Articles

Correction to: METTL14 promotes glomerular endothelial cell injury and diabetic nephropathy via m6A modification of α‑klotho

Authors: Manna Li, Le Deng and Gaosi Xu

Inhibition of β-catenin signaling attenuates arteriovenous fistula thickening in mice by suppressing myofibroblasts

Arteriovenous fistula (AVF) is the most important vascular access for hemodialysis; however, preventive treatment to maintain the patency of AVFs has not been developed. In endothelium, β-catenin functions in ...

Authors: Chung-Te Liu, Shih-Chang Hsu, Hui-Ling Hsieh, Cheng-Hsien Chen, Chun-You Chen, Yuh-Mou Sue, Tso-Hsiao Chen, Yung-Ho Hsu, Feng-Yen Lin, Chun-Ming Shih, Yan-Ting Shiu and Po-Hsun Huang

Long noncoding RNA XIST regulates brown preadipocytes differentiation and combats high-fat diet induced obesity by targeting C/EBPα

Activation of brown adipose tissue (BAT) increases energy expenditure, which makes it an attractive therapeutic strategy for obesity. LncRNAs play an important role in adipocyte differentiation and regulation....

Authors: Chunyan Wu, Shu Fang, Huijian Zhang, Xiaoqiang Li, Yuejun Du, Yudan Zhang, Xiaochun Lin, Ling Wang, Xiaoqin Ma, Yaoming Xue and Meiping Guan

Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity

Calcific aortic valve disease (CAVD) is the most prevalent heart valve disorder in the elderly. Valvular fibrocalcification is a characteristic pathological change. In diseased valves, monocyte accumulation is...

Authors: Peijian Zhang, Erlinda The, Zichao Luo, Yufeng Zhai, Qingzhou Yao, Lihua Ao, David A. Fullerton, Dingli Xu and Xianzhong Meng

Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCβ₁ signaling pathway in diabetic atherosclerosis

The unique mechanism of diabetic atherosclerosis has been a central research focus. Previous literature has reported that the inflammatory response mediated by dendritic cells (DCs) plays a vital role in the p...

Authors: Liding Zhao, Ya Li, Tian Xu, Qingbo Lv, Xukun Bi, Xianglan Liu, Guosheng Fu, Yunzeng Zou, Junbo Ge, Zhaoyang Chen and Wenbin Zhang

Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway

The mechanisms of chronic intermittent hypoxia (CIH)-induced cognitive deficits remain unclear. Here, our study found that about 3 months CIH treatment induced lipid droplets (LDs) accumulation in hippocampal ...

Authors: Dongze Li, Na Xu, Yanyan Hou, Wenjing Ren, Na Zhang, Xi Wang, Yeying Sun, Wenxue Lu, Guiwu Qu, Yan Yu, Changjun Lv and Fang Han

LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation, migration and EMT of epithelial ovarian cancer by targeting miR-29a/b

Although long noncoding RNA HLA complex group 18 (lncRNA HCG18) has been suggested to regulate cell growth in several tumours, the function of HCG18 in epithelial ovarian cancer (EOC) and its mechanism are sti...

Authors: Fan Zhang, Bai-Hua Luo, Qi-Hui Wu, Qing-Ling Li and Ke-Da Yang

Ketogenic diet ameliorates lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1

Previous reports implied a possible link between PES1 and lipid metabolism. However, the role of PES1 in regulating T2DM related lipid metabolism and the effect of ketogenic diet (KD) on PES1 have not been rep...

Authors: Jielin Zhou, Yao Lu, Yajing Jia, Jing Lu, Zhengxuan Jiang and Keyang Chen

Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 mi...

Authors: Svetlana P. Chapoval and Achsah D. Keegan

Targeting CK2 mediated signaling to impair/tackle SARS-CoV-2 infection: a computational biology approach

Similarities in the hijacking mechanisms used by SARS-CoV-2 and several types of cancer, suggest the repurposing of cancer drugs to treat Covid-19. CK2 kinase antagonists have been proposed for cancer treatmen...

Authors: Jamilet Miranda, Ricardo Bringas, Jorge Fernandez-de-Cossio and Yasser Perera-Negrin

Risk surveillance and mitigation: autoantibodies as triggers and inhibitors of severe reactions to SARS-CoV-2 infection

COVID-19 clinical presentation differs considerably between individuals, ranging from asymptomatic, mild/moderate and severe disease which in some cases are fatal or result in long-term effects. Identifying im...

Authors: Catherine Chen, Aisah Amelia, George W. Ashdown, Ivo Mueller, Anna K. Coussens and Emily M. Eriksson

Long non-coding RNA XIST: a novel oncogene in multiple cancers

Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions...

Authors: Jun Yang, Manlong Qi, Xiang Fei, Xia Wang and Kefeng Wang

Rab31-dependent regulation of transforming growth factor ß expression in breast cancer cells

The small GTP-binding protein Rab31 plays an important role in the modulation of tumor biological-relevant processes, including cell proliferation, adhesion, and invasion. As an underlying mechanism, Rab31 is ...

Authors: Susanne Soelch, Nathalie Beaufort, Daniela Loessner, Matthias Kotzsch, Ute Reuning, Thomas Luther, Thomas Kirchner and Viktor Magdolen

OTC intron 4 variations mediate pathogenic splicing patterns caused by the c.386G>A mutation in humans and spf^ash mice, and govern susceptibility to RNA-based therapies

Aberrant splicing is a common outcome in the presence of exonic or intronic variants that might hamper the intricate network of interactions defining an exon in a specific gene context. Therefore, the evaluati...

Authors: Claudia Sacchetto, Laura Peretto, Francisco Baralle, Iva Maestri, Francesca Tassi, Francesco Bernardi, Stan F. J. van de Graaf, Franco Pagani, Mirko Pinotti and Dario Balestra

Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way

Calcific aortic valve disease (CAVD) is the most prevalent valvular disease worldwide. However, no effective treatment could delay or prevent the progression of the disease due to the poor understanding of its...

Authors: Qiao En, Huang Zeping, Wang Yuetang, Wang Xu and Wang Wei

Retraction Note to: WRN inhibits oxidative stress-induced apoptosis of human lensepithelial cells through ATM/p53 signaling pathway and its expression is downregulated by DNA methylation

Authors: Shengqun Jiang and Jiansu Chen

The effect and mechanism of Jiao-tai-wan in the treatment of diabetes mellitus with depression based on network pharmacology and experimental analysis

The incidence of diabetes mellitus (DM) and depression is increasing year by year around the world, bringing a serious burden to patients and their families. Jiao-tai-wan (JTW), a well-known traditional Chines...

Authors: Yueheng Tang, Hao Su, Hongzhan Wang, Fuer Lu, Kexin Nie, Zhi Wang, Wenya Huang and Hui Dong

Microfibrillar-associated protein 5 regulates osteogenic differentiation by modulating the Wnt/β-catenin and AMPK signaling pathways

Dysfunctional osteogenesis of bone marrow mesenchymal stem cells (BMSCs) plays an important role in osteoporosis occurrence and development. However, the molecular mechanisms of osteogenic differentiation rema...

Authors: Haoran Li, Wuling Zhou, Shiwei Sun, Tianlong Zhang, Tieqi Zhang, Haitian Huang and Minghai Wang

IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors

Bone metastasis of colorectal cancer (CRC) often indicates a poor prognosis. Osteolysis can be observed in metastatic sites, implying an aberrant activation of osteoclasts. However, how osteoclastogenesis is r...

Authors: Qian Jin, He Yang, Zhao Jing, Wu Hong-hua, Song Ben-jing, Wang Li-ting, Ye Li-juan, Xu Wei, Kang Xia, Wu Juan and Zheng Wei

Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19

We investigated the feasibility of two biomarkers of endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), and their association with inflammation, coagulopathy, and mortal...

Authors: Dong Zhang, Liubing Li, Yu Chen, Jie Ma, Yanli Yang, Surita Aodeng, Qiuju Cui, Kedi Wen, Meng Xiao, Jing Xie, Yingchun Xu and Yongzhe Li

PIAS3 suppresses damage in an Alzheimer’s disease cell model by inducing the STAT3-associated STAT3/Nestin/Nrf2/HO-1 pathway

Alzheimer’s disease (AD), the most common form of dementia, is caused by the degeneration of the central nervous system (CNS). A previous study reported that signal transducer and activator of transcription 3 ...

Authors: Chen Li, Ruili Wang, Youyou Zhang, Chunting Hu and Qiaoya Ma

DMAG, a novel countermeasure for the treatment of thrombocytopenia

Thrombocytopenia is one of the most common hematological disease that can be life-threatening caused by bleeding complications. However, the treatment options for thrombocytopenia remain limited.

Authors: Jing Lin, Jing Zeng, Sha Liu, Xin Shen, Nan Jiang, Yue-Song Wu, Hong Li, Long Wang and Jian-Ming Wu

Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1

Imatinib (IM), targeting of BCR-ABL1 tyrosine kinase, is currently one of the first-line choices in the treatment of chronic myeloid leukemia (CML). This study aims to explore the molecular mechanisms underlyi...

Authors: Yao-hua Lu and Zhong-yi Huang

Fibroblast growth factor 21 attenuates salt-sensitive hypertension-induced nephropathy through anti-inflammation and anti-oxidation mechanism

Patients with salt-sensitive hypertension are often accompanied with severe renal damage and accelerate to end-stage renal disease, which currently lacks effective treatment. Fibroblast growth factor 21 (FGF21...

Authors: Hua-Chun Weng, Xin-Yu Lu, Yu-Peng Xu, Yi-Hong Wang, Dan Wang, Yi-Ling Feng, Zhang Chi, Xiao-Qing Yan, Chao-Sheng Lu and Hong-Wei Wang

ADSCs enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m⁶A modification to improve wound healing of diabetic foot ulcers

Adipose-derived mesenchymal stem cells (ADSCs) are an important focus in regenerative medicine. However, the biological function of ADSCs in the wound repair of diabetic foot ulcers (DFUs) remains unclear. Thi...

Authors: Jie Zhou, Tianhong Wei and Zhiyou He

Paediatric obesity: a systematic review and pathway mapping of metabolic alterations underlying early disease processes

The alarming trend of paediatric obesity deserves our greatest awareness to hinder the early onset of metabolic complications impacting growth and functionality. Presently, insight into molecular mechanisms of...

Authors: Margot De Spiegeleer, Ellen De Paepe, Lieven Van Meulebroek, Inge Gies, Jean De Schepper and Lynn Vanhaecke

Nuclear receptors: a bridge linking the gut microbiome and the host

The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological proc...

Authors: Zixuan Wang, Wei-Dong Chen and Yan-Dong Wang

LncRNA-ATB participates in the regulation of calcium oxalate crystal-induced renal injury by sponging the miR-200 family

LncRNA-ATB is a long noncoding RNA (lncRNA) activated by transforming growth factor β (TGF-β) and it has important biological functions in tumours and nontumour diseases. Meanwhile, TGF-β is the most critical ...

Authors: Yinhui Li, Tao Ding, Haiyan Hu, Tingting Zhao, Chao Zhu, Jiarong Ding, Jihang Yuan and Zhiyong Guo

Weighted gene co-expression network-based approach to identify key genes associated with anthracycline-induced cardiotoxicity and construction of miRNA-transcription factor-gene regulatory network

Cardiotoxicity is a common complication following anthracycline chemotherapy and represents one of the serious adverse reactions affecting life, which severely limits the effective use of anthracyclines in can...

Authors: Guoxing Wan, Peinan Chen, Xue Sun, Xiaojun Cai, Xiongjie Yu, Xianhe Wang and Fengjun Cao

lncRNA SNHG1 induced by SP1 regulates bone remodeling and angiogenesis via sponging miR-181c-5p and modulating SFRP1/Wnt signaling pathway

We aimed to investigate the functions and underlying mechanism of lncRNA SNHG1 in bone differentiation and angiogenesis in the development of osteoporosis.

Authors: Xiao Yu, Peng-Ze Rong, Meng-Sheng Song, Ze-Wen Shi, Gong Feng, Xian-Jun Chen, Lin Shi, Cheng-Hao Wang and Qing-Jiang Pang

Correction to: A Journey in Science: Immersion in the search for effective cancer immunotherapies

Authors: Steven A. Rosenberg

Cancer-associated fibroblasts impact the clinical outcome and treatment response in colorectal cancer via immune system modulation: a comprehensive genome-wide analysis

Cancer-associated fibroblasts (CAFs) in the tumour microenvironment are associated with poor prognosis and chemoresistance in multiple solid tumours. However, there is a lack of universal measures of CAFs in c...

Authors: Yu-feng Chen, Zhao-liang Yu, Min-yi Lv, Ze-rong Cai, Yi-feng Zou, Ping Lan, Xiao-jian Wu and Feng Gao

ARID1A serves as a receivable biomarker for the resistance to EGFR-TKIs in non-small cell lung cancer

ARID1A is a key component of the SWI/SNF chromatin remodeling complexes which is important for the maintaining of biological processes of cells. Recent studies had uncovered the potential role of ARID1A alteratio...

Authors: Dantong Sun, Fei Teng, Puyuan Xing and Junling Li

IκB kinase promotes Nrf2 ubiquitination and degradation by phosphorylating cylindromatosis, aggravating oxidative stress injury in obesity-related nephropathy

Obesity-related nephropathy (ORN) has become one of the leading causes of end-stage renal disease and has tripled over the past decade. Previous studies have demonstrated that decreased reactive oxygen species...

Authors: Yin-Yin Chen, Han Hong, Yu-Ting Lei, Jia Zou, Yi-Ya Yang and Li-Yu He

Correction to: Melatonin prevents bone destruction in mice with retinoic acid-induced osteoporosis

Authors: Xudong Wang, Tongzhou Liang, Yuanxin Zhu, Jincheng Qiu, Xianjian Qiu, Chengjie Lian, Bo Gao, Yan Peng, Anjing Liang, Hang Zhou, Xiaoming Yang, Zhiheng Liao, Yongyong Li, Caixia Xu, Peiqiang Su and Dongsheng Huang

Increased plasma disequilibrium between pro- and anti-oxidants during the early phase resuscitation after cardiac arrest is associated with increased levels of oxidative stress end-products

Cardiac arrest (CA) results in loss of blood circulation to all tissues leading to oxygen and metabolite dysfunction. Return of blood flow and oxygen during resuscitative efforts is the beginning of reperfusio...

Authors: Muhammad Shoaib, Nancy Kim, Rishabh C. Choudhary, Tai Yin, Koichiro Shinozaki, Lance B. Becker and Junhwan Kim

Correction to: MicroRNA‑214 promotes alveolarization in neonatal rat models of bronchopulmonary dysplasia via the PlGF‑dependent STAT3 pathway

Authors: Zhi‑Qun Zhang, Hui Hong, Jing Li, Xiao‑Xia Li and Xian‑Mei Huang

Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension

Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosyntheti...

Authors: Andrew Stiegler, Jian-Hua Li, Vivek Shah, Tea Tsaava, Aisling Tynan, Huan Yang, Yehuda Tamari, Michael Brines, Kevin J. Tracey and Sangeeta S. Chavan

Deregulation of circ_003912 contributes to pathogenesis of erosive oral lichen planus by via sponging microRNA-123, -647 and -31 and upregulating FOXP3

The FOXP3/miR-146a/NF-κB axis was previously reported to modulate the induction and function of CD4+ Treg cells to alleviate oral lichen planus. Also, other signaling pathways including microRNA-155-IFN-γ loop...

Authors: Zhen Huang, Fen Liu, Wenjuan Wang, Shaobo Ouyang, Ting Sang, Zikun Huang, Lan Liao and Jun Wu

Long noncoding RNA MAPKAPK5-AS1 promoted lipopolysaccharide-induced inflammatory damage in the myocardium by sponging microRNA-124-3p/E2F3

Myocardial dysfunction caused by sepsis (SIMD) leads to high mortality in critically ill patients. We investigated the function and mechanism of long non-coding RNA MAPKAPK5-AS1 (lncRNA MAPKAPK-AS1) on lipopol...

Authors: Weiwei Chen, Guangyuan Gao, Mengjie Yan, Ming Yu, Kaiyao Shi and Ping Yang

Hsp90 up-regulates PD-L1 to promote HPV-positive cervical cancer via HER2/PI3K/AKT pathway

HPV16 is the predominant cancer-causing strain that is responsible for over 50% of all cervical cancers. In this study, we aim to investigate the therapeutic effect of heat shock protein 90 (Hsp90) knockdown o...

Authors: Jie Zeng, Si-Li He, Li-Jie Li and Chen Wang

CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study

Host inflammation contributes to determine whether SARS-CoV-2 infection causes mild or life-threatening disease. Tools are needed for early risk assessment.

Authors: Nicola I. Lorè, Rebecca De Lorenzo, Paola M. V. Rancoita, Federica Cugnata, Alessandra Agresti, Francesco Benedetti, Marco E. Bianchi, Chiara Bonini, Annalisa Capobianco, Caterina Conte, Angelo Corti, Roberto Furlan, Paola Mantegani, Norma Maugeri, Clara Sciorati, Fabio Saliu…

Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway

Acute myeloid leukemia (AML) is a malignancy commonly seen in adults. Previous studies indicated that TRIM14 played a tumorigenic role in various types of cancer and miR-23b-5p was down-regulated in human mese...

Authors: Hui Cheng, Jie Ding, Gusheng Tang, Aijie Huang, Lei Gao, Jianmin Yang and Li Chen

d-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens

d-Serine is a crucial endogenous co-agonist of N-methyl-d-aspartate receptors (NMDARs) in the central nervous system and can affect the function of the brain derived neurotrophic factor (BDNF) system, which plays...

Authors: Zhenzhen Chen, Zhenyu Tang, Ke Zou, Zhihong Huang, Liuer Liu, Yuanjian Yang and Wei Wang

The role of ERBB4 mutations in the prognosis of advanced non-small cell lung cancer treated with immune checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) have witnessed the achievements of convincing clinical benefits that feature the significantly prolonged overall survival (OS) of patients suffering from advanced non-small ...

Authors: Xilin Hu, Hanlin Xu, Qianwen Xue, Ruran Wen, Wenjie Jiao and Kaihua Tian

The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2

C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types. Disc...

Authors: Ria Aryani Hayuningtyas, Myeonggil Han, Seoyeon Choi, Man Sup Kwak, In Ho Park, Ji-Hyun Lee, Ji Eun Choi, Dae Ki Kim, Myoungsun Son and Jeon-Soo Shin

Depression of lncRNA MINCR antagonizes LPS-evoked acute injury and inflammatory response via miR-146b-5p and the TRAF6-NFkB signaling

Inflammation plays an important role in the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The long non-coding RNA (lncRNA) MINCR is closely related to inflammation inju...

Authors: Wei Gao and Ying Zhang

New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases

Age-related cardiovascular disease is the leading cause of death in elderly populations. Coxibs, including celecoxib, valdecoxib, etoricoxib, parecoxib, lumiracoxib, and rofecoxib, are selective cyclooxygenase...

Authors: Wujun Chen, Yingjie Zhong, Nuan Feng, Zhu Guo, Shuai Wang and Dongming Xing

Role of long non-coding RNA H19 in the development of osteoporosis

Osteoporosis is a widespread and serious metabolic bone disease. At present, revealing the molecular mechanisms of osteoporosis and developing effective prevention and treatment methods are of great significan...

Authors: Senxiang Chen, Da Liu, Zimo Zhou and Sen Qin

Macrophages and cancer stem cells: a malevolent alliance

Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because their pro-tumor and immunosuppressive functions are relevant for disease progression and therapeutic responses. Th...

Authors: Paola Allavena, Elisabeth Digifico and Cristina Belgiovine