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  1. Early loss of neurites followed by delayed damage of neuronal somata is a feature of several neurodegenerative diseases. Death by apoptosis would ensure the rapid removal of injured neurons, whereas conditions...

    Authors: Christiane Volbracht, Marcel Leist and Pierluigi Nicotera
    Citation: Molecular Medicine 1999 5:BF03403541
    Content type: Original Articles Published on:

  2. The 19 kDa C-terminal region of the merozoite surface protein 1 (MSP119) has been suggested as candidate for part of a subunit vaccine against malaria. A major concern in vaccine development is the polymorphism o...

    Authors: Irene S. Soares, John W. Barnwell, Marcelo U. Ferreira, Maristela Gomes Da Cunha, Jomar P. Laurino, Beatriz A. Castilho and Mauricio M. Rodrigues
    Citation: Molecular Medicine 1999 5:BF03403539
    Content type: Original Articles Published on:

  3. Exceptional advances have been made recently in our understanding of the signaling pathways that control cellular growth, differentiation, and survival. These processes are regulated by extracellular stimuli s...

    Authors: David A. Frank
    Citation: Molecular Medicine 1999 5:BF03403538
    Content type: Review Article Published on:

  4. Prion diseases are associated with the accumulation of an abnormal isoform of host-encoded prion protein (PrPSc). A number of prion strains can be distinguished by “glycotyping” analysis of the respective deposit...

    Authors: Thorsten Kuczius and Martin H. Groschup
    Citation: Molecular Medicine 1999 5:BF03402129
    Content type: Original Articles Published on:

  5. The advanced stage of the Maillard reaction, which leads to the formation of advanced glycation end products (AGE), plays an important role in the pathogenesis of angiopathy in diabetic patients and in the agi...

    Authors: Masayoshi Takeuchi, Zenji Makita, Katsuyuki Yanagisawa, Yukihiko Kameda and Takao Koike
    Citation: Molecular Medicine 1999 5:BF03402128
    Content type: Original Articles Published on:

  6. Glomerular permeability for macromolecules depends partially on proper attachment of the glomerular epithelial cells (GEC) to the glomerular basement membrane (GBM). The latter requires integrity of the actin ...

    Authors: S. B. Koukouritaki, E. A. Vardaki, E. A. Papakonstanti, E. Lianos, C. Stournaras and D. S. Emmanouel
    Citation: Molecular Medicine 1999 5:BF03402127
    Content type: Original Articles Published on:

  7. Recent evidence implicates tumor necrosis factor (TNF), a cytokine with both cytotoxic and cytoprotective activities, in the pathogenesis of cerebral ischemia. The development of TNF cytotoxicity is dependent ...

    Authors: Galina I. Botchkina, Erika Geimonen, Michael L. Bilof, Omar Villarreal and Kevin J. Tracey
    Citation: Molecular Medicine 1999 5:BF03402126
    Content type: Original Articles Published on:

  8. It has been reported that macrophage migration inhibitory factor (MIF) stimulated insulin secretion from pancreatic islet β-cells in an autocrine manner, which suggests its pivotal role in the glucose metabolism....

    Authors: Shinji Sakaue, Jun Nishihira, Junichi Hirokawa, Haruhiko Yoshimura, Toshiro Honda, Kenji Aoki, Seiichi Tagami and Yoshikazu Kawakami
    Citation: Molecular Medicine 1999 5:BF03402125
    Content type: Original Articles Published on:

  11. Cathepsin S is a member of the family of cysteine lysosomal proteases preferentially expressed in macrophages and microglia and is active after prolonged incubation in neutral pH. Upon activation of macrophage...

    Authors: John P. Liuzzo, Suzana S. Petanceska and Lakshmi A. Devi
    Citation: Molecular Medicine 1999 5:BF03402069
    Content type: Original Articles Published on:

  12. Cathepsin S is a member of the family of cysteine lysosomal proteases. The distribution of cathepsin S is restricted to cells from the mononuclear lineage both in the brain and in the periphery. Also, its prot...

    Authors: John P. Liuzzo, Suzana S. Petanceska, David Moscatelli and Lakshmi A. Devi
    Citation: Molecular Medicine 1999 5:BF03402068
    Content type: Original Articles Published on:

  13. Efforts in metastasis research have centered on the phenotypic and genetic differences between primary site and metastatic site tumors. However, genes that may be used as molecular markers of metastasis in cir...

    Authors: Marcia V. Fournier, Maria da Gloria Costa Carvalho and Arthur B. Pardee
    Citation: Molecular Medicine 1999 5:BF03402067
    Content type: Original Articles Published on:

  14. We analyzed the γδ T cell composition and responses in the peripheral blood and cerebrospinal fluid (CSF) of children affected by tuberculous meningitis (TBM) and in control children.

    Authors: Francesco Dieli, Guido Sireci, Caterina Di Sano, Eric Champagne, Jean Jacques Fourniè, Juraj Ivanyi and Alfredo Salerno
    Citation: Molecular Medicine 1999 5:BF03402066
    Content type: Original Articles Published on:

  15. In spite of the large number of studies that have evaluated DNA-based immunization, few have directly compared the immune responses generated by different routes of immunization, particularly in non-human prim...

    Authors: Michael J. McCluskie, Cynthia L. Brazolot Millan, Robert A. Gramzinski, Harriet L. Robinson, Joseph C. Santoro, James T. Fuller, Georg Widera, Joel R. Haynes, Robert H. Purcell and Heather L. Davis
    Citation: Molecular Medicine 1999 5:BF03402065
    Content type: Original Articles Published on:

  18. The mouse strain sparse fur with abnormal skin and hair (spfash) is a model for the human ornithine transcarbamylase (OTC) deficiency, an X-linked inherited urea cycle disorder. The spfash mouse carries a single ...

    Authors: Klaus Peter Zimmer, Meike Bendiks, Masataka Mori, Eiki Kominami, Michael B. Robinson, Xuehai Ye and James M. Wilson
    Citation: Molecular Medicine 1999 5:BF03402122
    Content type: Original Articles Published on:

  19. The transmissible agent of Creutzfeldt-Jakob disease (CJD) is not readily destroyed by conventional sterilization and transmissions by surgical instruments have been reported. Decontamination studies have been...

    Authors: Eva Zobeley, Eckhard Flechsig, Antonio Cozzio, Masato Enari and Charles Weissmann
    Citation: Molecular Medicine 1999 5:BF03402121
    Content type: Original Articles Published on:

  20. There are two fundamental forms of cell death: apoptosis and necrosis. Molecular studies of cell death thus far favor a model in which apoptosis and necrosis share very few molecular regulators. It appears tha...

    Authors: You-Zhi Li, Chiang J. Li, Antonio Ventura Pinto and Arthur B. Pardee
    Citation: Molecular Medicine 1999 5:BF03402120
    Content type: Original Articles Published on:

  21. Although recombinant adenovirus vectors are attractive for use in gene expression studies and therapeutic applications, the construction of these vectors remains relatively time-consuming. We report here a str...

    Authors: Kazunori Aoki, Christopher Barker, Xavier Danthinne, Michael J. Imperiale and Gary J. Nabel
    Citation: Molecular Medicine 1999 5:BF03402119
    Content type: Original Articles Published on:

  22. The cystic fibrosis transmembrane conductance regulator gene (CFTR) shows a complex pattern of expression. The regulatory elements conferring tissue-specific and temporal regulation are thought to lie mainly outs...

    Authors: Danielle S. Moulin, Ania L. Manson, Hugh N. Nuthall, David J. Smith, Clare Huxley and Ann Harris
    Citation: Molecular Medicine 1999 5:BF03402118
    Content type: Original Articles Published on:

  24. Systemic inflammatory response syndrome (SIRS) is a mild inflammmatory episode which, in a minority of patients, may deteriorate into septic shock. In the mouse, injection of bacteria or bacterial endotoxin in...

    Authors: Grit Wiegand, Kathleen Selleng, Matthias Gründling and Robert S. Jack
    Citation: Molecular Medicine 1999 5:BF03402062
    Content type: Original Articles Published on:

  25. Macrophage migration inhibitory factor (MIF) has been shown to counterregulate glucocorticoid action and to play an essential role in the activation of macrophages and T cells in vivo. MIF also may function as...

    Authors: Jason Chesney, Christine Metz, Michael Bacher, Tina Peng, Andreas Meinhardt and Richard Bucala
    Citation: Molecular Medicine 1999 5:BF03402061
    Content type: Original Articles Published on:

  26. The Src-homology 2 domain-containing adaptor protein Shb was recently cloned as a serum-inducible gene in the insulin-producing β-TC1 cell line. Subsequent studies have revealed an involvement of Shb for apoptosi...

    Authors: Michael Welsh, Lars Christmansson, Torbjörn Karlsson, Stellan Sandler and Nils Welsh
    Citation: Molecular Medicine 1999 5:BF03402060
    Content type: Original Articles Published on:

  27. Most early-onset forms of Alzheimer’s disease are due to missense mutations located on two homologous proteins named presenilin 1 and 2 (PS1 and PS2). Several lines of evidence indicate that PS1 and PS2 underg...

    Authors: Cristine Alves da Costa, Karine Ancolio and Frédéric Checler
    Citation: Molecular Medicine 1999 5:BF03402059
    Content type: Original Articles Published on:

  28. Since human colon cancers often contain significant quantities of progastrin-processing intermediates, we sought to explore the possibility that the biosynthetic precursor of fully processed amidated gastrin, ...

    Authors: Vinzenz M. Stepan, Mitsutaka Sawada, Andrea Todisco and Chris J. Dickinson
    Citation: Molecular Medicine 1999 5:BF03402058
    Content type: Original Articles Published on:

  30. Developments in transgenic technology have greatly enhanced our ability to understand the functions of various genes in animal models and relevant human diseases. The tetracycline (tet)-regulated transactivati...

    Authors: Chang J. Huang, Francesca Spinella, Ramin Nazarian, Matthew M. Lee, Joel M. Dopp and Jean de Vellis
    Citation: Molecular Medicine 1999 5:BF03402147
    Content type: Original Articles Published on:

  31. Studies from our laboratory have shown that the earliest stages of atherosclerosis may be mediated by an autoimmune reaction against heat shock protein 60 (Hsp60). The interactions of Hsp60-specific T cells wi...

    Authors: Albert Amberger, Monika Hala, Maria Saurwein-Teissl, Bernhard Metzler, Beatrix Grubeck-Loebenstein, Qingbo Xu and Georg Wick
    Citation: Molecular Medicine 1999 5:BF03402146
    Content type: Original Articles Published on:

  32. CKMB, the cardiac-specific heterodimer of cytosolic creatine-kinase (CK), is developmentally and physiologically regulated, tissue hypoxia being a proposed regulator. In patients with cyanotic heart disease th...

    Authors: Gania Kessler-Icekson, Einat Birk, Hadassa Schlesinger, Yael Barhum, Niv Ad, Menahem Friedman and Bernardo A. Vidne
    Citation: Molecular Medicine 1999 5:BF03402145
    Content type: Original Articles Published on:

  33. Fifteen to thirty percent of AIDS patients develop some type of neurologic disorder during the course of their illness and the vast majority of these neurologic disorders will be HTV-associated dementia (HAD)....

    Authors: D. Cory Adamson, Justin C. McArthur, Ted M. Dawson and Valina L. Dawson
    Citation: Molecular Medicine 1999 5:BF03402144
    Content type: Original Articles Published on:

  34. One-third of women with breast cancer will develop bone metastases and eventually die from disease progression at these sites. Therefore, we analyzed the ability of human MG-63 osteoblast-like cells (MG-63 cel...

    Authors: Michael Koutsilieris, Carlos Reyes-Moreno, Isabelle Choki, Antigone Sourla, Charles Doillon and Nicolas Pavlidis
    Citation: Molecular Medicine 1999 5:BF03402143
    Content type: Original Articles Published on:

  38. Chronic myelogenous leukemia (CML) is thought to start with the acquisition of the t(9;22) chromosomal translocation that codes for the P210bcrabl tyrosine-specific protein kinase. The CML cells exhibit anchor...

    Authors: Cynthia M. Lane, Xiang-Yang Guo, Laurel H. Macaluso, Katherine C. Yung and Albert B. Deisseroth
    Citation: Molecular Medicine 1999 5:BF03402139
    Content type: Original Articles Published on:

  39. Borrelia Burgdorferi has a predilection for collagenous tissue and can interact with fibronectin and cellular collagens. While the molecular mechanisms of how B. burgdorferi targets connective tissues and causes ...

    Authors: Dennis J. Grab, H.-Norbert Lanners, Louis N. Martin, Jason Chesney, Chunbo Cai, Huston D. Adkisson and Richard Bucala
    Citation: Molecular Medicine 1999 5:BF03402138
    Content type: Original Articles Published on:

  40. Respiratory syncytial virus (RSV) infection is a major problem in the newborn and aging populations. Fully human monoclonal antibodies with the ability to neutralize RSV could have a major impact on the immuno...

    Authors: Cheryl Heard, Peter Brams, Edward Walsh, Tri Huynh, Soulaima Chamat, Mitchell Reff, Alex Owyang, William Shestowsky and Roland Newman
    Citation: Molecular Medicine 1999 5:BF03402137
    Content type: Original Articles Published on:

  41. The MDM2 oncogene functions as a negative feedback regulator of the p53 tumor suppressor. Abnormal expression of MDM2 in tumors may attenuate the p53-mediated growth arrest and apoptosis response, resulting in in...

    Authors: Lihong Chen, Wenge Lu, Sudhir Agrawal, Wenqiang Zhou, Ruiwen Zhang and Jiandong Chen
    Citation: Molecular Medicine 1999 5:BF03402136
    Content type: Original Articles Published on:

  42. In the setting of familial melanoma, the presence of atypical nevi, which are the precursors of melanoma, is associated with a nearly 100% risk of developing primary melanoma by age 70. In patients with sporad...

    Authors: John M. Kirkwood, Daniel L. Farkas, Arup Chakraborty, Kevin F. Dyer, David J. Tweardy, John L. Abernethy, Howard D. Edington, Sandra S. Donnelly and Dorothea Becker
    Citation: Molecular Medicine 1999 5:BF03402135
    Content type: Original Articles Published on:

  45. The p16-pRb pathway represents a vital cell-cycle checkpoint. In the present study we investigated the alterations of this G1-phase protein pathway using immunohistochemical and molecular methods in a series o...

    Authors: V. G. Gorgoulis, E. N. Koutroumbi, A. Kotsinas, P. Zacharatos, C. Markopoulos, L. Giannikos, V. Kyriakou, Z. Voulgaris, I. Gogas and C. Kittas
    Citation: Molecular Medicine 1998 4:BF03401773
    Content type: Original Articles Published on:

  46. Mutations disrupting the function or production of C1 inhibitor cause the disease hereditary angioneurotic edema. Patient mutations identified an imperfect inverted repeat sequence that was postulated to play ...

    Authors: John J. Bissler, Qin-Shao Meng and Theresa Emery
    Citation: Molecular Medicine 1998 4:BF03401772
    Content type: Original Articles Published on:

  47. The development of effective adjuvant therapies for the treatment of high-risk melanoma patients is critical for the prevention of metastatic disease and improvement of patient survival. Active specific immuno...

    Authors: Franak M. Batliwalla, Barbara A. Bateman, Davide Serrano, Douglas Murray, Stuart Macphail, V. C. Maino, John C. Ansel, Peter K. Gregersen and Cheryl A. Armstrong
    Citation: Molecular Medicine 1998 4:BF03401771
    Content type: Original Articles Published on:

  48. For many malarious regions outside of Africa, development of effective transmission-blocking vaccines will require coverage against both Plasmodium falciparum and P. vivax. Work on P. vivax transmission-blocking ...

    Authors: Takafumi Tsuboi, David C. Kaslow, Mary Margaret G. Gozar, Mayumi Tachibana, Ya-Ming Cao and Motomi Torii
    Citation: Molecular Medicine 1998 4:BF03401770
    Content type: Original Articles Published on:

  49. The band 4.1 domain was first identified in the red blood cell protein band 4.1, and subsequently in ezrin, radixin, and moesin (ERM proteins) and other proteins, including tumor suppressor merlin/schwannomin,...

    Authors: Jean-Antoine Girault, Gilles Labesse, Jean-Paul Mornon and Isabelle Callebaut
    Citation: Molecular Medicine 1998 4:BF03401769
    Content type: Minireviews Published on:
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Molecular Medicine

ISSN: 1528-3658