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  1. Recent reports identify the 3′-UTR of insulin mRNA as crucial for control of insulin messenger stability. This region contains a pyrimidine-rich sequence, which is similar to the hypoxia-responsive mRNA-stabil...

    Authors: Linda Tillmar and Nils Welsh
    Citation: Molecular Medicine 2002 8:BF03402152
    Content type: OriginalPaper Published on:

  2. There is a major need for a mouse model of Gaucher disease, but the glucocerebrosidase knockout mouse is not viable; it dies shortly before or immediately after birth, apparently because of involvement of the ...

    Authors: Ernest Beutler, Carol West, Bruce E. Torbett and Hiroshi Deguchi
    Citation: Molecular Medicine 2002 8:BF03402150
    Content type: OriginalPaper Published on:

  3. The trefoil factor 1 (TFF1/pS2) is a secreted gastrointestinal peptide that is often altered or lost in human gastric cancers. Consistently, mouse TFF1 deficiency leads to antropyloric tumors.

    Authors: Luis-Fernando Torres, Sherif M. Karam, Corinne Wendling, Marie-Pierre Chenard, David Kershenobich, Catherine Tomasetto and Marie-Christine Rio
    Citation: Molecular Medicine 2002 8:BF03402153
    Content type: OriginalPaper Published on:

  4. Glucagon is a 29-residue peptide produced in the a cells of the pancreas that interacts with hepatic receptors to stimulate glucose production and release, via a cAMP-mediated pathway. Type 2 diabetes patients ma...

    Authors: Anne-Marie Sapse, Robert Rothchild, Duli C. Jain and Cecilia G. Unson
    Citation: Molecular Medicine 2002 8:BF03402151
    Content type: OriginalPaper Published on:

  5. We hypothesized that ratios of pro- to anti-inflammatory cytokines can be associated with hepatic, cardiac, and renal function after a severe trauma and can be used as predictors for clinical outcome. Furtherm...

    Authors: Marc G. Jeschke, Robert E. Barrow, Fujiyo Suzuki, Jyoti Rai, Deb Benjamin and David N. Herndon
    Citation: Molecular Medicine 2002 8:BF03402149
    Content type: OriginalPaper Published on:

  6. Alterations in the p53 tumor suppressor gene constitute one of the most frequent genetic events associated with the development of human cancers. Determination of an individual’s p53 status may be of value in ...

    Authors: Darren R. Hodgson, Carole A. Foy, Maxine Partridge, Stelios Pateromichelakis and Neil J. Gibson
    Citation: Molecular Medicine 2002 8:BF03402148
    Content type: OriginalPaper Published on:

  8. The aim of this study was to determine whether crystals of hydroxyapatite (HA) or brushite (BR) formed in urine promote the epitaxial deposition of calcium oxalate (CaOx) from undiluted human urine in vitro an...

    Authors: Phulwinder K. Grover, Dong-Sun Kim and Rosemary Lyons Ryall
    Citation: Molecular Medicine 2002 8:BF03402012
    Content type: OriginalPaper Published on:

  9. The MDM2 oncogene is amplified or overexpressed in many human cancers and MDM2 levels are associated with poor prognosis. MDM2 not only serves as a negative regulator of p53 but also has p53-independent activi...

    Authors: Hui Wang, Li Nan, Dong Yu, J. Russell Lindsey, Sudhir Agrawal and Ruiwen Zhang
    Citation: Molecular Medicine 2002 8:BF03402011
    Content type: OriginalPaper Published on:

  10. Recent observations in the EURODIAB Complications Study demonstrated that markers of insulin resistance are strong risk factors for retinopathy incidence in patients with diabetes. However, the molecular mecha...

    Authors: Sho-ichi Yamagishi, Tamami Okamoto, Shinjiro Amano, Yosuke Inagaki, Kohachiro Koga, Mari Koga, Hiroshi Choei, Nobuyuki Sasaki, Seiji Kikuchi, Masayoshi Takeuchi and Zenji Makita
    Citation: Molecular Medicine 2002 8:BF03402010
    Content type: OriginalPaper Published on:

  11. The rat model of chronic intoxication by NG-nitro-l-arginine methyl ester (l-NAME) induces severe systemic arterial hypertension and progressive ischemic lesions in the central nervous system and kidneys. We inve...

    Authors: Delphine Corseaux, Véronique Ollivier, Vincent Fontaine, Marie-Geneviève Huisse, Monique Philippe, Liliane Louedec, Roger Vranckx, Catherine Ravanat, François Lanza, Edouardo Angles-Cano, Marie-Claude Guillin and Jean-Baptiste Michel
    Citation: Molecular Medicine 2002 8:BF03402009
    Content type: OriginalPaper Published on:

  12. The melanocortin system includes five receptors (MC1R to MC5R), and mouse and human MC4R has been shown to be involved in the regulation of feeding, and mouse MC3R in body composition. To verify a possible sim...

    Authors: N. Boucher, C. M. Lanouette, M. Larose, L. Pérusse, C. Bouchard and Y. C. Chagnon
    Citation: Molecular Medicine 2002 8:BF03402008
    Content type: Original Articles Published on:

  13. Perturbation in a level of any peptide from insulin-like growth factor (IGF) family (ligands, receptors, and binding proteins) seems to be implicated in lung cancer formation; IGF ligands and IGF-I receptor th...

    Authors: Jasminka Pavelić, Ljubomir Pavelić, Jerolim Karadža, Šimun Križanac, Josip Unešić, Šime Spaventi and Krešimir Pavelić
    Citation: Molecular Medicine 2002 8:BF03402007
    Content type: Original Articles Published on:

  14. A variety of methods for prediction of peptide binding to major histocompatibility complex (MHC) have been proposed. These methods are based on binding motifs, binding matrices, hidden Markov models (HMM), or ...

    Authors: Kun Yu, Nikolai Petrovsky, Christian Schönbach, Judice L. Y. Koh and Vladimir Brusic
    Citation: Molecular Medicine 2002 8:BF03402006
    Content type: Original Articles Published on:

  15. Glycosylphosphatidylinositol-anchored plasma membrane (GPI) proteins, such as Gce1, the dually acylated nonreceptor tyrosine kinases (NRTKs), such as pp59Lyn, and the membrane protein, caveolin, together with cho...

    Authors: Günter Müller, Nils Hanekop, Susanne Wied and Wendelin Frick
    Citation: Molecular Medicine 2002 8:BF03402005
    Content type: Original Articles Published on:

  17. Two prominent biological features of the advanced stages of human melanoma are their high degree of vascularity and high-level expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor r...

    Authors: Marianne Valesky, Aaron J. Spang, Gregory W. Fisher, Daniel L. Farkas and Dorothea Becker
    Citation: Molecular Medicine 2002 8:BF03402080
    Content type: OriginalPaper Published on:

  19. Among adrenergic receptor subtypes that regulate lipid mobilization, the α2-adrenergic receptor is involved in the inhibition of fatty acid mobilization from adipose tissue. A C-1291G polymorphism is located in t...

    Authors: Christophe Garenc, Louis Pérusse, Yvon C. Chagnon, Tuomo Rankinen, Jacques Gagnon, Ingrid B. Borecki, Arthur S. Leon, James S. Skinner, Jack H. Wilmore, D. C. Rao and Claude Bouchard
    Citation: Molecular Medicine 2002 8:BF03402078
    Content type: OriginalPaper Published on:

  20. Cystic fibrosis (CF) results from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a chloride channel localized at the plasma membrane of diverse epithelia. The m...

    Authors: Ana C. V. deCarvalho, Chi P. Ndi, Apollinaire Tsopmo, Pierre Tane, Johnson Ayafor, Joseph D. Connolly and John L. Teem
    Citation: Molecular Medicine 2002 8:BF03402077
    Content type: OriginalPaper Published on:

  21. Members of membrane-bound disintegrin metalloproteinases (ADAMs) were shown to be capable of cleaving amyloid precursor protein (APP) at the α-cleavage site in different cell systems. One of the candidate α-secre...

    Authors: Francesca Colciaghi, Barbara Borroni, Lucia Pastorino, Elena Marcello, Martina Zimmermann, Flaminio Cattabeni, Alessandro Padovani and Monica Di Luca
    Citation: Molecular Medicine 2002 8:BF03402076
    Content type: OriginalPaper Published on:

  22. Chediak-Higashi syndrome (CHS) is an inherited immunodeficiency disease characterized by giant lysosomes and impaired leukocyte degranulation. CHS results from mutations in the lysosomal trafficking regulator ...

    Authors: Velizar T. Tchernev, Traci A. Mansfield, Loic Giot, A. Madan Kumar, Krishnan Nandabalan, Ying Li, Vishnu S. Mishra, John C. Detter, Jonathan M. Rothberg, Margaret R. Wallace, Frederick S. Southwick and Stephen F. Kingsmore
    Citation: Molecular Medicine 2002 8:BF03402003
    Content type: OriginalPaper Published on:

  23. We sought to identify genes with altered expression during human breast cancer progression by applying mRNA comparisons of normal and tumor mammary cell lines with increasingly malignant phenotypes. The gene e...

    Authors: Georgia Sotiropoulou, Mari Kono, Anthony Anisowicz, Goran Stenman, Shuichi Tsuji and Ruth Sager
    Citation: Molecular Medicine 2002 8:BF03402002
    Content type: OriginalPaper Published on:

  24. MUC1, a membrane-tethered glycoprotein that is expressed on a number of epithelial cell types in vivo, is over-expressed in adenocarcinomas and thought to play a significant role in tumour progression and metasta...

    Authors: Toshiyuki Shiraga, David Smith, Hugh N. Nuthall, Michael A. Hollingsworth and Ann Harris
    Citation: Molecular Medicine 2002 8:BF03402001
    Content type: OriginalPaper Published on:

  25. Essential hypertension is a prevalent complex polygenic disease and a major risk factor for cardiovascular disease, the leading cause of death in developed countries. Because of its complex and multifactorial ...

    Authors: Nelson Ruiz-Opazo, Lyle V. Lopez and Victoria L. M. Herrera
    Citation: Molecular Medicine 2002 8:BF03402000
    Content type: OriginalPaper Published on:

  26. Cytoadherence and rosetting contribute to the development of severe Plasmodium falciparum malaria. In Brazil, severe falciparum malaria is mostly associated with renal or pulmonary complications and very rarely w...

    Authors: Karin Kirchgatter and Hernando A. del Portillo
    Citation: Molecular Medicine 2002 8:BF03401999
    Content type: OriginalPaper Published on:

  27. Binding of serum amyloid P component (SAP) to its ligands, including bacteria, chromatin and amyloid fibrils, protects them from degradation, is antiopsonic and anti-immunogenic. SAP thereby enhances the virul...

    Authors: Jeff Herbert, Winston L. Hutchinson, Jackie Carr, Jane Ives, Roland Jakob-Roetne, Ken-ichi Yamamura, Misao Suzuki and Mark B. Pepys
    Citation: Molecular Medicine 2002 8:BF03401998
    Content type: OriginalPaper Published on:

  28. Implantation of foreign materials into mice and humans has been noted to result in the appearance of soft tissue sarcomas at the site of implantation. These materials include metal replacement joints and Dacro...

    Authors: Baskaran Govindarajan, Robert Klafter, Mark Steven Miller, Claire Mansur, Melissa Mizesko, Xianhe Bai, Kenneth LaMontagne Jr and Jack L. Arbiser
    Citation: Molecular Medicine 2002 8:BF03401997
    Content type: OriginalPaper Published on:

  29. Cyclooxygenase-2 (COX-2) is an inducible enzyme involved in the conversion of arachadonic acid to prostaglandins and other eicosaniods. Persistent COX-2 expression is associated with multiple forms of cancer. ...

    Authors: Katherine Meyer-Siegler
    Citation: Molecular Medicine 2001 7:BF03401977
    Content type: Original Articles Published on:

  30. X-linked ichthyosis (XLI) is an inherited disorder due to steroid sulfatase deficiency (STS). Most XLI patients (>90%) have complete deletion of the STS gene and flanking sequences. The presence of low copy nu...

    Authors: Ana Luisa Jimenez Vaca, Margarita Valdes-Flores, Maria del Refugio Rivera-Vega, Luz María González-Huerta, Susana Helen Kofman-Alfaro and Sergio Alberto Cuevas-Covarrubias
    Citation: Molecular Medicine 2001 7:BF03401976
    Content type: Original Articles Published on:

  31. The mechanisms underlying the known interaction of two complex polygenic traits, hypertension and hyperlipidemia, resulting in exacerbation of coronary artery disease have not been elucidated. Identification o...

    Authors: Victoria L. M. Herrera, Tamara Didishvili, Lyle V. Lopez, Kimberly Zander, Sarah Traverse, Donald Gantz, Haya Herscovitz and Nelson Ruiz-Opazo
    Citation: Molecular Medicine 2001 7:BF03401975
    Content type: Original Articles Published on:

  32. Relatively few genes have been shown to directly affect the metastatic phenotype of breast cancer epithelial cells in vivo. The Rho family of proteins, including the Rho, Rac and Cdc42 subfamilies, are related to...

    Authors: Boumediene Bouzahzah, Chris Albanese, Fayyaz Ahmed, Fiona Pixley, Michael P. Lisanti, Jeffrey D. Segall, John Condeelis, David Joyce, Audrey Minden, Channing J. Der, Amanda Chan, Marc Symons and Richard G. Pestell
    Citation: Molecular Medicine 2001 7:BF03401974
    Content type: Original Articles Published on:

  33. Apolipoprotein E (apoE) mediates lipoprotein uptake by receptors such as the LDL receptor (LDLR). The isoform apoE4 has been linked to Alzheimer’s disease and to poor outcomes after brain injury. Astrocytes th...

    Authors: Nassia Methia, Patrick André, Ali Hafezi-Moghadam, Maria Economopoulos, Kennard L. Thomas and Denisa D. Wagner
    Citation: Molecular Medicine 2001 7:BF03401973
    Content type: Original Articles Published on:

  34. Some lines of mice homozygous for a disrupted prion protein gene (Prnp), including Ngsk Prnp0/0 mice, exhibit Purkinje cell degeneration as a consequence of the ectopic overexpression of the downstream gene for p...

    Authors: Ryuichiro Atarashi, Suehiro Sakaguchi, Kazuto Shigematsu, Kazuhiko Arima, Nobuhiko Okimura, Naohiro Yamaguchi, Aimin Li, Juraj Kopacek and Shigeru Katamine
    Citation: Molecular Medicine 2001 7:BF03401972
    Content type: Original Articles Published on:

  35. The biological activity of enediyne chemotherapeutic (anti-cancer) agents is attributed to their ability to cleave duplex DNA. Part of the reaction of cleavage is the abstraction of hydrogens from the deoxyrib...

    Authors: Anne-Marie Sapse, Robert Rothchild, Rohtash Kumar and J. William Lown
    Citation: Molecular Medicine 2001 7:BF03401971
    Content type: Original Articles Published on:

  37. The advanced stage of the Maillard reaction that leads to the formation of advanced glycation end-products (AGEs) plays an important role in the pathogenesis of angiopathy in diabetic patients and in the aging...

    Authors: Masayoshi Takeuchi, Yukiko Yanase, Nobuyasu Matsuura, Sho-ichi Yamagishi, Yukihiko Kameda, Richard Bucala and Zenji Makita
    Citation: Molecular Medicine 2001 7:BF03401969
    Content type: Original Articles Published on:

  38. Estrogen receptors (ER) are expressed in about two thirds of human breast cancer, and are an important pharmacological target for treatment of these tumors. Dominant negative forms of the ER have been suggeste...

    Authors: Eun Jig Lee, Monika Jakacka, W. Rachel Duan, Pei Yu Chien, Fred Martinson, Barry D. Gehm and J. Larry Jameson
    Citation: Molecular Medicine 2001 7:BF03401968
    Content type: Original Articles Published on:

  39. Arsenic has been considered as a carcinogen. Recently the issue of arsenic in drinking water raised an unprecedented social concern on human health, and yet the molecular mechanisms through which arsenic induc...

    Authors: Kailene Souza, David Audoen Maddock, Quanshun Zhang, Jianping Chen, Cheuk Chiu, Shashi Mehta and Yinsheng Wan
    Citation: Molecular Medicine 2001 7:BF03401967
    Content type: Original Articles Published on:

  40. Chronic stress, mediated by adrenal hormones, is a major risk factor in the progression and outcome of human disease. While the secretion of adrenal hormones is known to be the primary endocrine mediator of st...

    Authors: Deborah L. Drazen, Donna Bilu, Nancy Edwards and Randy J. Nelson
    Citation: Molecular Medicine 2001 7:BF03401966
    Content type: Original Articles Published on:

  41. All three major members of the MAPK family (i.e., p38 MAPK, p42/p44 MAPK, and c-Jun N terminal kinase (JNK)) have been shown to control cellular responses to inflammation in vitro. Therefore these kinases have...

    Authors: Bernt van den Blink, Judith Branger, Sebastiaan Weijer, Sander J. H. van Deventer, Tom van der Poll and Maikel P. Peppelenbosch
    Citation: Molecular Medicine 2001 7:BF03401965
    Content type: Original Articles Published on:

  42. Nitric oxide (NO) has frequently been shown to inhibit leukocyte adherence to activated endothelium thus displaying anti-adhesive and immunosuppressive activities. A molecular mechanism contributing to this ef...

    Authors: Denise Berendji-Grün, Victoria Kolb-Bachofen and Klaus-Dietrich Kröncke
    Citation: Molecular Medicine 2001 7:BF03401964
    Content type: Original Articles Published on:

  43. Lysozyme (LZ), a host-defense protein, contains an 18 amino-acid domain with high affinity binding for sugar-derived proteins or lipids, called advanced glycation endproducts (AGE), that are implicated in diab...

    Authors: Feng Zheng, Weijing Cai, Tomoko Mitsuhashi, Helen Vlassara and R. Bucala
    Citation: Molecular Medicine 2001 7:BF03401963
    Content type: Original Articles Published on:

  44. A long-standing goal in genetic therapy for cancer is a systemic gene delivery system that selectively targets tumor cells, including metastases. Here we describe a novel cationic immunolipoplex system that sh...

    Authors: Liang Xu, Wen-Hua Tang, Cheng-Cheng Huang, William Alexander, Lai-Man Xiang, Kathleen F. Pirollo, Antonina Rait and Esther H. Chang
    Citation: Molecular Medicine 2001 7:BF03401962
    Content type: Original Articles Published on:

  45. Non-Hodgkin’s B lymphomas (NHL) are often resistant to conventional treatments and, until now, immunotherapeutic approaches against NHL only aimed at inducing αβ anti-tumor effectors. Nevertheless, human blood Vγ

    Authors: Hélène Sicard, Talal Al Saati, Georges Delsol and Jean-Jacques Fournié
    Citation: Molecular Medicine 2001 7:BF03401961
    Content type: Original Articles Published on:

  46. Identification and validation of a drug discovery target is a prominent step in drug development. In the post-genomic era it is possible to reevaluate the association of a gene with a specific biological funct...

    Authors: Marcin P. Joachimiak, Calvin Chang, Philip J. Rosenthal and Fred E. Cohen
    Citation: Molecular Medicine 2001 7:BF03401960
    Content type: Original Articles Published on:

  47. The acute respiratory distress syndrome (ARDS) represents a form of severe acute inflammatory lung disease. We have previously demonstrated significantly raised interleukin-8 (IL-8) levels in the lungs of at-r...

    Authors: Nikhil Hirani, Frank Antonicelli, Robert M. Strieter, Michael S. Wiesener, Chris Haslett and Seamas C. Donnelly
    Citation: Molecular Medicine 2001 7:BF03401959
    Content type: Original Articles Published on:

  48. Prions are unusually resistant to conventional disinfection procedures. An electrode used intracerebrally on a Creutzfeldt-Jakob disease (CJD) patient transmitted the disease to two patients in succession and ...

    Authors: Eckhard Flechsig, Ivan Hegyi, Masato Enari, Petra Schwarz, John Collinge and Charles Weissmann
    Citation: Molecular Medicine 2001 7:BF03401958
    Content type: Original Articles Published on:

  49. Glucocorticoids (GC) such as dexamethasone (Dex) can directly upregulate human immunodeficiency virus type-1 (HIV-1) replication in acutely infected cells and potentiate HIV expression from chronically infecte...

    Authors: Audrey L. Kinter, Priscilla Biswas, Massimo Alfano, Jesse S. Justement, Barbara Mantelli, Chiara Rizzi, Alessandra R. Gatti, Elisa Vicenzi, Peter Bressler and Guido Poli
    Citation: Molecular Medicine 2001 7:BF03401957
    Content type: Original Articles Published on:

  50. Although current treatment modalities for malignant gliomas, such as surgery, radiation and chemotherapy, have been improved markedly in the past two decades, the prognosis of these neoplasms remains poor, the...

    Authors: Ariane Söling and Nikolai G. Rainov
    Citation: Molecular Medicine 2001 7:BF03401956
    Content type: Review Article Published on:
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Molecular Medicine

ISSN: 1528-3658