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  1. It is widely accepted that mechanical loading is necessary to construct the architecture of bone and to maintain bone mass. However, the molecular mechanisms whereby bone cells respond to mechanical stimuli re...

    Authors: Fiorenzo A. Peverali, Efthimia K. Basdra and Athanasios G. Papavassiliou
    Citation: Molecular Medicine 2001 7:BF03401840
    Content type: OriginalPaper Published on:

  2. Low levels of the cyclin-dependent kinase inhibitor p27Kip1 are associated with poor prognosis in cancer. It is unclear whether this is related strictly to p27Kip1-mediated cell cycle inhibition or to other, p...

    Authors: Beatrice B. Yaroslavskiy, Donna B. Stolz, Simon C. Watkins, Sean M. Alber, Neil A. Bradbury and Richard A. Steinman
    Citation: Molecular Medicine 2001 7:BF03401838
    Content type: OriginalPaper Published on:

  3. The cytokine macrophage migration inhibitory factor (MIF), originally described as a T cell product, has recently been identified to mediate cellular interactions in several endocrine organs. Western blots ana...

    Authors: Regina Eickhoff, Beate Wilhelm, Heiner Renneberg, Gunther Wennemuth, Michael Bacher, Dietmar Linder, Richard Bucala, Jürgen Seitz and Andreas Meinhardt
    Citation: Molecular Medicine 2001 7:BF03401836
    Content type: OriginalPaper Published on:

  4. Donor specific tolerance to heart allografts is induced in LEW.1A rat recipient by two donor LEW.1W blood transfusions prior engraftment. Although the tolerant allograft is infiltrated by leukocytes, graft inf...

    Authors: Elise Chiffoleau, Jean-Marie Heslan, Jean-Paul Soulillou and Maria Cristina Cuturi
    Citation: Molecular Medicine 2000 6:BF03402056
    Content type: Original Articles Published on:

  5. Using specific antibodies against bovine Cu/Zn-superoxide dismutase (EC 1.15.1.1, SOD1) we demonstrated that anti-SOD antibodies (IgG1) are able to promote the intracellular translocation of the antioxidant enzym...

    Authors: Ioanis Vouldoukis, Virginie Sivan, Marie Catherine Vozenin, Caroline Kamaté, Alphonse Calenda, Dominique Mazier and Bernard Dugas
    Citation: Molecular Medicine 2000 6:BF03402055
    Content type: Original Articles Published on:

  6. Tumor necrosis factor alpha (TNFα) plays a key role in pathogenesis of brain injury. However, TNFα exhibits no cytotoxicity in primary cultures of brain cells. This discrepancy suggests that other pathogenic stim...

    Authors: Irene Ginis, John M. Hallenbeck, Jie Liu, Maria Spatz, Rama Jaiswal and Esther Shohami
    Citation: Molecular Medicine 2000 6:BF03402054
    Content type: Original Articles Published on:

  7. Recently, we have reported a rapid and strong induction of interleukin-18 (IL-18) upon cutaneous injury in mice. In this paper, we investigated a possible role of IL-18 in triggering interferon-γ (IFN-γ) producti...

    Authors: Heiko Kämpfer, Jens Paulukat, Heiko Mühl, Christian Wetzler, Josef Pfeilschifter and Stefan Frank
    Citation: Molecular Medicine 2000 6:BF03402053
    Content type: Original Articles Published on:

  8. Human multiple myeloma (MM) remains an incurable hematological malignancy. We have reported that β-lapachone, a pure compound derived from a plant, can induce cell death in a variety of human carcinoma cells, inc...

    Authors: Youzhi Li, Chiang J. Li, Donghui Yu and Arthur B. Pardee
    Citation: Molecular Medicine 2000 6:BF03402052
    Content type: Original Articles Published on:

  9. Several mouse strains expressing human islet amyloid polypeptide (IAPP) have been created to study development of islet amyloid and its impact on islet cell function. The tendency to form islet amyloid has var...

    Authors: Gunilla T. Westermark, Samuel Gebre-Medhin, Donald F. Steiner and Per Westermark
    Citation: Molecular Medicine 2000 6:BF03402051
    Content type: Original Articles Published on:

  10. Gene transfer into vascular smooth muscle cells (vsmcs) holds promise for studying the pathogenesis of arterial disorders. However, a potential limitation of vectors with heterologous promoters is organ toxici...

    Authors: Levent M. Akyürek, Zhi-Yong Yang, Kazunori Aoki, Hong San, Gary J. Nabel, Michael S. Parmacek and Elizabeth G. Nabel
    Citation: Molecular Medicine 2000 6:BF03401832
    Content type: Original Articles Published on:

  11. Cystic fibrosis (CF) is a syndrome caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene. Despite advances in our understanding of the molecular pathogenesis of CF, the link between CF...

    Authors: Scott H. Donaldson, Eduardo R. Lazarowski, Maryse Picher, Michael R. Knowles, M. Jackson Stutts and Richard C. Boucher
    Citation: Molecular Medicine 2000 6:BF03401831
    Content type: Original Articles Published on:

  12. Spinal muscular atrophy (SMA) is a common recessive disorder, characterized by degeneration of motor neurons of the spinal cord. Deletions, conversions, or mutations of the survival motor neuron gene (SMN) are...

    Authors: Sophie Baron-Delage, Annie Abadie, Andoni Echaniz-Laguna, Judith Melki and Laura Beretta
    Citation: Molecular Medicine 2000 6:BF03401830
    Content type: Original Articles Published on:

  13. Endothelin-1 (ET-1) is involved in the pathogenesis of several ischemic diseases. We investigated the hypotheses that ET-1 is involved in the pathogenesis of experimental critical hind limb ischemia and that E...

    Authors: Charles-Edouard Luyt, Delphine Lepailleur-Enouf, Cédric-J. Gaultier, Olivier Valdenaire, Gabriel Steg and Jean-Baptiste Michel
    Citation: Molecular Medicine 2000 6:BF03401829
    Content type: Original Articles Published on:

  14. The pathogenesis of bilirubin encephalopathy and Alzheimer’s disease appears to result from accumulation of unconjugated bilirubin (UCB) and amyloid-β (Aβ) peptide, respectively, which may cause apoptosis. Permea...

    Authors: Cecília M. P. Rodrigues, Susana Solá, Rui Silva and Dora Brites
    Citation: Molecular Medicine 2000 6:BF03401828
    Content type: Original Articles Published on:

  16. Chronic Myeloid Leukaemia (CML) is characterised by the chromosomal translocation resulting in expression of the Bcr-Abl protein tyrosine kinase (PTK) in early stem cells and their progeny. However the precise...

    Authors: Anne-Marie Buckle, Rachel Mottram, Andrew Pierce, Guy S. Lucas, Nigel Russell, Jaleel A. Miyan and Anthony D. Whetton
    Citation: Molecular Medicine 2000 6:BF03401826
    Content type: Original Articles Published on:

  17. Mutations in the presenilin proteins cause early-onset, familial Alzheimer’s disease (FAD).

    Authors: Paul M. Mathews, Anne M. Cataldo, Benjamin H. Kao, Anna G. Rudnicki, Xi Qin, John L. Yang, Ying Jiang, Melanie Picciano, Christine Hulette, Carol F. Lippa, Thomas D. Bird, David Nochlin, Jochen Walter, Christian Haass, Lyne Lévesque, Paul E. Fraser…
    Citation: Molecular Medicine 2000 6:BF03401825
    Content type: Original Articles Published on:

  18. Synthetic oligodeoxynucleotides (ODN) containing immunostimulatory cytosine-guanine phosphate-linked dinucleotide (CpG) motifs are potent systemic and mucosal adjuvants in mice that have synergistic action wit...

    Authors: Michael J. McCluskie, Risini D. Weeratna and Heather L. Davis
    Citation: Molecular Medicine 2000 6:BF03401824
    Content type: Original Articles Published on:

  20. Deposition of uric acid in the kidney can lead to progressive tubulointerstitial injury with granuloma formation. We hypothesized that uric acid crystal deposition may induce granuloma formation by stimulating...

    Authors: Yoon-Goo Kim, Xiao-Ru Huang, Shin-ichi Suga, Marilda Mazzali, Dongjiang Tang, Christine Metz, Richard Bucala, Salah Kivlighn, Richard J. Johnson and Hui Y. Lan
    Citation: Molecular Medicine 2000 6:BF03401822
    Content type: Original Articles Published on:

  21. Tight skin mice (TSK) bear a mutated Fibrillin-1 (Fbn-1) gene. Genetic studies show that the TSK mutation is closely associated with the Fbn-1 locus (0–0.7 cM). A previous study showed two recombinants between...

    Authors: Shinichiro Saito, Hiroyuki Nishimura, Robert G. Phelps, Imre Wolf, Mihsa Suzuki, Tasuku Honjo and Constantin Bona
    Citation: Molecular Medicine 2000 6:BF03401821
    Content type: Original Articles Published on:

  22. The pattern of platelet amyloid precursor protein (APP) forms is altered in sporadic Alzheimer’s disease patients, compared with both control subjects and non-Alzheimer’s disease-demented patients. The aims of...

    Authors: Lucia Pastorino, Francesca Colciaghi, Gabriella Marcon, Barbara Borroni, Elisabetta Cottini, Flaminio Cattabeni, Alessandro Padovani and Monica Di Luca
    Citation: Molecular Medicine 2000 6:BF03401820
    Content type: Original Articles Published on:

  23. Using the lymphocytic choriomeningitis virus (LCMV) model in mice, a number of studies show that memory cytotoxic T-lymphocyte (CTL) responses are maintained in the presence of continuous antigenic stimulation...

    Authors: Xia Jin, Graham Ogg, Sabstian Bonhoeffer, Jeffrey Safrit, Mika Vesanen, Daniel Bauer, Donald Chen, Yunzhen Cao, Marie-Ange Demoitie, Linqi Zhang, Martin Markowitz, Douglas Nixon, Andrew McMichael and David D. Ho
    Citation: Molecular Medicine 2000 6:BF03402195
    Content type: Original Articles Published on:

  24. T cells recognizing as yet unknown antigens (Ags) are considered to play an important role in the development and perpetuation of the disease process of sarcoidosis. Several studies have shown that T cells tha...

    Authors: Toshiyuki Sawabe, Satoshi Shiokawa, Katsunori Sugisaki, Tomiyasu Tsuda and Kazuhiko Yamamoto
    Citation: Molecular Medicine 2000 6:BF03402194
    Content type: Original Articles Published on:

  25. (MRL)-lpr/lpr mice spontaneously develop autoimmune disease characterized by arthritis and glomerulonephritis. Nitric oxide is postulated to play a role in the disease pathogenesis, as mice treated with the nitri...

    Authors: Teresa Keng, Christopher T. Privalle, Gary S. Gilkeson and J. Brice Weinberg
    Citation: Molecular Medicine 2000 6:BF03402193
    Content type: Original Articles Published on:

  26. Small intestine permeability is frequently altered in inflammatory bowel disease and may be caused by the translocation of intestinal toxins through leaky small intestine tight junctions (TJ) and adherence (1,2)....

    Authors: Salvatore Cuzzocrea, Emanuela Mazzon, Angela De Sarro and Achille P. Caputi
    Citation: Molecular Medicine 2000 6:BF03402192
    Content type: Original Articles Published on:

  27. Complementary DNA array analysis of gene expression has a potential application for clinical diagnosis of disease processes. However, accessibility, affordability, reproducibility of results, and management of...

    Authors: Ann-Marie Martoglio, Brian D. M. Tom, Michael Starkey, Anthony N. Corps, D. Stephen Charnock-Jones and Stephen K. Smith
    Citation: Molecular Medicine 2000 6:BF03402191
    Content type: Original Articles Published on:

  28. Prior studies indicate that leukemias expressing high levels of the p21WAF1 cell cycle inhibitor have a poorer prognosis than p21WAF1-negative leukemias. Although p21WAF1 is up-regulated by p53 in the setting ...

    Authors: Richard A. Steinman and Daniel E. Johnson
    Citation: Molecular Medicine 2000 6:BF03402190
    Content type: Original Articles Published on:

  29. Along with the elucidation of the role of cytotoxic T lymphocytes in the immune responses against a number of pathogens and cancer, and with the increased understanding of the cellular processing mechanisms of...

    Authors: Thomas W. Dubensky Jr., Margaret A. Liu and Jeffrey B. Ulmer
    Citation: Molecular Medicine 2000 6:BF03402189
    Content type: Review Article Published on:

  31. Tissues undergoing a chronic inflammatory process, such as the synovium in rheumatoid arthritis, are characterized by the infiltration of lymphocytes of different subsets and activation of monocyte/macrophages...

    Authors: Franck B. Riquet, Wen-Fu T. Lai, James R. Birkhead, Lii-Fang Suen, Gerard Karsenty and Mary B. Goldring
    Citation: Molecular Medicine 2000 6:BF03402050
    Content type: Original Articles Published on:

  32. In colon cancer, K-Ras oncogenes, which appear to be linked to chemoresistance and poor prognosis, are activated in more than 50% of cases, whereas the tumor suppressor gene p53 is mutationally altered in abou...

    Authors: Julius Halaschek-Wiener, Volker Wacheck, Hermine Schlagbauer-Wadl, Klaus Wolff, Yoel Kloog and Burkhard Jansen
    Citation: Molecular Medicine 2000 6:BF03402049
    Content type: Original Articles Published on:

  33. Although the association between insulin resistance and cardiovascular risk is well established, the underlying molecular mechanisms are poorly understood. The antifibrinolytic molecule plasminogen activator i...

    Authors: Fahumiya Samad, Manjula Pandey, Philip A. Bell and David J. Loskutoff
    Citation: Molecular Medicine 2000 6:BF03402048
    Content type: Original Articles Published on:

  34. Acute intermittent porphyria (AIP) is an autosomal dominant disorder that results from the partial deficiency of porphobilinogen deaminase (PBGD) in the heme biosynthetic pathway. Patients with AIP can experie...

    Authors: Sami Mustajoki, Minna Laine, Maija Lahtela, Pertti Mustajoki, Leena Peltonen and Raili Kauppinen
    Citation: Molecular Medicine 2000 6:BF03402047
    Content type: Original Articles Published on:

  35. Protozoan parasites of the genus Trypanosoma cause disease in a wide range of mammalian hosts. Trypanosoma brucei brucei, transmitted by tsetse fly to cattle, causes a disease (Nagana) of great economic importanc...

    Authors: Linda Troeberg, Xiaowu Chen, Terrence M. Flaherty, Rory E. Morty, Maosheng Cheng, Huiming Hua, Clayton Springer, James H. McKerrow, George L. Kenyon, John D. Lonsdale-Eccles, Theresa H. T. Coetzer and Fred E. Cohen
    Citation: Molecular Medicine 2000 6:BF03402046
    Content type: Original Articles Published on:

  36. The cysteine proteinase cathepsin K has aroused intense interest as the main effector in the digestion of extracellular matrix during bone resorption by osteoclasts. The enzyme is not a housekeeping lysosomal ...

    Authors: Alvaro Díaz, Antony C. Willis and Robert B. Sim
    Citation: Molecular Medicine 2000 6:BF03402045
    Content type: Original Articles Published on:

  38. Monoclonal (mAbKT) and recombinant single-chain (scFvKT) anti-idiotypic antibodies were produced to represent the internal image of a yeast killer toxin (KT) characterized by a wide spectrum of antimicrobial a...

    Authors: S. Conti, W. Magliani, S. Arseni, E. Dieci, R. Frazzi, A. Salati, P. E. Varaldo and L. Polonelli
    Citation: Molecular Medicine 2000 6:BF03401799
    Content type: Original Articles Published on:

  39. Interferon (IFN)-γ is a key to protective immunity against a variety of intracellular bacterial infections, including Chlamydia trachomatis. Interleukin (IL)-18, a recently identified Th1 cytokine, together with ...

    Authors: Hang Lu, Xi Yang, Kiyoshi Takeda, Dongji Zhang, Yijun Fan, Ma Luo, Caixia Shen, Shuhe Wang, Shizuo Akira and Robert C. Brunham
    Citation: Molecular Medicine 2000 6:BF03401798
    Content type: Original Articles Published on:

  40. CD39 is the dominant vascular nucleoside triphosphate diphosphohydrolase (NTPDase) that exerts major effects on platelet reactivity by the regulated hydrolysis of extracellular adenine nucleotides. The effects...

    Authors: Christian Goepfert, Masato Imai, Sophie Brouard, Eva Csizmadia, Elzbieta Kaczmarek and Simon C. Robson
    Citation: Molecular Medicine 2000 6:BF03401797
    Content type: Original Articles Published on:

  42. Mutations in the presenilin (PSEN) genes are responsible for the majority of early-onset Alzheimer disease (AD) cases. PSEN1 is a component of a high molecular weight, endoplasmic reticulum, membrane-bound pro...

    Authors: Geert Van Gassen, Chris De Jonghe, Masaki Nishimura, Gang Yu, Sofie Kuhn, Peter St. George-Hyslop and Christine Van Broeckhoven
    Citation: Molecular Medicine 2000 6:BF03401795
    Content type: Original Articles Published on:

  43. Chemokines and chemokine receptors have been shown to play a critical role in HIV infection. Chemokine receptors have been identified as coreceptors for viral entry into susceptible target cells, and several m...

    Authors: Barbara Sherry, Helena Schmidtmayerova, Gabriele Zybarth, Larisa Dubrovsky, Tobias Raabe and Michael Bukrinsky
    Citation: Molecular Medicine 2000 6:BF03401793
    Content type: Original Articles Published on:

  44. Plant-derived flavonoids, which occur abundantly in our daily dietary intake, possess antitumor, antibacterial, and free radical scavenging properties. They form active constituents of a number of herbal and t...

    Authors: Bidyottam Mittra, Asim Saha, Arnab Roy Chowdhury, Chiranjib Pal, Suparna Mandal, Sibabrata Mukhopadhyay, Santu Bandyopadhyay and Hemanta K. Majumder
    Citation: Molecular Medicine 2000 6:BF03401792
    Content type: Original Articles Published on:

  45. Recent studies indicate that soluble Fas (sFas) may modulate T-cell apoptosis, since it inhibits Fas-ligand (Fas-L)-mediated cytotoxicity in vitro. Here, we explored whether the soluble receptor and its major ...

    Authors: Franco Silvestris, Paola Cafforio, Marco Tucci, Annalisa Del Prete and Franco Dammacco
    Citation: Molecular Medicine 2000 6:BF03401791
    Content type: Original Articles Published on:

  46. Previous studies have demonstrated that immunoglobulin G (IgG) antibodies to VEINCTR-N, a domain shared by Fas (CD95/Apo-I) and gp120, contribute to T-cell apoptosis during human immunodeficiency virus-type 1 ...

    Authors: Franco Silvestris, Tiziana Cocco, Paola Cafforio, Nicola Calvani and Franco Dammacco
    Citation: Molecular Medicine 2000 6:BF03401790
    Content type: Original Articles Published on:

  48. The notion that a deficit in immune cell functions permits tumor growth has received experimental support with the discovery of several different biochemical defects in T lymphocytes that infiltrate cancers. D...

    Authors: Sasa Radoja and Alan B. Frey
    Citation: Molecular Medicine 2000 6:BF03401788
    Content type: Review Article Published on:

  49. The vast majority of patients with high-grade gliomas (HGG) over-express interleukin 4 (IL4)-independent binding sites for IL13 in situ. In addition, mutated IL13-based cytotoxins directed specifically toward ...

    Authors: Waldemar Debinski and Denise M. Gibo
    Citation: Molecular Medicine 2000 6:BF03401786
    Content type: Original Articles Published on:

  50. Amyloid-β (Aβ) accumulates in plaques and as cerebral amyloid angiopathy (CAA) in the brains of both Alzheimer’s disease (AD) patients and transgenic AβPPswe/tg2576 (tg2576) mice. Increasingly, evidence in humans...

    Authors: Yu-Min Kuo, Fiona Crawford, Michael Mullan, Tyler A. Kokjohn, Mark R. Emmerling, Roy O. Weller and Alex E. Roher
    Citation: Molecular Medicine 2000 6:BF03401785
    Content type: Original Articles Published on:
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Molecular Medicine

ISSN: 1528-3658