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  1. During sepsis or sterile tissue injury, the nuclear protein high mobility group box 1 (HMGB1) can be released to the extracellular space and ultimately into systemic circulation, where it mediates systemic inf...

    Authors: Takaaki Totoki, Takashi Ito, Shingo Yamada, Goichi Honda, Tsuyoshi Hattori and Ikuro Maruyama

    Citation: Molecular Medicine 2021 27:59

    Content type: Research article

    Published on:

  2. High mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine activity. It is passively released during cell death and secreted by activated cells of many lineages. HMGB1 cont...

    Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson and Kevin J. Tracey

    Citation: Molecular Medicine 2021 27:58

    Content type: Research article

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  3. Acetaminophen (APAP) overdose causes hepatotoxicity and even acute liver failure. Recent studies indicate that sterile inflammation and innate immune cells may play important roles in damage-induced hepatocyte...

    Authors: Chen Zhang, Xiao Shi, Zhongping Su, Chao Hu, Xianmin Mu, Jinshun Pan, Mengjing Li, Fengmeng Teng, Tao Ling, Ting Zhao, Che Xu, Guozhong Ji and Qiang You

    Citation: Molecular Medicine 2021 27:57

    Content type: Research article

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  4. Hyaluronan (HA) metabolism by chondrocytes is important for cartilage development and homeostasis. However, information about the function of circular RNAs (circRNAs) in HA metabolism is limited. We therefore ...

    Authors: Hong-Xing Liao, Zhi-Hui Zhang, Hui-Lin Chen, Ying-Mei Huang, Zhan-Liang Liu and Jian Huang

    Citation: Molecular Medicine 2021 27:56

    Content type: Research article

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  5. Sepsis is a life-threatening disease syndrome caused by a dysregulated host response to infection and injury. Extracellular cold-inducible RNA-binding protein (eCIRP) acts as a damage-associated molecular patt...

    Authors: William Royster, Hui Jin, Ping Wang and Monowar Aziz

    Citation: Molecular Medicine 2021 27:55

    Content type: Research article

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  7. Chronic obstructive pulmonary disease (COPD) is characterized by airway obstruction and progressive lung inflammation. As the primary ingredient of a traditional Chinese medical herb, Baicalin has been previou...

    Authors: Dexun Hao, Yanshuang Li, Jiang Shi and Junguang Jiang

    Citation: Molecular Medicine 2021 27:53

    Content type: Research article

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  8. XRCC2, a homologous recombination-related gene, has been reported to be associated with a variety of cancers. However, its role in glioma has not been reported. This study aimed to find out the role of XRCC2 in g...

    Authors: Zhendong Liu, Wang Zhang, Xingbo Cheng, Hongbo Wang, Lu Bian, Jialin Wang, Zhibin Han, Yanbiao Wang, Xiaoyu Lian, Binfeng Liu, Zhishuai Ren, Bo Zhang, Zhenfeng Jiang, Zhiguo Lin and Yanzheng Gao

    Citation: Molecular Medicine 2021 27:52

    Content type: Research article

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  9. Long non-coding RNAs (lncRNAs) are a group of non-protein coding RNAs with a length of more than 200 bp. The lncRNA taurine up-regulated gene 1 (TUG1) is abnormally expressed in many human malignant cancers, wher...

    Authors: Miao Da, Jing Zhuang, Yani Zhou, Quan Qi and Shuwen Han

    Citation: Molecular Medicine 2021 27:51

    Content type: Review

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  10. To evaluate the taxonomic composition of the gut microbiome in gout patients with and without tophi formation, and predict bacterial functions that might have an impact on urate metabolism.

    Authors: Eder Orlando Méndez-Salazar, Janitzia Vázquez-Mellado, Carlos S. Casimiro-Soriguer, Joaquin Dopazo, Cankut Çubuk, Yessica Zamudio-Cuevas, Adriana Francisco-Balderas, Karina Martínez-Flores, Javier Fernández-Torres, Carlos Lozada-Pérez, Carlos Pineda, Austreberto Sánchez-González, Luis H. Silveira, Ana I. Burguete-García, Citlalli Orbe-Orihuela, Alfredo Lagunas-Martínez…

    Citation: Molecular Medicine 2021 27:50

    Content type: Research article

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  12. Macrophage activation syndrome (MAS) is a potentially fatal complication of systemic inflammation. HMGB1 is a nuclear protein released extracellularly during proinflammatory lytic cell death or secreted by act...

    Authors: Karin Palmblad, Hanna Schierbeck, Erik Sundberg, Anna-Carin Horne, Helena Erlandsson Harris, Jan-Inge Henter and Ulf Andersson

    Citation: Molecular Medicine 2021 27:48

    Content type: Research article

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  13. Despite recent advances in diagnostic and therapeutic approaches for gastric cancer (GC), the survival of patients with advanced GC remains very low. Islet-1 (ISL1) is a LIM-homeodomain transcription factor, w...

    Authors: Qiong Shi, Xiaomei Ni, Ming Lei, Quansong Xia, Yan Dong, Qiao Zhang and Weiping Wang

    Citation: Molecular Medicine 2021 27:47

    Content type: Research article

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  14. Antibody drug conjugates (ADCs) represent one of the most promising approaches in the current immuno-oncology research. The precise delivery of cytotoxic drugs to the cancer cells using ADCs specific for tumor...

    Authors: Marta Poźniak, Natalia Porębska, Mateusz Adam Krzyścik, Aleksandra Sokołowska-Wędzina, Kamil Jastrzębski, Martyna Sochacka, Jakub Szymczyk, Małgorzata Zakrzewska, Jacek Otlewski and Łukasz Opaliński

    Citation: Molecular Medicine 2021 27:46

    Content type: Research article

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  15. Circular RNA hsa_circ_0008305 (circPTK2), miR-181c-5p and High mobility group box-1 (HMGB1) had a targeted regulatory relationship through bioinformatics analysis. This study explained the effects of these gen...

    Authors: Min Li, Junwen Hu, Yucong Peng, Jingbo Li and Reng Ren

    Citation: Molecular Medicine 2021 27:45

    Content type: Research article

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  16. Leucine rich repeat containing 4 (LRRC4), also known as netrin-G ligand-2 (NGL-2), belongs to the superfamily of LRR proteins and serves as a receptor for netrin-G2. LRRC4 regulates the formation of excitatory...

    Authors: Yan Zhang, Di Li, Qiuming Zeng, Jianbo Feng, Haijuan Fu, Zhaohui Luo, Bo Xiao, Huan Yang and Minghua Wu

    Citation: Molecular Medicine 2021 27:44

    Content type: Research article

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  17. Osteoporosis seriously disturbs the life of people. Meanwhile, inhibition or weakening of osteogenic differentiation is one of the important factors in the pathogenesis of osteoporosis. It was reported that mi...

    Authors: Li-Rong Ren, Ru-Bin Yao, Shi-Yong Wang, Xiang-Dong Gong, Ji-Tao Xu and Kai-Shun Yang

    Citation: Molecular Medicine 2021 27:43

    Content type: Research article

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  19. Long non-coding RNA (lncRNA) XIST has been implicated in the progression of a variety of tumor diseases. The purpose of this study was to explore the molecular role of lncRNA XIST in human hepatitis B virus (H...

    Authors: Jiancheng Wang, Gang Yin, Hu Bian, Jiangli Yang, Pengcheng Zhou, Kai Yan, Cheng Liu, Pei Chen, Jun Zhu, Zhi Li and Tongqing Xue

    Citation: Molecular Medicine 2021 27:41

    Content type: Research article

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  21. Targeted inhibition of inflammatory response can reduce diabetic cerebral ischemia–reperfusion (I/R) injure. Pyroptosis is characterized by caspase-1 dependence and the release of a large number of pro-inflamm...

    Authors: Li-Qing Wang, Yue-Ying Zheng, Heng-Jun Zhou, Xiong-Xin Zhang, Pin Wu and Sheng-Mei Zhu

    Citation: Molecular Medicine 2021 27:39

    Content type: Research article

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  22. Gemcitabine (GEM) resistance remains a significant clinical challenge in pancreatic cancer treatment. Here, we investigated the therapeutic utility of everolimus (Evr), an inhibitor of mammalian target of rapa...

    Authors: Jing Cui, Yao Guo, Heshui Wu, Jiongxin Xiong and Tao Peng

    Citation: Molecular Medicine 2021 27:38

    Content type: Research article

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  23. Ovarian tumour domain deubiquitinase with linear linkage specificity (OTULIN) is a potent negative regulator of the nuclear factor-κB (NF-κB) signalling pathway, and it plays a strong neuroprotective role foll...

    Authors: Hongbei Xu, You Wang and Yong Luo

    Citation: Molecular Medicine 2021 27:37

    Content type: Research article

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  24. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, and its 5-year survival rate is less than 20%, despite various treatments being available. Increasing evidence indicates ...

    Authors: Shanshan Yu, Luya Cai, Chuan Liu, Ruihong Gu, Lingyi Cai and Leying Zhuo

    Citation: Molecular Medicine 2021 27:36

    Content type: Research article

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  25. Complement activation is a central mechanism in systemic inflammation and remote organ dysfunction following major trauma. Data on temporal changes of complement activation early after injury is largely missin...

    Authors: Ingrid Nygren Rognes, Søren Erik Pischke, William Ottestad, Jo Røislien, Jens Petter Berg, Christina Johnson, Torsten Eken and Tom Eirik Mollnes

    Citation: Molecular Medicine 2021 27:35

    Content type: Research article

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  26. Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), has been the world’s driving fatal bacterial contagious disease globally. It continues a public health emergency, and around one-third of the global ...

    Authors: Rasoul Mirzaei, Sajad Babakhani, Parisa Ajorloo, Razieh Heidari Ahmadi, Seyed Reza Hosseini-Fard, Hossein Keyvani, Yaghoub Ahmadyousefi, Ali Teimoori, Farhad Zamani, Sajad Karampoor and Rasoul Yousefimashouf

    Citation: Molecular Medicine 2021 27:34

    Content type: Review

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  27. Ovarian cancer is characterized by dysbiosis, referred to as oncobiosis in neoplastic diseases. In ovarian cancer, oncobiosis was identified in numerous compartments, including the tumor tissue itself, the upp...

    Authors: Adrienn Sipos, Gyula Ujlaki, Edit Mikó, Eszter Maka, Judit Szabó, Karen Uray, Zoárd Krasznai and Péter Bai

    Citation: Molecular Medicine 2021 27:33

    Content type: Review

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  28. An estimated 5–10 % of healthy vaccinees lack adequate antibody response following receipt of a standard three-dose hepatitis B vaccination regimen. The cellular mechanisms responsible for poor immunological r...

    Authors: Mingjuan Yin, Yongzhen Xiong, Dongmei Liang, Hao Tang, Qian Hong, Gang Liu, Jinmei Zeng, Tingyu Lian, Jingxiao Huang and Jindong Ni

    Citation: Molecular Medicine 2021 27:32

    Content type: Research article

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  29. Vascular endothelial cells (ECs) are subject to continuous shear stress due to blood circulation. Mechanical stress due to high shear flow can also cause arteriovenous malformation (AVM) when ECs respond hyper...

    Authors: Jeong Yeop Ryu, Yun Hyun Kim, Joon Seok Lee, Jeong Woo Lee, Eun Jung Oh, Hyun Mi Kim, Seok-Jong Lee, Jongmin Lee, Sang Yub Lee, Seung Huh, Ji Yoon Kim, Saewon Im and Ho Yun Chung

    Citation: Molecular Medicine 2021 27:31

    Content type: Research article

    Published on:

  30. SARS-CoV-2 Reverse Transcription Loop-mediated Isothermal Amplification (RT-LAMP) colorimetric detection is a sensitive and specific point-of-care molecular biology technique used to detect the virus in only 30 m...

    Authors: Bruna de Oliveira Coelho, Heloisa Bruna Soligo Sanchuki, Dalila Luciola Zanette, Jeanine Marie Nardin, Hugo Manuel Paz Morales, Bruna Fornazari, Mateus Nóbrega Aoki and Lucas Blanes

    Citation: Molecular Medicine 2021 27:30

    Content type: Research article

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  31. Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease,...

    Authors: Olav Sundnes, William Ottestad, Camilla Schjalm, Peter Lundbäck, Lars la Cour Poulsen, Tom Eirik Mollnes, Guttorm Haraldsen and Torsten Eken

    Citation: Molecular Medicine 2021 27:29

    Content type: Short report

    Published on:

  32. Glioblastoma is the most common primary brain tumor and remains uniformly fatal, highlighting the dire need for developing effective therapeutics. Significant intra- and inter-tumor heterogeneity and inadequat...

    Authors: Muhammad Babar Khan, Rosamaria Ruggieri, Eesha Jamil, Nhan L. Tran, Camila Gonzalez, Nancy Mugridge, Steven Gao, Jennifer MacDiarmid, Himanshu Brahmbhatt, Jann N. Sarkaria, John Boockvar and Marc Symons

    Citation: Molecular Medicine 2021 27:28

    Content type: Research article

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  33. Growth factors execute essential biological functions and affect various physiological and pathological processes, including peripheral nerve repair and regeneration. Our previous sequencing data showed that t...

    Authors: Yaxian Wang, Fuchao Zhang, Yunsong Zhang, Qi Shan, Wei Liu, Fengyuan Zhang, Feiyu Zhang and Sheng Yi

    Citation: Molecular Medicine 2021 27:27

    Content type: Research article

    Published on:

  34. Breast cancer is the most common neoplasia among women in developed countries. The risk factors of breast cancer can be distinguished in modifiable and unmodifiable factors and, among the latter, genetic facto...

    Authors: Maria Santa Rocca, Clara Benna, Elena Goldin, Andrea Di Nisio, Luca De Toni, Ilaria Cosci, Alberto Marchet, Donato Nitti and Carlo Foresta

    Citation: Molecular Medicine 2021 27:26

    Content type: Research article

    Published on:

  35. Diabetic nephropathy (DN) is one of the most important medical complications of diabetes mellitus. Autophagy is an important mediator of pathological response and plays a critical role in inflammation during t...

    Authors: Kyung-Hyun Kim, Geum-Lan Hong, Da-Young Jung, Shanika Karunasagara, Won-Il Jeong and Ju-Young Jung

    Citation: Molecular Medicine 2021 27:25

    Content type: Research article

    Published on:

  39. Studies have found that circular RNAs (circRNAs) play key roles in cardiovascular diseases. However, the function of circROBO2 in acute myocardial infarction (AMI) is unclear. This study aimed to investigate t...

    Authors: Tian-ping Chen, Nai-ju Zhang, Hong-ju Wang, Si-gan Hu and Xu Geng

    Citation: Molecular Medicine 2021 27:21

    Content type: Research article

    Published on:

  40. Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) embedded in a bio-compatible matrix has been demonstrated as a promising strategy for the treatment of bone defects. This study was desig...

    Authors: Zhongliu Cao, Yanfeng Wu, Lingling Yu, Lingfeng Zou, Liu Yang, Sijian Lin, Jue Wang, Zhen Yuan and Jianghua Dai

    Citation: Molecular Medicine 2021 27:20

    Content type: Research article

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  42. Hepatic ischemia/reperfusion (I/R) injury can be a major complication following liver surgery contributing to post-operative liver dysfunction. Maresin 1 (MaR1), a pro-resolving lipid mediator, has been shown ...

    Authors: Da Tang, Guang Fu, Wenbo Li, Ping Sun, Patricia A. Loughran, Meihong Deng, Melanie J. Scott and Timothy R. Billiar

    Citation: Molecular Medicine 2021 27:18

    Content type: Research article

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  43. Parkinson’s disease (PD) is the second more common neurodegenerative disease with increasing incidence worldwide associated to the population ageing. Despite increasing awareness and significant research advan...

    Authors: Theodora Ntetsika, Paraskevi-Evita Papathoma and Ioanna Markaki

    Citation: Molecular Medicine 2021 27:17

    Content type: Review

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  44. Cytokeratin 18 (CK18) is an intermediate filament protein of the cytokeratin acidic type I group and is primarily expressed in single-layered or “simple” epithelial tissues and carcinomas of different origin.

    Authors: Anne Menz, Timo Weitbrecht, Natalia Gorbokon, Franziska Büscheck, Andreas M. Luebke, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Sören Weidemann, Christoph Fraune, Katharina Möller, Christian Bernreuther, Patrick Lebok, Till Clauditz, Guido Sauter…

    Citation: Molecular Medicine 2021 27:16

    Content type: Research article

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  45. Cyclin-dependent kinases 2/4/6 (CDK2/4/6) play critical roles in cell cycle progression, and their deregulations are hallmarks of hepatocellular carcinoma (HCC).

    Authors: Ying Zhu, Kun-Bin Ke, Zhong-Kun Xia, Hong-Jian Li, Rong Su, Chao Dong, Feng-Mei Zhou, Lin Wang, Rong Chen, Shi-Guo Wu, Hui Zhao, Peng Gu, Kwong-Sak Leung, Man-Hon Wong, Gang Lu, Jian-Ying Zhang…

    Citation: Molecular Medicine 2021 27:15

    Content type: Research article

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  46. Myocardial ischemia is the most common form of cardiovascular disease and the leading cause of morbidity and mortality. Understanding the mechanisms is very crucial for the development of effective therapy. Th...

    Authors: Hui-Yong Chen, Ze-Zhou Xiao, Xiao Ling, Rong-Ning Xu, Peng Zhu and Shao-Yi Zheng

    Citation: Molecular Medicine 2021 27:14

    Content type: Research article

    Published on:

  47. Gestational diabetes mellitus is a risk factor for congenital heart defects. The article aimed to investigate the expression and roles of MST1, YAP1, Last1/2 and Survivin in modulating HG-induced cardiomyocyte...

    Authors: Dongmei Su, Yanhua Li, Lina Guan, Qian Li, Cuige Shi, Xu Ma and Yonghui Song

    Citation: Molecular Medicine 2021 27:13

    Content type: Research article

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  48. Osteoarthritis (OA) is the most common articular disorder, leading to joint malfunction and disability. Although the incidence of OA is increasing globally, the treatment of OA is very limited. LncRNA CIR has ...

    Authors: Feng Liu, De-Ye Song, Jun Huang, Hong-Qi Yang, Di You and Jiang-Dong Ni

    Citation: Molecular Medicine 2021 27:12

    Content type: Research article

    Published on:

  49. House dust mite (HDM) inhalation can cause airway epithelial damage which is implicated in the process of airway inflammation in asthma. High mobility group box 1 (HMGB1) is critically required for cellular da...

    Authors: Meixuan Liu, Jingjing Lu, Qian Zhang, Yunxuan Zhang and Zhongliang Guo

    Citation: Molecular Medicine 2021 27:11

    Content type: Research article

    Published on:

  50. LncRNA can regulate gene at various levels such as apparent genetics, alternative splicing, and regulation of mRNA degradation. However, the molecular mechanism of LncRNA in cholangiocarcinoma is still unclear...

    Authors: Hao Ji, Juan Wang, Binbin Lu, Juan Li, Jing Zhou, Li Wang, Shufen Xu, Peng Peng, Xuezhen Hu and Keming Wang

    Citation: Molecular Medicine 2021 27:10

    Content type: Research article

    Published on:

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Molecular Medicine

ISSN: 1528-3658