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  1. Mammalian cells expressing the small hepatitis B virus surface protein (HBs) secrete highly immunogenic 20 nm lipoprotein particles. Previous studies demonstrated that the fusion of foreign sequences into cert...

    Authors: Gerhard Wunderlich and Hernando A. del Portillo
    Citation: Molecular Medicine 2000 6:BF03402116
    Content type: Review Article Published on:

  2. Recent in vitro studies provide evidence that the cell cycle molecules pRb, p53 and MDM2 form a tightly regulated protein network. In this study, we examined the relationship of this protein network in a serie...

    Authors: V. G. Gorgoulis, P. Zacharatos, A. Kotsinas, G. Mariatos, T. Liloglou, T. Vogiatzi, P. Foukas, G. Rassidakis, G. Garinis, T. Ioannides, V. Zoumpourlis, J. Bramis, P. O. Michail, P. J. Asimacopoulos, J. K. Field and Ch. Kittas
    Citation: Molecular Medicine 2000 6:BF03402115
    Content type: Review Article Published on:

  3. Certain gene therapy protocols may require multiple administrations of vectors to achieve therapeutic benefit to the patient. This may be especially relevant for vectors such as adenoviral vectors that do not ...

    Authors: Wanda K. O’Neal, Heshan Zhou, Núria Morral, Claire Langston, Robin J. Parks, Frank L. Graham, Stefan Kochanek and Arthur L. Beaudet
    Citation: Molecular Medicine 2000 6:BF03402113
    Content type: Review Article Published on:

  4. Human breast carcinoma cell lines express high-affinity interleukin-4 receptors (IL-4R). We examined the expression and structure of these receptors on primary and cultured breast carcinoma cell lines and norm...

    Authors: P. Leland, J. Taguchi, S. R. Husain, R. J. Kreitman, I. Pastan and R. K. Puri
    Citation: Molecular Medicine 2000 6:BF03402112
    Content type: Review Article Published on:

  8. The Maillard reaction that leads to the formation of advanced glycation end-products (AGE) plays an important role in the pathogenesis of angiopathy in diabetic patients and in the aging process. Recently, it ...

    Authors: Masayoshi Takeuchi, Zenji Makita, Richard Bucala, Takako Suzuki, Takao Koike and Yukihiko Kameda
    Citation: Molecular Medicine 2000 6:BF03401779
    Content type: Original Articles Published on:

  9. The diagnosis of X-linked agammaglobulinemia (XLA) is not always clearcut. Not all XLA conform to the classic phenotype and less than 50% of affected boys have a family history of immunodeficiency. Mutations i...

    Authors: Viviana Moschese, Paola Orlandi, Alessandro Plebani, Konstantinos Arvanitidis, Maurilia Fiorini, Matthaios Speletas, Patrizia Mella, Kostas Ritis, Paschalis Sideras, Andrea Finocchi, Susanna Livadiotti and Paolo Rossi
    Citation: Molecular Medicine 2000 6:BF03401778
    Content type: Original Articles Published on:

  10. Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic cytokine with mitogenic, motogenic and morphogenic effects for a wide variety of cells. Previous studies have reported that the in vivo infusio...

    Authors: Daniel Phaneuf, Shu-Jen Chen and James M. Wilson
    Citation: Molecular Medicine 2000 6:BF03401777
    Content type: Original Articles Published on:

  11. Embryonic stem (ES) cells are lines of cells that are isolated from blastocysts. The murine ES cells were demonstrated to be true pluripotent cells as they differentiate into all embryonic lineages. Yet, in vi...

    Authors: Joseph Itskovitz-Eldor, Maya Schuldiner, Dorit Karsenti, Amir Eden, Ofra Yanuka, Michal Amit, Hermona Soreq and Nissim Benvenisty
    Citation: Molecular Medicine 2000 6:BF03401776
    Content type: Original Articles Published on:

  14. The oncogenic properties of murine double minute-2 (mdm2) protein over-expression, which mostly results from the interaction with the tumor suppressor p53, are well described and their negative impacts on the pro...

    Authors: Helge Taubert, Thomas Koehler, Axel Meye, Frank Bartel, Christiane Lautenschläger, Silke Borchert, Matthias Bache, Hannelore Schmidt and Peter Würl
    Citation: Molecular Medicine 2000 6:BF03401934
    Content type: Original Articles Published on:

  15. Impairment of the fertility in the platelet-activating factor (PAF) receptor transgenic female mice suggests changes in PAF functions can influence uterine receptivity. We hypothesized that vasodilatory action...

    Authors: Sharon Dearn, Mabhub Rahman, Aurélia Lewis, Zahra Ahmed, Margaret C. Eggo and Asif S. Ahmed
    Citation: Molecular Medicine 2000 6:BF03401933
    Content type: Original Articles Published on:

  16. A deletion of 32 base pairs in the CCR5 gene (Δ32 CCR5) has been linked to resistance to HIV-1 infection in exposed adults and to the delay of disease progression in infected adults.

    Authors: Maria Luisa Romiti, Claudia Colognesi, Caterina Cancrini, Antonio Mas, Monica Berrino, Francesca Salvatori, Paola Orlandi, Marianne Jansson, Elvia Palomba, Anna Plebani, Jose M. Bertran, Manuel Hernandez, Maurizio de Martino, Antonio Amoroso, Pier Angelo Tovo, Paolo Rossi…
    Citation: Molecular Medicine 2000 6:BF03401932
    Content type: Original Articles Published on:

  17. The epidermal growth factor receptor (EGFR) is expressed at different levels in many cell types and found overexpressed in many cancers. EGFR expression is increased or decreased in response to extracellular s...

    Authors: Alfred C. Johnson, Barbara A. Murphy, Christine M. Matelis, Yaffa Rubinstein, Elise C. Piebenga, LaTania M. Akers, Gila Neta, Charles Vinson and Michael Birrer
    Citation: Molecular Medicine 2000 6:BF03401931
    Content type: Original Articles Published on:

  18. ErbB-2 is a critical oncogenic marker in human breast cancer. Its appearance correlates with poor prognosis and it is, therefore, an important target for physiologic investigation and therapeutic intervention....

    Authors: Edward J. Weinstein, Daniel I. Kitsberg and Philip Leder
    Citation: Molecular Medicine 2000 6:BF03401930
    Content type: Original Articles Published on:

  19. Peptides derived from the HLA dass I heavy chain (a.a. 75–84) have been shown to modulate irnmune responses in vitro and in vivo in a non-allele-restricted fashion. In vivo studies in rodents have demonstrated...

    Authors: Maria Cristina Cuturi, Frank Christoph, Jacky Woo, Suhasini Iyer, Sophie Brouard, Jean Marie Heslan, Pascale Pignon, Jean-Paul Soulillou and Roland Buelow
    Citation: Molecular Medicine 1999 5:BF03401995
    Content type: Original Articles Published on:

  20. Highly active antiretroviral therapies (HAART) increase the CD4+ cell count, but complete normalization of this parameter has not been obtained in some patients. As oxidative stress plays an important role during...

    Authors: M. Djavad Mossalayi, Pierre-André Becherel and Patrice Debré
    Citation: Molecular Medicine 1999 5:BF03401994
    Content type: Original Articles Published on:

  21. Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from the deficient activity of the lysosomal exoglycohydrolase α-galactosidase A (EC 3.2.1.22; α-Gal A). The nature of the molecula...

    Authors: Ali K. Topaloglu, Grace A. Ashley, Bingzheng Tong, Junaid Shabbeer, Kenneth H. Astrin, Christine M. Eng and Robert J. Desnick
    Citation: Molecular Medicine 1999 5:BF03401993
    Content type: Original Articles Published on:

  22. Chemokine receptors on leukocytes play a key role in inflammation and HIV-1 infection. Chemokine receptors on endothelia may serve an important role in HIV-1 tissue invasion and angiogenesis.

    Authors: Omri Berger, Xiaohu Gan, Chandrasekhar Gujuluva, Alan R. Burns, Girija Sulur, Monique Stins, Dennis Way, Marlys Witte, Martin Weinand, Jonathan Said, Kwang-Sik Kim, Dennis Taub, Michael C. Graves and Milan Fiala
    Citation: Molecular Medicine 1999 5:BF03401992
    Content type: Original Articles Published on:

  23. The stages of melanocytic progression are defined as atypical (dysplastic) nevus, melanoma in situ, melanoma in the radial growth phase (RGP), melanoma in the vertical growth phase (VGP), and melanoma in the m...

    Authors: Peng Yang, Daniel L. Farkas, John M. Kirkwood, John L. Abernethy, Howard D. Edington and Dorothea Becker
    Citation: Molecular Medicine 1999 5:BF03401991
    Content type: Original Articles Published on:

  25. Cystic fibrosis (CF) is the most common lethal recessive disease affecting children in the U.S. and Europe. For this reason, a number of ongoing attempts are being made to treat the disease either by gene ther...

    Authors: Meera Srivastava, Ofer Eidelman and Harvey B. Pollard
    Citation: Molecular Medicine 1999 5:BF03402099
    Content type: Original Articles Published on:

  26. There is increasing evidence showing that extracellular nucleotides may be important mediators of vascular inflammation. Nucleotide triphosphate diphosphohydrolase-1 (NTPDase-1, identical to CD39), the major v...

    Authors: Masato Imai, Ko Takigami, Olaf Guckelberger, Keiichi Enjyoji, R. Neal Smith, Yuan Lin, Eva Csizmadia, Jean Sévigny, Robert D. Rosenberg, Fritz H. Bach and Simon C. Robson
    Citation: Molecular Medicine 1999 5:BF03402098
    Content type: Original Articles Published on:

  27. We have previously shown that dexamethasone (DEX) stimulates rapid polymerization of actin and stabilization of microfilaments in human endometrial adenocarcinoma cells. As the content of total cellular actin ...

    Authors: Sevasti B. Koukouritaki, Achille Gravanis and Christos Stournaras
    Citation: Molecular Medicine 1999 5:BF03402097
    Content type: Original Articles Published on:

  28. Nitric oxide (NO) has frequently been shown to display immunosuppressive activities. We describe here a molecular mechanism contributing to this effect.

    Authors: Denise Berendji, Victoria Kolb-Bachofen, Peter F. Zipfel, Christine Skerka, Carsten Carlberg and Klaus-D. Kröncke
    Citation: Molecular Medicine 1999 5:BF03402096
    Content type: Original Articles Published on:

  32. Hyperresponsiveness to histamine is a key feature of a variety of pathological conditions, including bronchial asthma, food allergy, colitis ulcerosa, and topical allergic disorders. Cells isolated from hyperr...

    Authors: Gwenda Pynaert, Johan Grooten, Sander J. H. van Deventer and Maikel P. Peppelenbosch
    Citation: Molecular Medicine 1999 5:BF03401987
    Content type: Original Articles Published on:

  34. Acute intermittent porphyria (AIP), an autosomal dominant inborn error, results from the half-normal activity of the heme biosynthetic enzyme hydroxymethylbilane synthase (EC 4.3.1.8; HMB-synthase). This disea...

    Authors: Constanza Solis, Idoia Lopez-Echaniz, David Sefarty-Graneda, Kenneth H. Astrin and Robert J. Desnick
    Citation: Molecular Medicine 1999 5:BF03401985
    Content type: Original Articles Published on:

  35. Heme oxygenase (HO) is believed to be a potent antioxidant enzyme in the nervous system; it degrades heme from heme-containing proteins, giving rise to carbon monoxide, iron, and biliverdin, which is rapidly r...

    Authors: Sylvain Doré, Kenji Sampei, Shozo Goto, Nabil J. Alkayed, Daniel Guastella, Seth Blackshaw, Michela Gallagher, Richard J. Traystman, Patricia D. Hurn, Raymond C. Koehler and Solomon H. Snyder
    Citation: Molecular Medicine 1999 5:BF03401984
    Content type: Original Articles Published on:

    The Erratum to this article has been published in Molecular Medicine 2013 19:Art20

  37. Butyrate, a fermentation product of intestinal bacteria, modifies chromatin structure through histone acetylation, thereby altering gene transcription. EL-8 and MCP-1 are chemokines, expressed by intestinal ep...

    Authors: Robert D. Fusunyan, Jessica J. Quinn, Mika Fujimoto, Richard P. MacDermott and Ian R. Sanderson
    Citation: Molecular Medicine 1999 5:BF03402075
    Content type: Original Articles Published on:

  38. Production of transgenic pigs for multiple transgenes is part of a potential strategy to prevent immunological events involved in xenograft rejection. Use of a genetically engineerable rodent as a donor in pri...

    Authors: Béatrice Charreau, Séverine Ménoret, Laurent Tesson, Agnès Azimzadeh, Maxime Audet, Philippe Wolf, Richard Marquet, Caroline Verbakel, John Ijzermans, Peter Cowan, Martin Pearse, Anthony d’Apice, Jean-Paul Soulillou and Ignacio Anegon
    Citation: Molecular Medicine 1999 5:BF03402074
    Content type: Original Articles Published on:

  39. Costimulatory and cellular adhesion molecules are thought to be essential components of antigen presentation in the immune response to cancer. The current studies examine gene transfer utilizing herpes viral a...

    Authors: Michael D’Angelica, Cindy Tung, Peter Allen, Marc Halterman, Keith Delman, Thomas Delohery, David Klimstra, Michael Brownlee, Howard Federoff and Yuman Fong
    Citation: Molecular Medicine 1999 5:BF03402073
    Content type: Original Articles Published on:

  40. The innate immune system functions as a defensive front line against pathogenic invasion, but the proinflammatory products of activated monocytes and macrophages (e.g., TNF and NO) can also injure normal cells...

    Authors: Minghuang Zhang, Lyudmila V. Borovikova, Haichao Wang, Christine Metz and Kevin J. Tracey
    Citation: Molecular Medicine 1999 5:BF03402072
    Content type: Original Articles Published on:

  41. Septic shock is a leading cause of mortality in intensive care units. No new interventions in the last 20 years have made a substantial impact on the outcome of patients with septic shock. Identification of in...

    Authors: Stephen R. Grobmyer, Robert C. Armstrong, Susan C. Nicholson, Cem Gabay, William P. Arend, Strite H. Potter, Maxine Melchior, Lawrence C. Fritz and Carl F. Nathan
    Citation: Molecular Medicine 1999 5:BF03402071
    Content type: Original Articles Published on:

  43. Domains 3 and 5 of high-molecular-weight kininogen (HK) have been shown to bind to platelets in a zinc-dependent reaction. However, the platelet-binding proteins responsible for this interaction have not been ...

    Authors: Kusumam Joseph, Yoshitaka Nakazawa, Wadie F. Bahou, Berhane Ghebrehiwet and Allen P. Kaplan
    Citation: Molecular Medicine 1999 5:BF03401982
    Content type: Original Articles Published on:

  44. Presenilins 1 (PS1) and 2 (PS2) are multispanning transmembrane proteins associated with familial Alzheimer disease (FAD). They are developmentally regulated, being expressed at highest levels during neuronal ...

    Authors: Lyne Lévesque, Willem Annaert, Katleen Craessaerts, Paul M. Mathews, Mary Seeger, Ralph A. Nixon, Fred Van Leuven, Sam Gandy, David Westaway, Peter St George-Hyslop, Bart De Strooper and Paul E. Fraser
    Citation: Molecular Medicine 1999 5:BF03401981
    Content type: Original Articles Published on:

  45. Invasive tumor cells are characterized by multiple phenotypic changes as a result of the large number of cDNAs being differentially expressed in tumor cells compared to normal progenitors. Expression genetics ...

    Authors: Anthony Anisowicz, Georgia Sotiropoulou and Ruth Sager
    Citation: Molecular Medicine 1999 5:BF03401980
    Content type: Original Articles Published on:

  46. Using fluorescently labeled superoxide dismutase (SOD) and flow cytometry, we have shown previously that the enzyme CuZn SOD (EC 1.15.1.1) from bovine erythrocytes binds rapidly to the cell surface with slow u...

    Authors: Paulo Filipe, Ingrid Emerit, Jany Vassy, Arlette Levy, Vanda Huang and Joao Freitas
    Citation: Molecular Medicine 1999 5:BF03401979
    Content type: Original Articles Published on:

  48. While certain genetic changes are frequently found in adrenocortical carcinoma cells, the molecular basis of adrenocortical tumorigenesis remains poorly understood. Given that the transcription factors GATA-4 ...

    Authors: Sanne Kiiveri, Susanna Siltanen, Nafis Rahman, Malgorzata Bielinska, Veli-Pekka Lehto, Ilpo T. Huhtaniemi, Louis J. Muglia, David B. Wilson and Markku Heikinheimo
    Citation: Molecular Medicine 1999 5:BF03403542
    Content type: Original Articles Published on:

  49. The recognition of phosphorylated nonpeptidic microbial metabolites by Vγ9Vδ2 T cells does not appear to require the presence of MHC molecules or antigen processing, permitting rapid responses against microbial p...

    Authors: Fabrizio Poccia, Miroslav Malkovsky, Aaron Pollak, Vittorio Colizzi, Guido Sireci, Alfredo Salerno and Francesco Dieli
    Citation: Molecular Medicine 1999 5:BF03403540
    Content type: Original Articles Published on:
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Molecular Medicine

ISSN: 1528-3658