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Page 38 of 43

  1. Nitric oxide (NO) is cytostatic for proliferating cells, inhibits microbial growth, and down-regulates the synthesis of specific proteins. Studies were undertaken to determine the mechanism by which NO inhibit...

    Authors: Young-Myeong Kim, Kyonghee Son, Sun-Joo Hong, Angela Green, Jane-Jane Chen, Edith Tzeng, Christian Hierholzer and Timothy R. Billiar

    Citation: Molecular Medicine 1998 4:BF03401915

    Content type: Original Articles

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  2. Acquired CI-inhibitor (C1-inh) deficiency is usually associated with the presence of circulating C1 -inh autoantibodies. These autoantibodies have been shown previously to bind to two synthetic peptides corres...

    Authors: Shiping He, Robert B. Sim, Keith Whaley and K. Austen

    Citation: Molecular Medicine 1998 4:BF03401735

    Content type: Original Articles

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  3. Attempts to optimize DNA vaccines in mice include using different routes of administration and different formulations. It may be more relevant to human use to carry such studies out in nonhuman primates. Here ...

    Authors: Robert A. Gramzinski, Cynthia L. Brazolot Millan, Nicanor Obaldia, Stephen L. Hoffman and Heather L. Davis

    Citation: Molecular Medicine 1998 4:BF03401734

    Content type: Original Articles

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  4. The molecular recognition theory (MRT) provides a conceptual framework that could explain the evolution of intermolecular and intramolecular interaction of peptides and proteins. As such, it predicts that bind...

    Authors: Nelson Ruiz-Opazo, Kenji Hirayama, Kaoru Akimoto and Victoria L. M. Herrera

    Citation: Molecular Medicine 1998 4:BF03401733

    Content type: Original Articles

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  5. Anthrax toxin, secreted by Bacillus anthracis, consists of protective antigen (PA) and either lethal factor (LF) or edema factor (EF). PA, the receptor-binding component of the toxin, translocates LF or EF into t...

    Authors: Mini Varughese, Angela Chi, Avelino V. Teixeira, Peter J. Nicholls, Jerry M. Keith and Stephen H. Leppla

    Citation: Molecular Medicine 1998 4:BF03401732

    Content type: Original Articles

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  6. A common genetic basis for IgA deficiency (IgAD) and common variable immunodeficiency (CVID) is suggested by their occurrence in members of the same family and the similarity of the underlying B cell different...

    Authors: Harry W. Schroeder Jr., Zeng-Bian Zhu, Ruth E. March, R. Duncan Campbell, Seth Mark Berney, Sergei A. Nedospasov, Regina L. Turetskaya, T. Prescott Atkinson, Rodney C. P. Go, Max D. Cooper and John E. Volanakis

    Citation: Molecular Medicine 1998 4:BF03401731

    Content type: Original Articles

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  7. Advanced glycation end products (AGEs) are the reactive derivatives of nonenzymatic glucose-macromolecule condensation products. Aging human tissues accumulate AGEs in an age-dependent manner and contribute to...

    Authors: Jenny J. Li, Dennis Dickson, Patrick R. Hof and Helen Vlassara

    Citation: Molecular Medicine 1998 4:BF03401729

    Content type: Original Articles

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  8. Photodynamic therapy employs photosensitive agents such as porphyrins to treat a variety of tumors accessible to light-emitting probes. This approach capitalizes on the selective retention of porphyrins by can...

    Authors: Ajay Verma, Stephen L. Facchina, David J. Hirsch, Shi-Yu Song, Larry F. Dillahey, Jerry R. Williams and Solomon H. Snyder

    Citation: Molecular Medicine 1998 4:BF03401728

    Content type: Original Articles

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  9. Amphiphysin I is a 128 kD protein highly concentrated in nerve terminals, where it has a putative role in endocytosis. It is a dominant autoantigen in patients with stiff-man syndrome associated with breast ca...

    Authors: Scott Floyd, Margaret Husta Butler, Ottavio Cremona, Carol David, Zachary Freyberg, Xiaomei Zhang, Michele Solimena, Akira Tokunaga, Hideki Ishizu, Kimiko Tsutsui and Pietro De Camilli

    Citation: Molecular Medicine 1998 4:BF03401727

    Content type: Original Articles

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  10. The synapsins are a family of neuron-specific proteins, associated with the cytoplasmic surface of synaptic vesicles, which have been shown to regulate neurotransmitter release in mature synapses and to accele...

    Authors: Adriana Ferreira, Lih-Shen Chin, Lian Li, Lorene M. Lanier, Kenneth S. Kosik and Paul Greengard

    Citation: Molecular Medicine 1998 4:BF03401726

    Content type: Original Articles

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  11. Tumor necrosis factor α (TNF-α) is often considered the main proinflammatory cytokine induced by lipopolysaccharide (LPS) and consequently the critical mediator of the lethality associated with septic shock.

    Authors: Franck Amiot, Catherine Fitting, Kevin J. Tracey, Jean-Marc Cavaillon and François Dautry

    Citation: Molecular Medicine 1997 3:BF03401722

    Content type: Original Articles

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  12. Substantial evidence has suggested that T cells play an important role in antitumor immunity. T cells with cytotoxic activity against tumors have been isolated from in vitro culture of tumor-infiltrated lympho...

    Authors: Koichi Ito, James Fetten, Houman Khalili, Steven Hajdu, Erna Busch, Robert Pergolizzi, Vincent Vinciguerra and Ming-der Y. Chang

    Citation: Molecular Medicine 1997 3:BF03401720

    Content type: Original Articles

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  13. GLI is an oncodevelopmental gene in the vertebrate hedgehog/patched signaling pathway that is spatiotemporally regulated during development and is amplified in a subset of human cancers. GLI is the prototype for ...

    Authors: Jian Tao Yang, Cheng Zheng Liu, Elisabeth H. Villavicencio, Joon Won Yoon, David Walterhouse and Philip M. Iannaccone

    Citation: Molecular Medicine 1997 3:BF03401719

    Content type: Original Articles

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  14. Vectors based on herpes simplex virus type 1 (HSV-1) can efficiently transduce hepatocytes in the mouse liver, and vector genomes can persist for at least 2 months. However, 24 hr after gene transfer, the numb...

    Authors: Cornel Fraefel, David R. Jacoby, Christopher Lage, Harold Hilderbrand, Janice Y. Chou, Fred W. Alt, Xandra O. Breakefield and Joseph A. Majzoub

    Citation: Molecular Medicine 1997 3:BF03401718

    Content type: Original Articles

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  15. Cerebral ischemia induces a rapid and dramatic up-regulation of tumor necrosis factor (TNF) protein and mRNA, but the cellular sources of TNF in the ischemic brain have not been defined. The diverse activities...

    Authors: Galina I. Botchkina, Malcolm E. Meistrell III, Inna L. Botchkina and Kevin J. Tracey

    Citation: Molecular Medicine 1997 3:BF03401714

    Content type: Original Articles

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  16. Excitotoxicity and excess generation of nitric oxide (NO) are believed to be fundamental mechanisms in many acute and chronic neurodegenerative disorders. Disturbance of Ca2+ homeostasis and protein nitration/nit...

    Authors: Marcel Leist, Christiane Volbracht, Simone Kühnle, Eugenio Fava, Elisa Ferrando-May and Pierluigi Nicotera

    Citation: Molecular Medicine 1997 3:BF03401713

    Content type: Original Articles

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  17. DNA modified by advanced glycation endproducts (AGEs) undergoes a high frequency of insertional mutagenesis. In mouse lymphoid cells, these mutations are due in part to the transposition of host genomic elemen...

    Authors: Tatiana Pushkarsky, Linda Rourke, Lori A. Spiegel, Michael F. Seldin and Richard Bucala

    Citation: Molecular Medicine 1997 3:BF03401712

    Content type: Original Articles

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  18. Brucelosis is a severe acute febrile disease caused by bacteria of the genus Brucella. Its current diagnosis is based on clinical observations that may be complemented by serology and microbiological culture test...

    Authors: Ana M. Sifuentes-Rincón, Agnès Revol and Hugo A. Barrera-Saldaña

    Citation: Molecular Medicine 1997 3:BF03401711

    Content type: Original Articles

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  19. The adoptive transfer of cytotoxic T lymphocytes (CTLs) derived from tumor-infiltrating lymphocytes (TIL) along with interleukin 2 (IL-2) into autologous patients with cancer resulted in the objective regressi...

    Authors: Rong-Fu Wang

    Citation: Molecular Medicine 1997 3:BF03401710

    Content type: Review

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  20. In Alzheimer’s disease (AD), the main histological lesion is a proteinaceous deposit, the senile plaque, which is mainly composed of a peptide called Aβ. The aggregation process is thought to occur through enhanc...

    Authors: Hélène Barelli, Anthony Lebeau, Jean Vizzavona, Pia Delaere, Nathalie Chevallier, Cyril Drouot, Philippe Marambaud, Karine Ancolio, Joseph D. Buxbaum, Olga Khorkova, Jeff Heroux, Sudhir Sahasrabudhe, Jean Martinez, Jean-Marie Warter, Michel Mohr and Frédéric Checler

    Citation: Molecular Medicine 1997 3:BF03401708

    Content type: Original Articles

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  21. IgE/allergen-dependent activation of skin mast cells is involved in acute urticaria and leads to their EL-4 release. Previously we have demonstrated in vitro the induction of the low-affinity receptor for IgE ...

    Authors: Pierre-André Bécherel, Olivier Chosidow, Liliane Le Goff, Camille Francès, Patrice Debré, M. Djavad Mossalayi and Michel Arock

    Citation: Molecular Medicine 1997 3:BF03401707

    Content type: Original Articles

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  22. Raf-1, a cytoplasmic serine/threonine protein kinase, plays an important role in mitogen- and damage-responsive cellular signal transduction pathways. Consistent with this notion is the fact that constitutive ...

    Authors: Sonal Patel, Fuh-Han Wang, Theresa L. Whiteside and Usha Kasid

    Citation: Molecular Medicine 1997 3:BF03401706

    Content type: Original Articles

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  23. The agouti yellow mouse shows adult onset of moderate obesity and diabetes. A depressed basal lipolytic rate in adipocytes or a decreased adrenergic tone arising from antagonizing α-melanocyte-stimulating hormone...

    Authors: Yvon C. Chagnon, Wen-Ji Chen, Louis Pérusse, Monique Chagnon, André Nadeau, William O. Wilkison and Claude Bouchard

    Citation: Molecular Medicine 1997 3:BF03401705

    Content type: Original Articles

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  24. Spontaneous animal models of human autoimmune diseases provide the means to study the very first pathogenetic events, which is not possible in their human counterparts. This is particularly true for connective...

    Authors: Michael J. Ausserlechner, Roswitha Sgonc, Hermann Dietrich and Georg Wick

    Citation: Molecular Medicine 1997 3:BF03401704

    Content type: Original Articles

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  25. Advanced glycation endproducts (AGEs) are implicated in the pathogenesis of atherosclerotic vascular disease of diabetic and nondiabetic etiology. Recent research suggests that advanced glycation of ApoB contr...

    Authors: Alan William Stitt, Cijiang He, Steven Friedman, Larry Scher, Peter Rossi, Larry Ong, Hank Founds, Yong Ming Li, Richard Bucala and Helen Vlassara

    Citation: Molecular Medicine 1997 3:BF03401819

    Content type: Original Articles

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  26. Mice with targeted disruption of the gene for the neuronal isoform of nitric oxide synthase (nNOS) display exaggerated aggression. Behavioral studies of mice with targeted gene deletions suffer from the critic...

    Authors: Gregory E. Demas, Mikael J. L. Eliasson, Ted M. Dawson, Valina L. Dawson, Lance J. Kriegsfeld, Randy J. Nelson and Solomon H. Snyder

    Citation: Molecular Medicine 1997 3:BF03401818

    Content type: Original Articles

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  27. Cardiopulmonary bypass (CPB) and hypothermic circulatory arrest (HCA) are important components of congenital cardiac surgery. Ischemia/reperfusion injury and inflammatory cascade activation result in endotheli...

    Authors: Sarah Tabbutt, David P. Nelson, Nina Tsai, Takuya Miura, Paul R. Hickey, John E. Mayer and Ellis J. Neufeld

    Citation: Molecular Medicine 1997 3:BF03401817

    Content type: Original Articles

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  28. Balloon injury of the arterial wall induces increased vascular smooth cell proliferation, enhanced elastic recoil, and abnormalities in thrombosis, each of which contribute to regrowth of intima and the lesion...

    Authors: Dominique Stephan, Hong San, Zhi-yong Yang, David Gordon, Susan Goelz, Gary J. Nabel and Elizabeth G. Nabel

    Citation: Molecular Medicine 1997 3:BF03401816

    Content type: Original Articles

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  29. The sickle-cell trait protects against severe Plasmodium falciparum malaria and reduces susceptibility to mild malaria but does not prevent infection. The exact mechanism of this protection remains unclear. We ha...

    Authors: Francine Ntoumi, Christophe Rogier, Alioune Dieye, Jean-François Trape, Pascal Millet and Odile Mercereau-Puijalon

    Citation: Molecular Medicine 1997 3:BF03401815

    Content type: Original Articles

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  30. HIV-1 invades the central nervous system early after infection when macrophage infiltration of the brain is low but myelin pallor is suggestive of blood-brain-barrier damage. High-level plasma viremia is a lik...

    Authors: Milan Fiala, David J. Looney, Monique Stins, Dennis D. Way, Ling Zhang, Xiaohu Gan, Francesco Chiappelli, Erik S. Schweitzer, Paul Shapshak, Martin Weinand, Michael C. Graves, Marlys Witte and Kwang Sik Kim

    Citation: Molecular Medicine 1997 3:BF03401701

    Content type: Original Articles

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  31. Human natural antibodies have been found that owe their candidacidal action to the mimicry of a yeast killer toxin produced by the yeast Pichia anomala (PaKT). Candidacidal human natural antibodies (KTAb) are eli...

    Authors: Nathalie Séguy, Jean-Charles Cailliez, Philippe Delcourt, Stefania Conti, Daniel Camus, Eduardo Dei-Cas and Luciano Polonelli

    Citation: Molecular Medicine 1997 3:BF03401700

    Content type: Original Articles

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  32. Giant cell arteritis (GCA) is a systemic vasculitis that preferentially targets medium-sized and large arteries. The etiopathogenesis of the syndrome is not known, and because of the paucity of information con...

    Authors: Alexander Brack, Annette Geisler, Victor M. Martinez-Taboada, Brian R. Younge, Jörg J. Goronzy and Cornelia M. Weyand

    Citation: Molecular Medicine 1997 3:BF03401699

    Content type: Original Articles

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  33. The pleiotropic cytokine interleukin-6 mediates its multiple effects at the cell level through a multimeric receptor consisting of a binding protein (gp80) and a signal transducer (gp130). A soluble form of gp...

    Authors: Vincent Thibault, Bernard Terlain, Frank L. Graham and Jack Gauldie

    Citation: Molecular Medicine 1997 3:BF03401698

    Content type: Original Articles

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  34. Chondroitin-4-sulfate (CSA) was recently described as a Plasmodium falciparum cytoadherence receptor present on Saimiri brain microvascular and human lung endothelial cells.

    Authors: Bruno Pouvelle, Pascal Meyer, Claire Robert, Laurence Bardel and Jürg Gysin

    Citation: Molecular Medicine 1997 3:BF03401697

    Content type: Original Articles

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  35. DNA damage in mammalian cells stabilizes the p53 protein which then functions as a cell cycle checkpoint by leading to growth arrest or apoptosis. p53 is a transcription factor and positively regulates the exp...

    Authors: Lin Wu and Arnold J. Levine

    Citation: Molecular Medicine 1997 3:BF03401691

    Content type: Original Articles

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Annual Journal Metrics

  • Speed
    43 days to first decision for reviewed manuscripts only
    28 days to first decision for all manuscripts
    128 days from submission to acceptance
    24 days from acceptance to publication


    Citation Impact
    6.354 - 2-year Impact Factor
    5.230 - 5-year Impact Factor

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