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  1. Regulation of transgene expression in target cells represents a critical and challenging aspect of gene therapy. Recently, a two-plasmid tetracycline-inducible system was developed in which the tetracycline re...

    Authors: Sandra B. Ogueta, Feng Yao and Wayne A. Marasco
    Citation: Molecular Medicine 2001 7:BF03401863
    Content type: OriginalPaper Published on:

  2. The retinoblastoma-interacting zinc-finger gene RIZ is expressed in two forms (RIZ1 and RIZ2) that differ for the presence near the N-terminus of RIZ1 of a conserved domain, defined PR (PRDI-BF1-RIZ homology),...

    Authors: Patrizia Gazzerro, Paola Bontempo, Ettore M. Schiavone, Ciro Abbondanza, Bruno Moncharmont, Ignazio Armetta, Nicola Medici, Mariacarla De Simone, Ernesto Nola, Giovanni A. Puca and Anna Maria Molinari
    Citation: Molecular Medicine 2001 7:BF03401861
    Content type: OriginalPaper Published on:

  4. Expression and enzymatic activity of heme oxygenase (HO) has been implicated in the development, as well as in the resolution, of inflammatory conditions. Because inflammation is central to tissue repair, we i...

    Authors: Heiko Kämpfer, Nicole Kolb, Markus Manderscheid, Christian Wetzler, Josef Pfeilschifter and Stefan Frank
    Citation: Molecular Medicine 2001 7:BF03401854
    Content type: OriginalPaper Published on:

  5. We have recently demonstrated that 17β-estradiol (E2) inhibits the increase of inducible nitric oxide synthetase (iNOS) activity in selected model systems such as macrophages, microglia, smooth muscle cells, and ...

    Authors: Salvatore Cuzzocrea, Emanuela Mazzon, Lidia Sautebin, Ivana Serraino, Laura Dugo, Giusi Calabró, Achille P. Caputi and Adriana Maggi
    Citation: Molecular Medicine 2001 7:BF03401853
    Content type: OriginalPaper Published on:

  6. Keratoconus is a noninflammatory disease characterized by thinning and scarring of the central portion of the cornea. The etiology is unclear. In this study, we sought to identify mRNAs that are differentially...

    Authors: Kelly Wentz-Hunter, E. Lillian Cheng, Jun Ueda, Joel Sugar and Beatrice Y. J. T. Yue
    Citation: Molecular Medicine 2001 7:BF03401852
    Content type: OriginalPaper Published on:

  7. Fibroblast activation protein (FAP) is a type II membrane protein expressed on tumor stroma fibroblasts in more than 90% of all carcinomas. FAP serves as a diagnostic marker and is potential therapeutic target...

    Authors: Bodo Brocks, Pilar Garin-Chesa, Eva Behrle, John E. Park, Wolfgang J. Rettig, Klaus Pfizenmaier and Dieter Moosmayer
    Citation: Molecular Medicine 2001 7:BF03401851
    Content type: OriginalPaper Published on:

  8. Signal transduction through the hydrolysis of glycosyl-phosphatidylinositol (GPI) leading to the release of the water-soluble inositol phosphoglycan (IPG) molecules has been demonstrated to be important for me...

    Authors: Covadonga Pañeda, Ana Victoria Villar, Alicia Alonso, Félix M. Goñi, Federico Varela, Urs Brodbeck, Yolanda León, Isabel Varela-Nieto and David R. Jones
    Citation: Molecular Medicine 2001 7:BF03401850
    Content type: OriginalPaper Published on:

  9. Human FHIT (fragile histidine triad) gene is highly conserved gene homologous to a group of genes identified in prokaryotes and eukaryotes. Loss of FHIT function may be important in the development and/or progres...

    Authors: Krešimir Pavelić, Šimun Križanac, Tamara Čačev, Marijana Popović Hadžija, Senka Radošević, Ivana Crnić, Sonja Levanat and Sanja Kapitanović
    Citation: Molecular Medicine 2001 7:BF03401849
    Content type: OriginalPaper Published on:

  10. UCP3 is a mitochondrial membrane transporter that is postulated to uncouple oxidative phosphorylation from ATP synthesis producing heat instead of ATP. Human UCP3 is mainly expressed in skeletal muscle, which ...

    Authors: Christian-Marc Lanouette, Jean-Paul Giacobino, Louis Pérusse, Michel Lacaille, Cédric Yvon, Monique Chagnon, Françoise Kuhne, Claude Bouchard, Patrick Muzzin and Yvon C. Chagnon
    Citation: Molecular Medicine 2001 7:BF03401848
    Content type: OriginalPaper Published on:

  11. Down-regulation or overexpression of the cyclin-dependent kinase inhibitor p27 have been observed in a range of malignancies, including lung cancer. To further elucidate the role of the molecule in tumor growt...

    Authors: Efthymia Tsoli, Vassilis G. Gorgoulis, Panayotis Zacharatos, Athanassios Kotsinas, George Mariatos, Nikolaos G. Kastrinakis, Stavros Kokotas, Panayotis Kanavaros, Panayotis Asimacopoulos, John Bramis, Dimitris Kletsas, Athanasios G. Papavassiliou and Christos Kittas
    Citation: Molecular Medicine 2001 7:BF03402188
    Content type: Review Article Published on:

  12. Activation of the nuclear enzyme poly (ADP-ribose) synthetase (PARS) in response to oxidant-mediated DNA injury has been shown to play an important role in the pathogenesis of reperfusion injury. Here we inves...

    Authors: Lucas Liaudet, Zequan Yang, El-Bachir Al-Affar and Csaba Szabó
    Citation: Molecular Medicine 2001 7:BF03402187
    Content type: Review Article Published on:

  13. Although alcohol abuse is known to cause a wide array of adverse effects on blood cell formation, the molecular mechanisms by which alcohol exerts its toxic actions remain poorly defined. We examine here the f...

    Authors: Jaana Latvala, Seppo Parkkila, Jukka Melkko and Onni Niemelä
    Citation: Molecular Medicine 2001 7:BF03402186
    Content type: Review Article Published on:

  14. The transcription factor Stat3 has been reported to play a key role in protecting cells against apoptosis by up-regulating expression of the anti-apoptotic gene Bcl-xL. This investigation analyzes the relationshi...

    Authors: Abdelhadi Rebbaa, Pauline M. Chou and Bernard L. Mirkin
    Citation: Molecular Medicine 2001 7:BF03402185
    Content type: Review Article Published on:

  15. Atherosclerosis, the major cause of mortality and invalidity in industrialized countries, is a multi-factorial disease associated with high plasma cholesterol levels and inflammation in the vessel wall. Many d...

    Authors: Dirk Marcus Wuttge, Allan Sirsjö, Per Eriksson and Sten Stemme
    Citation: Molecular Medicine 2001 7:BF03402184
    Content type: Review Article Published on:

  16. The complement cascade plays a deleterious role in multiple models of ischemia/reperfusion (I/R) injury, including stroke. Investigation of the complement cascade may provide a critical approach to identifying...

    Authors: Anthony L. D’Ambrosio, David J. Pinsky and E. Sander Connolly Jr
    Citation: Molecular Medicine 2001 7:BF03402183
    Content type: Review Article Published on:

  17. Nitric oxide (NO) is an inorganic gas produced by a family of NO synthase (NOS) proteins. The presence and the distribution of inducible-NOS (NOS II or iNOS), and NADPH-diaphorase (NADPH-d), a marker for NOS c...

    Authors: Jean-Pierre Louboutin, Karl Rouger, Jonathon M. Tinsley, Jeff Halldorson and James M. Wilson
    Citation: Molecular Medicine 2001 7:BF03402218
    Content type: OriginalPaper Published on:

  18. A major allergen from the lymphatic filarial parasite Brugia malayi implicated in the pathogenesis of tropical pulmonary eosinophilia (TPE) has recently been cloned and identified as the homolog of the membrane-b...

    Authors: Abdelhila Soussi Gounni, Katharina Spanel-Borowski, Miriam Palacios, Christoph Heusser, Salvador Moncada and Edgar Lobos
    Citation: Molecular Medicine 2001 7:BF03402217
    Content type: OriginalPaper Published on:

  20. Variegate porphyria (VP) is an inherited disorder of heme biosynthesis that results from a partial deficiency of protoporphyrinogen oxidase (PPOX). Patients with VP may experience acute neurovisceral attacks a...

    Authors: Mikael von und zu Fraunberg, Raimo Tenhunen and Raili Kauppinen
    Citation: Molecular Medicine 2001 7:BF03402215
    Content type: OriginalPaper Published on:

  21. Glucagon-producing α cells play a crucial role during the perinatal period. Because of their peri-islet localization near the early dendritic and macrophage cell infiltration, we thought it pertinent to investiga...

    Authors: Carme Pelegri, Judith G. M. Rosmalen, Sylvie Durant, Marc Throsby, Véronique Alvès, Josiane Coulaud, Anne Esling, Jean-Marie Pléau, Hemmo A. Drexhage and Françoise Homo-Delarche
    Citation: Molecular Medicine 2001 7:BF03402214
    Content type: OriginalPaper Published on:

  22. The loss of β cells in type 1 diabetes may involve protein kinases because they control cell growth, differentiation, and survival. Previous studies have revealed that GTK, a Src-like protein tyrosine kinase expr...

    Authors: Cecilia Annerén and Michael Welsh
    Citation: Molecular Medicine 2001 7:BF03402213
    Content type: OriginalPaper Published on:

  24. Classical Hodgkin’s disease (HD) and B-cell non-Hodgkin lymphoma (NHL) occasionally occur in the same patient. Such composite lymphomas represent interesting models to study the pathogenesis of B-cell lymphoma...

    Authors: Ralf Küppers, Ana B. Sousa, Audrey S. Baur, John G. Strickler, Klaus Rajewsky and Martin-Leo Hansmann
    Citation: Molecular Medicine 2001 7:BF03402211
    Content type: OriginalPaper Published on:

  25. The mda-7 gene (melanoma differentiation associated gene-7) is a novel tumor suppressor gene. The anti-proliferative activity of MDA-7 has been previously reported. In this report, we analyze the antitumor eff...

    Authors: Abner M. Mhashilkar, Robert D. Schrock, Mustafa Hindi, Jennifer Liao, Kerry Sieger, Famourou Kourouma, X. Helena Zou-Yang, Eric Onishi, Oksana Takh, Thomas S. Vedvick, Gary Fanger, Lorna Stewart, Graham J. Watson, David Snary, Paul B. Fisher, Tomoyuki Saeki…
    Citation: Molecular Medicine 2001 7:BF03401847
    Content type: OriginalPaper Published on:

  26. The balance between proteinases and antiproteinases plays an important role in tissue destruction and remodelling. In chronic obstructive pulmonary disease (COPD) and emphysema, an imbalance between matrix met...

    Authors: Marion Frankenberger, Rainer W. Hauck, Bernhard Frankenberger, Karl Häußinger, Konrad L. Maier, Joachim Heyder and H. W. Löms Ziegler-Heitbrock
    Citation: Molecular Medicine 2001 7:BF03401846
    Content type: OriginalPaper Published on:

  27. Although a clear correlation exists between cumulative alcohol intake and liver disease, only some of the alcohol abusers develop signs of ethanol-induced liver damage. To identify some of the genetic variatio...

    Authors: Adriana Monzoni, Flora Masutti, Gioconda Saccoccio, Stefano Bellentani, Claudio Tiribelli and Mauro Giacca
    Citation: Molecular Medicine 2001 7:BF03401845
    Content type: OriginalPaper Published on:

  28. Plasmodium falciparum merozoites bind to and invade human erythrocytes via specific erythrocyte receptors. This establishes the erythrocytic stage of the parasite life cycle that causes clinical disease resulting...

    Authors: B. Kim Lee Sim, David L. Narum, Hong Liang, Steven R. Fuhrmann, Nicanor Obaldia III, Robert Gramzinski, Joao Aguiar, J. David Haynes, J. Kathleen Moch and Stephen L. Hoffman
    Citation: Molecular Medicine 2001 7:BF03401844
    Content type: OriginalPaper Published on:

  31. We have proposed that an increased interaction between monocyte/macrophages and blood vessel endothelium predisposes subjects to strokes. The effect of chronic monocyte activation on the development of cerebra...

    Authors: Anna-Leena Sirén, Richard McCarron, Lan Wang, Patricia Garcia-Pinto, Christl Ruetzler, David Martin and John M. Hallenbeck
    Citation: Molecular Medicine 2001 7:BF03401841
    Content type: OriginalPaper Published on:

  32. Apoptosis plays an important pathophysiologic role in neuronal cell loss and associated neurologic deficits following traumatic brain injury (TBI). DNA fragmentation represents one of the characteristic bioche...

    Authors: Alexander G. Yakovlev, Xiao Di, Vilen Movsesyan, Paul G. M. Mullins, Geping Wang, Hamid Boulares, Jianhua Zhang, Ming Xu and Alan I. Faden
    Citation: Molecular Medicine 2001 7:BF03401955
    Content type: Original Articles Published on:

  33. The G52S mutation in the Arg50 loop of thymidylate synthase leads to decreased binding of FdUMP. It has been suggested that the mutation affects the Arg50 residue (within the Arg50 loop) responsible for binding t...

    Authors: Anne-Marie Sapse, Gina M. Capiaux and Joseph R. Bertino
    Citation: Molecular Medicine 2001 7:BF03401954
    Content type: Original Articles Published on:

  34. In the dementia associated with acquired immunodeficiency syndrome (AIDS), indirect pathomechanisms are important mediators of progressive neuronal injury and variable candidate molecules of potential pathogen...

    Authors: Brigitte Wildemann, Juergen Haas, Karoline Stingele, Brigitte Storch-Hagenlocher, Justin C. McArthur, Ted M. Dawson and Valina L. Dawson
    Citation: Molecular Medicine 2001 7:BF03401953
    Content type: Original Articles Published on:

  35. Recently, we synthesized a nonviral gene vector capable of transfecting cell lines taking advantage of neurotensin (NT) internalization. The vector is NT cross-linked with poly-L-lysine, to which a plasmid DNA wa...

    Authors: Ikuri Alvarez-Maya, Ivan Navarro-Quiroga, Marco Antonio Meraz-Ríos, Jorge Aceves and Daniel Martinez-Fong
    Citation: Molecular Medicine 2001 7:BF03401952
    Content type: Original Articles Published on:

  36. Prolonged exposure of alveolar macrophages (AM) to components of tobacco smoke, including nicotine and aromatic hydrocarbons, may lead to alterations in activation of cellular signaling pathways. In this study...

    Authors: Keiko Mochida-Nishimura, Krystyna Surewicz, Janet V. Cross, Rana Hejal, Dennis Templeton, Elizabeth A. Rich and Zahra Toossi
    Citation: Molecular Medicine 2001 7:BF03401951
    Content type: Original Articles Published on:

  37. The pathogenesis of HIV-1-related cardiomyopathy is poorly understood, but HIV-1 has been detected in cardiomyocytes. Whether HIV-1 penetrates into the myocardium by infection of coronary artery endothelial ce...

    Authors: Chandrasekhar Gujuluva, Alan R. Burns, Tatiana Pushkarsky, Waldemar Popik, Omri Berger, Michael Bukrinsky, Michael C. Graves and Milan Fiala
    Citation: Molecular Medicine 2001 7:BF03401950
    Content type: Original Articles Published on:

  38. Receptors for advanced glycation endproducts (AGE-R) mediate AGE turnover, but can also trigger inflammatory genes that promote diabetic tissue injury and diabetic complications (DC). High AGE levels and reduc...

    Authors: Ci-jiang He, Theodore Koschinsky, Christina Buenting and Helen Vlassara
    Citation: Molecular Medicine 2001 7:BF03401949
    Content type: Original Articles Published on:

  39. The transporter associated with antigen processing (TAP), a member of the family of ABC transporters, plays a crucial role in the processing and presentation of the major histocompatibility complex (MHC) class...

    Authors: Ulrike Ritz and Barbara Seliger
    Citation: Molecular Medicine 2001 7:BF03401948
    Content type: Review Article Published on:

  40. The induction of phase 2 enzymes by dithiolethiones such as oltipraz is an effective means for achieving protection against environmental carcinogens in animals and humans. Transcriptional control of the expre...

    Authors: Mi-Kyoung Kwak, Ken Itoh, Masayuki Yamamoto, Thomas R. Sutter and Thomas W. Kensler
    Citation: Molecular Medicine 2001 7:BF03401947
    Content type: OriginalPaper Published on:

  41. Essential (multigenic) hypertension is a complex multifactorial disease whose genetic etiology has not been unraveled on a major locus-effect investigative paradigm. As with other complex genetic diseases, app...

    Authors: Victoria L. M. Herrera, Lyle V. Lopez and Nelson Ruiz-Opazo
    Citation: Molecular Medicine 2001 7:BF03401946
    Content type: OriginalPaper Published on:

  42. Hirschsprung’s disease (HSCR) is one the most common congenital intestinal disease. It leads to aganglionic megacolon in the early childhood. Several susceptibility genes have been identified: RET protooncogen...

    Authors: Sébastien Fuchs, Jeanne Amiel, Sophie Claudel, Stanislas Lyonnet, Pierre Corvol and Florence Pinet
    Citation: Molecular Medicine 2001 7:BF03401945
    Content type: OriginalPaper Published on:

  43. The ability to manipulate the development of pancreatic insulin-producing β cells has implications for the treatment of type 1 diabetes. Previously, we found that laminin-1, a basement membrane trimeric glycoprot...

    Authors: Fang-Xu Jiang, E. Georges-Labouesse and Leonard C. Harrison
    Citation: Molecular Medicine 2001 7:BF03401944
    Content type: OriginalPaper Published on:

  44. Psychological stress induces rapid and long-lasting changes in blood cell composition, implying the existence of stress-induced factors that modulate hematopoiesis. Here we report the involvement of the stress...

    Authors: Dan Grisaru, Varda Deutsch, Michael Shapira, Marjorie Pick, Meira Sternfeld, Naomi Melamed-Book, Daniela Kaufer, Nilly Galyam, Michael J. Gait, David Owen, Joseph B. Lessing, Amiram Eldor and Hermona Soreq
    Citation: Molecular Medicine 2001 7:BF03401943
    Content type: OriginalPaper Published on:

  45. Previous studies show that macrophages, lung fibroblasts, and their soluble mediators are responsible for the onset and development of pulmonary fibrosis. This study was conducted to determine whether airway e...

    Authors: Maria Bodo, Tiziano Baroni, Silvia Bellocchio, Mario Calvitti, Cinzia Lilli, Alessandra D’Alessandro, Giacomo Muzi, Alessandro Lumare and Giuseppe Abbritti
    Citation: Molecular Medicine 2001 7:BF03401942
    Content type: OriginalPaper Published on:

  46. The action of the steroid hormone estradiol (E2) is mediated via interaction with a specific receptor (ER) that initiates a series of events downstream, leading to the modulation of hormone-responsive genes an...

    Authors: Debajit K. Biswas, Antonio Cruz, Nicole Pettit, George L. Mutter and Arthur B. Pardee
    Citation: Molecular Medicine 2001 7:BF03401839
    Content type: OriginalPaper Published on:

  47. There is growing evidence of apoptosis in neurodegenerative disease. However, it is still unclear whether the pathological manifestations observed in slow neurodegenerative diseases are due to neuronal loss or...

    Authors: Christiane Volbracht, Marcel Leist, Stefan A. Kolb and Pierluigi Nicotera
    Citation: Molecular Medicine 2001 7:BF03401837
    Content type: OriginalPaper Published on:

  48. The peritoneal fluid (PF) of women with endometriosis contains protease(s) activity able to hydrolyze insulin-like growth factor-binding protein 3 (IGFBP-3), increasing the bioavailability of insulin-like grow...

    Authors: Michael Koutsilieris, George Mastrogamvrakis, Panayiotis Lembessis, Antigone Sourla, Spyros Miligos and Stelios Michalas
    Citation: Molecular Medicine 2001 7:BF03401835
    Content type: OriginalPaper Published on:

  49. Hepatitis C infection induces an acute and chronic liver inflammation that may lead to cirrhosis, liver failure, or hepatocarcinoma. Since the role of αβ T lymphocytes in hepatitis C virus (HCV) immunopathology h...

    Authors: Chiara Agrati, Giampiero D’Offizi, Pasquale Narciso, Sergio Abrignani, Giuseppe Ippolito, Vittorio Colizzi and Fabrizio Poccia
    Citation: Molecular Medicine 2001 7:BF03401834
    Content type: OriginalPaper Published on:

  50. The gastric mucosal protective barrier consists of two essential elements: mucus glycoprotein, mucin, secreted by gastric mucosal cells, and the mucin binding protein (MBP), an integral component of the apical...

    Authors: Amalia Slomiany, Maria Grabska and Bronislaw L. Slomiany
    Citation: Molecular Medicine 2001 7:BF03401833
    Content type: OriginalPaper Published on:
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Molecular Medicine

ISSN: 1528-3658