daosen Chen, Pei Fan and Huachen Yu
    Citation: Molecular Medicine 2022 28:36
    Content type: Research article Published on:

  6. Authors: Carlo Calissano, Rajendra N. Damle, Sonia Marsilio, Xiao-Jie Yan, Sophia Yancopoulos, Gregory Hayes, Claire Emson, Elizabeth J. Murphy, Marc K. Hellerstein, Cristina Sison, Matthew S. Kaufman, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Ivana Ivanovic, Igor M. Dozmorov…
    Citation: Molecular Medicine 2022 28:35
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2011 17:Art28

  7. IDH-mutant astrocytoma and oligodendroglioma have an indolent natural history and are recognized as distinct entities of neoplasms. There is little knowledge on the molecular differences between IDH-mutant ast...

    Authors: Binghao Zhao, Yu Xia, Fengchun Yang, Yaning Wang, Yuekun Wang, Yadong Wang, Congxin Dai, Yu Wang and Wenbin Ma
    Citation: Molecular Medicine 2022 28:34
    Content type: Research article Published on:

  8. Long non-coding RNAs (lncRNAs) play critically in the pathogenesis of myocardial ischemia–reperfusion (I/R) injury. Thus, it was proposed to investigate the mechanism of LINC00461 in the disease through mediat...

    Authors: Feng Gao, Xiaochen Wang, Tingting Fan, Zhidan Luo, Mengqing Ma, Guangquan Hu, Yue Li, Yi Liang, Xianhe Lin and Banglong Xu
    Citation: Molecular Medicine 2022 28:33
    Content type: Research article Published on:

  9. Sepsis induces group 2 innate lymphoid cell (ILC2) expansion in the lung. However, the origin of these lung-recruited ILC2 and the mechanism of ILC2 expansion are unclear. This study aims to determine the orig...

    Authors: Dengming Lai, Weiwei Chen, Kai Zhang, Melanie J. Scott, Yuehua Li, Timothy R. Billiar, Mark A. Wilson and Jie Fan
    Citation: Molecular Medicine 2022 28:32
    Content type: Research article Published on:

  10. Caloric restriction and exercise are lifestyle interventions that effectively attenuate cardiometabolic impairment. However, cardioprotective effects of long-term lifestyle interventions and short-term lifesty...

    Authors: Chanisa Thonusin, Patcharapong Pantiya, Natticha Sumneang, Titikorn Chunchai, Wichwara Nawara, Busarin Arunsak, Natthaphat Siri-Angkul, Sirawit Sriwichaiin, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Molecular Medicine 2022 28:31
    Content type: Research article Published on:

  11. Advanced type 2 diabetes mellitus (T2DM) accelerates vascular smooth muscle cell (VSMC) dysfunction which contributes to the development of vasculopathy, associated with the highest degree of morbidity of T2DM...

    Authors: Maria Alicia Carrillo-Sepulveda, Nicole Maddie, Christina Mary Johnson, Cameron Burke, Osina Lutz, Bamwa Yakoub, Benjamin Kramer and Dhandevi Persand
    Citation: Molecular Medicine 2022 28:30
    Content type: Research article Published on:

  12. Parkinson's disease (PD) is the second most common neurodegenerative disease without cure or effective treatment. This study explores whether the yeast internal NADH-quinone oxidoreductase (NDI1) can functiona...

    Authors: Hongzhi Li, Bohao Sun, Yuting Huang, Jing Zhang, Xuejing Xu, Yuqi Shen, Zhuo Chen, Jifeng Yang, Luxi Shen, Yongwu Hu and Haihua Gu
    Citation: Molecular Medicine 2022 28:29
    Content type: Research article Published on:

  13. The underlying pathophysiology of Parkinson's disease is complex, involving different molecular pathways, including brain iron deposition and mitochondrial dysfunction. At a molecular level, these disease mech...

    Authors: Jannik Prasuhn, Martin Göttlich, Friederike Gerkan, Sofia Kourou, Britt Ebeling, Meike Kasten, Henrike Hanssen, Christine Klein and Norbert Brüggemann
    Citation: Molecular Medicine 2022 28:28
    Content type: Research article Published on:

  15. Oxidized Low-Density-Lipoprotein (Ox-LDL) is the core factor in the development of atherosclerosis. However, there are few therapies aimed at eliminating Ox-LDL. Here in this study, we investigate whether the ...

    Authors: Zhiwen Wang, Juan Chen, Zhuanglin Zeng, Qing Zhang, Gaohui Du, Xiaopeng Guo and Yumiao Wei
    Citation: Molecular Medicine 2022 28:26
    Content type: Research article Published on:

  16. Authors: Sofia Masuelli, Sebastian Real, Emanuel Campoy, Maria Teresita Branham, Diego Matias Marzese, Matthew Salomon, Gerardo De Blas, Rodolfo Arias, Michael Levin and Maria Roque
    Citation: Molecular Medicine 2022 28:25
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2022 28:15

  17. Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial proliferation and bone destruction. Adenosine deaminase (ADA) is a key inflammatory enzyme that increases joint stiff...

    Authors: Karim Samy El-Said, Amira Atta, Maysa A. Mobasher, Mousa O. Germoush, Tarek M. Mohamed and Maha M. Salem
    Citation: Molecular Medicine 2022 28:24
    Content type: Research article Published on:

  18. The inhibition of osteogenic differentiation is a major factor in glucocorticoid-induced bone loss, but there is currently no effective treatment. Dopamine, a major neurotransmitter, transmits signals via five...

    Authors: Jie Zhu, Chengcheng Feng, Weicheng Zhang, Zhidong Wang, Mengdan Zhong, Wenkai Tang, Zhifang Wang, Haiwei Shi, Zhengyu Yin, Jiandong Shi, Yu Huang, Long Xiao, Dechun Geng and Zhirong Wang
    Citation: Molecular Medicine 2022 28:23
    Content type: Research article Published on:

  19. Phosphorylation modification of BCL2 is involved in receptor activator of nuclear factor-κB ligand (RANKL)-induced autophagy of osteoclast precursors (OCPs) and osteoclastogenesis. As an antiapoptotic molecule...

    Authors: Dianshan Ke, Yunlong Yu, Chenglong Li, Junyong Han and Jie Xu
    Citation: Molecular Medicine 2022 28:22
    Content type: Research article Published on:

  20. Many clinical studies have shown a correlation between proton pump inhibitors (PPIs) and osteoporosis or fractures. The purpose of this study was to establish a murine model of chronic oral PPI administration ...

    Authors: Ziping Cheng, Yangjie Liu, Mengyuan Ma, Shiyu Sun, Zengqing Ma, Yu Wang, Liyuan Yu, Xuping Qian, Luning Sun, Xuehui Zhang, Yun Liu and Yongqing Wang
    Citation: Molecular Medicine 2022 28:21
    Content type: Research article Published on:

  21. Adaptive immune responses have been studied extensively in the course of mRNA vaccination against COVID-19. Considerably fewer studies have assessed the effects on innate immune cells. Here, we characterized N...

    Authors: Angelica Cuapio, Caroline Boulouis, Iva Filipovic, David Wullimann, Tobias Kammann, Tiphaine Parrot, Puran Chen, Mira Akber, Yu Gao, Quirin Hammer, Benedikt Strunz, André Pérez Potti, Olga Rivera Ballesteros, Joshua Lange, Jagadeeswara Rao Muvva, Peter Bergman…
    Citation: Molecular Medicine 2022 28:20
    Content type: Research article Published on:

  22. Myocardial fibrosis after myocardial infarction (MI) is one of the leading causes of cardiovascular diseases. Cardiac fibroblasts (CFs) are activated and promoted by MI to undergo myofibroblast transformation ...

    Authors: Pengfei Chen, Junyu Pei, Xiaopu Wang, Shi Tai, Liang Tang and Xinqun Hu
    Citation: Molecular Medicine 2022 28:19
    Content type: Research article Published on:

  23. Although type 1 diabetes (T1D) is typically described as a T cell-mediated autoimmune disease, increasing evidence for a role of B cells has emerged. However, the pivotal disease-relevant B cell subset and its...

    Authors: Qing Ling, Lei Shen, Wei Zhang, DuoDuo Qu, Hongdong Wang, Bin Wang, Yong Liu, Jing Lu, Dalong Zhu and Yan Bi
    Citation: Molecular Medicine 2022 28:18
    Content type: Research article Published on:

  24. Maternal obesity impairs embryonic developmental potential and significantly increases the risks of metabolic disorders in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnorm...

    Authors: Jiliang Huang, Gaizhen Ru, Jiajia Sun, Luying Sun and Zhiling Li
    Citation: Molecular Medicine 2022 28:17
    Content type: Research article Published on:

  25. Hepatocellular carcinoma (HCC) remains one of the most common malignant tumors with poor survival. Pyroptosis is a kind of programmed cell death that can regulate the proliferation, invasion, and metastasis of...

    Authors: Min Deng, Shiquan Sun, Rongce Zhao, Renguo Guan, Zhen Zhang, Shaohua Li, Wei Wei and Rongping Guo
    Citation: Molecular Medicine 2022 28:16
    Content type: Research article Published on:

  26. During embryogenesis lateral symmetry is broken, giving rise to Left/Right (L/R) breast tissues with distinct identity. L/R-sided breast tumors exhibit consistently-biased incidence, gene expression, and DNA m...

    Authors: Sofía Masuelli, Sebastián Real, Emanuel Campoy, María Teresita Branham, Diego Matías Marzese, Matthew Salomon, Gerardo De Blas, Rodolfo Arias, Michael Levin and María Roqué
    Citation: Molecular Medicine 2022 28:15
    Content type: Research article Published on:

    The Correction to this article has been published in Molecular Medicine 2022 28:25

  28. Previously, we observed that hypothermia, widely used for organ preservation, elicits mitochondrial fission in different cell types. However, temperature dependence, mechanisms and consequences of this cold-in...

    Authors: Leonard Quiring, Björn Walter, Niklas Lohaus, Dhanusha Schwan, Anja Rech, Andrea Dlugos and Ursula Rauen
    Citation: Molecular Medicine 2022 28:13
    Content type: Research article Published on:

  29. The increasing incidence of non-alcoholic fatty liver disease (NAFLD) has been reported worldwide, which urges understanding of its pathogenesis and development of more effective therapeutical methods for this...

    Authors: Fei Zhao, Jinjing Ke, Wensheng Pan, Hanghai Pan and Miao Shen
    Citation: Molecular Medicine 2022 28:12
    Content type: Research article Published on:

  30. Alzheimer’s disease (AD) is the most common type of neurodegenerative disease in the contemporary era, and it is still clinically incurable. Eriodictyol, a natural flavonoid compound that is mainly present in ...

    Authors: Lin Li, Wen-Jun Li, Xiang-Ru Zheng, Qing-Long Liu, Qian Du, Yu-Jie Lai and Song-Qing Liu
    Citation: Molecular Medicine 2022 28:11
    Content type: Research article Published on:

  31. Biofilm is a community of bacteria embedded in an extracellular matrix, which can colonize different human cells and tissues and subvert the host immune reactions by preventing immune detection and polarizing ...

    Authors: Rasoul Mirzaei, Niloofar Sabokroo, Yaghoub Ahmadyousefi, Hamid Motamedi and Sajad Karampoor
    Citation: Molecular Medicine 2022 28:10
    Content type: Review Published on:

  32. Sepsis is a troublesome syndrome that can cause intestinal injury and even high mortality rates. Omega-3 fatty acids (FAs) are known to protect against intestinal damage. Accordingly, the current study set out...

    Authors: You-Lian Chen, Yin-Jing Xie, Zhen-Mi Liu, Wei-Bu Chen, Ru Zhang, Hong-Xing Ye, Wei Wang, Xue-Yan Liu and Huai-Sheng Chen
    Citation: Molecular Medicine 2022 28:9
    Content type: Research article Published on:

  34. Arteriovenous fistula (AVF) is the most important vascular access for hemodialysis; however, preventive treatment to maintain the patency of AVFs has not been developed. In endothelium, β-catenin functions in ...

    Authors: Chung-Te Liu, Shih-Chang Hsu, Hui-Ling Hsieh, Cheng-Hsien Chen, Chun-You Chen, Yuh-Mou Sue, Tso-Hsiao Chen, Yung-Ho Hsu, Feng-Yen Lin, Chun-Ming Shih, Yan-Ting Shiu and Po-Hsun Huang
    Citation: Molecular Medicine 2022 28:7
    Content type: Research article Published on:

  35. Activation of brown adipose tissue (BAT) increases energy expenditure, which makes it an attractive therapeutic strategy for obesity. LncRNAs play an important role in adipocyte differentiation and regulation....

    Authors: Chunyan Wu, Shu Fang, Huijian Zhang, Xiaoqiang Li, Yuejun Du, Yudan Zhang, Xiaochun Lin, Ling Wang, Xiaoqin Ma, Yaoming Xue and Meiping Guan
    Citation: Molecular Medicine 2022 28:6
    Content type: Research article Published on:

  36. Calcific aortic valve disease (CAVD) is the most prevalent heart valve disorder in the elderly. Valvular fibrocalcification is a characteristic pathological change. In diseased valves, monocyte accumulation is...

    Authors: Peijian Zhang, Erlinda The, Zichao Luo, Yufeng Zhai, Qingzhou Yao, Lihua Ao, David A. Fullerton, Dingli Xu and Xianzhong Meng
    Citation: Molecular Medicine 2022 28:5
    Content type: Research article Published on:

  37. The unique mechanism of diabetic atherosclerosis has been a central research focus. Previous literature has reported that the inflammatory response mediated by dendritic cells (DCs) plays a vital role in the p...

    Authors: Liding Zhao, Ya Li, Tian Xu, Qingbo Lv, Xukun Bi, Xianglan Liu, Guosheng Fu, Yunzeng Zou, Junbo Ge, Zhaoyang Chen and Wenbin Zhang
    Citation: Molecular Medicine 2022 28:4
    Content type: Research article Published on:

  38. The mechanisms of chronic intermittent hypoxia (CIH)-induced cognitive deficits remain unclear. Here, our study found that about 3 months CIH treatment induced lipid droplets (LDs) accumulation in hippocampal ...

    Authors: Dongze Li, Na Xu, Yanyan Hou, Wenjing Ren, Na Zhang, Xi Wang, Yeying Sun, Wenxue Lu, Guiwu Qu, Yan Yu, Changjun Lv and Fang Han
    Citation: Molecular Medicine 2022 28:3
    Content type: Research article Published on:

  39. Although long noncoding RNA HLA complex group 18 (lncRNA HCG18) has been suggested to regulate cell growth in several tumours, the function of HCG18 in epithelial ovarian cancer (EOC) and its mechanism are sti...

    Authors: Fan Zhang, Bai-Hua Luo, Qi-Hui Wu, Qing-Ling Li and Ke-Da Yang
    Citation: Molecular Medicine 2022 28:2
    Content type: Research article Published on:

  40. Previous reports implied a possible link between PES1 and lipid metabolism. However, the role of PES1 in regulating T2DM related lipid metabolism and the effect of ketogenic diet (KD) on PES1 have not been rep...

    Authors: Jielin Zhou, Yao Lu, Yajing Jia, Jing Lu, Zhengxuan Jiang and Keyang Chen
    Citation: Molecular Medicine 2022 28:1
    Content type: Research article Published on:

  42. Similarities in the hijacking mechanisms used by SARS-CoV-2 and several types of cancer, suggest the repurposing of cancer drugs to treat Covid-19. CK2 kinase antagonists have been proposed for cancer treatmen...

    Authors: Jamilet Miranda, Ricardo Bringas, Jorge Fernandez-de-Cossio and Yasser Perera-Negrin
    Citation: Molecular Medicine 2021 27:161
    Content type: Research article Published on:

  43. COVID-19 clinical presentation differs considerably between individuals, ranging from asymptomatic, mild/moderate and severe disease which in some cases are fatal or result in long-term effects. Identifying im...

    Authors: Catherine Chen, Aisah Amelia, George W. Ashdown, Ivo Mueller, Anna K. Coussens and Emily M. Eriksson
    Citation: Molecular Medicine 2021 27:160
    Content type: Mini-review Published on:

  44. Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions...

    Authors: Jun Yang, Manlong Qi, Xiang Fei, Xia Wang and Kefeng Wang
    Citation: Molecular Medicine 2021 27:159
    Content type: Review Published on:

  45. The small GTP-binding protein Rab31 plays an important role in the modulation of tumor biological-relevant processes, including cell proliferation, adhesion, and invasion. As an underlying mechanism, Rab31 is ...

    Authors: Susanne Soelch, Nathalie Beaufort, Daniela Loessner, Matthias Kotzsch, Ute Reuning, Thomas Luther, Thomas Kirchner and Viktor Magdolen
    Citation: Molecular Medicine 2021 27:158
    Content type: Research article Published on:

  46. Aberrant splicing is a common outcome in the presence of exonic or intronic variants that might hamper the intricate network of interactions defining an exon in a specific gene context. Therefore, the evaluati...

    Authors: Claudia Sacchetto, Laura Peretto, Francisco Baralle, Iva Maestri, Francesca Tassi, Francesco Bernardi, Stan F. J. van de Graaf, Franco Pagani, Mirko Pinotti and Dario Balestra
    Citation: Molecular Medicine 2021 27:157
    Content type: Research article Published on:

  47. Calcific aortic valve disease (CAVD) is the most prevalent valvular disease worldwide. However, no effective treatment could delay or prevent the progression of the disease due to the poor understanding of its...

    Authors: Qiao En, Huang Zeping, Wang Yuetang, Wang Xu and Wang Wei
    Citation: Molecular Medicine 2021 27:156
    Content type: Research article Published on:

  49. The incidence of diabetes mellitus (DM) and depression is increasing year by year around the world, bringing a serious burden to patients and their families. Jiao-tai-wan (JTW), a well-known traditional Chines...

    Authors: Yueheng Tang, Hao Su, Hongzhan Wang, Fuer Lu, Kexin Nie, Zhi Wang, Wenya Huang and Hui Dong
    Citation: Molecular Medicine 2021 27:154
    Content type: Research article Published on:

  50. Dysfunctional osteogenesis of bone marrow mesenchymal stem cells (BMSCs) plays an important role in osteoporosis occurrence and development. However, the molecular mechanisms of osteogenic differentiation rema...

    Authors: Haoran Li, Wuling Zhou, Shiwei Sun, Tianlong Zhang, Tieqi Zhang, Haitian Huang and Minghai Wang
    Citation: Molecular Medicine 2021 27:153
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658