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Page 38 of 44

  1. Studies from our laboratory have shown that the earliest stages of atherosclerosis may be mediated by an autoimmune reaction against heat shock protein 60 (Hsp60). The interactions of Hsp60-specific T cells wi...

    Authors: Albert Amberger, Monika Hala, Maria Saurwein-Teissl, Bernhard Metzler, Beatrix Grubeck-Loebenstein, Qingbo Xu and Georg Wick
    Citation: Molecular Medicine 1999 5:BF03402146
  2. Chronic myelogenous leukemia (CML) is thought to start with the acquisition of the t(9;22) chromosomal translocation that codes for the P210bcrabl tyrosine-specific protein kinase. The CML cells exhibit anchor...

    Authors: Cynthia M. Lane, Xiang-Yang Guo, Laurel H. Macaluso, Katherine C. Yung and Albert B. Deisseroth
    Citation: Molecular Medicine 1999 5:BF03402139
  3. Borrelia Burgdorferi has a predilection for collagenous tissue and can interact with fibronectin and cellular collagens. While the molecular mechanisms of how B. burgdorferi targets connective tissues and causes ...

    Authors: Dennis J. Grab, H.-Norbert Lanners, Louis N. Martin, Jason Chesney, Chunbo Cai, Huston D. Adkisson and Richard Bucala
    Citation: Molecular Medicine 1999 5:BF03402138
  4. Respiratory syncytial virus (RSV) infection is a major problem in the newborn and aging populations. Fully human monoclonal antibodies with the ability to neutralize RSV could have a major impact on the immuno...

    Authors: Cheryl Heard, Peter Brams, Edward Walsh, Tri Huynh, Soulaima Chamat, Mitchell Reff, Alex Owyang, William Shestowsky and Roland Newman
    Citation: Molecular Medicine 1999 5:BF03402137
  5. The MDM2 oncogene functions as a negative feedback regulator of the p53 tumor suppressor. Abnormal expression of MDM2 in tumors may attenuate the p53-mediated growth arrest and apoptosis response, resulting in in...

    Authors: Lihong Chen, Wenge Lu, Sudhir Agrawal, Wenqiang Zhou, Ruiwen Zhang and Jiandong Chen
    Citation: Molecular Medicine 1999 5:BF03402136
  6. In the setting of familial melanoma, the presence of atypical nevi, which are the precursors of melanoma, is associated with a nearly 100% risk of developing primary melanoma by age 70. In patients with sporad...

    Authors: John M. Kirkwood, Daniel L. Farkas, Arup Chakraborty, Kevin F. Dyer, David J. Tweardy, John L. Abernethy, Howard D. Edington, Sandra S. Donnelly and Dorothea Becker
    Citation: Molecular Medicine 1999 5:BF03402135
  7. The p16-pRb pathway represents a vital cell-cycle checkpoint. In the present study we investigated the alterations of this G1-phase protein pathway using immunohistochemical and molecular methods in a series o...

    Authors: V. G. Gorgoulis, E. N. Koutroumbi, A. Kotsinas, P. Zacharatos, C. Markopoulos, L. Giannikos, V. Kyriakou, Z. Voulgaris, I. Gogas and C. Kittas
    Citation: Molecular Medicine 1998 4:BF03401773
  8. Mutations disrupting the function or production of C1 inhibitor cause the disease hereditary angioneurotic edema. Patient mutations identified an imperfect inverted repeat sequence that was postulated to play ...

    Authors: John J. Bissler, Qin-Shao Meng and Theresa Emery
    Citation: Molecular Medicine 1998 4:BF03401772
  9. The development of effective adjuvant therapies for the treatment of high-risk melanoma patients is critical for the prevention of metastatic disease and improvement of patient survival. Active specific immuno...

    Authors: Franak M. Batliwalla, Barbara A. Bateman, Davide Serrano, Douglas Murray, Stuart Macphail, V. C. Maino, John C. Ansel, Peter K. Gregersen and Cheryl A. Armstrong
    Citation: Molecular Medicine 1998 4:BF03401771
  10. For many malarious regions outside of Africa, development of effective transmission-blocking vaccines will require coverage against both Plasmodium falciparum and P. vivax. Work on P. vivax transmission-blocking ...

    Authors: Takafumi Tsuboi, David C. Kaslow, Mary Margaret G. Gozar, Mayumi Tachibana, Ya-Ming Cao and Motomi Torii
    Citation: Molecular Medicine 1998 4:BF03401770
  11. The band 4.1 domain was first identified in the red blood cell protein band 4.1, and subsequently in ezrin, radixin, and moesin (ERM proteins) and other proteins, including tumor suppressor merlin/schwannomin,...

    Authors: Jean-Antoine Girault, Gilles Labesse, Jean-Paul Mornon and Isabelle Callebaut
    Citation: Molecular Medicine 1998 4:BF03401769
  12. Functional heterogeneity in the tumor necrosis factor α (TNF-α) gene may be responsible for the TNF-α response in infectious and autoimmune diseases. Recently, the TNF-238 promoter polymorphism was observed as be...

    Authors: Eric L. Kaijzel, Michiel V. van Krugten, Brigitta M. N. Brinkman, Tom W. J. Huizinga, Tahar van der Straaten, J. Mieke W. Hazes, H. W. Loems Ziegler-Heitbrock, Sergei A. Nedospasov, Ferdinand C. Breedveld and Cornelis L. Verweij
    Citation: Molecular Medicine 1998 4:BF03401767
  13. The physiopathological maturation of the β-amyloid precursor protein can be modulated by effectors targeting a protein kinase C-dependent pathway. These agents increase the recovery of APPα, the physiological α-s...

    Authors: P. Marambaud, N. Chevallier, K. Ancolio and F. Checler
    Citation: Molecular Medicine 1998 4:BF03401766
  14. Macrophage migration inhibitory factor (MIF) was recently rediscovered as a cytokine, pituitary hormone, and glucocorticoid-induced immunomodulator. MIF is constitutively expressed in various cells and enhance...

    Authors: Norihiko Takahashi, Jun Nishihira, Yuji Sato, Masao Kondo, Hideaki Ogawa, Takahiro Ohshima, Yoshie Une and Satoru Todo
    Citation: Molecular Medicine 1998 4:BF03401765
  15. The cytomegalovirus immediate early (CMV IE) promoter has been widely used for heterologous expression. Further enhancements of gene expression from this potent promoter may allow for the development of improv...

    Authors: Robert D. Simari, Zhi-Yong Yang, Xu Ling, Dominique Stephan, Neil D. Perkins, Gary J. Nabel and Elizabeth G. Nabel
    Citation: Molecular Medicine 1998 4:BF03401764
  16. The Lasp-1 gene, which has been localized to the q12-q21 region of human chromosome 17, is amplified and overexpressed in human breast cancers. In addition to the previously reported LIM and SH3 domains of Lasp-1...

    Authors: Valérie Schreiber, Christel Moog-Lutz, Catherine H. Régnier, Marie-Pierre Chenard, Hélène Boeuf, Jean-Luc Vonesch, Catherine Tomasetto and Marie-Christine Rio
    Citation: Molecular Medicine 1998 4:BF03401929
  17. Allelic association case-control analysis of a deletion/insertion polymorphism in the serotonin transporter-linked polymorphic region (5-HTTLPR) has suggested associations with unipolar disorder, bipolar disor...

    Authors: Lee Naylor, Brian Dean, Avril Pereira, Andrew Mackinnon, Alexander Kouzmenko and David Copolov
    Citation: Molecular Medicine 1998 4:BF03401928
  18. 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol) was used clinically three decades ago as an oral antiparasitic agent and to increase intestinal absorption of zinc in patients with acrodermatitis enteropathica,...

    Authors: Jack L. Arbiser, Stine-Kathrein Kraeft, Robert van Leeuwen, Selwyn J. Hurwitz, Martin Selig, G. R. Dickersin, Alan Flint, H. Randolph Byers and Lan Bo Chen
    Citation: Molecular Medicine 1998 4:BF03401927
  19. Nitric oxide (NO) plays an important role in numerous reproductive processes. To date, most studies have assessed the role of NO by using nonspecific pharmacological inhibitors of the precursor to NO, nitric o...

    Authors: Sabra L. Klein, David Carnovale, Arthur L. Burnett, Edward E. Wallach, Howard A. Zacur, Julie K. Crone, Valina L. Dawson, Randy J. Nelson and Ted M. Dawson
    Citation: Molecular Medicine 1998 4:BF03401926
  20. The macrophage occupies a central role in the host response to invasion, exerting its control over the developing inflammatory response largely through the elaboration of an assortment of endogenous mediators ...

    Authors: Barbara Sherry, Marisol Espinoza, Kirk R. Manogue and Anthony Cerami
    Citation: Molecular Medicine 1998 4:BF03401925
  21. One major barrier to successful xenotransplantation is acute vascular rejection, a process pathologically characterized by microvascular thrombosis and diffuse fibrin deposition in transplant blood vessels. Th...

    Authors: Matthew F. Kalady, Jeffrey H. Lawson, Rachelle D. Sorrell and Jeffrey L. Platt
    Citation: Molecular Medicine 1998 4:BF03401762
  22. Mutations in the mouse formin (Fmn) gene result in limb deformities and incompletely penetrant renal aplasia. A molecular genetic approach was taken to characterize novel circular RNAs from the Fmn gene and to un...

    Authors: Cindy Wang Chao, David C. Chan, Ann Kuo and Philip Leder
    Citation: Molecular Medicine 1998 4:BF03401761
  23. Laminin-5 (ln-5), a large heterotrimeric glycoprotein consisting of an α3, β3, and γ2 chain, is a component of epithelial cell basement membranes that functions as a ligand of the α3βl and α6β4 integrins to regul...

    Authors: Katherine J. Martin, Chi-Pong Kwan, Koichi Nagasaki, Xiaohong Zhang, Michael J. O’Hare, Carolyn M. Kaelin, Robert E. Burgeson, Arthur B. Pardee and Ruth Sager
    Citation: Molecular Medicine 1998 4:BF03401760
  24. Advanced glycation endproducts (AGEs) arise from the spontaneous reaction of reducing sugars with the amino groups of macromolecules. AGEs accumulate in tissue as a consequence of diabetes and aging and have b...

    Authors: Iain D. Nicholl, Alan W. Stitt, Jonathan E. Moore, Andrew J. Ritchie, Desmond B. Archer and Richard Bucala
    Citation: Molecular Medicine 1998 4:BF03401759
  25. In rheumatoid arthritis (RA), B-lineage cells in the synovial membrane secrete large amounts of immunoglobulin that contribute to tissue destruction. The CDR3 of an immunoglobulin light chain is formed by rear...

    Authors: S. Louis Bridges Jr.
    Citation: Molecular Medicine 1998 4:BF03401757
  26. Hereditary argininemia manifests as neurological disturbance and mental retardation, features not observed in other amino acidemias. The cytotoxic effect of a high concentration of L-arginine (L-Arg) was investig...

    Authors: Sachiko Todoroki, Shinji Goto, Yoshishige Urata, Kazuki Komatsu, Koji Sumikawa, Tsutomu Ogura, Ichiro Matsuda and Takahito Kondo
    Citation: Molecular Medicine 1998 4:BF03401756
  27. The 12 kD FK506 binding protein FKBP12 is a cytosolic receptor for the immunosuppressant drugs FK506 and rapamycin. In addition to its critical role in drug-induced T-cell immunosuppression, FKBP12 associates ...

    Authors: Loren D. Walensky, Ted M. Dawson, Joseph P. Steiner, David M. Sabatini, Juan D. Suarez, Gary R. Klinefelter and Solomon H. Snyder
    Citation: Molecular Medicine 1998 4:BF03401755
  28. The non-obese diabetic (NOD) mouse is a model of human type 1 diabetes in which autoreactive T cells mediate destruction of pancreatic islet β cells. Although known to be triggered by cytotoxic T cells, apoptosis...

    Authors: Petra Augstein, Leigh A. Stephens, Janette Allison, Andrew G. Elefanty, Merryn Ekberg, Thomas W. H. Kay and Leonard C. Harrison
    Citation: Molecular Medicine 1998 4:BF03401754
  29. Aside from numerous parenchymal and vascular deposits of amyloid β (Aβ) peptide, neurofibrillary tangles, and neuronal and synaptic loss, the neuropathology of Alzheimer’s disease is accompanied by a subtle and c...

    Authors: Milan Fiala, Ling Zhang, Xiaohu Gan, Barbara Sherry, Dennis Taub, Michael C. Graves, Suzan Hama, Dennis Way, Martin Weinand, Marlys Witte, Diane Lorton, Yu-Min Kuo and Alex E. Roher
    Citation: Molecular Medicine 1998 4:BF03401753
  30. Fanconi anemia (FA) is an autosomal recessive cancer susceptibility syndrome with at least eight complementation groups (A–H). Two of the FA genes (FAA and FAC) have been cloned, and mutations in these genes acco...

    Authors: Michael Pulsipher, Gary M. Kupfer, Dieter Naf, Ahmed Suliman, Jeng-Shin Lee, Petra Jakobs, Markus Grompe, Hans Joenje, Colin Sieff, Eva Guinan, Richard Mulligan and Alan D. D’Andrea
    Citation: Molecular Medicine 1998 4:BF03401752
  31. The receptor (ER) for estrogen (E2) is routinely assayed as a marker to determine the feasibility of anti-hormone therapy against breast cancer because ER-positive (ER+) tumors are much more likely to respond ...

    Authors: Debajit K. Biswas, Lidia Averboukh, Shijie Sheng, Kathy Martin, Darren S. Ewaniuk, Teddy F. Jawde, Feilan Wang and Arthur B. Pardee
    Citation: Molecular Medicine 1998 4:BF03401751
  32. Macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine that also counter-regulates glucocorticoid action. We investigated whether immunoneutralization of MIF could reverse establish...

    Authors: Niansheng Yang, David J. Nikolic-Paterson, Yee-Yung Ng, Wei Mu, Christine Metz, Michael Bacher, Andreas Meinhardt, Richard Bucala, Robert C. Atkins and Hui Y. Lan
    Citation: Molecular Medicine 1998 4:BF03401748
  33. Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes a 442 amino acid polypeptide-desig-nated viral interferon regulatory factor (vIRF) that displays homology to members of the interferon regulatory factor (...

    Authors: C. Clay Flowers, Scarlett P. Flowers and Gary J. Nabel
    Citation: Molecular Medicine 1998 4:BF03401747
  34. Members of the Ets family of winged helix-loop-helix transcription factors play important roles in the development and function of multiple mammalian cell lineages. Elf-1 is an Ets-related transcription factor...

    Authors: Alexander G. Bassuk, Kevin P. Barton, Roshani T. Anandappa, Min M. Lu and Jeffrey M. Leiden
    Citation: Molecular Medicine 1998 4:BF03401746
  35. 3B3 is a high-affinity anti-gp120 antibody that neutralizes a wide range of primary and laboratory isolates of HIV-1. The parental antibody was isolated from a combinatorial phage display library constructed f...

    Authors: Tapan K. Bera, Paul E. Kennedy, Edward A. Berger, Carlos F. Barbas and Ira Pastan
    Citation: Molecular Medicine 1998 4:BF03401745
  36. Curcumin is a small-molecular-weight compound that is isolated from the commonly used spice turmeric. In animal models, curcumin and its derivatives have been shown to inhibit the progression of chemically ind...

    Authors: Jack L. Arbiser, Nancy Klauber, Richard Rohan, Robert van Leeuwen, Mou-Tuan Huang, Carolyn Fisher, Evelyn Flynn and H. Randolph Byers
    Citation: Molecular Medicine 1998 4:BF03401744
  37. Collagen V plays a major regulatory role in the formation of heterotypic fibers of the dermis and cartilaginous tissues as well as in the assembly of extracellular matrix. The pN/pN mouse, which is defective i...

    Authors: Robert G. Phelps, Chihiro Murai, Shinichiro Saito, Akira Hatakeyama, Konstantinos Andrikopoulos, Kuppuswamy N. Kasturi and Constantin A. Bona
    Citation: Molecular Medicine 1998 4:BF03401742
  38. Massive neurofilament conglomeration in motor neurons has been described to occur in the early stages of both familial and sporadic amyotrophic lateral sclerosis (ALS). Previously, neurofilament conglomerates ...

    Authors: Samuel M. Chou, Helen S. Wang, Akira Taniguchi and Richard Bucala
    Citation: Molecular Medicine 1998 4:BF03401739
  39. Phosphoinositolglycan molecules isolated from insulin-sensitive mammalian tissues have been demonstrated in numerous in vitro studies to exert partial insulin-mimetic activity on glucose and lipid metabolism i...

    Authors: Günter Müller, Susanne Wied, Christine Piossek, Andrea Bauer, Jochen Bauer and Wendelin Frick
    Citation: Molecular Medicine 1998 4:BF03401738

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