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Page 32 of 36

  1. Although studies have shown an inverse association between cardiorespiratory fitness (CRF) and C-reactive protein (CRP) levels, the underlying mechanisms are not fully understood. There is emerging evidence th...

    Authors: Sae Young Jae, Kevin S. Heffernan, Eun Sun Yoon, Moon-Kyu Lee, Bo Fernhall and Won Hah Park
    Citation: Molecular Medicine 2009 15:1509291
  2. Because the complex heterogeneity of traumatic brain injury (TBI) is believed by many to be a major reason for the failed clinical trials of monotherapies, combining two (or more) drugs with some potentially d...

    Authors: Fahim Atif, Iqbal Sayeed, Tauheed Ishrat and Donald G. Stein
    Citation: Molecular Medicine 2009 15:1509328
  3. Aberrant coronary vascular smooth muscle cell (CSMC) proliferation is a pivotal event underlying intimal hyperplasia, a phenomenon impairing the long-term efficacy of bypass surgery and angioplasty procedures....

    Authors: Barbara Dapas, Rossella Farra, Mario Grassi, Carlo Giansante, Nicola Fiotti, Laura Uxa, Giuseppe Rainaldi, Alberto Mercatanti, Alfonso Colombatti, Paola Spessotto, Valentina Lacovich, Gianfranco Guarnieri and Gabriele Grassi
    Citation: Molecular Medicine 2009 15:1509297
  4. Severe burn injury results in liver dysfunction and damage, with subsequent metabolic derangements contributing to patient morbidity and mortality. On a cellular level, significant postburn hepatocyte apoptosi...

    Authors: Juquan Song, Celeste C. Finnerty, David N. Herndon, Darren Boehning and Marc G. Jeschke
    Citation: Molecular Medicine 2009 15:1509316
  5. The lung is one of the organs to which cancers from solid tumors frequently metastasize. Multiple tumors in the lung are usually treated by systemic chemotherapy because of the lack of efficient methods of tar...

    Authors: Hong Xin, Ruowen Sun, Masahiko Kanehira, Takenori Takahata, Jugoh Itoh, Hiroyuki Mizuguchi and Yasuo Saijo
    Citation: Molecular Medicine 2009 15:1509321
  6. Our previous studies showed that tetraspanin CD151 promotes neovascularization in rat hindlimb and myocardial ischemia models. This study is to assess whether CD151 induces arteriogenesis and promotes functional ...

    Authors: Houjuan Zuo, Zhengxiang Liu, Xiaochun Liu, Jun Yang, Tao Liu, Sha Wen, Xin A. Zhang, Katherine Cianflone and Daowen Wang
    Citation: Molecular Medicine 2009 15:1509307
  7. Conventional treatment options, including corticosteroids, intravenous immunoglobulin, or plasma exchange, often fail to treat dysimmune neuropathies, such as chronic inflammatory demyelinating polyneuropathy,...

    Authors: Andreas A. Argyriou
    Citation: Molecular Medicine 2009 15:15070283
  8. The pathogenesis of sepsis is partly attributable to dysregulated inflammatory response mediated by pathogen-associated molecular patterns (PAMPs) (for example, endotoxin) and damage-associated molecular patte...

    Authors: Shu Zhu, Mala Ashok, Jianhua Li, Wei Li, Huan Yang, Ping Wang, Kevin J. Tracey, Andrew E. Sama and Haichao Wang
    Citation: Molecular Medicine 2009 15:15070275
  9. Exposure to ricin, either by accident through ingestion of castor oil plant seeds or intentionally through its use as a bioweapon, invariably leads to multiple organ damage and death. Currently there is only a...

    Authors: Jon G. Mabley, Pal Packer and Csaba Szabo
    Citation: Molecular Medicine 2009 15:15050166
  10. The aim of this study was to determine the existence of association between the genetic polymorphisms of metabolizing genes GSTM-1, GSTT-1, and NAT-2, and the presence of mitochondrial genome instability (mtGI) i...

    Authors: Walter H. Pavicic, Martin Laguens and Silvina M. Richard
    Citation: Molecular Medicine 2009 15:15050160
  11. Bone marrow (BM)-derived endothelial progenitor cells (EPC) contribute to vascular maintenance by participating in angiogenesis, re-endothelialization, and remodeling. Myeloid progenitor cells in the BM are fu...

    Authors: Cindy J. M. Loomans, Rien van Haperen, Jacques M. Duijs, Caroline Verseyden, Rini de Crom, Pieter J. M. Leenen, Hemmo A. Drexhage, Hetty C. de Boer, Eelco J. P. de Koning, Ton J. Rabelink, Frank J. T. Staal and Anton Jan van Zonneveld
    Citation: Molecular Medicine 2009 15:15050152
  12. Noninvasive and repetitive monitoring of a virus in target tissues and/or specific organs of the body is highly desirable for the development of safe and efficient cancer virotherapeutics. We have previously s...

    Authors: Nanhai Chen, Qian Zhang, Yong A. Yu, Jochen Stritzker, Peter Brader, Andreas Schirbel, Samuel Samnick, Inna Serganova, Ronald Blasberg, Yuman Fong and Aladar A. Szalay
    Citation: Molecular Medicine 2009 15:15050144
  13. We carried out a genome-wide association study of genetic predictors of anti-cyclic citrullinated peptide antibody (anti-CCP) level in 531 self-reported non-Hispanic Caucasian Rheumatoid Arthritis (RA) patient...

    Authors: Jing Cui, Kimberly E. Taylor, Anita L. DeStefano, Lindsey A. Criswell, Elena S. Izmailova, Alex Parker, Ronenn Roubenoff, Robert M. Plenge, Michael E. Weinblatt, Nancy A. Shadick and Elizabeth W. Karlson
    Citation: Molecular Medicine 2009 15:15050136
  14. Insulinlike growth factor-1 (IGF-1) expression is implicated in myocardial pathophysiology, and two IGF-1 mRNA splice variants have been detected in rodents, IGF-1Ea and mechano-growth factor (MGF). We investi...

    Authors: Anastasia Stavropoulou, Antonios Halapas, Antigone Sourla, Anastassios Philippou, Efstathia Papageorgiou, Apostolos Papalois and Michael Koutsilieris
    Citation: Molecular Medicine 2009 15:15050127
  15. To investigate a possible common environmental exposure that may partially explain the observed decrease in human semen quality, we correlated seminal plasma and blood cadmium levels with sperm concentration a...

    Authors: Susan Benoff, Russ Hauser, Joel L. Marmar, Ian R. Hurley, Barbara Napolitano and Grace M. Centola
    Citation: Molecular Medicine 2009 15:15070248
  16. Insulin resistance and type 2 diabetes (T2D) are closely linked to obesity. Numerous prospective studies have reported on weight gain, insulin resistance, and insulin signaling in experimental animals, but not...

    Authors: Anna Danielsson, Siri Fagerholm, Anita Öst, Niclas Franck, Preben Kjolhede, Fredrik H. Nystrom and Peter Strålfors
    Citation: Molecular Medicine 2009 15:15070228
  17. The ability to quit smoking successfully displays substantial heritability in classical and molecular genetic studies. Twin studies suggest that some of the genetics for the ability to quit overlap with geneti...

    Authors: Tomas Drgon, Catherine Johnson, Donna Walther, Anthony P. Albino, Jed E. Rose and George R. Uhl
    Citation: Molecular Medicine 2009 15:15070268
  18. The cholinergic antiinflammatory pathway modulates Inflammatory cytokine production through a mechanism dependent on the vagus nerve and the α7 subunit of the nicotinic acetylcholine receptor. GTS-21 [3-(2,4-d...

    Authors: Mauricio Rosas-Ballina, Richard S. Goldstein, Margot Gallowitsch-Puerta, Lihong Yang, Sergio Iván Valdés-Ferrer, Nirav B. Patel, Sangeeta Chavan, Yousef Al-Abed, Huan Yang and Kevin J. Tracey
    Citation: Molecular Medicine 2009 15:15070195
  19. Erythropoietin (EPO) is a type I cytokine that utilizes different receptor isoforms either to maintain hematopoiesis or protect against injuries that arise from widely diverse etiologies. EPO also facilitates ...

    Authors: Zübeyde Erbayraktar, Serhat Erbayraktar, Osman Yilmaz, Anthony Cerami, Thomas Coleman and Michael Brines
    Citation: Molecular Medicine 2009 15:15070235
  20. Hypothalamic growth hormone (GH)-releasing hormone (GHRH) regulates the release of GH from the pituitary gland. The receptors for GHRH (GHRH-R) are expressed predominantly in the pituitary. Recent evidence dem...

    Authors: Elena Theophanous, Constantina Petraki, Andreas Scorilas, Vassilios Komborozos, George Veloudis, Jozsef L. Varga, Marta Zarandi, Andrew V. Schally and Michael Koutsilieris
    Citation: Molecular Medicine 2009 15:15070242
  21. Traumatic injuries frequently lead to infection, organ failure, and death. Health care providers rely on several Injury scoring systems to quantify the extent of injury and to help predict clinical outcome. Ph...

    Authors: H. Shaw Warren, Constance M. Elson, Douglas L. Hayden, David A. Schoenfeld, J. Perren Cobb, Ronald V. Maier, Lyle L. Moldawer, Ernest E. Moore, Brian G. Harbrecht, Kimberly Pelak, Joseph Cuschieri, David N. Herndon, Marc G. Jeschke, Celeste C. Finnerty, Bernard H. Brownstein, Laura Hennessy…
    Citation: Molecular Medicine 2009 15:15070220
  22. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an oxidant-responsive transcription factor known to induce detoxifying and antioxidant genes. Cigarette smoke, with its large oxidant content, is a major s...

    Authors: Ralf-Harto Hübner, Jamie D. Schwartz, Bishnu P. De, Barbara Ferris, Larsson Omberg, Jason G. Mezey, Neil R. Hackett and Ronald G. Crystal
    Citation: Molecular Medicine 2009 15:15070203
  23. This review critically evaluates current knowledge of molecularly targeted therapies of malignant gliomas. Various molecularly targeted single-agent therapies, including targeted therapies of growth and surviv...

    Authors: Andreas A. Argyriou and Haralabos P. Kalofonos
    Citation: Molecular Medicine 2009 15:15030115
  24. Disseminated malignancy is the major cause of prostate cancer-related mortality. Circulating tumor cells (CTCs) are essential for the establishment of metastasis. Various contemporary and molecular methods usi...

    Authors: Zacharoula Panteleakou, Peter Lembessis, Antigone Sourla, Nikolaos Pissimissis, Aristides Polyzos, Charalambos Deliveliotis and Michael Koutsilieris
    Citation: Molecular Medicine 2009 15:15030101
  25. The main objective of this study was to determine whether elevated blood β-amyloid (Aβ) levels among the first-degree relatives of patients with Alzheimer’s Disease (AD) are associated with vascular risk facto...

    Authors: Laila Abdullah, Cheryl Luis, Daniel Paris, Ghania Ait-ghezala, Benoit Mouzon, Elizabeth Allen, Julia Parrish, Myles A. Mullan, Scott Ferguson, Marcie Wood, Fiona Crawford and Michael Mullan
    Citation: Molecular Medicine 2009 15:15030095
  26. The role of chronic hepatitis C virus (HCV) in the pathogenesis of HCV-associated hepatocellular carcinoma (HCC) remains controversial. To understand the transition from benign to malignant, we studied the gen...

    Authors: Valeria R. Mas, Daniel G. Maluf, Kellie J. Archer, Kenneth Yanek, Xiangrong Kong, Laura Kulik, Chris E. Freise, Kim M. Olthoff, Rafik M. Ghobrial, Paula McIver and Robert Fisher
    Citation: Molecular Medicine 2009 15:15030085
  27. Nicotinamide adenine dinucleotide (NAD+), a precursor of molecules involved in cell regulatory processes, is released in extracellular compartments after stress or inflammation. This study investigates the exp...

    Authors: Alberto L. Horenstein, Federico Sizzano, Riccardo Lusso, Federico Genzano Besso, Enza Ferrero, Silvia Deaglio, Franco Corno and Fabio Malavasi
    Citation: Molecular Medicine 2009 15:15030076
  28. Chronic kidney disease (CKD) carries an increased risk of cardiovascular disease (CVD). Macrophage migration inhibiting factor (MIF) is a proinflammatory cytokine implicated in the pathogenesis of sepsis, auto...

    Authors: Annette Bruchfeld, Juan J. Carrero, Abdul R. Qureshi, Bengt Lindholm, Peter Barany, Olof Heimburger, Maowen Hu, Xinchun Lin, Peter Stenvinkel and Edmund J. Miller
    Citation: Molecular Medicine 2009 15:15030070
  29. Molecular medicine is transforming everyday clinical practice from an empirical art to a rational ortho-molecular science. The prevailing concept in this emerging framework of molecular medicine is a personali...

    Authors: Panagiotis A. Konstantinopoulos, Michalis V. Karamouzis and Athanasios G. Papavassiliou
    Citation: Molecular Medicine 2009 15:15010060
  30. Antimicrobial peptides (AMP) are a heterogeneous group of molecules involved in the nonspecific immune responses of a variety of organisms ranging from prokaryotes to mammals, including humans. AMP have variou...

    Authors: Roland Pálffy, Roman Gardlík, Michal Behuliak, Ludevit Kadasi, Jan Turna and Peter Celec
    Citation: Molecular Medicine 2009 15:15010051
  31. Oxidative stress plays a key role in the pathogenesis of aging and many metabolic diseases; therefore, an effective antioxidant therapy would be of great importance in these circumstances. Nutritional, environ...

    Authors: Ahmet Korkmaz, Russel J. Reiter, Turgut Topal, Lucien C. Manchester, Sukru Oter and Dun-Xian Tan
    Citation: Molecular Medicine 2009 15:15010043
  32. Complement activation resulting in significant increases of C4a split product may be a marker of postexertional malaise in individuals with chronic fatigue syndrome (CFS). This study focused on identification ...

    Authors: Bristol Sorensen, James F. Jones, Suzanne D. Vernon and Mangalathu S. Rajeevan
    Citation: Molecular Medicine 2009 15:15010034
  33. We recently demonstrated that early administration of rat adrenomedullin (AM), a vasoactive peptide, in combination with its binding protein (human AMBP-1) produces various beneficial effects in sepsis. Human ...

    Authors: Rongqian Wu, Shinya Higuchi, Weifeng Dong, Youxin Ji, Mian Zhou, Corrado P. Marini, Thanjavur S. Ravikumar and Ping Wang
    Citation: Molecular Medicine 2009 15:15010028
  34. Phenotypes related to both nicotine dependence and ability to successfully quit smoking display substantial heritabilities in classical and molecular genetic studies. Twin studies suggest that some genetic com...

    Authors: Tomas Drgon, Ivan Montoya, Catherine Johnson, Qing-Rong Liu, Donna Walther, Dean Hamer and George R. Uhl
    Citation: Molecular Medicine 2009 15:15010021
  35. The human epidermal growth factor (EGF) receptor (HER) family members cooperate in malignancy. Of this family, HER2 does not bind growth factors and HER3 does not encode an active tyrosine kinase. This diversi...

    Authors: Pei Jin, Juan Zhang, Malgorzata Beryt, Lisa Turin, Cathleen Brdlik, Ying Feng, Xiaomei Bai, Jim Liu, Brett Jorgensen and H. Michael Shepard
    Citation: Molecular Medicine 2009 15:15010011
  36. A growing body of evidence implicates macrophage migration inhibitory factor (MIF) in tumorigenesis and metastasis. In this study, we investigated whether MIF expression was associated with clinicopathologic f...

    Authors: Xing-Xiang He, Ken Chen, Jun Yang, Xiao-Yu Li, Huo-Ye Gan, Cheng-Yong Liu, Thomas R. Coleman and Yousef Al-Abed
    Citation: Molecular Medicine 2009 15:15010001
  37. The abstract for this article (14[3–4]: 213–221, March–April 2008) included an incorrect statement. The original sentence appeared as: “Studies have also shown that the survival rate and the induction of subse...

    Authors: Raghavan Raju, Kirby I. Bland and Irshad H. Chaudry
    Citation: Molecular Medicine 2008 14:1411752

    The original article was published in Molecular Medicine 2008 14:Art15

  38. Obesity is associated with an array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae has advanced rapidly over the past decades. Adipo...

    Authors: Katja Rabe, Michael Lehrke, Klaus G. Parhofer and Uli C. Broedl
    Citation: Molecular Medicine 2008 14:1411741
  39. Ischemia and reperfusion injury (IRI) contributes to the development of chronic interstitial fibrosis/tubular atrophy in renal allograft patients. Cyclooxygenase (COX) 1 and 2 actively participate in acute isc...

    Authors: Carla Q. Feitoza, Giselle M. Gonçalves, Patricia Semedo, Marcos A. Cenedeze, Hélady S. Pinheiro, Felipe Caetano Beraldo, Oscar Fernando, Pavão dos Santos, Vicente de Paula A. Teixeira, Marlene A. dos Reis, Marilda Mazzali, Alvaro Pacheco-Silva and Niels Olsen Saraiva Câmara
    Citation: Molecular Medicine 2008 14:1411724
  40. Acute insulin resistance can develop following critical illness and severe injury, and the mortality of critically ill patients can be reduced by intensive insulin therapy. Thus, compensating for the insulin r...

    Authors: LaWanda H. Thompson, Hyeong T. Kim, Yuchen Ma, Natalia A. Kokorina and Joseph L. Messina
    Citation: Molecular Medicine 2008 14:1411715
  41. Steroid hormones induce changes in gene expression by binding to intracellular receptors that then translocate to the nucleus. Steroids have also been shown to rapidly modify cell function by binding to surfac...

    Authors: L. Jorge Góñez, Gaetano Naselli, Ilia Banakh, Hideo Niwa and Leonard C. Harrison
    Citation: Molecular Medicine 2008 14:1411697
  42. Although administration of 17β-estradiol (estrogen) following trauma-hemorrhage attenuates the elevation of cytokine production and mitogen-activated protein kinase (MAPK) activation in epidermal keratinocytes...

    Authors: Fariba Moeinpour, Mashkoor A. Choudhry, Luiz F. Poli de Figueiredo, Kirby I. Bland and Irshad H. Chaudry
    Citation: Molecular Medicine 2008 14:1411689
  43. Erythropoietin (EPO) is of great interest as a therapy for many of the central nervous system (CNS) diseases and its administration is protective in experimental autoimmune encephalomyelitis (EAE), an animal m...

    Authors: Manuela Mengozzi, Ilaria Cervellini, Paolo Bigini, Sara Martone, Antonella Biondi, Rosetta Pedotti, Barbara Gallo, Sara Barbera, Tiziana Mennini, Mariaserena Boraso, Marina Marinovich, Edwige Petit, Myriam Bernaudin, Roberto Bianchi, Barbara Viviani and Pietro Ghezzi
    Citation: Molecular Medicine 2008 14:1411682
  44. Previous studies have shown that both murine and human anti-double-stranded DNA (anti-dsDNA) antibodies can develop from non-DNA-reactive B cells and suggest a crucial role for somatic mutation in dsDNA bindin...

    Authors: Jie Zhang, Annett M. Jacobi, Tao Wang and Betty Diamond
    Citation: Molecular Medicine 2008 14:1411675

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